Wnt signaling in kidney disease (Homo sapiens)

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1, 2Non-Canonical TranscriptionCytoskeleton/planar cell PolarityCanonical INVSCTNNB1CalciumRHOANPHP3-ACAD11LRP5LRP6WNT1WNT10AWNT10BWNT7AWNT16WNT6WNT5AWNT2BWNT11WNT4WNT3AWNT5BWNT9BWNT2WNT3WNT7BFZD1FZD8FZD4FZD2FZD7FZD9FZD5FZD6FZD3FZD1FZD8FZD4FZD2FZD7FZD9FZD5FZD6FZD3DVL2DVL3DVL1MAPK9MAPK10MAPK8DVL2DVL3DVL1cytoplasmicdisheveledmembrane-bounddisheveled


Description

This pathway is modeled after Figure 5 of the article "Glomerulocystic kidney disease" (Bissler, et al. 2010). The gene product Wnt signals two different paths titled canonical and non-canonical. The non-canonical path is mediated by the membrane bound protein Disheveled (Dvl) which then controls the planar cell Polarity. The canonical path on the other hand is mediated by the cytoplasmic protein Disheveled (Dvl) and then is effected through b-catenin transcription. The complex of Nphp2 and Nphp3 seem to help facilitate the process by controlling the Wnt signaling. Bergmann, et al. (2008) showed that Nphp3 deficiency in Xenopus resulted to planar cell polarity defects.

Comments

HomologyMapper 
This pathway was inferred from Mus musculus pathway WP3857 (rev 90797) with a 100.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Bissler JJ, Siroky BJ, Yin H; ''Glomerulocystic kidney disease.''; Pediatr Nephrol, 2010 PubMed Europe PMC Scholia
  2. Bergmann C, Fliegauf M, Brüchle NO, Frank V, Olbrich H, Kirschner J, Schermer B, Schmedding I, Kispert A, Kränzlin B, Nürnberg G, Becker C, Grimm T, Girschick G, Lynch SA, Kelehan P, Senderek J, Neuhaus TJ, Stallmach T, Zentgraf H, Nürnberg P, Gretz N, Lo C, Lienkamp S, Schäfer T, Walz G, Benzing T, Zerres K, Omran H; ''Loss of nephrocystin-3 function can cause embryonic lethality, Meckel-Gruber-like syndrome, situs inversus, and renal-hepatic-pancreatic dysplasia.''; Am J Hum Genet, 2008 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129330view14:10, 26 March 2024MkutmonOntology Term : 'disease pathway' added !
128396view03:29, 4 February 2024EweitzStandardize case
116677view12:58, 9 May 2021EweitzOntology Term : 'PW:0000003' removed !
116676view12:58, 9 May 2021EweitzOntology Term : 'DOID:557' removed !
116675view12:58, 9 May 2021EweitzModified title
116674view12:57, 9 May 2021EweitzOntology Term : 'PW:0000200' removed !
116673view12:57, 9 May 2021EweitzOntology Term : 'PW:0000008' removed !
116672view12:56, 9 May 2021EweitzOntology Term : 'DOID:557' removed !
106778view13:25, 17 September 2019MaintBotHMDB identifier normalization
105856view23:18, 15 August 2019KhanspersModified description
94404view12:38, 6 September 2017MkutmonOntology Term : 'kidney disease' added !
94403view12:38, 6 September 2017MkutmonOntology Term : 'signaling pathway' added !
94402view12:38, 6 September 2017MkutmonOntology Term : 'Wnt signaling, the planar cell polarity pathway' added !
94401view12:38, 6 September 2017MkutmonOntology Term : 'Wnt signaling pathway' added !
94400view12:38, 6 September 2017MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CTNNB1GeneProductENSG00000168036 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000006932
CalciumMetaboliteHMDB00464 (HMDB)
DVL1GeneProductENSG00000107404 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13542
DVL2GeneProductENSG00000004975 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13543
DVL3GeneProductENSG00000161202 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13544
FZD1GeneProductENSG00000157240 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14362
FZD2GeneProductENSG00000180340 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:57265
FZD3GeneProductENSG00000104290 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14365
FZD4GeneProductENSG00000174804 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14366
FZD5GeneProductENSG00000163251 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14367
FZD6GeneProductENSG00000164930 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14368
FZD7GeneProductENSG00000155760 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14369
FZD8GeneProductENSG00000177283 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14370
FZD9GeneProductENSG00000188763 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14371
INVSGeneProductENSG00000119509 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000028344
LRP5GeneProductENSG00000162337 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000024913
LRP6GeneProductENSG00000070018 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030201
MAPK10GeneProductENSG00000109339 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26414
MAPK8GeneProductENSG00000107643 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26419
MAPK9GeneProductENSG00000050748 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26420
NPHP3-ACAD11GeneProductENSG00000274810 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000032558
RHOAGeneProductENSG00000067560 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000007815
WNT10AGeneProductENSG00000135925 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22409
WNT10BGeneProductENSG00000169884 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22410
WNT11GeneProductENSG00000085741 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22411
WNT16GeneProductENSG00000002745 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:93735
WNT1GeneProductENSG00000125084 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22408
WNT2BGeneProductENSG00000134245 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22414
WNT2GeneProductENSG00000105989 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22413
WNT3AGeneProductENSG00000154342 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22416
WNT3GeneProductENSG00000108379 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22415
WNT4GeneProductENSG00000162552 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22417
WNT5AGeneProductENSG00000114251 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22418
WNT5BGeneProductENSG00000111186 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22419
WNT6GeneProductENSG00000115596 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22420
WNT7AGeneProductENSG00000154764 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22421
WNT7BGeneProductENSG00000188064 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22422
WNT9BGeneProductENSG00000158955 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22412

Annotated Interactions

No annotated interactions
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