Eicosanoid synthesis (Bos taurus)

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1Cell MembraneProstaglandin I2PLA2G2APTGES2Leukotriene B4ALOX12PTGESPNPLA8GSH peroxidaseProstaglandin F2aLeukotriene E4PTGISLeukotriene D412-HETEALOX5APPGD2 11-ketoreducALOX5LTC4SArachidonic acidLTA4HALOX5AP15-HETEPGE2 9-ketoreduc5-HETEDPEP1PGHS-2GSH peroxidaseALOX5Prostaglandin D2Thromboxane A2Prostaglandin H2ALOX15BTBXAS1PeroxidaseThromboxane B2ALOX155-HPETELeukotriene A4PTGS1ALOX15PLA2G6PNPLA3GGT1PTGDSLeukotriene C412-HPETE15-HPETEProstaglandin E215-oxo-prostaglandin I2dehydrogenaseThromboxane A3


Description

In biochemistry, eicosanoids are signaling molecules made by oxidation of twenty-carbon essential fatty acids, (EFAs). They exert complex control over many bodily systems, mainly in inflammation or immunity, and as messengers in the central nervous system. Source: Wikipedia

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP167(79809) with a 79.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Funk CD; ''Prostaglandins and leukotrienes: advances in eicosanoid biology.''; Science, 2001 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117503view11:04, 21 May 2021EweitzModified title
105992view11:52, 16 August 2019MaintBotHMDB identifier normalization
89456view13:09, 15 September 2016Mkutmonremove space in ontology term id
80925view15:31, 30 June 2015Mkutmonhomology conversion
78598view14:51, 7 January 2015MaintBotadded missing graphIds
71397view19:00, 17 October 2013MaintBotAutomated update of data sources
67188view10:18, 26 June 2013Christine ChichesterOntology Term : 'eicosanoid biosynthetic pathway' added !
63319view21:06, 9 May 2013MaintBotUpdated to 2013 gpml schema
62701view23:16, 1 May 2013MaintBotUpdated UniProt data source
40500view19:28, 1 March 2011MaintBotRemoved redundant pathway information and comments
35481view12:15, 12 February 2010Thomasadded literature
35477view12:13, 12 February 2010ThomasModified description
33744view23:56, 8 December 2009MaintBotAutomatic update of empty xrefs
33620view10:02, 1 December 2009MaintBotRemoved group label
30541view21:56, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
12-HETEMetabolite70608-72-9 (CAS)
12-HPETEMetabolite71030-35-8 (CAS)
15-HETEMetabolite70608-72-9 (CAS)
15-HPETEMetabolite70981-96-3 (CAS)
15-oxo-prostaglandin I2Metabolite
5-HETEMetabolite70608-72-9 (CAS)
5-HPETEMetaboliteHMDB01193 (HMDB)
ALOX12GeneProductENSBTAG00000021933 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:239
ALOX15BGeneProductENSBTAG00000008779 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:247
ALOX15GeneProductENSBTAG00000011990 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:246
ALOX5APGeneProductENSBTAG00000013201 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:241
ALOX5GeneProductENSBTAG00000020319 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:240
Arachidonic acidMetaboliteHMDB01043 (HMDB)
DPEP1GeneProductENSBTAG00000033326 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1800
GGT1GeneProductENSBTAG00000046900 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2678
GSH peroxidaseGeneProduct
LTA4HGeneProductENSBTAG00000016415 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4048
LTC4SGeneProductENSBTAG00000009737 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4056
Leukotriene A4MetaboliteHMDB01337 (HMDB)
Leukotriene B4MetaboliteHMDB01085 (HMDB)
Leukotriene C4MetaboliteHMDB01198 (HMDB)
Leukotriene D4MetaboliteHMDB03080 (HMDB)
Leukotriene E4MetaboliteHMDB02200 (HMDB)
PGD2 11-ketoreducGeneProduct
PGE2 9-ketoreducGeneProduct
PGHS-2GeneProductENSBTAG00000014127 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5743
PLA2G2AGeneProductENSBTAG00000005759 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5320
PLA2G6GeneProductENSBTAG00000014015 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8398
PNPLA3GeneProductENSBTAG00000045746 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:PNPLA3
PNPLA8GeneProductENSBTAG00000024387 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:50640
PTGDSGeneProductENSBTAG00000015074 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5730
PTGES2GeneProductENSBTAG00000016218 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:80142
PTGESGeneProductENSBTAG00000019453 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9536
PTGISGeneProductENSBTAG00000017537 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5740
PTGS1GeneProductENSBTAG00000006716 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5742
PeroxidaseGeneProduct
Prostaglandin D2MetaboliteHMDB01403 (HMDB)
Prostaglandin E2Metabolite363-24-6 (CAS)
Prostaglandin F2aMetaboliteHMDB01139 (HMDB)
Prostaglandin H2MetaboliteHMDB01381 (HMDB)
Prostaglandin I2MetaboliteHMDB01335 (HMDB)
TBXAS1GeneProductENSBTAG00000020225 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6916
Thromboxane A2MetaboliteHMDB01452 (HMDB)
Thromboxane A3Metabolite
Thromboxane B2MetaboliteHMDB03252 (HMDB)
dehydrogenaseGeneProduct

Annotated Interactions

No annotated interactions
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