Ciliary landscape (Homo sapiens)

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1ProteasomeMAK/ICK/KIAA0556MCMARL/NPHP/UNC119ANKS/NEKcomplex 28complex 39IFT-Acomplex 15complex 44HSF1/HSPA1L/MAPRE2Nucleuscomplex 5complex 5IFT-B1complex 47U5-snRNPDynein-1complex 12Axonemecomplex 31complex 9complex 53NOTcomplex 3complex 19GIDIQ/CALM1Exosomecomplex 29COP9 signalosomecomplex FOX/RFXBBSomeU4/U6-snRNPcomplex 49Basal bodyTRAPPTUBG/NMEcomplex 21complex 26complex 16complex 7Cell membraneCiliumTransition zoneCNOT1EHBP1RBM14NME8IFT20TFAP2BTTC8SSNA1POM121RQCD1MCM3SNRPB2CREBBPAPCNUDCBBS9COPS6UQCC1DYNLL1IFT81IFT74DNPEPYAP1TMED1CTBP2DCAF11COPS3CTSACLUAP1EXOSC9EFTUD2ARFGAP3DYNLL2MCM10IFT43TNKS1BP1LZTFL1RB1TFAP2AUBE2D2CNOT10MCM5IFT122MCM2SNAP29MCM6GDI1ARHGDIASPATA7CAMK2ACTNNB1EXOC8NUP133IFT27LSM4MCM9BBIP1NUP88IFT140ERFCOPS8LCA5ECHS1WEE1TFAP2DTFAP2CNDUFA9RAB3IL1IFT52MSH2IFT46CEP170MCM7DVL3COPS7ACD2BP2RABEP2RAB14ACSL3IFT57MFAP1USH1CMCM4CDH23MCM8CBSCOPS2RAB21DCAF7AIMP1H3F3ACOPS7BHDAC2RPGRTSSC1DGKEMKS1CCDC40COPS5CDR2RHBDD2NINLCOPS1HDAC1CLTCEP97NFKB1COPS4GLAARL8BWNK1TFAP2ERAB2ACNOT6LNDUFA5Cytosolcomplex 46IFT-B1IFT88IFT80IFT172IFT-B2DynactinDynein-2IFT-B2IFT22TTC30BTTC30ATTC26HSPB11CLUAP1TRAF3IP1EXOC6BEXOC6EXOC7EXOC5EXOC2EXOC3EXOC1EXOC4exocyst-2exocyst-1EXOC2EXOC3EXOC1EXOC6BEXOC6EXOC7EXOC5EXOC4RALBBBSomeBBS1BBS2BBS5BBS4BBS7TCTEX1D2PAFAH1B1DYNLRB2DYNLRB1MAPRE2Dynein-1WDR60DYNLT1WDR34DYNLT3TIPRLTCTEX1D2DYNLT3DYNC1H1DYNLT1PAFAH1B1DYNC1I2DYNC1LI1Dynein-2WHRNVIMZYG11BGLB1NEFLNEFMXPNPEP3NEFGID4ARMC8RANBP9RMND5BRANBP10MAEAMKLN1GID8LCN2WDR26YPEL5EFHC2PGRMC2UBE2HRMND5AHTRA2DDX5ZMYND19RAB8AANKS6ANKS3NEK7NEK8MYL6TBC1D4CEP290IQGAP2CALM1LRPPRCIQCB1IQGAP3IQGAP1COX6CSTOMMYL6BRAC1EIF5B


Description

Ciliary landscape pathway - according to Boldt et al. 2016 - was constructed using the results of affinity proteomics for 217 proteins with known or suspected involvement in ciliary function, resulting in a landscape of 1319 proteins and 4905 interactions of which the most important are shown here (derived from Figure 1). Ciliary function is impaired in a wide spectrum of diseases (ciliopathies) including polycystic kidney disease, Usher syndrome, Bardet-Biedl syndrome, Meckel-Gruber syndrome, and Jeune syndrome.

