Folate-alcohol and cancer pathway (Bos taurus)
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AlexanderPico
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Methionine synthase
Methionine synthase reductase
Folate receptors
Methyltransferases
DNA
NON-COMPETITIVE
INHIBITION
Methylated DNA
NUCLEUS
Cystathionine
SAM
Acetaldehyde
C/EBPB
ALDH1L1
Nucleotide Synthesis
Methionine
CREB1
Homocysteine
ALDH1A1
SAH
ADH5
ALDH1L1
Cysteine
Folate
ALDH1A1
CYP2E1
MTHFR
Ethanol
THF
Acetate
CYP2E1
5,10-Methylene-THF
5-Methyl THF
CBS
Description
No description
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP1589(78797)
with a 90.0% conversion rate.
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Bibliography
No bibliography
History
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Compare
Revision
Action
Time
User
Comment
117516
view
11:06, 21 May 2021
Eweitz
Modified title
105966
view
11:49, 16 August 2019
MaintBot
HMDB identifier normalization
87510
view
01:49, 25 July 2016
AlexanderPico
Ontology Term : 'disease pathway' added !
87509
view
01:49, 25 July 2016
AlexanderPico
Ontology Term : 'cancer pathway' added !
80666
view
15:21, 30 June 2015
Mkutmon
New pathway
External references
DataNodes
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Name
Type
Database reference
Comment
5,10-Methylene-THF
Metabolite
HMDB01533 (HMDB)
5-Methyl THF
Metabolite
CHEBI:15641 (ChEBI)
ADH5
GeneProduct
ENSBTAG00000016007 (Ensembl)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197894
ALDH1A1
GeneProduct
ENSBTAG00000008103 (Ensembl)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:216
ALDH1L1
GeneProduct
ENSBTAG00000014470 (Ensembl)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10840
Acetaldehyde
Metabolite
HMDB00990 (HMDB)
Acetate
Metabolite
CHEBI:30089 (ChEBI)
C/EBPB
GeneProduct
CBS
GeneProduct
ENSBTAG00000000160 (Ensembl)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:875
CREB1
GeneProduct
ENSBTAG00000005474 (Ensembl)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1385
CYP2E1
GeneProduct
ENSBTAG00000018365 (Ensembl)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1571
Cystathionine
Metabolite
HMDB00099 (HMDB)
Cysteine
Metabolite
HMDB00574 (HMDB)
Ethanol
Metabolite
HMDB00108 (HMDB)
Folate
Metabolite
CHEBI:62501 (ChEBI)
Homocysteine
Metabolite
HMDB00742 (HMDB)
MTHFR
GeneProduct
ENSBTAG00000020698 (Ensembl)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4524
Methionine
Metabolite
HMDB00696 (HMDB)
Nucleotide Synthesis
Pathway
WP404 (WikiPathways)
SAH
Metabolite
CHEBI:16680 (ChEBI)
SAM
Metabolite
8041295 (Chemspider)
THF
Metabolite
CHEBI:20506 (ChEBI)
Annotated Interactions
No annotated interactions
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