Ciliary landscape (Homo sapiens)

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1complex 16complex 44complex 12complex 3complex 29complex 31IFT-ATUBG/NMECOP9 signalosomeNOTcomplex 5ARL/NPHP/UNC119U5-snRNPMCMIQ/CALM1MAK/ICK/KIAA0556complex 9complex 5complex 15BBSomeExosomecomplex 39ProteasomeNEFcomplex 49complex 7HSF1/HSPA1L/MAPRE2complex 53GIDDynein-1IFT-B1exocyst-1complex 47Nucleuscomplex FOX/RFXcomplex 21TRAPPcomplex 26complex 28AxonemeBasal bodyANKS/NEKcomplex 19U4/U6-snRNPCell membraneCiliumTransition zoneDCAF7IFT140LSM4YAP1COPS2RB1SNRPB2CNOT1TFAP2DIFT57GDI1RBM14NUDCRAB3IL1IFT52ACSL3MCM4IFT46AIMP1CDH23MCM8IFT27SSNA1HDAC2IFT43EHBP1CEP97WNK1RAB21HDAC1UBE2D2CTBP2USH1CMCM3NDUFA9SPATA7MCM2IFT20COPS5DYNLL2TFAP2CMSH2TMED1RPGRMCM5TNKS1BP1CD2BP2EXOSC9MCM9NINLERFTFAP2BNME8TFAP2ARABEP2DCAF11CCDC40MKS1ARL8BCTSALCA5CNOT10COPS3POM121DGKEUQCC1TFAP2ERHBDD2DNPEPH3F3AAPCMCM10MCM6CREBBPNDUFA5TSSC1CLTWEE1CEP170IFT122CNOT6LCTNNB1RAB14NFKB1CAMK2ACOPS6ARFGAP3SNAP29IFT74COPS7BCOPS1CBSIFT81DVL3EFTUD2RQCD1GLACOPS8RAB2ACDR2DYNLL1ECHS1NUP133COPS4NUP88MFAP1COPS7AARHGDIAMCM7Cytosolcomplex 46exocyst-2IFT-BIFT88IFT80IFT172IFT-B2DynactinDynein-2


