White fat cell differentiation (Homo sapiens)

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1-4Differentiated adipocytePreadipocyteMECOMPPARGFBSGATA2RARACEBPBNR2F2TCF7L1ZNF423KLF15FOXO1STAT5BEBF1NR1H3KLF5GATA3EGR2CEBPDIRF3SREBF1KLF4STAT5ARORAWNT10BcAMPCREB1DDIT3CEBPACTNNA1TLE35INSGlucocorticoidsNR3C1IRF4KLF2


Description

The transcription factors involved in white fat cell differentiation are shown, specifically their pattern of activity from the preadipocyte to the adipocyte (fat cells) stage. Adipose tissue, composed of white and brown adipose tissue, is composed of adipocytes. This pathway is primarily studied to understand factors that contribute to obesity and diabetes. Transcriptional and hormonal regulators of adipocyte formation are indicated.

Comments

HomologyMapper 
This pathway was inferred from Mus musculus pathway WP2872 (rev 90848) with a 100.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Siersbæk R, Nielsen R, Mandrup S; ''Transcriptional networks and chromatin remodeling controlling adipogenesis.''; Trends Endocrinol Metab, 2012 PubMed Europe PMC Scholia
  2. Rosen ED, Spiegelman BM; ''Molecular regulation of adipogenesis.''; Annu Rev Cell Dev Biol, 2000 PubMed Europe PMC Scholia
  3. Gubelmann C, Schwalie PC, Raghav SK, Röder E, Delessa T, Kiehlmann E, Waszak SM, Corsinotti A, Udin G, Holcombe W, Rudofsky G, Trono D, Wolfrum C, Deplancke B; ''Identification of the transcription factor ZEB1 as a central component of the adipogenic gene regulatory network.''; Elife, 2014 PubMed Europe PMC Scholia
  4. Villanueva CJ, Waki H, Godio C, Nielsen R, Chou WL, Vargas L, Wroblewski K, Schmedt C, Chao LC, Boyadjian R, Mandrup S, Hevener A, Saez E, Tontonoz P; ''TLE3 Is a Dual-Function Transcriptional Coregulator of Adipogenesis.''; Cell Metab, 2011 PubMed Europe PMC Scholia
  5. Rosen ED, MacDougald OA; ''Adipocyte differentiation from the inside out.''; Nat Rev Mol Cell Biol, 2006 PubMed Europe PMC Scholia

History

CompareRevisionActionTimeUserComment
107159view14:24, 17 September 2019MaintBotChEBI identifier normalization
94399view12:36, 6 September 2017MkutmonOntology Term : 'white fat cell' added !
94398view12:36, 6 September 2017MkutmonOntology Term : 'signaling pathway' added !
94397view12:35, 6 September 2017MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CEBPAGeneProductENSG00000245848 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12606
CEBPBGeneProductENSG00000172216 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12608
CEBPDGeneProductENSG00000221869 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12609
CREB1GeneProductENSG00000118260 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12912
CTNNA1GeneProductENSG00000044115 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12385
DDIT3GeneProductENSG00000175197 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13198
EBF1GeneProductENSG00000164330 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13591
EGR2GeneProductENSG00000122877 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13654
FBSMetabolite
FOXO1GeneProductENSG00000150907 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:56458
GATA2GeneProductENSG00000179348 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14461
GATA3GeneProductENSG00000107485 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14462
GlucocorticoidsMetaboliteCHEBI:24261 (ChEBI)
INSGeneProductENSG00000254647 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16333
IRF3GeneProductENSG00000126456 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:54131
IRF4GeneProductENSG00000137265 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16364
KLF15GeneProductENSG00000163884 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66277
KLF2GeneProductENSG00000127528 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16598
KLF4GeneProductENSG00000136826 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16600
KLF5GeneProductENSG00000102554 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12224
MECOMGeneProductENSG00000085276 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14013
NR1H3GeneProductENSG00000025434 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22259
NR2F2GeneProductENSG00000185551 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11819
NR3C1GeneProductENSG00000113580 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14815
PPARGGeneProductENSG00000132170 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19016
RARAGeneProductENSG00000131759 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19401
RORAGeneProductENSG00000069667 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19883
SREBF1GeneProductENSG00000072310 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20787
STAT5AGeneProductENSG00000126561 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20850
STAT5BGeneProductENSG00000173757 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20851
TCF7L1GeneProductENSG00000152284 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21415
TLE3GeneProductENSG00000140332 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21887
WNT10BGeneProductENSG00000169884 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22410
ZNF423GeneProductENSG00000102935 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:94187
cAMPMetabolite17489 (ChEBI)

Annotated Interactions

No annotated interactions
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