Mevalonate pathway (Homo sapiens)

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11Hypodermal cellIntestinal cellGolgiNeuronGut granules1Intestinal lumenPseudocoelomCUC-1CuCuCuIntestinal cellHypodermal cellIntestinal cellCUA-1.11CuCuUnknown copper importerLow dietary Cu++CuCUA-1.11CUA-1.21CUA-1.11CuCuCUA-1.11CuCUA-1.21Cu1


Description

test

Comments

 
"Figure 7. Cu homeostasis in worms is maintained by distinctly localized intestinal CUA-1 isoforms.

(A) Confocal images of transgenic animals [Pvha-6::CUA-1.2::GFP::unc-54 3’UTR] expressing CUA-
1.2::GFP in the intestine in the presence of 50 μM of supplemental Cu or BCS. Scale bar, 10 μm. (B) A
model of Cu homeostasis in C. elegans is shown. Dietary Cu ions are transported from the lumen of the
intestine to the enterocytes by an unidentified Cu importer, and CUC-1 delivers Cu to CUA-1. Under
basal Cu or Cu-deficient conditions, CUA-1.1 isoform localizes to the basolateral membrane and Golgi to
either export Cu ions to peripheral tissues, or to direct Cu into the secretory pathway. CUA-1.2
consistently localizes to the basolateral membrane of enterocytes regardless of Cu conditions. CUA-1.1 is
redistributed to the gut-granule membranes in response to elevated Cu levels in order to promote Cu
detoxification in C. elegans."

 
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Bibliography

  1. Mullen PJ, Yu R, Longo J, Archer MC, Penn LZ; ''the interplay between cell signalling and the mevalonate pathway in cancer''; ,

History

View all...
CompareRevisionActionTimeUserComment
107557view00:00, 20 October 2019AlexanderPicoModified description
106770view13:25, 17 September 2019MaintBotHMDB identifier normalization
103308view00:19, 22 February 2019AlexanderPicostandard node sizes and less empty space
97112view22:53, 29 April 2018AlexanderPicoReverted to version '01:07, 1 April 2018' by AlexanderPico
97111view22:20, 29 April 2018WpblockedModified title
96733view08:07, 1 April 2018EgonwReplaced another secondary ChEBI identifier with a primary identifier.
96717view13:52, 30 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
94743view15:10, 5 October 2017Mkutmonfix unconnected line
91920view04:43, 6 April 2017KhanspersOntology Term : 'isoprenoid metabolic pathway' added !
91361view14:13, 10 February 2017JacobwindsorNew pathway
91351view21:29, 6 February 2017KhanspersNew pathway

External references

DataNodes

NameTypeDatabase referenceComment
CUA-1.1GeneProductY76A2A.2 (WormBase)
CUA-1.2GeneProductY76A2A.2 (WormBase) "CUA-1.2 consistently localizes to the basolateral membrane of enterocytes regardless of Cu conditions. "
CUC-1GeneProductZK652.11 (WormBase)
CuMetaboliteCHEBI:37404 (ChEBI)
Low dietary Cu++MetaboliteCHEBI:37404 (ChEBI)

Annotated Interactions

SourceTargetTypeDatabase referenceComment
ArrowWP:CE26305 (WormBase) "CUA-1.1 is redistributed to the gut-granule membranes in response to elevated Cu levels in order to promote Cu detoxification in C. elegans."
CUA-1.2ArrowWP:CE19271 (WormBase) "CUA-1.2 consistently localizes to the basolateral membrane of enterocytes regardless of Cu conditions." Evidence: "Confocal images of transgenic animals [Pvha-6::CUA-1.2::GFP::unc-54 3’UTR] expressing CUA-1.2::GFP in the intestine in the presence of 50 μM of supplemental Cu or BCS."
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