Interactions between LOXL4 and oxidative stress pathway (Homo sapiens)
From WikiPathways
Description
This pathway Involved in chemo-resistance of cells in bladder cancer begins with LOXL2 activation of CDC37 and COL2A1. COL2A1 activates the complex NRF1/2 and two other complexes that trigger RTK/MAPK and TGFB pathways. These pathways along with oxidative stress promotes NRF1/2 activation of theoxidative stress pathway. This pathway promotes the transcription of NQO1, ECSIT, EXOC6, and SIRT1. SIRT1 then activates SUV39H1. LOXL2 also activates some of these proteins downstream in the pathway (SUV39H1, EXOC6, ECSIT). This pathway has been modeled after figure 7 in Deng et al.
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Ontology Terms
Saving...Bibliography
- Deng H, Lv L, Li Y, Zhang C, Meng F, Pu Y, Xiao J, Qian L, Zhao W, Liu Q, Zhang D, Wang Y, Zhang H, He Y, Zhu J; ''miR-193a-3p regulates the multi-drug resistance of bladder cancer by targeting the LOXL4 gene and the oxidative stress pathway.''; Mol Cancer, 2014 PubMed Europe PMC Scholia
History
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External references
DataNodes
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| Name | Type | Database reference | Comment |
|---|---|---|---|
| ANXA5 | GeneProduct | ENSG00000164111 (Ensembl)  | |
| BMP2 | GeneProduct | ENSG00000125845 (Ensembl) | |
| CDC37 | GeneProduct | ENSG00000105401 (Ensembl) | |
| COL2A1 | GeneProduct | ENSG00000139219 (Ensembl) | |
| DDR1 | GeneProduct | ENSG00000204580 (Ensembl) | |
| ECSIT | GeneProduct | ENSG00000130159 (Ensembl) | |
| EXOC6 | GeneProduct | ENSG00000138190 (Ensembl) | |
| FGF7 | GeneProduct | ENSG00000140285 (Ensembl) | |
| FN1 | GeneProduct | ENSG00000115414 (Ensembl) | |
| IGFBP7 | GeneProduct | ENSG00000163453 (Ensembl) | |
| LOXL4 | GeneProduct | ENSG00000138131 (Ensembl) | |
| NQO1 | GeneProduct | ENSG00000181019 (Ensembl) | |
| NRF1 | GeneProduct | ENSG00000106459 (Ensembl) | |
| NRF2 | GeneProduct | 4780 (NCBI Protein) | |
| Oxidative Stress Pathway | Pathway | WP408 (WikiPathways) | |
| PKD1 | GeneProduct | ENSG00000008710 (Ensembl) | |
| RTK/MAPK Pathway | Pathway | WP382 (WikiPathways) | |
| SIRT1 | GeneProduct | ENSG00000096717 (Ensembl) | |
| SUV39H1 | GeneProduct | ENSG00000101945 (Ensembl) | |
| TGFB Pathway | Pathway | WP560 (WikiPathways) | |
| TGFB1 | GeneProduct | ENSG00000105329 (Ensembl) |
Annotated Interactions
No annotated interactions
