miR-509-3p alteration of YAP1/ECM axis (Homo sapiens)

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1Direct target, experimentally validatedPredicted target, qPCR supportIndirect target, qPCR supportmir-509-3p interactionsConnectorssignal transducersECMReceptorsStromal cellsCytoskeletonBCAR1EDNRAFN1SPARCTHBS2GPC6COL1A1COL3A1COL5A1PBX3TWIST1SNAI2YAP1MIR509-3YAP1Tumor cellsExtracellular matrix glycoproteins, proteoclycans, collagens,Extracellular matrix-affiliated, secreted factors, ECM regulatorsExtracellular matrix ligandsTEAD1TEAD2TEAD3TEAD4CollagensProteoglycansGlycoproteins


Description

Summary of findings for miR-509-3p and the YAP1/ECM axis. Reference: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041955/ Collectively, the results suggest that miR-509-3p-mediated changes in levels of YAP1 and ECM genes impair migration, invasion, and spheroid formation and so may attenuate metastatic progression in advanced stage ovarian cancer. Further, results suggest that the direct downstream miR-509-3p target YAP1 is likely a critical driver of cellular migration and spheroid formation in ovarian cancers in which levels of YAP1 protein are high.

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Bibliography

  1. Pan Y, Robertson G, Pedersen L, Lim E, Hernandez-Herrera A, Rowat AC, Patil SL, Chan CK, Wen Y, Zhang X, Basu-Roy U, Mansukhani A, Chu A, Sipahimalani P, Bowlby R, Brooks D, Thiessen N, Coarfa C, Ma Y, Moore RA, Schein JE, Mungall AJ, Liu J, Pecot CV, Sood AK, Jones SJ, Marra MA, Gunaratne PH; ''miR-509-3p is clinically significant and strongly attenuates cellular migration and multi-cellular spheroids in ovarian cancer.''; Oncotarget, 2016 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
108139view10:33, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
105859view23:19, 15 August 2019KhanspersModified description
94301view05:15, 1 September 2017Khanspersclarified interactions
91491view21:33, 6 March 2017KhanspersModified title
91485view21:28, 6 March 2017Khanspersupdated legend
91483view20:46, 6 March 2017KhanspersOntology Term : 'Hippo signaling pathway' added !
91482view20:45, 6 March 2017KhanspersOntology Term : 'ovarian cancer' added !
91481view20:45, 6 March 2017KhanspersModified description
91480view20:44, 6 March 2017KhanspersOntology Term : 'cancer' added !
91479view20:44, 6 March 2017KhanspersModified description
91478view20:37, 6 March 2017KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
BCAR1GeneProductENSG00000050820 (Ensembl)
COL1A1GeneProductENSG00000108821 (Ensembl)
COL3A1GeneProductENSG00000168542 (Ensembl)
COL5A1GeneProductENSG00000130635 (Ensembl)
EDNRAGeneProductENSG00000151617 (Ensembl)
FN1GeneProductENSG00000115414 (Ensembl)
GPC6GeneProductENSG00000183098 (Ensembl)
MIR509-3GeneProductMIR509-3 (HGNC)
PBX3GeneProductENSG00000167081 (Ensembl)
SNAI2GeneProductENSG00000019549 (Ensembl)
SPARCGeneProductENSG00000113140 (Ensembl)
TEAD1GeneProductENSG00000187079 (Ensembl)
TEAD2GeneProductENSG00000074219 (Ensembl)
TEAD3GeneProductENSG00000007866 (Ensembl)
TEAD4GeneProductENSG00000197905 (Ensembl)
THBS2GeneProductENSG00000186340 (Ensembl)
TWIST1GeneProductENSG00000122691 (Ensembl)
YAP1GeneProductENSG00000137693 (Ensembl)

Annotated Interactions

No annotated interactions

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