Description

Ciliary landscape pathway - according to Boldt et al. 2016 - was constructed using the results of affinity proteomics for 217 proteins with known or suspected involvement in ciliary function, resulting in a landscape of 1319 proteins and 4905 interactions of which the most important are shown here (derived from Figure 1). Ciliary function is impaired in a wide spectrum of diseases (ciliopathies) including polycystic kidney disease, Usher syndrome, Bardet-Biedl syndrome, Meckel-Gruber syndrome, and Jeune syndrome.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Boldt K, van Reeuwijk J, Lu Q, Koutroumpas K, Nguyen TM, Texier Y, van Beersum SE, Horn N, Willer JR, Mans DA, Dougherty G, Lamers IJ, Coene KL, Arts HH, Betts MJ, Beyer T, Bolat E, Gloeckner CJ, Haidari K, Hetterschijt L, Iaconis D, Jenkins D, Klose F, Knapp B, Latour B, Letteboer SJ, Marcelis CL, Mitic D, Morleo M, Oud MM, Riemersma M, Rix S, Terhal PA, Toedt G, van Dam TJ, de Vrieze E, Wissinger Y, Wu KM, Apic G, Beales PL, Blacque OE, Gibson TJ, Huynen MA, Katsanis N, Kremer H, Omran H, van Wijk E, Wolfrum U, Kepes F, Davis EE, Franco B, Giles RH, Ueffing M, Russell RB, Roepman R; ''An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.''; Nat Commun, 2016 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134800view02:56, 27 July 2024EweitzOntology Term : 'Meckel syndrome' added !
134799view02:55, 27 July 2024EweitzOntology Term : 'Bardet-Biedl syndrome' added !
134798view02:55, 27 July 2024EweitzOntology Term : 'Usher syndrome' added !
134797view02:55, 27 July 2024EweitzOntology Term : 'polycystic kidney disease' added !
102218view20:44, 11 December 2018Khanspersfixed unconnected interactions
98719view14:32, 1 October 2018FehrhartProteasome
98718view14:20, 1 October 2018FehrhartIQ/GAP
98717view14:07, 1 October 2018FehrhartGID
98716view13:45, 1 October 2018FehrhartNEF
98715view13:21, 1 October 2018Fehrhartadded BBSome and dynein complexes
98714view12:52, 1 October 2018Fehrhartadded complexes IFTB1 and B2
98599view14:12, 20 September 2018FehrhartModified description
98598view14:06, 20 September 2018FehrhartOntology Term : 'ciliopathy' added !
98597view14:05, 20 September 2018FehrhartOntology Term : 'transport pathway' added !
98596view13:56, 20 September 2018FehrhartNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACSL3GeneProductENSG00000123983 (Ensembl)
AIMP1GeneProductENSG00000164022 (Ensembl)
APCGeneProductENSG00000134982 (Ensembl)
ARFGAP3GeneProduct26286 (Entrez Gene)
ARHGDIAGeneProductENSG00000141522 (Ensembl)
ARL8BGeneProductENSG00000134108 (Ensembl)
CAMK2AGeneProductENSG00000070808 (Ensembl)
CBSGeneProductENSG00000160200 (Ensembl)
CCDC40GeneProductENSG00000141519 (Ensembl)
CD2BP2GeneProductENSG00000169217 (Ensembl)
CDH23GeneProductENSG00000107736 (Ensembl)
CDR2GeneProductENSG00000140743 (Ensembl)
CEP170GeneProductENSG00000143702 (Ensembl)
CEP97GeneProductENSG00000182504 (Ensembl)
CLTGeneProductno idea what that should be
CNOT10GeneProductENSG00000182973 (Ensembl)
CNOT1GeneProductENSG00000125107 (Ensembl)
CNOT6LGeneProductENSG00000138767 (Ensembl)
COPS1GeneProductno annotation found yet
COPS2GeneProductENSG00000166200 (Ensembl)
COPS3GeneProductENSG00000141030 (Ensembl)
COPS4GeneProductENSG00000138663 (Ensembl)
COPS5GeneProductCOPS5 (HGNC)
COPS6GeneProductENSG00000168090 (Ensembl)
COPS7AGeneProductENSG00000111652 (Ensembl)
COPS7BGeneProductENSG00000144524 (Ensembl)
COPS8GeneProductENSG00000198612 (Ensembl)
CREBBPGeneProductENSG00000005339 (Ensembl)
CTBP2GeneProductENSG00000175029 (Ensembl)
