Thyroid stimulating hormone (TSH) signaling pathway (Bos taurus)

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CCND3CCND3MAP2K1PMAPK3PPIK3R2DAGPIP2PKAPIP3IP3cAMPReceptorLigandCell proliferationNUEnzyme ComplexProteinCYTSH Signal Transduction PathwaymRNATSHBSTAT1TTF1CGAFOSGNB1RAF1EGR1HRASTTF2JUNPAX8KCNIP3GNG2MYCE2F1SCRIBBRAFPTSHRSTAT3PPDPK1PPIK3CAPIK3R1PCDK2PSRCpMAP2K3PMAP2K6PAKT1PRBL2RPS6KB1MAPK1PPRB1PCREB1PPDE4DPGNAI1GNA13GTPGTPGNAI2GNA12GTPGTPGNAO1GNAQGTPGTPGNAI3GTPMYL12BDePRALGDSGNASGTPJAK2PJAK1PRPS6MTORPADCY2ADCY3CDK2PCDK4PRPS6KA1PPRKCSHPLCB1RAP1BRAP1AGTPGTPIGF1RCCNE1MAPK14CDKN1BPCCND3CDK4RAP1GAPPPNUCYPKANUCYSmall moleculeInduced activationInhibitionAuto catalysisTransportPositive regulation of gene expressionLeads to through unknown mechanismNegative regulation of gene expressionTranslocation UbiquitinationDeubiquitinationSumoylationInduced catalysisProtein-protein interactionAcetylationDephosphorylationLEGENDPhosphorylationDeacetylationGolgi apparatusEndosomeNucleusMitochondrionDesumoylationMethylationDemethylationPalmitoylationCytoplasmECPlasma membraneMTEndoplasmic reticulumCYPMGONUExtracellularERENProteolytic cleavageMoleculeAPEX1APEX1NUCYProteinProtein


Description

Human thyroid stimulating hormone (TSH) is a glycoprotein hormone secreted from the anterior pituitary lobe, which plays an important physiological role in regulation of the hypothalamus-pituitary-thyroid by stimulating production and secretion of the thyroid hormone from the thyroid gland. TSH binds to TSH receptor which is a member of the G protein-coupled receptor superfamily of integral membrane proteins. TSH exerts its action through various signaling cascades such as cAMP cascade and the phospholipase C beta-mediated inositol phosphate generation. Further, it will give signaling to NF-kappa B, mitogen activated protein kinases, protein kinase C modules.


NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP2032(79960) with a 97.0% conversion rate.

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Ontology Terms

 

