PPAR signaling pathway (Danio rerio)
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Description
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake.
Source: KEGG (http://www.genome.jp/dbget-bin/www_bget?pathway+dre03320)
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- Lehrke M, Lazar MA; ''The many faces of PPARgamma.''; Cell, 2005 PubMed Europe PMC Scholia
- Takahashi N, Goto T, Kusudo T, Moriyama T, Kawada T; ''[The structures and functions of peroxisome proliferator-activated receptors (PPARs)].''; Nihon Rinsho, 2005 PubMed Europe PMC Scholia
- Mandard S, Müller M, Kersten S; ''Peroxisome proliferator-activated receptor alpha target genes.''; Cell Mol Life Sci, 2004 PubMed Europe PMC Scholia
- Hauner H; ''The mode of action of thiazolidinediones.''; Diabetes Metab Res Rev, 2002 PubMed Europe PMC Scholia
- Inoue H; ''[Endogenous ligands for PPARs].''; Nihon Rinsho, 2005 PubMed Europe PMC Scholia
- Feige JN, Gelman L, Michalik L, Desvergne B, Wahli W; ''From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions.''; Prog Lipid Res, 2006 PubMed Europe PMC Scholia
- Fujii H; ''[PPARs-mediated intracellular signal transduction].''; Nihon Rinsho, 2005 PubMed Europe PMC Scholia
- Desvergne B, Wahli W; ''Peroxisome proliferator-activated receptors: nuclear control of metabolism.''; Endocr Rev, 1999 PubMed Europe PMC Scholia
- Savage DB; ''PPAR gamma as a metabolic regulator: insights from genomics and pharmacology.''; Expert Rev Mol Med, 2005 PubMed Europe PMC Scholia
- Desvergne B, Michalik L, Wahli W; ''Transcriptional regulation of metabolism.''; Physiol Rev, 2006 PubMed Europe PMC Scholia
- Semple RK, Chatterjee VK, O'Rahilly S; ''PPAR gamma and human metabolic disease.''; J Clin Invest, 2006 PubMed Europe PMC Scholia
- Takada I, Kato S; ''[PPARs target genes].''; Nihon Rinsho, 2005 PubMed Europe PMC Scholia
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