Class I MHC mediated antigen processing and presentation (Homo sapiens)

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34, 58, 63, 67, 70...36, 74, 8639, 44, 11050, 64, 99, 118611, 109, 11412, 20, 26, 84, 126...4, 27, 28, 83, 105...40, 106, 116, 14213260, 74, 12326101, 1163742, 5913040, 5918, 8538, 50, 99, 11840, 12933, 57, 9578, 100, 10113, 2116, 37, 7630, 46, 54, 103, 124...42, 52, 596, 10, 23, 29, 7153, 9236, 8660, 79, 91, 1233, 15, 73, 75, 136...48, 55, 69, 87, 96...62, 74, 83, 9750, 99, 11847, 104, 11131, 41, 43, 9436, 8611311, 46, 80, 102, 12436, 861326, 10, 23, 29, 717, 36, 8650, 99, 11837, 132phagocytic vesiclecytosolendoplasmic reticulum-Golgi intermediate compartmentERGICphagolysosomeCOPII-coated ER to Golgi transport vesicleendoplasmic reticulum lumenrecycling endosomeGolgi lumenclathrin-coated endocytic vesicleearly endosomeclass I MHC B37 class I MHC B81 class I MHC B15 class I MHC B52 KLHL2 HLA class I histocompatibility antigen, alpha chain F precursor PSMD3 HLA class I histocompatibility antigen, Cw-1 alpha chain HLA class I histocompatibility antigen, alpha chain G precursor THOP1TRIM39 TRIM50 MKRN1 class I MHC B78 UBE2V2 PSMD11 class I MHC B7 ASB3 HLA class I histocompatibility antigen, Cw-2 alpha chain class I MHC B40 HLA class I histocompatibility antigen, A-36 alpha chain class I MHC B13 PSMD5 class I MHC B13 HLA class I histocompatibility antigen, Cw-1 alpha chain class I MHC B41 SOCS3 UBE2W UBE2G2 class I MHC B53 HLA class I histocompatibility antigen, A-30 alpha chain HLA class I histocompatibility antigen, A-33 alpha chain SEC24KCTD6 BTBD6 KLHL25 SEC23:SEC24VAMP3 LTN1 TRIM71 class I MHC B42 HLA class I histocompatibility antigen, A-25 alpha chain PPiHLA class I histocompatibility antigen, A-30 alpha chain PPiclass I MHC B47 SAR1B:GTP:SEC23:SEC24class I MHC B56 class I MHC B39 FBXL4 HLA class I histocompatibility antigen, A-2 alpha chain HLA class I histocompatibility antigen, Cw-17 alpha chain CALRANAPC7 HLA class I histocompatibility antigen, Cw-15 alpha chain HLA class I histocompatibility antigen, Cw-16 alpha chain RPS27A(1-76) HLA class I histocompatibility antigen, A-3 alpha chain precursor HLA class I histocompatibility antigen, Cw-14 alpha chain SH3RF1 WWP1 class I MHC B52 class I MHC B49 FBXL14 UBE2D4 CBLB HLA class I histocompatibility antigen, A-25 alpha chain PSMD9 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor RCHY1 HLA class I histocompatibility antigen, A-23 alpha chain FBXO22 UBE2G2 class I MHC B51 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor KLHL11 class I MHC B42 UBC(153-228) HLA class I histocompatibility antigen, A-36 alpha chain HECTD3 class I MHC B59 BTBD1 Exogenous Particulate antigen (Ag) class I MHC B53 HLA class I histocompatibility antigen, Cw-16 alpha chain UBA6 KBTBD8 ATPUNKL RNF182 class I MHC B54 class I MHC B55 class I MHC B38 HLA class I histocompatibility antigen, Cw-7 alpha chain precursor CTSL2 RNF7 (RBX2) FBXO22 ATPASB15 FBXL18 HLA class I histocompatibility antigen, A-34 alpha chain NEDD4L HLA class I histocompatibility antigen, Cw-14 alpha chain HERC4 UBAC1 HLA class I histocompatibility antigen, A-29 alpha chain HLA-B CALRRNF19A HLA class I histocompatibility antigen, A-68 alpha chain HLA class I histocompatibility antigen, A-69 alpha chain HLA class I histocompatibility antigen, Cw-15 alpha chain CDC26 FBXO17 class I MHC B27 RNF19B PSMB11 class I MHC B81 FBXL18 FBXW11 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor class I