Bibliography

  1. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD, Mathivanan S, Pecquet C, Gollapudi SK, Tattikota SG, Mohan S, Padhukasahasram H, Subbannayya Y, Goel R, Jacob HK, Zhong J, Sekhar R, Nanjappa V, Balakrishnan L, Subbaiah R, Ramachandra YL, Rahiman BA, Prasad TS, Lin JX, Houtman JC, Desiderio S, Renauld JC, Constantinescu SN, Ohara O, Hirano T, Kubo M, Singh S, Khatri P, Draghici S, Bader GD, Sander C, Leonard WJ, Pandey A; ''NetPath: a public resource of curated signal transduction pathways.''; Genome Biol, 2010 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117637view11:47, 21 May 2021EweitzModified title
115996view15:52, 28 March 2021EgonwCopied the NetPath paper to the literature list.
115978view18:09, 23 March 2021EgonwModified description
96289view15:01, 7 March 2018Fehrhartconnected lines
89825view12:00, 6 October 2016MkutmonOntology Term : 'thyroid-stimulating hormone signaling pathway' added !
89824view11:59, 6 October 2016MkutmonModified description
89819view11:54, 6 October 2016MkutmonModified title
80831view15:27, 30 June 2015MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADCY2GeneProductENSBTAG00000019210 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:108
ADCY3GeneProductENSBTAG00000018705 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:109
AKT1GeneProductENSBTAG00000017636 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:207
APEX1GeneProductENSBTAG00000002745 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:328
BRAFGeneProductENSBTAG00000021761 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:673
CCND3GeneProductENSBTAG00000010106 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:896
CCNE1GeneProductENSBTAG00000004735 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:898
CDK2GeneProductENSBTAG00000004021 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1017
CDK4GeneProductENSBTAG00000046091 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1019
CDKN1BGeneProductENSBTAG00000018254 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1027
CGAGeneProductENSBTAG00000016138 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1081
CREB1GeneProductENSBTAG00000005474 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1385
E2F1RnaENSBTAG00000003971 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1869
EGR1RnaENSBTAG00000010069 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1958
FOSRnaENSBTAG00000004322 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2353
GNA12GeneProductENSBTAG00000017871 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2768
GNA13GeneProductENSBTAG00000046174 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10672
GNAI1GeneProductENSBTAG00000002714 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2770
GNAI2GeneProductENSBTAG00000020645 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2771
GNAI3GeneProductENSBTAG00000013016 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2773
GNAO1GeneProductENSBTAG00000003794 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2775
GNAQGeneProductENSBTAG00000009789 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2776
GNASGeneProductENSBTAG00000017475 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2778
GNB1GeneProductENSBTAG00000000215 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2782
GNG2GeneProductENSBTAG00000003043 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:54331
HRASGeneProductENSBTAG00000046644 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3265
IGF1RGeneProductENSBTAG00000021527 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3480
JAK1GeneProductENSBTAG00000003147 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3716
JAK2GeneProductENSBTAG00000012047 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3717
JUNRnaENSBTAG00000004037 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3725
KCNIP3GeneProduct
MAP2K1GeneProductENSBTAG00000033983 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5604
MAP2K3GeneProductENSBTAG00000010576 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5606
MAP2K6GeneProductENSBTAG00000001609 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5608
MAPK14GeneProductENSBTAG00000020783 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1432
MAPK1GeneProductENSBTAG00000010312 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594
MAPK3GeneProductENSBTAG00000016156 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5595
MTORGeneProductENSBTAG00000015325 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2475
MYCRnaENSBTAG00000008409 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4609
MYL12BGeneProductENSBTAG00000026266 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:103910
PAX8RnaENSBTAG00000019354 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7849
PDE4DGeneProductENSBTAG00000000494 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5144
PDPK1GeneProductENSBTAG00000034436 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5170
PIK3CAGeneProductENSBTAG00000009232 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5290
PIK3R1GeneProductENSBTAG00000010989 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5295
PIK3R2GeneProductHomologyConvert: Multiple homologues found: En:ENSBTAG00000002350;En:ENSBTAG00000002350;
PLCB1GeneProductENSBTAG00000008338 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23236
PRKCSHGeneProductENSBTAG00000017490 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5337
RAF1GeneProductENSBTAG00000045748 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5894
RALGDSGeneProductENSBTAG00000004194 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5900
RAP1AGeneProductENSBTAG00000014710 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5906
RAP1BGeneProductENSBTAG00000008967 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5908
RAP1GAPGeneProductENSBTAG00000008952 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5909
RB1GeneProductENSBTAG00000006640 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5925
RBL2GeneProductENSBTAG00000016243 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5934
RPS6GeneProductENSBTAG00000014449 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6194
RPS6KA1GeneProductENSBTAG00000014447 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6195
RPS6KB1GeneProductENSBTAG00000016851 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6198
SCRIBGeneProductENSBTAG00000008421 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23513
SRCGeneProductENSBTAG00000008938 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6714
STAT1GeneProductENSBTAG00000007867 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772
STAT3GeneProductENSBTAG00000021523 (Ensembl)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6774
TSHBGeneProductENSBTAG00000006295 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7252
TSHRGeneProductENSBTAG00000017489 (Ensembl)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7253
TTF1RnaENSBTAG00000018710 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7270
TTF2RnaENSBTAG00000015392 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8458

Annotated Interactions

No annotated interactions
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