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Bibliography

  1. Boldt K, van Reeuwijk J, Lu Q, Koutroumpas K, Nguyen TM, Texier Y, van Beersum SE, Horn N, Willer JR, Mans DA, Dougherty G, Lamers IJ, Coene KL, Arts HH, Betts MJ, Beyer T, Bolat E, Gloeckner CJ, Haidari K, Hetterschijt L, Iaconis D, Jenkins D, Klose F, Knapp B, Latour B, Letteboer SJ, Marcelis CL, Mitic D, Morleo M, Oud MM, Riemersma M, Rix S, Terhal PA, Toedt G, van Dam TJ, de Vrieze E, Wissinger Y, Wu KM, Apic G, Beales PL, Blacque OE, Gibson TJ, Huynen MA, Katsanis N, Kremer H, Omran H, van Wijk E, Wolfrum U, Kepes F, Davis EE, Franco B, Giles RH, Ueffing M, Russell RB, Roepman R; ''An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.''; Nat Commun, 2016 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
102218view20:44, 11 December 2018Khanspersfixed unconnected interactions
98719view14:32, 1 October 2018FehrhartProteasome
98718view14:20, 1 October 2018FehrhartIQ/GAP
98717view14:07, 1 October 2018FehrhartGID
98716view13:45, 1 October 2018FehrhartNEF
98715view13:21, 1 October 2018Fehrhartadded BBSome and dynein complexes
98714view12:52, 1 October 2018Fehrhartadded complexes IFTB1 and B2
98599view14:12, 20 September 2018FehrhartModified description
98598view14:06, 20 September 2018FehrhartOntology Term : 'ciliopathy' added !
98597view14:05, 20 September 2018FehrhartOntology Term : 'transport pathway' added !
98596view13:56, 20 September 2018FehrhartNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACSL3GeneProductENSG00000123983 (Ensembl)
AIMP1GeneProductENSG00000164022 (Ensembl)
ANKS3GeneProductENSG00000168096 (Ensembl)
ANKS6GeneProductENSG00000165138 (Ensembl)
APCGeneProductENSG00000134982 (Ensembl)
ARFGAP3GeneProduct26286 (Entrez Gene)
ARHGDIAGeneProductENSG00000141522 (Ensembl)
ARL8BGeneProductENSG00000134108 (Ensembl)
ARMC8GeneProductENSG00000114098 (Ensembl)
BBIP1GeneProductENSG00000214413 (Ensembl)
BBS1GeneProductENSG00000174483 (Ensembl)
BBS2GeneProductENSG00000125124 (Ensembl)
BBS4GeneProductENSG00000140463 (Ensembl)
BBS5GeneProductENSG00000163093 (Ensembl)
BBS7GeneProductENSG00000138686 (Ensembl)
BBS9GeneProductENSG00000122507 (Ensembl)
CALM1GeneProductENSG00000198668 (Ensembl)
CAMK2AGeneProductENSG00000070808 (Ensembl)
CBSGeneProductENSG00000160200 (Ensembl)
CCDC40GeneProductENSG00000141519 (Ensembl)
CD2BP2GeneProductENSG00000169217 (Ensembl)
CDH23GeneProductENSG00000107736 (Ensembl)
CDR2GeneProductENSG00000140743 (Ensembl)
CEP170GeneProductENSG00000143702 (Ensembl)
CEP290GeneProductENSG00000198707 (Ensembl)
CEP97GeneProductENSG00000182504 (Ensembl)
CLTGeneProductno idea what that should be
CLUAP1GeneProductENSG00000103351 (Ensembl)
CNOT10GeneProductENSG00000182973 (Ensembl)
CNOT1GeneProductENSG00000125107 (Ensembl)
CNOT6LGeneProductENSG00000138767 (Ensembl)
COPS1GeneProductno annotation found yet
COPS2GeneProductENSG00000166200 (Ensembl)
COPS3GeneProductENSG00000141030 (Ensembl)
COPS4GeneProductENSG00000138663 (Ensembl)
COPS5GeneProductCOPS5 (HGNC)
COPS6GeneProductENSG00000168090 (Ensembl)
COPS7AGeneProductENSG00000111652 (Ensembl)
COPS7BGeneProductENSG00000144524 (Ensembl)
COPS8GeneProductENSG00000198612 (Ensembl)
COX6CGeneProductENSG00000164919 (Ensembl)
CREBBPGeneProductENSG00000005339 (Ensembl)
