Glutathione and one-carbon metabolism (Mus musculus)

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vitamin B2vitamin B6Taurine and hypotaurinemetabolismGlycineSerineg-GlutamylCycleglutathione recyclingCyanoaminoacid metabolismGlutamate metabolismGlutathione utilizationAmino acid metabolismCysteine metabolismChdhAMT1.1.1.43GSRCholineBHMTG6PD1.8.4.3L-GlutamateS-adenosylhomocysteineDNMT11.8.4.4BetaineGGTLA1ANPEP2.8.1.3g-L-Glutamyl-L-cysteineMTHFRMTRDNMT3aGGT1Cysteinyl-glycineGPX1ChdhMethionineGPX2DMGGCLCNADP+L-Cysteine5,10-Methylene TetrahydrofolateGlycine1.8.3.33.4.11.41.8.4.2cystathionineKIAA08282.3.2.4GSS5-Methyl TetrahydrofolateL-Amino acid(5-L-Glutamyl)-L-amino acidMAT1ATetrahydrofolateGGTLA12.3.2.4OplahOxidized glutathioneHomocysteineNADPHMAT2B5-OxoprolineIDH11.11.1.121.5.4.1GGT1AHCYGPX4S-AdenosylmethionineGPX3DNMT3bMTRR1.8.4.7betaine aldehydeSHMT2GCLM1.8.5.11.8.4.1SHMT1Glutathione (reduced)111111111111111CBSCTH


Description

This pathway provides a combined view on the one-carbon and glutathione metabolism pathways.

Based on existing pathways:

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Quality Tags

Ontology Terms

 

