Tryptophan metabolism (Mus musculus)

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C01144IsophenoxazineBenzoate degradation via hydroxylationXanthurenic3-Hydroxy-L-kynurenine4,6-Dihydroxyquinoline2,3-DihydroxyindoleN-MethylserotoninPhenylAla, Tyr and Trp biosynthesisIndolepyruvate5-HydroxykynurenamineIndole-3-ethanol6-Hydroxykynurenate4,8-DihydroxyquinolineCinnavalininate8-MethoxykynurenateAnthranilateOxaloacetate5-Hydroxyindoleacetaldehyde4-(2-Aminophenyl)-2,4-dioxobutanoate(Z)-5-Oxohex-2-enedioateC005273-Methyldioxyindole5-(3'-Carboxy-3'-oxopropyl) -4,6-dihydroxypicolinate5-(2'-Carboxyethyl)-4,6-dihydroxypicolinate6-Hydroxyindolelactate7,8-Dihydro-7,8-dihydroxykynurenate2-Formylaminobenzaldehyde4-(2-Amino-5-hydroxyphenyl)-2,4-dioxobutanoateN-Methyltryptamine3-HydroxykynurenamineC008773-(2-Aminoethyl)-1H-indol-5-olFormylanthranilate5-Hydroxy-N-formylkynurenine5-Hydroxy-L-tryptophanQuinolinateFormyl-5-hydroxykynurenamine5-(2'-Formylethyl)-4,6-dihydroxypicolinate2-AminomuconateL-Tryptophanyl-tRNA5-(3'-Carboxy-3'-oxopropenyl)-4,6-dihydroxypicolinGlucobrassicinIndolelactateIndole-3-acetaldoximeC003323-Indoleglycolaldehyde2-AminomuconateNicotinate and nicotinamide metabolism2-Amino-3-carboxymuconate5-Hydroxyindolepyruvate4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate2-Oxoglutarate2-Formaminobenzoylacetate3-HydroxyanthranilateKynurenate5-Hydroxyindoleacetate3-Methylindolepyruvate5-Hydroxyindoleacetylglycine3-MethoxyanthranilateIndole-3-acetate2-OxoadipateN-AcetylindoxylIndole-3-acetaldehydeGlycolysis / GluconeogenesisFormyl-N-acetyl-5-methoxykynurenamineAnthranilate7,8-Dihydroxykynurenate5-MethoxyindoleacetateBenzoate degradation via hydroxylationMelatoninAanatKynu5-HydroxykynurenineCyp2b151.14.99.2ASMTAfmid3.5.1.9Abp11.2.3.7KynuUbe3a1.14.16.36-Hydroxymelatonin1.13.12.3L-Tryptophan3.2.1.147AadatIndole-3-acetamideCyp2a2Cyp2c125-MethoxytryptamineL-Kynurenine1.1.1.1903.5.5.1Tryptamine4.1.99.13.5.1.494.2.1.84Acetyl-CoAPrmt1Aldh9a1HaaoAldh3a2Ubr51.13.11.23Aldh1a11.5.1.-1.10.3.4Gcdh1.13.11.-ASMTCYP2A13CatTdo2Rnf251.1.1.191Ido13.5.99.5Cyp1a1MaobMdm21.13.11.172.1.1.47Aldh1a42.6.1.27Aldh1a21.14.16.-KynuDdcCyp2j63.5.1.4N-AcetylserotoninHsd17b10Cyp4f141.3.1.181.4.3.2FormylkynurenineMaobPrmt12.1.1.49Dhcr24GcdhInmt2-AminophenolCYP3A41.13.11.10MaobMdm2OgdhAldh3a2Aldh1a2IndoleAldh1a4Cyp2f24.1.1.431.14.13.9Cyp2e11.1.1.110Acmsd1.2.1.-Cyp2c55Aldh1a1Ido1Mdm24.1.1.-HadhMaobTph1Aldh9a1WarsN-AcetylisatinIdo1Cyp7b1Ube3aDdcCyp2a1Aldh21.13.99.3Cyp19a1Cyp1b12.6.1.27Rnf25Acat1Echs12.6.1.27Ddc3-IndoleacetonitrilePrmt1Cyp1a21.2.1.32Aox1Aadat1.7.3.2Cyp2d2Aldh2


Description

No description

Comments

GenMAPP notes 
Converted from rat to human using ortholog information. Link to original KEGG map: http://www.genome.ad.jp/dbget-bin/show pathway?rno00380
GenMAPP remarks 
Edited by Sebastien Burel
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP465(r30270) with a 57% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
128037view18:00, 21 January 2024EweitzUpgrade label to identified pathway, fix some truncated labels
104913view19:21, 24 June 2019KhanspersModified description
104912view19:21, 24 June 2019Khanspersremoved genmapp comments
104819view12:55, 19 June 2019FehrhartModified description
91016view07:21, 21 December 2016EgonwOne more ChemSpider ID update.