CTBP2GeneProductENSG00000175029 (Ensembl)
CTNNB1GeneProductENSG00000168036 (Ensembl)
CTSAGeneProductENSG00000064601 (Ensembl)
DCAF11GeneProductENSG00000100897 (Ensembl)
DCAF7GeneProductENSG00000136485 (Ensembl)
DDX5GeneProductENSG00000108654 (Ensembl)
DGKEGeneProductENSG00000153933 (Ensembl)
DNPEPGeneProductENSG00000123992 (Ensembl)
DVL3GeneProductENSG00000161202 (Ensembl)
DYNC1H1GeneProductENSG00000197102 (Ensembl)
DYNC1I2GeneProductENSG00000077380 (Ensembl)
DYNC1LI1GeneProductENSG00000144635 (Ensembl)
DYNLL1GeneProductENSG00000088986 (Ensembl)
DYNLL2GeneProductENSG00000264364 (Ensembl)
DYNLRB1GeneProductENSG00000125971 (Ensembl)
DYNLRB2GeneProductENSG00000168589 (Ensembl)
DYNLT1GeneProductENSG00000146425 (Ensembl)
DYNLT3GeneProductENSG00000165169 (Ensembl)
ECHS1GeneProductENSG00000127884 (Ensembl)
EFHC2GeneProductENSG00000183690 (Ensembl)
EFTUD2GeneProductENSG00000108883 (Ensembl)
EHBP1GeneProductENSG00000115504 (Ensembl)
EIF5BGeneProductENSG00000158417 (Ensembl)
ERFGeneProductENSG00000105722 (Ensembl)
EXOC1GeneProductENSG00000090989 (Ensembl)
EXOC2GeneProductENSG00000112685 (Ensembl)
EXOC3GeneProductENSG00000180104 (Ensembl)
EXOC4GeneProductENSG00000131558 (Ensembl)
EXOC5GeneProductENSG00000070367 (Ensembl)
EXOC6BGeneProductENSG00000144036 (Ensembl)
EXOC6GeneProductENSG00000138190 (Ensembl)
EXOC7GeneProductENSG00000182473 (Ensembl)
EXOC8GeneProductENSG00000116903 (Ensembl)
EXOSC9GeneProductENSG00000123737 (Ensembl)
GDI1GeneProductENSG00000203879 (Ensembl)
GID4GeneProductENSG00000141034 (Ensembl)
GID8GeneProductENSG00000101193 (Ensembl)
GLAGeneProductENSG00000102393 (Ensembl)
GLB1GeneProductENSG00000170266 (Ensembl)
H3F3AGeneProductENSG00000163041 (Ensembl)
HDAC1GeneProductENSG00000116478 (Ensembl)
HDAC2GeneProductENSG00000196591 (Ensembl)
HSPB11GeneProductENSG00000081870 (Ensembl)
HTRA2GeneProductENSG00000115317 (Ensembl)
IFT122GeneProductENSG00000163913 (Ensembl)
IFT140GeneProductENSG00000187535 (Ensembl)
IFT172GeneProductENSG00000138002 (Ensembl)
IFT20GeneProductENSG00000109083 (Ensembl)
IFT22GeneProductENSG00000128581 (Ensembl)
IFT27GeneProductENSG00000100360 (Ensembl)
IFT43GeneProductENSG00000119650 (Ensembl)
IFT46GeneProductENSG00000118096 (Ensembl)
IFT52GeneProductENSG00000101052 (Ensembl)
IFT57GeneProductENSG00000114446 (Ensembl)
IFT74GeneProductENSG00000096872 (Ensembl)
IFT80GeneProductENSG00000068885 (Ensembl)
IFT81GeneProductENSG00000122970 (Ensembl)
IFT88GeneProductENSG00000032742 (Ensembl)
IQCB1GeneProductENSG00000173226 (Ensembl)
IQGAP1GeneProductENSG00000140575 (Ensembl)
IQGAP2GeneProductENSG00000145703 (Ensembl)
IQGAP3GeneProductENSG00000183856 (Ensembl)
LCA5GeneProductENSG00000135338 (Ensembl)
LCN2GeneProductENSG00000148346 (Ensembl)
LRPPRCGeneProductENSG00000138095 (Ensembl)
LSM4GeneProductENSG00000130520 (Ensembl)
LZTFL1GeneProductENSG00000163818 (Ensembl)
MAEAGeneProductENSG00000090316 (Ensembl)
MAPRE2GeneProductENSG00000166974 (Ensembl)
MCM10GeneProductENSG00000065328 (Ensembl)
MCM2GeneProductENSG00000073111 (Ensembl)
MCM3GeneProductENSG00000112118 (Ensembl)
MCM4GeneProductENSG00000104738 (Ensembl)
MCM5GeneProductENSG00000100297 (Ensembl)
MCM6GeneProductENSG00000076003 (Ensembl)
MCM7GeneProductENSG00000166508 (Ensembl)
MCM8GeneProductENSG00000125885 (Ensembl)
MCM9GeneProductENSG00000111877 (Ensembl)