CTNNB1GeneProductENSG00000168036 (Ensembl)
CTSAGeneProductENSG00000064601 (Ensembl)
DCAF11GeneProductENSG00000100897 (Ensembl)
DCAF7GeneProductENSG00000136485 (Ensembl)
DGKEGeneProductENSG00000153933 (Ensembl)
DNPEPGeneProductENSG00000123992 (Ensembl)
DVL3GeneProductENSG00000161202 (Ensembl)
DYNLL1GeneProductENSG00000088986 (Ensembl)
DYNLL2GeneProductENSG00000264364 (Ensembl)
ECHS1GeneProductENSG00000127884 (Ensembl)
EFTUD2GeneProductENSG00000108883 (Ensembl)
EHBP1GeneProductENSG00000115504 (Ensembl)
ERFGeneProductENSG00000105722 (Ensembl)
EXOSC9GeneProductENSG00000123737 (Ensembl)
GDI1GeneProductENSG00000203879 (Ensembl)
GLAGeneProductENSG00000102393 (Ensembl)
H3F3AGeneProductENSG00000163041 (Ensembl)
HDAC1GeneProductENSG00000116478 (Ensembl)
HDAC2GeneProductENSG00000196591 (Ensembl)
IFT122GeneProductENSG00000163913 (Ensembl)
IFT140GeneProductENSG00000187535 (Ensembl)
IFT172GeneProductENSG00000138002 (Ensembl)
IFT20GeneProductENSG00000109083 (Ensembl)
IFT27GeneProductENSG00000100360 (Ensembl)
IFT43GeneProductENSG00000119650 (Ensembl)
IFT46GeneProductENSG00000118096 (Ensembl)
IFT52GeneProductENSG00000101052 (Ensembl)
IFT57GeneProductENSG00000114446 (Ensembl)
IFT74GeneProductENSG00000096872 (Ensembl)
IFT80GeneProductENSG00000068885 (Ensembl)
IFT81GeneProductENSG00000122970 (Ensembl)
IFT88GeneProductENSG00000032742 (Ensembl)
LCA5GeneProductENSG00000135338 (Ensembl)
LSM4GeneProductENSG00000130520 (Ensembl)
MCM10GeneProductENSG00000065328 (Ensembl)
MCM2GeneProductENSG00000073111 (Ensembl)
MCM3GeneProductENSG00000112118 (Ensembl)
MCM4GeneProductENSG00000104738 (Ensembl)
MCM5GeneProductENSG00000100297 (Ensembl)
MCM6GeneProductENSG00000076003 (Ensembl)
MCM7GeneProductENSG00000166508 (Ensembl)
MCM8GeneProductENSG00000125885 (Ensembl)
MCM9GeneProductENSG00000111877 (Ensembl)
MFAP1GeneProductENSG00000140259 (Ensembl)
MKS1GeneProductENSG00000011143 (Ensembl)
MSH2GeneProductENSG00000095002 (Ensembl)
NDUFA5GeneProductENSG00000128609 (Ensembl)
NDUFA9GeneProductENSG00000139180 (Ensembl)
NFKB1GeneProductENSG00000109320 (Ensembl)
NINLGeneProductENSG00000101004 (Ensembl)
NME8GeneProductENSG00000086288 (Ensembl)
NUDCGeneProductENSG00000090273 (Ensembl)
NUP133GeneProductENSG00000069248 (Ensembl)
NUP88GeneProductENSG00000108559 (Ensembl)
POM121GeneProductENSG00000196313 (Ensembl)
RAB14GeneProductENSG00000119396 (Ensembl)
RAB21GeneProductENSG00000080371 (Ensembl)
RAB2AGeneProductENSG00000104388 (Ensembl)
RAB3IL1GeneProductENSG00000167994 (Ensembl)
RABEP2GeneProductENSG00000177548 (Ensembl)
RB1GeneProductENSG00000139687 (Ensembl)
RBM14GeneProductENSG00000239306 (Ensembl)
RHBDD2GeneProductENSG00000005486 (Ensembl)
RPGRGeneProductENSG00000156313 (Ensembl)
RQCD1ProteinD5MQE1 (Uniprot-TrEMBL)
SNAP29GeneProductENSG00000099940 (Ensembl)
SNRPB2GeneProductENSG00000125870 (Ensembl)
SPATA7GeneProductENSG00000042317 (Ensembl)
SSNA1GeneProductENSG00000176101 (Ensembl)
TFAP2AGeneProductENSG00000137203 (Ensembl)
TFAP2BGeneProductENSG00000008196 (Ensembl)
TFAP2CGeneProductENSG00000087510 (Ensembl)
TFAP2DGeneProductENSG00000008197 (Ensembl)
TFAP2EGeneProductENSG00000116819 (Ensembl)
TMED1GeneProductENSG00000099203 (Ensembl)
TNKS1BP1GeneProductENSG00000149115 (Ensembl)
TSSC1GeneProductENSG00000032389 (Ensembl)
UBE2D2GeneProductENSG00000131508 (Ensembl)
UQCC1GeneProductENSG00000101019 (Ensembl)
USH1CGeneProductENSG00000006611 (Ensembl)
WEE1GeneProductENSG00000166483 (Ensembl)
WNK1GeneProductENSG00000060237 (Ensembl)
YAP1GeneProductENSG00000137693 (Ensembl)

Annotated Interactions

No annotated interactions

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