91009view00:38, 21 December 2016AlexanderPicoupdated deprecated chemspider id
91008view17:51, 20 December 2016AlexanderPicoupdated deprecated chemspider id
79761view07:02, 10 April 2015EgonwReplaced an incorrectly KEGG Compound formatted identifier with a ChEBI identifier.
76163view15:21, 13 June 2014EgonwAdded a few missing metabolite identifiers.
73389view16:57, 25 January 2014EgonwAdded a bunch of missing metabolite identifiers.
73231view20:11, 12 January 2014EgonwAdded a bunch of missing metabolite identifiers.
72319view07:39, 3 November 2013EgonwAdded a few metabolite identifiers.
71752view20:20, 17 October 2013MaintBotAutomated update of data sources
71178view14:19, 11 October 2013EgonwAdded metabolite identifiers.
70995view15:19, 22 September 2013EgonwAdded ChemSpider and ChEBI identifiers for metabolites.
69193view18:23, 8 July 2013MaintBotUpdated to 2013 gpml schema
67726view11:55, 26 June 2013DdiglesOntology Term : 'tryptophan metabolic pathway' added !
54741view13:17, 8 December 2012EgonwReplaced multiple general nodes by Metabolite DataNode's.
47759view05:02, 6 April 2012Khanspersupdated xrefs
47756view04:53, 6 April 2012Khanspersupdated xrefs
41384view00:29, 2 March 2011MaintBotRemoved redundant pathway information and comments
34424view23:19, 9 December 2009MaintBotAutomatic update of empty xrefs
33468view15:04, 30 November 2009MaintBotRemoved group label
31518view21:39, 13 August 2009MaintBotFixed text labels
30850view00:07, 30 July 2009MaintBotConverted from Homo sapiens
20845view11:30, 14 November 2008MaintBot[[Pathway:Mus musculus:Tryptophane Metabolism KEGG]] moved to [[Pathway:WP79]]: Moved to stable identifier
8466view13:46, 7 January 2008MaintBot[[Pathway:Mouse:Tryptophane Metabolism KEGG]] moved to [[Pathway:Mus musculus:Tryptophane Metabolism KEGG]]: Renaming species
7849view16:23, 18 December 2007MaintBotfixed category names
7408view12:42, 4 November 2007MaintBotAdded categories to GPML
6506view22:19, 22 May 2007L.M.Ferrantegpml file for [[Mouse:Tryptophane_Metabolism_KEGG]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(Z)-5-Oxohex-2-enedioateMetaboliteCHEBI:16967 (ChEBI) (Z)-5-Oxohex-2-enedioate
1.1.1.110GeneProduct
1.1.1.190GeneProduct
1.1.1.191GeneProduct
1.10.3.4GeneProduct
1.13.11.-GeneProduct
1.13.11.10GeneProduct
1.13.11.17GeneProduct
1.13.11.23GeneProduct
1.13.12.3GeneProduct
1.13.99.3GeneProduct
1.14.13.9GeneProduct
1.14.16.-GeneProduct
1.14.16.3GeneProduct
1.14.99.2GeneProduct
1.2.1.-GeneProduct
1.2.1.32GeneProduct
