Benzo(a)pyrene metabolism (Bos taurus)

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1-7IsomerisationDNA adductsAutoxidationDNA adducts+ Reactive oxygen species7,8-dihydroxy-7,8-dihydro-benzo[a]pyreneAKR1C47,8-epoxy-benzo[a]pyreneCYP1B1AKR1C1Benzo[a]pyrene-3,6-dioneAKR1C39,10-epoxy-7,8-dihydroxy-7,8-dihydro-benzo[a]pyreneBenzo[a]pyrene-7-sulfateSULTCytochrome P450 peroxidase6-hydroxy-benzo[a]pyreneCYP1A1EPHX1Benzo[a]pyrene-9-glucuronideBenzo[a]pyrene-6,12-dioneCYP3A47-hydroxy-benzo[a]pyreneGlucuronosyltransferaseBenzo[a]pyreneBenzo[a]pyrene radical cationAKR1A1Benzo[a]pyrene-7-glucuronideBenzo[a]pyrene-9-sulfateCYP1A1Benzo[a]pyrene-7,8-dione9-hydroxy-benzo[a]pyreneCYP1B1AKR1C2Benzo[a]pyrene-1,6-dione3-hydroxy-benzo[a]pyrene


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP696(72081) with a 78.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Kisselev P, Schwarz D, Platt KL, Schunck WH, Roots I; ''Epoxidation of benzo[a]pyrene-7,8-dihydrodiol by human CYP1A1 in reconstituted membranes. Effects of charge and nonbilayer phase propensity of the membrane.''; Eur J Biochem, 2002 PubMed Europe PMC Scholia
  2. Boysen G, Hecht SS; ''Analysis of DNA and protein adducts of benzo[a]pyrene in human tissues using structure-specific methods.''; Mutat Res, 2003 PubMed Europe PMC Scholia
  3. Malejka-Giganti D, Ritter CL; ''Peroxidative metabolism of carcinogenic N-arylhydroxamic acids: implications for tumorigenesis.''; Environ Health Perspect, 1994 PubMed Europe PMC Scholia
  4. Jiang H, Gelhaus SL, Mangal D, Harvey RG, Blair IA, Penning TM; ''Metabolism of benzo[a]pyrene in human bronchoalveolar H358 cells using liquid chromatography-mass spectrometry.''; Chem Res Toxicol, 2007 PubMed Europe PMC Scholia
  5. Jin Y, Penning TM; ''Aldo-keto reductases and bioactivation/detoxication.''; Annu Rev Pharmacol Toxicol, 2007 PubMed Europe PMC Scholia
  6. Snyder R, Hedli CC; ''An overview of benzene metabolism.''; Environ Health Perspect, 1996 PubMed Europe PMC Scholia
  7. Luch A; ''Nature and nurture - lessons from chemical carcinogenesis.''; Nat Rev Cancer, 2005 PubMed Europe PMC Scholia

History

CompareRevisionActionTimeUserComment
97778view13:49, 7 June 2018LorasimonsModified description
89452view13:01, 15 September 2016Mkutmonremove space in ontology term id
88166view08:33, 29 July 2016Mkutmonunconnected lines
80906view15:30, 30 June 2015MkutmonNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
3-hydroxy-benzo[a]pyreneMetabolite
6-hydroxy-benzo[a]pyreneMetabolite
7,8-dihydroxy-7,8-dihydro-benzo[a]pyreneMetabolite24123 (Chemspider)
7,8-epoxy-benzo[a]pyreneMetabolite
7-hydroxy-benzo[a]pyreneMetabolite
9,10-epoxy-7,8-dihydroxy-7,8-dihydro-benzo[a]pyreneMetabolite46738 (Chemspider)
9-hydroxy-benzo[a]pyreneMetabolite
AKR1A1GeneProductENSBTAG00000000497 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000117448
AKR1C1GeneProductENSBTAG00000039356 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000187134
AKR1C2GeneProductENSBTAG00000039356 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000151632
AKR1C3GeneProductENSBTAG00000039356 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000196139
AKR1C4GeneProductENSBTAG00000039356 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000198610
Benzo[a]pyreneMetabolite
Benzo[a]pyrene radical cationMetabolite
Benzo[a]pyrene-1,6-dioneMetabolite
Benzo[a]pyrene-3,6-dioneMetabolite
Benzo[a]pyrene-6,12-dioneMetabolite
Benzo[a]pyrene-7,8-dioneMetabolite105020 (PubChem-compound)
Benzo[a]pyrene-7-glucuronideMetabolite
Benzo[a]pyrene-7-sulfateMetabolite
Benzo[a]pyrene-9-glucuronideMetabolite
Benzo[a]pyrene-9-sulfateMetabolite
CYP1A1GeneProductENSBTAG00000001021 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000140465
CYP1B1GeneProductENSBTAG00000010531 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138061
CYP3A4GeneProductENSBTAG00000047379 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160868
Cytochrome P450 peroxidaseGeneProduct
EPHX1GeneProductENSBTAG00000000140 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000143819
GlucuronosyltransferaseGeneProduct
SULTGeneProduct

Annotated Interactions

No annotated interactions
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