IL-17 signaling pathway (Bos taurus)

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INFLAMMATORY FACTORSERK1/2NFkBJAK1MAPK1IL25IL17RBCEBPDIL17FIL17RANFKB1RELAIKBKGPI3KIL17RDIL17RCSTAT3MAP3K7IL17REGSK3BIL17CEBPBIL17BTRAF3AKT1TRAF6NFKBIBIL17CJAK2IL17DMAPK1IKBKBTRAF3IP2MAP3K14SP1TRAF3IP2MAP3K7TRAF6TRAF3IP2MAPKHOST DEFENSE GENESmRNA STABILITYTH2 CYTOKINESNFkBNFKB1RELAMAPK3


Description

Interleukin 17 is a family of cytokines that acts as potent mediators in delayed-type reactions by increasing chemokine production in various tissues to recruit monocytes and neutrophils to the site of inflammation, similar to Interferon gamma. IL-17 is produced by T-helper cells and is induced by IL-23 which results in destructive tissue damage in delayed-type reactions. Interleukin 17 as a family functions as proinflammatory cytokines that responds to the invasion of the immune system by extracellular pathogens. Interleukin 17 acts synergistically with tumor necrosis factor and interleukin-1.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP2112(63216) with a 87.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

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History

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CompareRevisionActionTimeUserComment
117959view10:52, 23 May 2021EweitzModified title
97392view05:05, 14 May 2018Khanspersconnected interaction
97045view15:06, 26 April 2018Mick EikelhofFixed unconnected lines
97040view14:55, 26 April 2018Mick EikelhofFixed unconnected lines
89840view12:12, 6 October 2016MkutmonOntology Term : 'cytokine mediated signaling pathway' added !
89839view12:12, 6 October 2016MkutmonModified description
80753view15:24, 30 June 2015MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProductENSBTAG00000017636 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:207
CEBPBGeneProduct
CEBPDGeneProduct
GSK3BGeneProductENSBTAG00000048057 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2932
IKBKBGeneProductENSBTAG00000007599 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3551
IKBKGGeneProductENSBTAG00000006268 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8517
IL17BGeneProductENSBTAG00000010578 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:27190
IL17CGeneProductENSBTAG00000047128 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:27189
IL17DGeneProductENSBTAG00000025402 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:53342
IL17GeneProductENSBTAG00000002150 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3605
IL17FGeneProductENSBTAG00000016835 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:112744
IL17RAGeneProductENSBTAG00000011067 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23765
IL17RBGeneProductENSBTAG00000011178 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55540
IL17RCGeneProductENSBTAG00000033669 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:84818
IL17RDGeneProductENSBTAG00000010999 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:54756
IL17REGeneProductENSBTAG00000010833 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:132014
IL25GeneProductENSBTAG00000009701 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64806
JAK1GeneProductENSBTAG00000003147 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3716
JAK2GeneProductENSBTAG00000012047 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3717
MAP3K14GeneProductNIK or p38
MAP3K7GeneProductENSBTAG00000002625 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6885
MAPKProtein
MAPK1GeneProductENSBTAG00000010312 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594
MAPK3GeneProductENSBTAG00000016156 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5595
NFKB1GeneProductENSBTAG00000020270 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4790
NFKBIBGeneProductENSBTAG00000001778 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4793
PI3KProtein
RELAGeneProductENSBTAG00000013895 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5970
SP1GeneProductENSBTAG00000003021 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6667
STAT3GeneProductENSBTAG00000021523 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6774
TRAF3GeneProductENSBTAG00000013475 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7187
TRAF3IP2GeneProductENSBTAG00000008600 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10758
TRAF6GeneProductENSBTAG00000036009 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7189

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP3176"
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