1.2.3.7GeneProduct
1.3.1.18GeneProduct
1.4.3.2GeneProduct
1.5.1.-GeneProduct
1.7.3.2GeneProduct
2,3-DihydroxyindoleMetaboliteCHEBI:17828 (ChEBI)
2-Amino-3-carboxymuconateMetabolite2-Amino-3-carboxymuconate
2-AminomuconateMetabolite27 (Chemspider) 2-Aminomuconate
2-AminophenolMetaboliteCHEBI:18112 (ChEBI) 2-Aminophenol
2-Formamino benzoylacetateMetabolite2-Formaminobenzoylacetate
2-FormylaminobenzaldehydeMetaboliteCHEBI:18033 (ChEBI)
2-OxoadipateMetabolite70 (Chemspider) 2-Oxoadipate
2-OxoglutarateMetaboliteCHEBI:30916 (ChEBI) 2-Oxoglutarate
2.1.1.47GeneProduct
2.1.1.49GeneProduct
2.6.1.27GeneProduct
3-(2-Aminoethyl) -1H-indol-5-olMetabolite5202 (PubChem-compound) 3-(2-Aminoethyl)-1H-indol-5-ol
3-Hydroxy- L-kynurenineMetaboliteCHEBI:17380 (ChEBI) 3-Hydroxy-L-kynurenine
3-HydroxyanthranilateMetabolite7822291 (Chemspider) 3-Hydroxyanthranilate
3-HydroxykynurenamineMetabolite144400 (Chemspider) 3-Hydroxykynurenamine
3-IndoleacetonitrileMetaboliteCHEBI:17566 (ChEBI) 3-Indoleacetonitrile
3-IndoleglycolaldehydeMetaboliteCHEBI:15976 (ChEBI)
3-MethoxyanthranilateMetaboliteCHEBI:20109 (ChEBI) 3-Methoxyanthranilate
3-MethyldioxyindoleMetaboliteCHEBI:28254 (ChEBI)
3-MethylindolepyruvateMetabolite440740 (PubChem-compound) 3-Methylindolepyruvate
3.2.1.147GeneProduct
3.5.1.4GeneProduct
3.5.1.49GeneProduct
3.5.1.9GeneProduct
3.5.5.1GeneProduct
3.5.99.5GeneProduct
4,6-DihydroxyquinolineMetabolite389609 (Chemspider) 4,6-Dihydroxyquinoline
4,8-DihydroxyquinolineMetaboliteCHEBI:28883 (ChEBI) 4,8-Dihydroxyquinoline
4-(2-Amino-3-hydroxyphenyl) -2,4-dioxobutanoateMetabolite4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
4-(2-Amino-5-hydroxyphenyl) -2,4-dioxobutanoateMetabolite20016012 (Chemspider) 4-(2-Amino-5-hydroxyphenyl)-2,4-dioxobutanoate
4-(2-Aminophenyl)-2,4-dioxobutanoateMetaboliteCHEBI:58147 (ChEBI) 4-(2-Aminophenyl)-2,4-dioxobutanoate
4.1.1.-GeneProduct
4.1.1.43GeneProduct
4.1.99.1GeneProduct
4.2.1.84GeneProduct
5-(2'-Carboxyethyl)-4,6-dihydroxypicolinateMetabolite389619 (Chemspider) 5-(2'-Carboxyethyl)-4,6-dihydroxypicolinate
5-(2'-Formylethyl)-4,6-dihydroxypicolinateMetabolite389618 (Chemspider) 5-(2'-Formylethyl)-4,6-dihydroxypicolinate
5-(3'-Carboxy-3'-oxopropenyl)-4,6-dihydroxypicolinMetabolite5-(3'-Carboxy-3'-oxopropenyl)-4,6-dihydroxypicolinate
5-(3'-Carboxy-3'-oxopropyl) -4,6-dihydroxypicolinateMetabolite389620 (Chemspider) 5-(3'-Carboxy-3'-oxopropyl)-4,6-dihydroxypicolinate
5-Hydroxy- L-tryptophanMetaboliteCHEBI:17780 (ChEBI) 5-Hydroxy-L-tryptophan