MHC B40 class I MHC B37 TRAIP class I MHC B58 class I MHC B42 class I MHC B27 RNF217 RNF123 HLA class I histocompatibility antigen, A-2 alpha chain SKP2 HLA class I histocompatibility antigen, alpha chain G precursor BAP31 oligomer UBE3C HLA class I histocompatibility antigen, Cw-5 alpha chain precursor RPS27A(1-76) ATG7 HLA class I histocompatibility antigen, Cw-8 alpha chain PSMD5 HLA class I histocompatibility antigen, A-11 alpha chain HLA class I histocompatibility antigen, A-68 alpha chain HLA class I histocompatibility antigen, A-31 alpha chain class I MHC B67 HLA class I histocompatibility antigen, alpha chain G precursor ASB17 TAP1 KLHL9 ZNF645 PSMA8 B2M(21-119) MGRN1 HLA class I histocompatibility antigen, A-24 alpha chain FBXO4 class I MHC B57 FBXO9 ANAPC2 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor FBXO2 class I MHC B73 HLA class I histocompatibility antigen, A-43 alpha chain PSMD4 class I MHC B18 BTBD1 class I MHC B14 SEC24D BAP31 oligomer HLA-B HLA class I histocompatibility antigen, Cw-14 alpha chain RNF111 PSMB4 HLA class I histocompatibility antigen, Cw-12 alpha chain HLA class I histocompatibility antigen, alpha chain F precursor class I MHC B53 HLA class I histocompatibility antigen, A-25 alpha chain LMO7 PJA2 class I MHC B14 class I MHC B44 HLA class I histocompatibility antigen, A-11 alpha chain TRIM37 ANAPC2 class I MHC B46 HLA class I histocompatibility antigen, A-25 alpha chain FBXL19 Mg2+UBR1 GTP KCTD7 UBA52(1-76) ASB10 UBE4A HLA class I histocompatibility antigen, Cw-7 alpha chain precursor Antigen HLA class I histocompatibility antigen, Cw-3 alpha chain precursor HLA class I histocompatibility antigen, A-69 alpha chain HLA class I histocompatibility antigen, A-34 alpha chain HLA class I histocompatibility antigen, Cw-18 alpha chain HLA class I histocompatibility antigen, A-11 alpha chain UBA52(1-76) KLHL11 SEC24B GPIN-CD14(20-345) class I MHC B44 FBXO15 HLA class I histocompatibility antigen, Cw-18 alpha chain class I MHC B45 ATPHLA class I histocompatibility antigen, A-25 alpha chain antigenic substrate Antigen peptide BTRC HLA class I histocompatibility antigen, alpha chain F precursor HLA class I histocompatibility antigen, alpha chain G precursor HLA-H CD36 class I MHC B49 HLA class I histocompatibility antigen, A-26 alpha chain PSME3 HLA class I histocompatibility antigen, A-30 alpha chain HLA class I histocompatibility antigen, alpha chain F precursor RBX1 UBR4 KCTD7 ASB18 HLA class I histocompatibility antigen, A-32 alpha chain class I MHC B37 class I MHC B82 class I MHC B59 HLA class I histocompatibility antigen, A-30 alpha chain HACE1 class I MHC B13 TAP2 HLA class I histocompatibility antigen, A-25 alpha chain FCGR HLA class I histocompatibility antigen, A-74 alpha chain PSMB4 HLA class I histocompatibility antigen, A-68 alpha chain class I MHC B67 PiASB9 MGRN1 TAPBP CUL1 ASB16 class I MHC B27 LMO7 PSMA3 FBXO31 PSMC4 HLA class I histocompatibility antigen, A-74 alpha chain RLIM class I MHC B57 HLA class I histocompatibility antigen, A-34 alpha chain HLA class I histocompatibility antigen, A-29 alpha chain SEC24D TRIM39 class I MHC B37 HLA class I histocompatibility antigen, A-32 alpha chain B2M(21-119) FBXL12 HLA class I histocompatibility antigen, A-31 alpha chain HLA class I histocompatibility antigen, A-80 alpha chain HLA class I histocompatibility antigen, A-1 alpha chain precursor UBC(609-684) HLA class I histocompatibility antigen, Cw-8 alpha chain B2M(21-119) UBC(229-304) SEC61B