Non-homologous end joining (Drosophila melanogaster)

From WikiPathways

Revision as of 13:03, 25 July 2016 by Elisa (Talk | contribs)
Jump to: navigation, search
Ligase Vmre11Ku80IrbpLigase VXRCC4DNA-PKcsNbs1 ?IrbpKu80DNA-PKcsDNA-PKcsXLFDNA-PKcsrad50NHEJ1Ku80IrbpIrbpKu80DNA-PKcsIrbpDNA-PKcsKu80XRCC4Ku80IrbpKu80Ku80DNA-PKcsIrbpIrbpKu80Ku80IrbpDNA-PKcsIrbp


Description

(From http://en.wikipedia.org/wiki/Non-homologous_end_joining) Non-homologous end joining (NHEJ) is a pathway that repairs double-strand breaks in DNA. NHEJ is referred to as "non-homologous" because the break ends are directly ligated without the need for a homologous template, in contrast to homologous recombination, which requires a homologous sequence to guide repair. NHEJ is evolutionarily conserved throughout all kingdoms of life and is the predominant double-strand break repair pathway in mammalian cells.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP438(r29612) with a 59% conversion rate.

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
116927view09:45, 16 May 2021EweitzModified title
87936view13:03, 25 July 2016ElisaOntology Term : 'DNA repair pathway' added !
87933view13:03, 25 July 2016ElisaOntology Term : 'regulatory pathway' added !
79375view19:48, 21 March 2015Khanspersupdate schema
79374view19:47, 21 March 2015KhanspersModified title
79373view19:47, 21 March 2015KhanspersReverted to version '00:18, 21 February 2013' by Khanspers
70184view01:40, 13 July 2013AlexanderPicoModified title
68714view21:41, 6 July 2013MaintBotUpdated to 2013 gpml schema
58864view00:18, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
40880view22:34, 1 March 2011MaintBotRemoved redundant pathway information and comments
35400view09:53, 12 February 2010MartijnVanIerselModified description
31811view12:21, 14 August 2009MaintBotFixed group labels
30770view23:17, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
DNA-PKcsGeneProduct
IrbpGeneProductFBgn0011774 (Ensembl)
Ku80GeneProductFBgn0041627 (Ensembl)
Ligase VGeneProduct
NHEJ1GeneProduct
Nbs1 ?GeneProduct
XLFGeneProduct
XRCC4GeneProduct
mre11GeneProductFBgn0020270 (Ensembl)
rad50GeneProductFBgn0034728 (Ensembl)

Annotated Interactions

No annotated interactions
Personal tools