5-Hydroxy-N-formylkynurenineMetabolite389615 (Chemspider) 5-Hydroxy-N-formylkynurenine
5-HydroxyindoleacetaldehydeMetabolite74688 (PubChem-compound) 5-Hydroxyindoleacetaldehyde
5-HydroxyindoleacetateMetabolite1826 (PubChem-compound) 5-Hydroxyindoleacetate
5-HydroxyindoleacetylglycineMetabolite440806 (PubChem-compound)
5-HydroxyindolepyruvateMetabolite389613 (Chemspider)
5-HydroxykynurenamineMetabolite144400 (Chemspider) 5-Hydroxykynurenamine
5-HydroxykynurenineMetabolite389616 (Chemspider)
5-MethoxyindoleacetateMetabolite18986 (PubChem-compound) 5-Methoxyindoleacetate
5-MethoxytryptamineMetaboliteCHEBI:2089 (ChEBI)
6-HydroxyindolelactateMetaboliteCHEBI:27524 (ChEBI) 6-Hydroxyindolelactate
6-HydroxykynurenateMetabolite389622 (Chemspider) 6-Hydroxykynurenate
6-HydroxymelatoninMetabolite1864 (PubChem-compound)
7,8-Dihydro-7,8-dihydroxykynurenateMetabolite388563 (Chemspider) 7,8-Dihydro-7,8-dihydroxykynurenate
7,8-DihydroxykynurenateMetaboliteCHEBI:58171 (ChEBI) 7,8-Dihydroxykynurenate
8-MethoxykynurenateMetaboliteCHEBI:20109 (ChEBI) 8-Methoxykynurenate
ASMTGeneProduct107626 (Entrez Gene)
AadatGeneProduct23923 (Entrez Gene)
AanatGeneProduct11298 (Entrez Gene)
Abp1GeneProduct76507 (Entrez Gene)
Acat1GeneProduct110446 (Entrez Gene)
Acetyl-CoAMetaboliteCHEBI:15351 (ChEBI) Acetyl-CoA
AcmsdGeneProduct266645 (Entrez Gene)
AfmidGeneProduct71562 (Entrez Gene)
Aldh1a1GeneProduct11668 (Entrez Gene)
Aldh1a2GeneProduct19378 (Entrez Gene)
Aldh1a4GeneProduct
Aldh2GeneProduct11669 (Entrez Gene)
Aldh3a2GeneProduct11671 (Entrez Gene)
Aldh9a1GeneProduct56752 (Entrez Gene)
AnthranilateMetaboliteCHEBI:16567 (ChEBI) Anthranilate
Aox1GeneProduct11761 (Entrez Gene)
C00332MetaboliteC00332 (KEGG Compound) Acetoacetyl-CoA
C00527MetaboliteC00527 (KEGG Compound) Glutaryl-CoA
C00877MetaboliteC00877 (KEGG Compound) Crotonoyl-CoA
C01144MetaboliteC01144 (KEGG Compound) (S)-3-Hydroxybutanoyl-CoA
CYP2A13GeneProduct
CYP3A4GeneProduct
CatGeneProduct12359 (Entrez Gene)
CinnavalininateMetabolite102864 (Chemspider) Cinnavalininate
Cyp19a1GeneProduct13075 (Entrez Gene)
Cyp1a1GeneProduct13076 (Entrez Gene)
Cyp1a2GeneProduct13077 (Entrez Gene)
Cyp1b1GeneProduct13078 (Entrez Gene)
Cyp2a1GeneProduct
Cyp2a2GeneProduct
Cyp2b15GeneProduct
Cyp2c12GeneProduct
Cyp2c55GeneProduct72082 (Entrez Gene)
Cyp2d2GeneProduct
Cyp2e1GeneProduct13106 (Entrez Gene)
Cyp2f2GeneProduct13107 (Entrez Gene)
Cyp2j6GeneProduct13110 (Entrez Gene)
Cyp4f14GeneProduct64385 (Entrez Gene)
Cyp7b1GeneProduct13123 (Entrez Gene)
