miR-127 in mesendoderm differentiation (Mus musculus)
From WikiPathways
Description
Schematic representation depicts the mechanism of miR-127 in accelerating mesendoderm differentiation. miR-127, through the complementary pairing, suppresses the expression of Lefty2, which is referred to as antagonist to the nodal pathway. Thus, miR-127 induces p-Smad2 expression and finally up-regulates expression of mesendoderm markers.
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Ontology Terms
Saving...Bibliography
- Ma H, Lin Y, Zhao ZA, Lu X, Yu Y, Zhang X, Wang Q, Li L; ''MicroRNA-127 Promotes Mesendoderm Differentiation of Mouse Embryonic Stem Cells by Targeting Left-Right Determination Factor 2.''; J Biol Chem, 2016 PubMed Europe PMC Scholia
History
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External references
DataNodes
| View all... |
| Name | Type | Database reference | Comment |
|---|---|---|---|
| Acvr1 | GeneProduct | ENSMUSG00000026836 (Ensembl)  | |
| Acvr2a | GeneProduct | ENSMUSG00000052155 (Ensembl) | |
| Cfc1 | GeneProduct | ENSMUSG00000026124 (Ensembl) | |
| Foxa2 | GeneProduct | ENSMUSG00000037025 (Ensembl) | |
| Lefty2 | GeneProduct | ENSMUSG00000066652 (Ensembl) | |
| Mir127 | GeneProduct | ENSMUSG00000070076 (Ensembl) | |
| Nodal | GeneProduct | ENSMUSG00000037171 (Ensembl) | |
| Smad2 | GeneProduct | ENSMUSG00000024563 (Ensembl) | |
| Smad4 | GeneProduct | ENSMUSG00000024515 (Ensembl) | |
| T | GeneProduct | 20997 (Entrez Gene) |
Annotated Interactions
No annotated interactions
