DNA replication (Bos taurus)

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RFC36Cdt1Pre-replicative complexCdt1UbiquitinOrc2Processive complexOrc3Orc3Orc complexMcm6Mcm4Cdc6DNA polymerase alpha:primase: origin complexMcm5Orc3RNA primer-DNA primerOrc3Phosphorylated Cdc6Degraded by proteasome in cytosolRNA primer-DNA primerOrc2Orc4Mcm 4,6,7 trimer forms andassociates with the replication forkMcm6Orc13. DNA replication initiationMcm7Mcm4RFC40RFC37Ubiquitinated Cdc6Degraded byproteasomein cytosolCdc6Mcm7PrimaseCdc6RFC1405. Leading/lagging strand synthesisCdt1Orc5p49RNA primer-DNA primer:origin duplex:PCNAMcm10DNA polymerase alpha:primase: origin complexDNAPolymerase ACdt1Orc5p70Orc complexMcm31. Assembly of the pre-replicative complexCdt1Orc complexMcm5RFC Heteropentamer:RNA primer-DNA primerMcm22. Activation of the pre-replicative complexOrc2UbiquitinUbiquitinated Orc1p180Mcm2RNA PrimerOrc complexPhosphorylated Orc1Mcm10Orc4Mcm3Orc5RFC38Geminin4. Switching of origins to post-replicative stateRFC Heteropentamer:RNA primer-DNA primerPCNA homotrimerPhosphorylation ofMcm 2-7 complexCdc6Orc2p58Pre-replicative complexOrc complexOriginORC1RFC4MCM2RFC5RPA2UTPPOLD2ATPMCM10RFC3ATPADPPCNAPOLE2GMNNdCTPRPA3POLD1PRIM1POLEdUTPCDK2ORC6RFC1CTPORC5LMCM5CDC7L1UBA52RFC2RPA4ATPPOLD3dATPORC4ORC3MCM6MCM4ORC2MCM7dGTPMCM3PRIM2DBF4POLD4GTPADPCDC6CDT1UBCCDC45LATPPOLA1POLA2RPA1


Description

No description

Comments

GenMAPP notes 
http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.reactome.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP466(79981) with a 95.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
129334view09:08, 27 March 2024MkutmonOntology Term : 'DNA replication pathway' added !
128701view17:08, 20 February 2024Khanspersremoved brackets and connected interactions
117497view11:03, 21 May 2021EweitzModified title
107078view14:16, 17 September 2019MaintBotChEBI identifier normalization
96303view18:26, 7 March 2018EgonwReplaced a secondary ChEBI identifier with a primary identifier.
89896view13:12, 6 October 2016MkutmonModified description
89894view13:10, 6 October 2016MkutmonModified description
89892view13:08, 6 October 2016MkutmonReverted to version '15:28, 30 June 2015' by Mkutmon
89890view13:08, 6 October 2016MkutmonModified description
80850view15:28, 30 June 2015Mkutmonhomology conversion
71396view19:00, 17 October 2013MaintBotAutomated update of data sources
67167view10:15, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
63318view21:06, 9 May 2013MaintBotUpdated to 2013 gpml schema
40499view19:28, 1 March 2011MaintBotRemoved redundant pathway information and comments
35220view15:52, 11 February 2010Thomasadded literature
35208view15:43, 11 February 2010ThomasModified description
35206view15:42, 11 February 2010ThomasModified description
33743view23:56, 8 December 2009MaintBotAutomatic update of empty xrefs
33627view10:04, 1 December 2009MaintBotRemoved group label
31638view22:25, 13 August 2009MaintBotFixed text labels
30552view22:00, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADPMetabolite58-64-0 (CAS)
ATPMetabolite1927-31-7 (CAS)
CDC45LGeneProductENSBTAG00000004286 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8318
CDC6GeneProductENSBTAG00000010384 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:990
CDC7L1GeneProductENSBTAG00000016307 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8317
CDK2GeneProductENSBTAG00000004021 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1017
CDT1GeneProductENSBTAG00000000638 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:81620
CTPMetabolite65-47-4 (CAS)
DBF4GeneProductENSBTAG00000014711 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10926
GMNNGeneProductENSBTAG00000017329 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51053
GTPMetabolite2564-35-4 (CAS)
MCM10GeneProductENSBTAG00000016406 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55388
MCM2GeneProductENSBTAG00000014380 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4171
MCM3GeneProductENSBTAG00000010721 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4172
MCM4GeneProductENSBTAG00000017021 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4173
MCM5GeneProductENSBTAG00000015595 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4174
MCM6GeneProductENSBTAG00000015172 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4175
MCM7GeneProductENSBTAG00000030965 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4176
ORC1GeneProductENSBTAG00000002719 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4998
ORC2GeneProductENSBTAG00000031473 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4999
ORC3GeneProductENSBTAG00000016969 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23595
ORC4GeneProductENSBTAG00000015291 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5000
ORC5LGeneProductENSBTAG00000040058 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5001
ORC6GeneProductENSBTAG00000001872 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23594
PCNAGeneProductENSBTAG00000006065 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5111
POLA1GeneProductENSBTAG00000008170 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5422
POLA2GeneProductENSBTAG00000011455 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23649
POLD1GeneProductENSBTAG00000011083 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5424
POLD2GeneProductENSBTAG00000012241 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5425
POLD3GeneProductENSBTAG00000016869 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10714
POLD4GeneProductENSBTAG00000017951 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:57804
POLE2GeneProductENSBTAG00000004931 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5427
POLEGeneProductENSBTAG00000000590 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5426
PRIM1GeneProductENSBTAG00000044000 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5557
PRIM2GeneProductENSBTAG00000007937 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000146143
RFC1GeneProductENSBTAG00000014515 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5981
RFC2GeneProductENSBTAG00000018589 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5982
RFC3GeneProductENSBTAG00000010787 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5983
RFC4GeneProductENSBTAG00000014727 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5984
RFC5GeneProductENSBTAG00000007137 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5985
RPA1GeneProductENSBTAG00000009711 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6117
RPA2GeneProductENSBTAG00000006225 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6118
RPA3GeneProductENSBTAG00000013168 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6119
RPA4GeneProduct
UBA52GeneProductENSBTAG00000007737 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7311
UBCGeneProduct
UTPMetabolite9850 (ChEBI)
dATPMetabolite1927-31-7 (CAS)
dCTPMetabolite2056-98-6 (CAS)
dGTPMetabolite2564-35-4 (CAS)
dUTPMetabolite17625 (ChEBI)

Annotated Interactions

No annotated interactions
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