Extracellular vesicle-mediated signaling in recipient cells (Homo sapiens)
From WikiPathways
Description
Protein sorting during formation of multivesicular bodies results in packaging of key molecules in exosomes. Exosomes bound-signaling ligands once released from host cells interacts with the receptors on the recipient cells to induce downstream signaling cascades pivotal in the initiation and progression of cancer. This horizontal transfer of proteomic content of exosomes can mediate signaling pathways including Wnt, PI3K and TGF-beta in recipient cells.
Quality Tags
Ontology Terms
Bibliography
- Gangoda L, Boukouris S, Liem M, Kalra H, Mathivanan S; ''Extracellular vesicles including exosomes are mediators of signal transduction: Are they protective or pathogenic?''; Proteomics, 2014 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
AKT1 | GeneProduct | 207 (Entrez Gene) | |
APC | GeneProduct | 324 (Entrez Gene) | |
AXIN1 | GeneProduct | 8312 (Entrez Gene) | |
CD133 | GeneProduct | 8842 (Entrez Gene) | |
CTNNB1 | GeneProduct | 1499 (Entrez Gene) | |
DKK4 | GeneProduct | 27121 (Entrez Gene) | |
EGFR | GeneProduct | 1956 (Entrez Gene) | |
ERBB2 | GeneProduct | 2064 (Entrez Gene) | |
Frizzled | GeneProduct | ||
HGF | GeneProduct | 3082 (Entrez Gene) | |
HGFR | GeneProduct | 4233 (Entrez Gene) | |
HRAS | GeneProduct | 3265 (Entrez Gene) | |
KRAS | GeneProduct | 3845 (Entrez Gene) | |
MAPK | GeneProduct | ||
MFGE8 | GeneProduct | 4240 (Entrez Gene) | |
MTOR | GeneProduct | 2475 (Entrez Gene) | |
NRAS | Protein | 4893 (Entrez Gene) | |
PI3K | GeneProduct | 23533 (Entrez Gene) | |
RAF1 | GeneProduct | 5894 (Entrez Gene) | |
SMAD2 | GeneProduct | 4087 (Entrez Gene) | |
SMAD3 | GeneProduct | 4088 (Entrez Gene) | |
SMAD4 | GeneProduct | 4089 (Entrez Gene) | |
TGFA | GeneProduct | 7039 (Entrez Gene) | |
TGFB1 | GeneProduct | 7040 (Entrez Gene) | |
TGFB2 | GeneProduct | 7042 (Entrez Gene) | |
TGFB3 | GeneProduct | 7043 (Entrez Gene) | |
TGFBR1 | GeneProduct | 7046 (Entrez Gene) | |
TGFBR2 | Protein | 7048 (Entrez Gene) | |
TGFBR3 | GeneProduct | 7049 (Entrez Gene) | |
TSPAN8 | GeneProduct | 7103 (Entrez Gene) | |
WNT | GeneProduct | ||
WNT3A | GeneProduct | 89780 (Entrez Gene) | |
WNT5A | GeneProduct | 7474 (Entrez Gene) |
Annotated Interactions
No annotated interactions