HLA class I histocompatibility antigen, A-68 alpha chain class I MHC B54 HECTD2 HLA class I histocompatibility antigen, A-25 alpha chain ANAPC1 class I MHC B38 PI(4,5)P2 HLA class I histocompatibility antigen, A-29 alpha chain class I MHC B38 HLA class I histocompatibility antigen, A-69 alpha chain HLA class I histocompatibility antigen, alpha chain G precursor CALR:SEC22B:STX4:TAP:TAPBPclass I MHC B39 B2M(21-119) TRAF7 class I MHC B40 class I MHC B50 HLA class I histocompatibility antigen, A-33 alpha chain VPRBP DET1 HLA class I histocompatibility antigen, A-33 alpha chain HERC3 HLA class I histocompatibility antigen, A-33 alpha chain HLA class I histocompatibility antigen, A-34 alpha chain UBAC1 FBXO2 FBXW12 HLA class I histocompatibility antigen, Cw-14 alpha chain class I MHC B7 HLA class I histocompatibility antigen, A-24 alpha chain PSMC5 HLA class I histocompatibility antigen, Cw-2 alpha chain ANAPC1 TRAIP NADP+KLHL20 class I MHC B40 HLA class I histocompatibility antigen, Cw-17 alpha chain UBB(1-76) class I MHC B38 HLA class I histocompatibility antigen, A-29 alpha chain FBXO7 oligopeptidefragment (3-7aa)PSMD13 FBXO17 RNF19A class I MHC B8 HLA class I histocompatibility antigen, A-29 alpha chain HECW2 HECTD3 KLHL20 MYLIP HLA class I histocompatibility antigen, A-1 alpha chain precursor HLA class I histocompatibility antigen, A-69 alpha chain HLA class I histocompatibility antigen, Cw-15 alpha chain HLA class I histocompatibility antigen, Cw-15 alpha chain class I MHC B41 VAMP8,VAMP3RNF4 HLA class I histocompatibility antigen, Cw-8 alpha chain FBXO27 class I MHC B15 HLA class I histocompatibility antigen, A-32 alpha chain class I MHC B58 RNF19B HLA class I histocompatibility antigen, Cw-18 alpha chain UBC(533-608) HLA class I histocompatibility antigen, Cw-5 alpha chain precursor class I MHC B14 RNF123 RLIM UBR4 HLA class I histocompatibility antigen, A-34 alpha chain HLA-H Diacyl lipopeptide class I MHC B41 class I MHC B27 HLA class I histocompatibility antigen, A-26 alpha chain HLA class I histocompatibility antigen, Cw-18 alpha chain class I MHC B51 FBXL8 HLA class I histocompatibility antigen, Cw-14 alpha chain HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 26S proteasomeH2OKLHL42 FBXO31 SIAH2 class I MHC B13 PSMB11 class I MHC B37 class I MHC B46 HLA class I histocompatibility antigen, A-36 alpha chain HLA class I histocompatibility antigen, alpha chain G precursor RNF4 HLA class I histocompatibility antigen, alpha chain G precursor FBXW9 PSMA7 class I MHC B38 BTBD1 class I MHC B8 ARIH2 class I MHC B38 HLA class I histocompatibility antigen, A-68 alpha chain PDIA3 UBE3D HLA class I histocompatibility antigen, A-68 alpha chain RNF130 HLA class I histocompatibility antigen, A-26 alpha chain TRIM63 L-amino acidUBA5 HLA class I histocompatibility antigen, E alpha chain precursor HERC5 class I MHC B73 UBE2H class I MHC B81 HLA class I histocompatibility antigen, Cw-8 alpha chain class I MHC B27 class I MHC B41 SEC13 HLA class I histocompatibility antigen, A-26 alpha chain class I MHC B49 class I MHC B14 HLA class I histocompatibility antigen, A-24 alpha chain class I MHC B47 class I MHC B47 ANAPC13 class I MHC B52 HLA class I histocompatibility antigen, E alpha chain precursor class I MHC B47 UBE2H PSMD14 class I MHC B59 FBXO40 HLA class I histocompatibility antigen, Cw-16 alpha chain CDC23 KLHL11 HLA class I histocompatibility antigen, A-1 alpha chain precursor HLA class I histocompatibility