Extracellular vesicles in the crosstalk of cardiac cells (Homo sapiens)

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1CMFibroblastsEVsMSC exosomePlasma EV'sEVs in exerciseddiabetic miceB. ApoptosisA. HypertrophyMIR455mir21-3pEGFPDGFmir-29b2mir-19aMAPK SignalingHSP90VEGFR2CD63GATA4HSP20HSPB1Renin angiotensinsystem (RAS)FGFNF-kB SignalingPTENBIRC5HSP70SORBS2SPP1CD81TLR4C. FibrosisD. AngiogenesisSOD1MMP9STAT3IL6EVsEVsEGFREVsPDLIM5MIR320AEVsIGF1ETS2HSP20MSCmir-29b1p-Akt


Description

(A) FB-derived exosomes enriched with miR-21-3p or Spp1 and EGFR proteins are transferred to CMs, leading to CM hypertrophy. (B) EVs secreted from CMs or MSCs, as well as circulating EVs exert regulatory effects on CM apoptosis. (C) CM-derived exosomal HSP90 together with secreted IL-6 are able to activate STAT-3 signaling in cardiac FBs, leading to cardiac fibrosis; whereas CM-derived exosomes from exercised diabetic mice express high levels of miR-29b and miR-455, thus reducing cardiac fibrosis. (D) EVs secreted from CMs or MSCs are transferred to ECs, exerting pro- or anti-angiogenic activities.

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Bibliography

  1. Bei Y, Das S, Rodosthenous RS, Holvoet P, Vanhaverbeke M, Monteiro MC, Monteiro VVS, Radosinska J, Bartekova M, Jansen F, Li Q, Rajasingh J, Xiao J; ''Extracellular Vesicles in Cardiovascular Theranostics.''; Theranostics, 2017 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129338view09:11, 27 March 2024MkutmonOntology Term : 'regulatory pathway' added !
123361view04:57, 18 July 2022EgonwMade three pathways clickable
105311view22:27, 29 July 2019AriuttaHGNC -> HGNC Accession number. Remove HGNC prefix.
97801view19:37, 8 June 2018Khanspersadded pathway node xrefs
97710view17:59, 6 June 2018Khanspersdecreased board height
97709view17:59, 6 June 2018Khanspersdecreased board height
97653view20:46, 31 May 2018KhanspersModified title
97648view19:27, 31 May 2018KhanspersModified description
97647view19:26, 31 May 2018Khansperslabels
97646view19:13, 31 May 2018KhanspersOntology Term : 'fibroblast of cardiac tissue' added !
97645view19:12, 31 May 2018KhanspersOntology Term : 'cardiac endothelial cell' added !
97644view19:12, 31 May 2018KhanspersOntology Term : 'cardiac muscle cell' added !
97643view19:11, 31 May 2018KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
A. HypertrophyPathway
B. ApoptosisPathway
BIRC5GeneProductENSG00000089685 (Ensembl)
C. FibrosisPathway
CD63GeneProductENSG00000135404 (Ensembl)
CD81GeneProductENSG00000110651 (Ensembl)
D. AngiogenesisPathway
EGFGeneProductENSG00000138798 (Ensembl)
EGFRGeneProductENSG00000146648 (Ensembl)
ETS2GeneProductENSG00000157557 (Ensembl)
FGFGeneProduct
GATA4GeneProductENSG00000136574 (Ensembl)
HSP20GeneProduct
HSP20GeneProductENSG00000142168 (Ensembl)
HSP70GeneProduct
HSP90GeneProduct
HSPB1GeneProductENSG00000106211 (Ensembl)
IGF1GeneProductENSG00000017427 (Ensembl)
IL6GeneProductENSG00000136244 (Ensembl)
MAPK SignalingPathwayWP382 (WikiPathways)
MIR320AGeneProductENSG00000208037 (Ensembl)
MIR455GeneProductENSG00000207726 (Ensembl)
MMP9GeneProductENSG00000100985 (Ensembl)
NF-kB SignalingPathway
PDGFGeneProduct
PDLIM5GeneProductENSG00000163110 (Ensembl)
PTENGeneProductENSG00000171862 (Ensembl)
Renin angiotensin system (RAS)Pathway
SOD1GeneProductENSG00000142168 (Ensembl)
SORBS2GeneProductENSG00000154556 (Ensembl)
SPP1GeneProductENSG00000118785 (Ensembl)
STAT3GeneProductENSG00000168610 (Ensembl)
TLR4GeneProductENSG00000136869 (Ensembl)
VEGFR2GeneProductENSG00000128052 (Ensembl)
mir-19aGeneProduct406979 (Entrez Gene)
mir-29b1GeneProductHGNC:31619 (HGNC)
mir-29b2GeneProductHGNC:31620 (HGNC)
mir21-3pGeneProductHGNC:31586 (HGNC)
p-AktGeneProduct

Annotated Interactions

No annotated interactions

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