Transcriptional cascade regulating adipogenesis (Homo sapiens)
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Description
Peroxisome proliferator-activated receptor γ (PPARγ) lies at the core of the transcriptional cascade that regulates adipogenesis. The expression of Pparg is regulated by several pro-adipogenic (green) and anti-adipogenic (orange) factors. PPARγ itself is activated by an as-yet-uncharacterized ligand. CCAAT-enhancer-binding protein α (C/EBPα) is regulated through a series of inhibitory protein–protein interactions. Some transcription-factor families have several members that participate in adipogenesis, such as the Krüppel-like factors (KLFs). Rosen et al. Figure 2a
Quality Tags
Ontology Terms
Saving...Bibliography
- Rosen ED, MacDougald OA; ''Adipocyte differentiation from the inside out.''; Nat Rev Mol Cell Biol, 2006 PubMed Europe PMC Scholia
History
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External references
DataNodes
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| Name | Type | Database reference | Comment |
|---|---|---|---|
| CEBPA | GeneProduct | ENSG00000245848 (Ensembl)  | C/EBPα |
| CEBPB | GeneProduct | ENSG00000172216 (Ensembl) | C/EBPβ |
| CEBPD | GeneProduct | ENSG00000221869 (Ensembl) | C/EBPδ |
| CEBPG | GeneProduct | ENSG00000153879 (Ensembl) | C/EBPγ |
| DDIT3 | GeneProduct | ENSG00000175197 (Ensembl) | CHOP |
| EGR2 | GeneProduct | ENSG00000122877 (Ensembl) | KROX20 |
| GATA2 | GeneProduct | ENSG00000179348 (Ensembl) | GATA2/3 |
| GATA3 | GeneProduct | ENSG00000107485 (Ensembl) | GATA2/3 |
| KLF15 | GeneProduct | ENSG00000163884 (Ensembl) | |
| KLF2 | GeneProduct | ENSG00000127528 (Ensembl) | |
| KLF5 | GeneProduct | ENSG00000102554 (Ensembl) | |
| PPARG | GeneProduct | ENSG00000132170 (Ensembl) | PPARγ |
| SREBF1 | GeneProduct | ENSG00000072310 (Ensembl) | SREBP1c |
Annotated Interactions
No annotated interactions