antigen, A-43 alpha chain HLA class I histocompatibility antigen, A-33 alpha chain HLA class I histocompatibility antigen, A-69 alpha chain UBA7 class I MHC B57 class I MHC B44 BTBD6 HLA class I histocompatibility antigen, Cw-2 alpha chain class I MHC B42 ATG7 SEC24B UBE2Q1 class I MHC B78 HLA class I histocompatibility antigen, A-33 alpha chain class I MHC B47 class I MHC B47 HLA class I histocompatibility antigen, A-34 alpha chain ZNF645 FBXL15 PSMA4 HLA class I histocompatibility antigen, A-29 alpha chain TAP1 SAR1B class I MHC B15 UBE2E2 class I MHC B73 HLA class I histocompatibility antigen, A-26 alpha chain HLA class I histocompatibility antigen, A-11 alpha chain SEC13 class I MHC B7 Antigen peptidebound class I MHCPSMB8 SPSB1 HLA class I histocompatibility antigen, A-11 alpha chain ASB10 FBXO44 LRRC41 RNF6 class I MHC B44 UBA6 FBXL3 HLA class I histocompatibility antigen, A-23 alpha chain B2M(21-119) FBXW8 class I MHC B49 RNF19A UBR4 CUL3 HLA-B class I MHC B50 ELOC O2.-HLA class I histocompatibility antigen, A-74 alpha chain ANAPC11 KCTD6 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor class I MHC B73 TRIM9 CDC23 class I MHC B59 class I MHC B35 ASB12 HLA class I histocompatibility antigen, A-2 alpha chain HLA class I histocompatibility antigen, A-80 alpha chain HLA class I histocompatibility antigen, Cw-15 alpha chain HLA class I histocompatibility antigen, Cw-17 alpha chain HLA class I histocompatibility antigen, alpha chain F precursor HLA class I histocompatibility antigen, A-2 alpha chain HLA class I histocompatibility antigen, A-3 alpha chain precursor FBXL20 UBB(77-152) class I MHC B50 ASB2 class I MHC B7 MYD88 SKP1 HLA class I histocompatibility antigen, A-23 alpha chain KBTBD7 KBTBD7 PSMB10 PSMF1 CUL5 SMURF1 TRIM9 class I MHC B41 HERC6 class I MHC B55 class I MHC B49 H2OO2class I MHC B73 HLA class I histocompatibility antigen, A-23 alpha chain HLA class I histocompatibility antigen, Cw-12 alpha chain class I MHC B7 MEX3C class I MHC B15 class I MHC B13 UBC(381-456) CANX FBXO15 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor class I MHC B15 HLA class I histocompatibility antigen, A-25 alpha chain class I MHC B37 FBXL4 class I MHC B41 LRSAM1 HLA class I histocompatibility antigen, Cw-2 alpha chain UBE2S FBXL14 SPSB4 FBXW10 PSMD4 HLA-H UBE2V1 HLA class I histocompatibility antigen, A-66 alpha chain CUL5 class I MHC B18 PSMD3 FBXO44 RNF41 HLA class I histocompatibility antigen, Cw-7 alpha chain precursor class I MHC B8 class I MHC B73 HLA class I histocompatibility antigen, A-43 alpha chain HLA class I histocompatibility antigen, alpha chain G precursor HLA class I histocompatibility antigen, A-31 alpha chain HLA class I histocompatibility antigen, A-30 alpha chain HUWE1 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor ITCH class I MHC B55 HLA class I histocompatibility antigen, Cw-17 alpha chain HLA class I histocompatibility antigen, A-74 alpha chain SEC24A KCTD7 UBB(153-228) PSMC3 PSMC2 LRR1 KLHL11 HLA class I histocompatibility antigen, Cw-15 alpha chain class I MHC B39 class I MHC B27 TPP2 CCNF HERC4 class I MHC B42 HLA class I histocompatibility antigen, A-68 alpha chain class I MHC B57 HLA class I histocompatibility antigen, Cw-2 alpha chain UBC(77-152) class I MHC B81 HLA class I histocompatibility antigen, A-3 alpha chain precursor PSMC3 class I MHC B52 RNF126 HLA class I histocompatibility antigen, A-66 alpha chain FBXO31 HECTD1 ExogenousParticulate antigen(Ag)HLA class I histocompatibility