Bibliography

  1. Hazra A, Wu K, Kraft P, Fuchs CS, Giovannucci EL, Hunter DJ; ''Twenty-four non-synonymous polymorphisms in the one-carbon metabolic pathway and riskof colorectal adenoma in the Nurses' Health Study.''; Carcinogenesis, 2007 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116583view11:08, 8 May 2021EweitzModified title
114034view15:51, 17 December 2020NhungPConnecting lines
109451view10:13, 18 March 2020L DupuisConnected lines
106908view13:38, 17 September 2019MaintBotHMDB identifier normalization
87554view02:12, 25 July 2016AlexanderPicoOntology Term : 'classic metabolic pathway' added !
87553view02:12, 25 July 2016AlexanderPicoOntology Term : 'carbon fixation pathway' added !
87552view02:12, 25 July 2016AlexanderPicoOntology Term : 'glutathione metabolic pathway' added !
85645view17:07, 4 June 2016EgonwFixed the KEGG id.
72143view10:03, 25 October 2013Mkutmonadded datasource to EC numbers
71993view11:25, 24 October 2013MkutmonChanged Unknown -> GeneProduct for all annotated data nodes
71335view17:19, 17 October 2013MaintBotAutomated update of data sources
69210view18:25, 8 July 2013MaintBotUpdated to 2013 gpml schema
41399view00:30, 2 March 2011MaintBotRemoved redundant pathway information and comments
33716view20:04, 7 December 2009MaintBotModified categories
33428view14:54, 30 November 2009MaintBotRemoved group label
31163view11:21, 6 August 2009Lbrennupdate
31162view11:20, 6 August 2009LbrennPeriodical save, work in progress
31161view11:00, 6 August 2009LbrennPeriodical save, work in progress
31160view10:50, 6 August 2009LbrennPeriodical save, work in progress
31159view10:40, 6 August 2009LbrennPeriodical save, work in progress
31120view10:00, 31 July 2009Lbrennupdate
31119view09:55, 31 July 2009LbrennPeriodical save, work in progress
31118view08:35, 31 July 2009LbrennPeriodical save, work in progress
31117view07:09, 31 July 2009Lbrennupdate
31116view07:06, 31 July 2009LbrennPeriodical save, work in progress
30240view10:00, 17 July 2009Thomaschanged ec-number annotation to entrez and connected lines
30219view15:19, 16 July 2009LbrennGSH and one carbon
30218view15:16, 16 July 2009LbrennPeriodical save, work in progress
30217view15:04, 16 July 2009LbrennPeriodical save, work in progress
30216view14:12, 16 July 2009LbrennPeriodical save, work in progress
30215view13:57, 16 July 2009LbrennPeriodical save, work in progress
30188view08:18, 8 July 2009Thomasfixed title
30187view08:17, 8 July 2009ThomasNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(5-L-Glutamyl)-L-amino acidMetaboliteC03740 (KEGG Compound)
1.1.1.43GeneProduct1.1.1.43 (Enzyme Nomenclature)
1.11.1.12GeneProduct1.11.1.12 (Enzyme Nomenclature)
1.5.4.1GeneProduct1.5.4.1 (Enzyme Nomenclature)
1.8.3.3GeneProduct1.8.3.3 (Enzyme Nomenclature)
1.8.4.1GeneProduct1.8.4.1 (Enzyme Nomenclature)
1.8.4.2GeneProduct1.8.4.2 (Enzyme Nomenclature)
1.8.4.3GeneProduct1.8.4.3 (Enzyme Nomenclature)
1.8.4.4GeneProduct1.8.4.4 (Enzyme Nomenclature)
1.8.4.7GeneProduct1.8.4.7 (Enzyme Nomenclature)
1.8.5.1GeneProduct1.8.5.1 (Enzyme Nomenclature)
2.3.2.4GeneProduct2.3.2.4 (Enzyme Nomenclature)
2.8.1.3GeneProduct2.8.1.3 (Enzyme Nomenclature)
3.4.11.4GeneProduct3.4.11.4 (Enzyme Nomenclature)
5,10-Methylene TetrahydrofolateMetabolite25513-46-6 (CAS)
5-Methyl TetrahydrofolateMetabolite134-35-0 (CAS)
5-OxoprolineMetaboliteC01879 (KEGG Compound)
AHCYGeneProduct269378 (Entrez Gene) KEGG Database Methionine metabolism - Homo sapiens (human)
AMTGeneProduct434437 (Entrez Gene) KEGG database: One carbon pool by folate - Homo sapiens (human)
ANPEPGeneProduct16790 (Entrez Gene)
BHMTGeneProduct12116 (Entrez Gene)
BetaineMetabolite107-43-7 (CAS)
CBSGeneProduct12411 (Entrez Gene)
CTHGeneProduct107869 (Entrez Gene)
ChdhGeneProduct218865 (Entrez Gene)
CholineMetabolite
Cysteinyl-glycineMetaboliteC01419 (KEGG Compound)
DMGMetabolite107-43-7 (CAS)
DNMT1GeneProduct13433 (Entrez Gene)
DNMT3aGeneProduct13435 (Entrez Gene) KEGG Database Methionine metabolism - Homo sapiens (human)
DNMT3bGeneProduct13436 (Entrez Gene) KEGG database: Methionine metabolism - Homo sapiens (human)
G6PDGeneProduct14381 (Entrez Gene)
GCLCGeneProduct14629 (Entrez Gene)
GCLMGeneProduct14630 (Entrez Gene)
GGT1GeneProduct14598 (Entrez Gene)
GGTLA1GeneProduct23887 (Entrez Gene)
GPX1GeneProduct14775 (Entrez Gene)
GPX2GeneProduct14776 (Entrez Gene)
GPX3GeneProduct14778 (Entrez Gene)
GPX4GeneProduct625249 (Entrez Gene)
GSRGeneProduct14782 (Entrez Gene)
GSSGeneProduct14854 (Entrez Gene)
Glutathione (reduced)MetaboliteC00051 (KEGG Compound)
GlycineMetaboliteHMDB00123 (HMDB)
HomocysteineMetabolite6027-13-0 (CAS)
IDH1GeneProduct15926 (Entrez Gene)
KIAA0828GeneProduct74340 (Entrez Gene) KEGG Database Methionine metabolism - Homo sapiens (human)
L-Amino acidMetaboliteC00151 (KEGG Compound)
L-CysteineMetaboliteC00097 (KEGG Compound)
L-GlutamateMetaboliteC00025 (KEGG Compound)
MAT1AGeneProduct11720 (Entrez Gene) KEGG Database Methionine metabolism - Homo sapiens (human)
MAT2BGeneProduct108645 (Entrez Gene) KEGG Database Methionine metabolism - Homo sapiens (human)
MTHFRGeneProduct17769 (Entrez Gene)
MTRGeneProduct238505 (Entrez Gene)
MTRRGeneProduct210009 (Entrez Gene)
MethionineMetabolite63-68-3 (CAS)
NADP+MetaboliteHMDB00217 (HMDB)
NADPHMetaboliteHMDB00221 (HMDB)
OplahGeneProduct75475 (Entrez Gene)
Oxidized glutathioneMetaboliteC00127 (KEGG Compound)
S-AdenosylmethionineMetabolite29908-03-0 (CAS)
S-adenosylhomocysteineMetabolite979-92-0 (CAS)
SHMT1GeneProduct20425 (Entrez Gene)
SHMT2GeneProduct108037 (Entrez Gene) KEGG database: One carbon pool by folate - Homo sapiens (human)
TetrahydrofolateMetabolite135-16-0 (CAS)
betaine aldehydeMetabolite
cystathionineMetabolite
g-L-Glutamyl-L-cysteineMetaboliteC00669 (KEGG Compound)

Annotated Interactions

No annotated interactions

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