Oxidative stress response (Danio rerio)
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Eweitz
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TF inhibition
Activation
Stress-regulated MAP kinase
Induction of
antioxidant genes
Repression of ROS-
producing systems
TF activation
Immediate-early
gene induction
Reactive Oxygen Species
Adaptive response
Inhibition of oxidases
Repression
sp1
gclc
nqo1
hmox1
sod2
LOC555669
zgc:110010
mapk10
Nrf2
txn2
GPX1a
MT1X
MGST1
si:dkey-117m1.6
NFKB1
MAOA
mapk14a
TXNRD1
JUNB
sod1
cat
UGT1A6
GPX3
cyba
xdh
fos
GSTT1b
cyp1a
TXNRD2
GPX1b
GSTT1a
Description
No description
Comments
GenMAPP notes
Adapted from Biochem J 1999 Sep 15;342 Pt 3:481-96 Morel Y, Barouki R. Repression of gene expression by oxidative stress. Biochem J 1999 Sep 15;342 Pt 3:481-96
GenMAPP remarks
Adapted from rat by GenMAPP.org
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP408(r21540)
with a 58% conversion rate.
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Bibliography
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History
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Revision
Action
Time
User
Comment
116901
view
11:31, 15 May 2021
Eweitz
Modified title
91955
view
13:58, 6 April 2017
LWackers
Updated annotations. Split GSTT2 into its zebrafish orthologues.
88284
view
14:42, 1 August 2016
Fehrhart
Ontology Term : 'oxidative stress response pathway' added !
71514
view
19:22, 17 October 2013
MaintBot
Automated update of data sources
68644
view
04:58, 6 July 2013
MaintBot
Updated to 2013 gpml schema
40812
view
22:17, 1 March 2011
MaintBot
Removed redundant pathway information and comments
34200
view
21:28, 9 December 2009
MaintBot
Automatic update of empty xrefs
32338
view
13:32, 15 August 2009
MaintBot
Fixed text labels
31951
view
13:01, 14 August 2009
MaintBot
Fixed group labels
31382
view
20:41, 13 August 2009
MaintBot
Fixed text labels
31084
view
01:34, 30 July 2009
MaintBot
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
GPX1a
GeneProduct
ENSDARG00000018146 (Ensembl)
GPX1b
GeneProduct
NM_001004634 (RefSeq)
GPX3
GeneProduct
798788 (Entrez Gene)
GSTT1a
GeneProduct
ENSDARG00000042428 (Ensembl)
GSTT1b
GeneProduct
ENSDARG00000017388 (Ensembl)
JUNB
GeneProduct
407086 (Entrez Gene)
LOC555669
GeneProduct
555669 (Entrez Gene)
MAOA
GeneProduct
ENSDARG00000023712 (Ensembl)
MGST1
GeneProduct
449784 (Entrez Gene)
MT1X
GeneProduct
NFKB1
GeneProduct
565756 (Entrez Gene)
Nrf2
GeneProduct
TXNRD1
GeneProduct
352924 (Entrez Gene)
TXNRD2
GeneProduct
ENSDARG00000075923 (Ensembl)
UGT1A6
GeneProduct
cat
GeneProduct
30068 (Entrez Gene)
cyba
GeneProduct
393551 (Entrez Gene)
Probe set ID: u18729
cyp1a
GeneProduct
140634 (Entrez Gene)
fos
GeneProduct
394198 (Entrez Gene)
gclc
GeneProduct
326857 (Entrez Gene)
hmox1
GeneProduct
791518 (Entrez Gene)
mapk10
GeneProduct
569698 (Entrez Gene)
mapk14a
GeneProduct
65237 (Entrez Gene)
nqo1
GeneProduct
322506 (Entrez Gene)
si:dkey-117m1.6
GeneProduct
794006 (Entrez Gene)
sod1
GeneProduct
30553 (Entrez Gene)
sod2
GeneProduct
335799 (Entrez Gene)
sp1
GeneProduct
324109 (Entrez Gene)
txn2
GeneProduct
402938 (Entrez Gene)
xdh
GeneProduct
560486 (Entrez Gene)
zgc:110010
GeneProduct
553575 (Entrez Gene)
Annotated Interactions
No annotated interactions
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