antigen, A-80 alpha chain class I MHC B56 class I MHC B8 FBXO11 SHFM1 (Glc)1 (GlcNAc)2 (Man)9 PSMC6 HLA class I histocompatibility antigen, Cw-18 alpha chain HLA class I histocompatibility antigen, A-32 alpha chain class I MHC B51 class I MHC B35 FBXO10 CUL3 class I MHC B67 class I MHC B53 HLA class I histocompatibility antigen, A-23 alpha chain KBTBD7 26S proteasomeRPS27A(1-76) HLA class I histocompatibility antigen, Cw-18 alpha chain class I MHC B35 SEC24B HLA class I histocompatibility antigen, A-33 alpha chain CUL3 HLA class I histocompatibility antigen, A-26 alpha chain HLA class I histocompatibility antigen, Cw-4 alpha chain precursor ASB15 ASB5 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor HLA class I histocompatibility antigen, Cw-7 alpha chain precursor ANAPC5 HLA class I histocompatibility antigen, A-43 alpha chain HLA class I histocompatibility antigen, A-25 alpha chain HLA class I histocompatibility antigen, A-69 alpha chain Antigen peptide class I MHC B55 class I MHC B54 TAP2 KBTBD8 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor TAPBP PSMC2 class I MHC B49 LRSAM1 RBCK1 HLA class I histocompatibility antigen, A-33 alpha chain UBC(609-684) ATPSIAH1 ARIH2 PSME4 ERAP1/2CYBB class I MHC B40 FZR1 HERC1 class I MHC B53 SEC31A HERC2 CDC34 class I MHC B73 MHCclassIHC:Calnexin/BiP:Erp57UBA7 HLA-B ASB5 class I MHC B13 UBA52(1-76) UBC(305-380) DET1 class I MHC B58 HLA class I histocompatibility antigen, A-11 alpha chain HLA class I histocompatibility antigen, A-29 alpha chain HLA-H HLA class I histocompatibility antigen, Cw-12 alpha chain HECTD2 class I MHC B53 class I MHC B44 class I MHC B58 HLA class I histocompatibility antigen, E alpha chain precursor class I MHC B67 SH3RF1 UBE2D1 FZR1 class I MHC B55 B2M(21-119) HLA class I histocompatibility antigen, A-3 alpha chain precursor class I MHC B7 RPS27A(1-76) HLA class I histocompatibility antigen, A-34 alpha chain HLA class I histocompatibility antigen, Cw-3 alpha chain precursor K48polyUb-partiallydigested Agclass I MHC B53 UNKL HLA class I histocompatibility antigen, A-74 alpha chain HLA-H HLA class I histocompatibility antigen, A-36 alpha chain HLA class I histocompatibility antigen, Cw-18 alpha chain class I MHC B38 HLA class I histocompatibility antigen, A-66 alpha chain Unknown hydrolaseERAP1 class I MHC B8 HLA class I histocompatibility antigen, A-66 alpha chain HLA class I histocompatibility antigen, Cw-5 alpha chain precursor class I MHC B78 PDIA3 HLA class I histocompatibility antigen, Cw-17 alpha chain class I MHC B41 PSMD14 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor class I MHC B37 TRIM4 class I MHC B42 ASB1 monoglucosylated MHCclass IHC:Calnexin/BiPoligopeptidefragment (8-16aa)FBXL20 SMURF1 class I MHC B37 L-amino acidRBX1 class I MHC B55 class I MHC B37 CUL5 HLA class I histocompatibility antigen, A-3 alpha chain precursor CUL2 HLA class I histocompatibility antigen, Cw-18 alpha chain ZNF645 class I MHC B51 TAPBP HLA class I histocompatibility antigen, A-80 alpha chain class I MHC B27 SEC24A HLA class I histocompatibility antigen, A-30 alpha chain FBXW2 class I MHC B54 HLA class I histocompatibility antigen, A-11 alpha chain RNF144B RNF220 SKP2 STUB1 class I MHC B56 SEC24B HLA class I histocompatibility antigen, A-29 alpha chain UBC(381-456) PSME3 ASB16 class I MHC B81 HLA class I histocompatibility antigen, A-23 alpha chain HLA class I histocompatibility antigen, Cw-14 alpha chain RNF7 (RBX2) PSMC1 HLA class I