MFAP1GeneProductENSG00000140259 (Ensembl)
MKLN1GeneProductENSG00000128585 (Ensembl)
MKS1GeneProductENSG00000011143 (Ensembl)
MSH2GeneProductENSG00000095002 (Ensembl)
MYL6BGeneProductENSG00000196465 (Ensembl)
MYL6GeneProductENSG00000092841 (Ensembl)
NDUFA5GeneProductENSG00000128609 (Ensembl)
NDUFA9GeneProductENSG00000139180 (Ensembl)
NEFLGeneProductENSG00000277586 (Ensembl)
NEFMGeneProductENSG00000104722 (Ensembl)
NEK7GeneProductENSG00000151414 (Ensembl)
NEK8GeneProductENSG00000160602 (Ensembl)
NFKB1GeneProductENSG00000109320 (Ensembl)
NINLGeneProductENSG00000101004 (Ensembl)
NME8GeneProductENSG00000086288 (Ensembl)
NUDCGeneProductENSG00000090273 (Ensembl)
NUP133GeneProductENSG00000069248 (Ensembl)
NUP88GeneProductENSG00000108559 (Ensembl)
PAFAH1B1GeneProductENSG00000007168 (Ensembl)
PGRMC2GeneProductENSG00000164040 (Ensembl)
POM121GeneProductENSG00000196313 (Ensembl)
RAB14GeneProductENSG00000119396 (Ensembl)
RAB21GeneProductENSG00000080371 (Ensembl)
RAB2AGeneProductENSG00000104388 (Ensembl)
RAB3IL1GeneProductENSG00000167994 (Ensembl)
RAB8AGeneProductENSG00000167461 (Ensembl)
RABEP2GeneProductENSG00000177548 (Ensembl)
RAC1GeneProductENSG00000136238 (Ensembl)
RALBGeneProductENSG00000144118 (Ensembl)
RANBP10GeneProductENSG00000141084 (Ensembl)
RANBP9GeneProductENSG00000010017 (Ensembl)
RB1GeneProductENSG00000139687 (Ensembl)
RBM14GeneProductENSG00000239306 (Ensembl)
RHBDD2GeneProductENSG00000005486 (Ensembl)
RMND5AGeneProductENSG00000153561 (Ensembl)
RMND5BGeneProductENSG00000145916 (Ensembl)
RPGRGeneProductENSG00000156313 (Ensembl)
RQCD1ProteinD5MQE1 (Uniprot-TrEMBL)
SNAP29GeneProductENSG00000099940 (Ensembl)
SNRPB2GeneProductENSG00000125870 (Ensembl)
SPATA7GeneProductENSG00000042317 (Ensembl)
SSNA1GeneProductENSG00000176101 (Ensembl)
STOMGeneProductENSG00000148175 (Ensembl)
TBC1D4GeneProductENSG00000136111 (Ensembl)
TCTEX1D2GeneProductENSG00000213123 (Ensembl)
TFAP2AGeneProductENSG00000137203 (Ensembl)
TFAP2BGeneProductENSG00000008196 (Ensembl)
TFAP2CGeneProductENSG00000087510 (Ensembl)
TFAP2DGeneProductENSG00000008197 (Ensembl)
TFAP2EGeneProductENSG00000116819 (Ensembl)
TIPRLGeneProductENSG00000143155 (Ensembl)
TMED1GeneProductENSG00000099203 (Ensembl)
TNKS1BP1GeneProductENSG00000149115 (Ensembl)
TRAF3IP1GeneProductENSG00000204104 (Ensembl)
TSSC1GeneProductENSG00000032389 (Ensembl)
TTC26GeneProductENSG00000105948 (Ensembl)
TTC30AGeneProductENSG00000197557 (Ensembl)
TTC30BGeneProductENSG00000196659 (Ensembl)
TTC8GeneProductENSG00000165533 (Ensembl)
UBE2D2GeneProductENSG00000131508 (Ensembl)
UBE2HGeneProductENSG00000186591 (Ensembl)
UQCC1GeneProductENSG00000101019 (Ensembl)
USH1CGeneProductENSG00000006611 (Ensembl)
VIMGeneProductENSG00000026025 (Ensembl)
WDR26GeneProductENSG00000162923 (Ensembl)
WDR34GeneProductENSG00000119333 (Ensembl)
WDR60GeneProductENSG00000126870 (Ensembl)
WEE1GeneProductENSG00000166483 (Ensembl)
WHRNGeneProductENSG00000095397 (Ensembl)
WNK1GeneProductENSG00000060237 (Ensembl)
XPNPEP3GeneProductENSG00000196236 (Ensembl)
YAP1GeneProductENSG00000137693 (Ensembl)
YPEL5GeneProductENSG00000119801 (Ensembl)
ZMYND19GeneProductENSG00000165724 (Ensembl)
ZYG11BGeneProductENSG00000162378 (Ensembl)

Annotated Interactions

No annotated interactions

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