MAPK and NFkB signaling inhibited by Yersinia YopJ (Homo sapiens)
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Description
This pathway is based on the figure 24.1 of “ In Vitro Signaling by MAPK and NFκB Pathways Inhibited by Yersinia YopJ”(see bibliography). In the MAPK and NFkB pathways, YopJ is the main inhibitor of Raf and TRAF6, NIK, or MEKK1. YopJ, in the NFkB pathway, may inhibit TRAF6,NIK, or MEKK. The pathway is activated by the stimulus of the genes TRAF6, NIK, or MEKK1, or the stimulus on the interactions between Ras to Raf. In the NFkB pathway along with the MAPK pathway, with the use of activators such as kinases, G-proteins, and E3 ligases, are catalysts to initiate of signaling cascades with a concentrated lysate.
Quality Tags
Ontology Terms
Saving...Bibliography
- Mukherjee S, Orth K; ''In vitro signaling by MAPK and NFkappaB pathways inhibited by Yersinia YopJ.''; Methods Enzymol, 2008 PubMed Europe PMC Scholia
History
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External references
DataNodes
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| Name | Type | Database reference | Comment |
|---|---|---|---|
| IKK Complex | GeneProduct | 7288878 (NCBI Protein)  | General Term |
| IkB | GeneProduct | Identifier Not Found | |
| MAPK | GeneProduct | ENSG00000100030 (Ensembl) | MAPK not specified |
| MEKK1 | GeneProduct | 218512139 (NCBI Protein) | |
| MKK | GeneProduct | 1170596 (NCBI Protein) | |
| NFKB | GeneProduct | ENSG00000109320 (Ensembl) | NFKB Not Specified |
| NIK | GeneProduct | 3721838 (NCBI Protein) | |
| Phosphate | Metabolite | HMDB01429 (HMDB) | |
| RAF | GeneProduct | ENSG00000132155 (Ensembl) | |
| Ras | GeneProduct | 190938 (NCBI Protein) | |
| TRAF6 | GeneProduct | ENSG00000175104 (Ensembl) | |
| YopJ | GeneProduct | 844574223 (NCBI Protein) |
Annotated Interactions
No annotated interactions