histocompatibility antigen, A-66 alpha chain class I MHC B45 HLA class I histocompatibility antigen, Cw-18 alpha chain HLA class I histocompatibility antigen, Cw-17 alpha chain LRR1 FBXL14 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor class I MHC B56 TRAIP class I MHC B39 HLA class I histocompatibility antigen, A-26 alpha chain RNF138 RNF130 SEC24A class I MHC B45 FBXO6 FBXL16 HLA class I histocompatibility antigen, A-26 alpha chain UBOX5 HLA class I histocompatibility antigen, A-68 alpha chain HLA class I histocompatibility antigen, Cw-4 alpha chain precursor class I MHC B82 UBA7 class I MHC B78 class I MHC B52 DZIP3 HLA class I histocompatibility antigen, A-25 alpha chain class I MHC B15 class I MHC B42 class I MHC B58 HLA class I histocompatibility antigen, A-68 alpha chain HLA class I histocompatibility antigen, A-43 alpha chain UBE2L6 RNF25 ADPASB4 SPSB2 class I MHC B49 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor HLA class I histocompatibility antigen, A-80 alpha chain HLA class I histocompatibility antigen, A-23 alpha chain GLMN HLA class I histocompatibility antigen, A-80 alpha chain class I MHC B45 BTBD6 HLA class I histocompatibility antigen, A-43 alpha chain class I MHC B50 HLA class I histocompatibility antigen, A-2 alpha chain CTSS HLA class I histocompatibility antigen, Cw-15 alpha chain class I MHC B40 HLA class I histocompatibility antigen, Cw-7 alpha chain precursor ASB9 HLA class I histocompatibility antigen, A-80 alpha chain CALRASB7 ANAPC5 HLA class I histocompatibility antigen, A-24 alpha chain HLA-H HLA class I histocompatibility antigen, Cw-16 alpha chain SAR1B HLA class I histocompatibility antigen, A-1 alpha chain precursor UBE2K RNF34 L-amino acidclass I MHC B15 HLA class I histocompatibility antigen, Cw-14 alpha chain HLA class I histocompatibility antigen, Cw-15 alpha chain HLA class I histocompatibility antigen, Cw-3 alpha chain precursor HLA class I histocompatibility antigen, A-11 alpha chain RNF19B HLA class I histocompatibility antigen, alpha chain G precursor class I MHC B67 RBBP6 RNF126 FBXL22 HLA class I histocompatibility antigen, Cw-8 alpha chain (Glc)1 (GlcNAc)2 (Man)9 class I MHC B52 ASB14 HLA class I histocompatibility antigen, Cw-7 alpha chain precursor FCGRA HLA-H ANAPC10 class I MHC B54 class I MHC B47 HLA class I histocompatibility antigen, A-80 alpha chain HLA-B class I MHC B38 PSMB10 SEC22B:STX4UBE2V2 UBA52(1-76) FBXO41 2xN4GlycoAsn-LY96 CTSL1(114-288) PSMC1 HLA class I histocompatibility antigen, A-3 alpha chain precursor DZIP3 MRC1 PSMA6 HLA class I histocompatibility antigen, A-24 alpha chain HLA class I histocompatibility antigen, A-36 alpha chain CDC20 (Glc)1 (GlcNAc)2 (Man)9 SIAH2 HLA class I histocompatibility antigen, A-74 alpha chain (Glc)1 (GlcNAc)2 (Man)9 class I MHC B15 class I MHC B35 HLA class I histocompatibility antigen, A-1 alpha chain precursor class I MHC B27 KLHL13 class I MHC B58 HECTD1 class I MHC B37 class I MHC B54 HLA class I histocompatibility antigen, A-36 alpha chain HLA class I histocompatibility antigen, Cw-14 alpha chain HLA class I histocompatibility antigen, Cw-6 alpha chain precursor HLA class I histocompatibility antigen, alpha chain G precursor SEC23A PSME4 HLA class I histocompatibility antigen, Cw-7 alpha chain precursor PSMB8 CD207 HLA class I histocompatibility antigen, Cw-18 alpha chain ASB3 class I MHC B49 UBE2A DTX3L WWP1 class I MHC B56 PSMA6 class I MHC B13 ASB10 class I MHC B39 class I MHC B59 TRIM36 HLA class I