DdcGeneProduct13195 (Entrez Gene)
Dhcr24GeneProduct74754 (Entrez Gene) predicted
Echs1GeneProduct93747 (Entrez Gene)
Formyl-5-hydroxykynurenamineMetabolite440743 (PubChem-compound)
Formyl-N-acetyl-5- methoxykynurenamineMetabolite171161 (PubChem-compound) Formyl-N-acetyl-5-methoxykynurenamine
FormylanthranilateMetaboliteCHEBI:18410 (ChEBI) Formylanthranilate
FormylkynurenineMetaboliteCHEBI:30249 (ChEBI) Formylkynurenine
GcdhGeneProduct270076 (Entrez Gene) predicted
GlucobrassicinMetaboliteCHEBI:29028 (ChEBI) Glucobrassicin
HaaoGeneProduct107766 (Entrez Gene)
HadhGeneProduct15107 (Entrez Gene)
Hsd17b10GeneProduct15108 (Entrez Gene)
Ido1GeneProduct15930 (Entrez Gene)
Indole-3-acetaldehydeMetaboliteCHEBI:18086 (ChEBI) Indole-3-acetaldehyde
Indole-3-acetaldoximeMetaboliteCHEBI:28311 (ChEBI) Indole-3-acetaldoxime
Indole-3-acetamideMetaboliteCHEBI:16031 (ChEBI) Indole-3-acetamide
Indole-3-acetateMetabolite780 (Chemspider) Indole-3-acetate
Indole-3-ethanolMetabolite10685 (PubChem-compound)
IndoleMetabolite798 (PubChem-compound)
IndolelactateMetabolite92904 (PubChem-compound) Indolelactate
IndolepyruvateMetabolite803 (PubChem-compound) Indolepyruvate
InmtGeneProduct21743 (Entrez Gene)
IsophenoxazineMetabolite65565 (Chemspider) Isophenoxazine
KynuGeneProduct70789 (Entrez Gene)
KynurenateMetaboliteCHEBI:18344 (ChEBI) 4-Hydroxy-2-quinolinecarboxylic
L-KynurenineMetaboliteCHEBI:16946 (ChEBI) L-Kynurenine
L-TryptophanMetabolite6305 (PubChem-compound)
L-Tryptophanyl-tRNAUnknown
MaobGeneProduct109731 (Entrez Gene)
Mdm2GeneProduct17246 (Entrez Gene)
MelatoninMetabolite896 (PubChem-compound)
N-AcetylindoxylMetaboliteCHEBI:15363 (ChEBI) N-Acetylindoxyl
N-AcetylisatinMetaboliteCHEBI:16050 (ChEBI) N-Acetylisatin
N-AcetylserotoninMetaboliteCHEBI:17697 (ChEBI) N-Acetylserotonin
N-MethylserotoninMetabolite150885 (PubChem-compound) N-Methylserotonin
N-MethyltryptamineMetaboliteCHEBI:28136 (ChEBI) N-Methyltryptamine
OgdhGeneProduct18293 (Entrez Gene)
OxaloacetateMetaboliteCHEBI:16452 (ChEBI) Oxaloacetate
Prmt1GeneProduct15469 (Entrez Gene)
QuinolinateMetabolite2777129 (Chemspider)
Rnf25GeneProduct57751 (Entrez Gene)
Tdo2GeneProduct56720 (Entrez Gene)
Tph1GeneProduct21990 (Entrez Gene)
TryptamineMetaboliteCHEBI:16765 (ChEBI)
Ube3aGeneProduct22215 (Entrez Gene)
Ubr5GeneProduct70790 (Entrez Gene)
WarsGeneProduct22375 (Entrez Gene)
XanthurenicMetabolite5497 (Chemspider) Xanthurenic

Annotated Interactions

No annotated interactions
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