Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling (Mus musculus)
From WikiPathways
Description
The signaling pathway that involves insulin-like growth factor 1 (IGF1), and a variety of other components that affect the pathway, plays an important role in the regulation of skeletal muscle growth. The kinase Akt, or protein kinase B (PKB), is a central component in the pathway and is involved in both muscle synthesis, through mammalian target of rapmycin (mTOR) and glycogen synthase kinase 3B (GSK3B), and muscle degradation, through the transcription factors of the FoxO family. The pathway also involves several feedback loops such as the negative feedback of S6K, phosphorylated by mTORC1, which inhibits IRS, or the positive feedback of mTORC2, which is necessary to maximize the activation of Akt. A variety of other factors and pathways also influence the IGF1-Akt signaling pathway at various points. This pathway is based on figure 1 from Schiaffino et al.
Quality Tags
Ontology Terms
Saving...Bibliography
- Schiaffino S, Mammucari C; ''Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models.''; Skelet Muscle, 2011 PubMed Europe PMC Scholia
History
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External references
DataNodes
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| Name | Type | Database reference | Comment |
|---|---|---|---|
| 4EPB | GeneProduct | ENSMUSG00000028156 (Ensembl)  | EIF4E |
| AKT1 | GeneProduct | ENSMUSG00000001729 (Ensembl) | |
| AMPK | GeneProduct | ENSMUSG00000029513 (Ensembl) | |
| ActRIIB | GeneProduct | ENSMUSG00000061393 (Ensembl) | |
| Actin polymerization & Myofibrillogenesis | Pathway | WP523 (WikiPathways) | |
| EIF2B2 | GeneProduct | ENSMUSG00000004788 (Ensembl) | |
| FoxO | GeneProduct | Q9R1E0 (Uniprot-TrEMBL) | family of transcription factors |
| GSK3B | GeneProduct | ENSMUSG00000022812 (Ensembl) | |
| IGF1 | GeneProduct | ENSMUSG00000020053 (Ensembl) | |
| IGF1rec | GeneProduct | ENSMUSG00000005533 (Ensembl) | |
| ILK | GeneProduct | ENSMUSG00000030890 (Ensembl) | |
| IRS1 | GeneProduct | ENSMUSG00000055980 (Ensembl) | not sure, because also 2, 3, 4 |
| Igfbp5 | GeneProduct | ENSMUSG00000026185 (Ensembl) | most important of grup of IGF binding proteins that inhibit binding of IGF1 to its receptor |
| Integrin B1 | GeneProduct | ENSMUSG00000025809 (Ensembl) | |
| JNK | Protein | Q8BI36 (Uniprot-TrEMBL) | |
| LC3 | GeneProduct | ENSMUSG00000027602 (Ensembl) | |
| MAFbx | GeneProduct | ENSMUSG00000022358 (Ensembl) | FBXO32/atrogin-1 |
| MTOR | GeneProduct | ENSMUSG00000028991 (Ensembl) |
|
| MURF1 | GeneProduct | ENSMUSG00000028834 (Ensembl) | TRIM63 |
| Myostatin | GeneProduct | ENSMUSG00000026100 (Ensembl) | |
| N-WASP | GeneProduct | ENSMUSG00000029684 (Ensembl) | |
| NEB | GeneProduct | ENSMUSG00000026950 (Ensembl) | |
| NFKB1 | GeneProduct | ENSMUSG00000028163 (Ensembl) | |
| PDK1 | GeneProduct | ENSMUSG00000006494 (Ensembl) | |
| PGC1 | GeneProduct | ENSMUSG00000029167 (Ensembl) | |
| PI3K | GeneProduct | ENSMUSG00000020573 (Ensembl) | phosphatidlinositol 3-kinase |
| PLD1 | GeneProduct | ENSMUSG00000027695 (Ensembl) | |
| PTEN | GeneProduct | ENSMUSG00000013663 (Ensembl) | |
| Protein degradation | Pathway | WP519 (WikiPathways) | |
| Protein synthesis | Pathway | ||
| S6K | GeneProduct | ENSMUSG00000020516 (Ensembl) | |
| SMAD2 | GeneProduct | ENSMUSG00000024563 (Ensembl) | |
| SMAD3 | GeneProduct | ENSMUSG00000032402 (Ensembl) | |
| TNFa | GeneProduct | ENSMUSG00000024401 (EcoGene) | |
| TNFa | GeneProduct | ENSMUSG00000024401 (Ensembl) | |
| TNFrec | GeneProduct | ENSMUSG00000030341 (Ensembl) | |
| TWEAK | GeneProduct | ENSMUSG00000035678 (Ensembl) | |
| mTORC1 |
| ||
| mTORC2 |
|
Annotated Interactions
No annotated interactions