histocompatibility antigen, A-24 alpha chain CBLB class I MHC B8 class I MHC B18 RNF34 class I MHC B56 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor ZNRF2 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor partially digestedAgclass I MHC B45 HLA class I histocompatibility antigen, Cw-7 alpha chain precursor UBE3B HLA class I histocompatibility antigen, Cw-8 alpha chain HLA class I histocompatibility antigen, A-69 alpha chain TRIM4 PARK2 HLA class I histocompatibility antigen, A-26 alpha chain CDC23 GLMN CUL2 HLA class I histocompatibility antigen, A-36 alpha chain ANAPC7 PSMD12 KBTBD13 HECTD1 HLA class I histocompatibility antigen, A-74 alpha chain Class I MHCHC:B2M:Erp57SEC31A HLA class I histocompatibility antigen, A-26 alpha chain SPSB1 class I MHC B42 NEDD4L LRRC41 STX4 class I MHC B52 HLA class I histocompatibility antigen, A-32 alpha chain SEC23A HLA class I histocompatibility antigen, A-36 alpha chain KCTD6 NEDD4 KCTD7 ASB3 TRIM11 class I MHC B37 HACE1 HUWE1 TRIM50 class I MHC B15 class I MHC B67 class I MHC B47 (Glc)1 (GlcNAc)2 (Man)9 CTSS-like proteinsclass I MHC B8 CD14(20-345) DC receptorsrecognizingapoptotic cellsclass I MHC B53 SPSB2 UBE2F PSMB6 class I MHC B59 HLA class I histocompatibility antigen, A-36 alpha chain RNF115 FBXO30 HLA class I histocompatibility antigen, A-68 alpha chain HLA class I histocompatibility antigen, Cw-12 alpha chain HLA class I histocompatibility antigen, A-24 alpha chain class I MHC B45 HSPA5 HLA class I histocompatibility antigen, Cw-14 alpha chain TRIM50 HLA class I histocompatibility antigen, Cw-2 alpha chain UFL1 HLA class I histocompatibility antigen, Cw-7 alpha chain precursor PSME2 class I MHC B50 SAR1B RNF34 class I MHC B7 RNF123 HLA class I histocompatibility antigen, Cw-8 alpha chain class I MHC B45 class I MHC B15 SIAH1 KLHL20 LNX1 class I MHC B52 class I MHC B51 class I MHC B78 ASB9 B2M(21-119) NEDD4 HLA-B class I MHC B56 HLA class I histocompatibility antigen, alpha chain G precursor class I MHC B59 MIB2 HLA-H CDC27 26S proteasomeHLA class I histocompatibility antigen, E alpha chain precursor class I MHC B78 HLA class I histocompatibility antigen, A-26 alpha chain HLA class I histocompatibility antigen, A-34 alpha chain UBR4 HLA class I histocompatibility antigen, A-36 alpha chain SEC24C p-S95-SNAP23HLA class I histocompatibility antigen, A-66 alpha chain PSMA3 class I MHC B15 COPIISNAP23HLA class I histocompatibility antigen, Cw-16 alpha chain ASB6 class I MHC B50 UBE3D STUB1 ZBTB16 LRR1 HLA class I histocompatibility antigen, Cw-16 alpha chain Antigen peptide Antigen peptide PJA2 ZNRF2 ASB7 B2M(21-119) class I MHC B73 class I MHC B14 UBC(1-76) class I MHC B42 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor Antigen peptide UbRNF19A HLA class I histocompatibility antigen, Cw-1 alpha chain class I MHC B58 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor HLA class I histocompatibility antigen, Cw-1 alpha chain FBXO7 RBCK1 FBXW5 KBTBD8 HLA-H ELOB UBE2Q2 HLA class I histocompatibility antigen, E alpha chain precursor class I MHC B55 ASB11 HLA class I histocompatibility antigen, A-2 alpha chain HLA class I histocompatibility antigen, A-26 alpha chain NADPHLipoteichoic acid PSMA4 class I MHC B35 HLA class I histocompatibility antigen, Cw-2 alpha chain HLA class I histocompatibility antigen, Cw-2 alpha chain class I MHC B42 HLA class I histocompatibility antigen, Cw-17 alpha chain ITCH HLA class I histocompatibility antigen, Cw-5 alpha chain precursor