G13 signaling pathway (Canis familiaris)

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1CytokinesisActin PolymerizationFilopodia FormationActin PolymerizationStress FiberDisappearanceMembrane RufflingActin ReorganizationCell-Cell AdhesionActivated Rho A13Anti-ApoptoticContraction & Actin-MyosinInteraction, Focal AdhesionStress Fiber ContractionDisassembly of ActinGGNA13LIMK1PFN1CDC42RTKNMYBPHIQGAP2ARHGDIBDIAPH1PIK3CBARHGEF1SH3RF1PIK3CACFL2WASPIK3CDPPP1CBIQGAP1ROCK1CFL1RAC1MYL1WASLRHOARPS6KB1MAPK10ARHGDIGCITCYFIP1PKN1TNK2ROCK2RHPN2MAP3K4PIP5K2APIK3R2CALM1PAK3


Description

The G13 subunit is an alpha unit of heterotrimeric G proteins that regulates cell processes through the use of guanine nucleotide exchange factors. G13 regulates actin cytoskeletal remodeling in cells and is essential for receptor tyrosine kinase-induced migration of fibroblast and endothelial cells. Source: Wikipedia

Comments

HomologyMapper 
This pathway was inferred from Homo sapiens pathway WP524 (r95116) with a 100.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Neves SR, Ram PT, Iyengar R; ''G protein pathways.''; Science, 2002 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117451view10:53, 21 May 2021EweitzModified title
95739view13:26, 19 January 2018Mkutmonupdated homology conversion
71475view19:18, 17 October 2013MaintBotAutomated update of data sources
68567view22:52, 5 July 2013MaintBotUpdated to 2013 gpml schema
67274view10:30, 26 June 2013Christine ChichesterOntology Term : 'G protein mediated signaling pathway via Galpha12/Galpha13 family' added !
62723view03:17, 2 May 2013MaintBotUpdated UniProt data source
40725view21:52, 1 March 2011MaintBotRemoved redundant pathway information and comments
35423view10:50, 12 February 2010ThomasModified description
35422view10:49, 12 February 2010Thomasremoved braces, fixed labels, added literature,
34004view18:39, 9 December 2009MaintBotAutomatic update of empty xrefs
32371view16:39, 15 August 2009MaintBotFixed text labels
32263view13:02, 15 August 2009MaintBotFixed text labels
31790view12:15, 14 August 2009MaintBotFixed group labels
31290view20:07, 13 August 2009MaintBotFixed text labels
30748view23:06, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ARHGDIBGeneProductENSCAFG00000012883 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:397
ARHGDIGGeneProductENSCAFG00000015363 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:398
ARHGEF1GeneProductENSCAFG00000030005 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:9138
CALM1GeneProductENSCAFG00000017563 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:801
CDC42GeneProductENSCAFG00000014707 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:998
CFL1GeneProductENSCAFG00000020009 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1072
CFL2GeneProductENSCAFG00000032562 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1073
CITGeneProductENSCAFG00000010114 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:11113
CYFIP1GeneProductENSCAFG00000009720 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:23191
DIAPH1GeneProductENSCAFG00000006149 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1729
GNA13GeneProductENSCAFG00000011108 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:10672
IQGAP1GeneProductENSCAFG00000012639 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:8826
IQGAP2GeneProductENSCAFG00000009293 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:10788
LIMK1GeneProductENSCAFG00000012073 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3984
MAP3K4GeneProductENSCAFG00000000760 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4216
MAPK10GeneProductENSCAFG00000009396 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5602
MYBPHGeneProductENSCAFG00000010288 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4608
MYL1GeneProductENSCAFG00000013875 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4632
PAK3GeneProductENSCAFG00000018154 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5063
PFN1GeneProductENSCAFG00000015827 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5216
PIK3CAGeneProductENSCAFG00000011212 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5290
PIK3CBGeneProductENSCAFG00000007579 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5291
PIK3CDGeneProductENSCAFG00000019735 (Ensembl)
  • P42338
  • Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5293
PIK3R2GeneProductENSCAFG00000014978 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5296
PIP5K2AGeneProductENSCAFG00000013718 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5305
PKN1GeneProductENSCAFG00000016316 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5585
PPP1CBGeneProductENSCAFG00000005238 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5500
RAC1GeneProductENSCAFG00000015716 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5879
RHOAGeneProductENSCAFG00000018512 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:387
RHPN2GeneProductENSCAFG00000007465 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:85415
ROCK1GeneProductENSCAFG00000018282 (Ensembl)
  • S69211
  • Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6093
ROCK2GeneProductENSCAFG00000003549 (Ensembl)
  • BAA31594
  • Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:9475
RPS6KB1GeneProductENSCAFG00000017679 (Ensembl)
  • A41687
  • Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6198
RTKNGeneProductENSCAFG00000008519 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6242
SH3RF1GeneProductENSCAFG00000007608 (Ensembl)
  • Posh
  • Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:57630
TNK2GeneProductENSCAFG00000012918 (Ensembl)
  • S33596
  • Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:10188
WASGeneProductENSCAFG00000015519 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:7454
WASLGeneProductENSCAFG00000001771 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:8976

Annotated Interactions

No annotated interactions
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