HLA class I histocompatibility antigen, A-26 alpha chain FBXO7 ANAPC4 PSME3 GLMN HLA class I histocompatibility antigen, A-32 alpha chain class I MHC B14 HLA class I histocompatibility antigen, Cw-8 alpha chain HLA class I histocompatibility antigen, Cw-3 alpha chain precursor class I MHC B59 PSMD13 UBC(153-228) HLA-B class I MHC B47 CDC20 HLA class I histocompatibility antigen, A-80 alpha chain KEAP1 HLA class I histocompatibility antigen, Cw-15 alpha chain HLA class I histocompatibility antigen, Cw-12 alpha chain class I MHC B46 class I MHC B67 class I MHC B50 LONRF1 HECW2 UBE2N HLA class I histocompatibility antigen, A-24 alpha chain class I MHC B50 UBE2Q1 HLA class I histocompatibility antigen, A-69 alpha chain class I MHC B54 HLA-B class I MHC B14 class I MHC B46 ASB1 PSMB3 class I MHC B82 FBXO40 PSMC2 KLHL41 MHC HC:B2M:Erp57class I MHC B41 class I MHC B15 HLA class I histocompatibility antigen, A-74 alpha chain SEC24D HLA class I histocompatibility antigen, A-34 alpha chain UBB(1-76) KLHL25 KBTBD13 SKP2 class I MHC B50 UBC(77-152) HLA class I histocompatibility antigen, Cw-17 alpha chain FBXL16 class I MHC B35 class I MHC B55 RLIM UBE2C TAPBPclass I MHC B14 UBE2L6 class I MHC B7 UBC(305-380) FBXW4 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor TRIM71 HLA class I histocompatibility antigen, Cw-8 alpha chain class I MHC B56 FBXL18 class I MHC B18 HLA class I histocompatibility antigen, A-43 alpha chain HLA class I histocompatibility antigen, A-30 alpha chain UBC(609-684) HLA class I histocompatibility antigen, Cw-14 alpha chain ASB13 CALR RBBP6 PSMD6 RBX1 class I MHC B56 class I MHC B55 4xPalmC-CD36 FBXL21 SEC24C ITGB5 class I MHC B45 FBXO15 TRIM9 HLA class I histocompatibility antigen, Cw-15 alpha chain HLA class I histocompatibility antigen, Cw-14 alpha chain ASB11 PSMA4 class I MHC B67 CCNF class I MHC B44 UBE2B ARIH2 Antigen peptidebound class I MHCFBXW5 (Glc)1 (GlcNAc)2 (Man)9 HLA class I histocompatibility antigen, A-66 alpha chain SOCS3 HLA class I histocompatibility antigen, Cw-15 alpha chain PJA1 UBC(77-152) VAMP8 KLHL3 TRIM21 ASB1 class I MHC B58 SMURF2 Antigen peptidebound class I MHCHLA class I histocompatibility antigen, A-2 alpha chain HLA class I histocompatibility antigen, alpha chain G precursor HLA class I histocompatibility antigen, alpha chain F precursor PSMA7 SEC23A Transloconclass I MHC B52 class I MHC B54 class I MHC B42 class I MHC B46 class I MHC B14 (Glc)1 (GlcNAc)2 (Man)9 UBR2 KLHL25 ASB12 class I MHC B18 TRIM69 class I MHC B15 STUB1 SEC24C HLA class I histocompatibility antigen, Cw-4 alpha chain precursor Antigen peptidebound class IMHC:BAP31 oligomerKBTBD8 HLA class I histocompatibility antigen, A-1 alpha chain precursor class I MHC B7 LTN1 FBXW2 class I MHC B49 COPII vesicle withMHC class IFBXW4 class I MHC B18 HLA class I histocompatibility antigen, A-3 alpha chain precursor class I MHC B50 2xN4GlycoAsn-TLR4 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor FBXO9 HLA class I histocompatibility antigen, A-32 alpha chain CANX HECTD2 HLA class I histocompatibility antigen, A-29 alpha chain CDC34 HLA class I histocompatibility antigen, A-66 alpha chain class I MHC B73 UBC(229-304) class I MHC B7 PSMA1 SPSB1 UBE3A UNKL TRIM41 SEC24B ITGAV(31-1048) TRIP12 HLA class I histocompatibility antigen, A-11 alpha chain UBE2J2 HLA class I histocompatibility antigen, Cw-8 alpha chain TAP1 UBE2F MIB2 Exogenous soluble antigen class I MHC B40 ANAPC5 class I MHC B14 UBC(457-532) ASB16 HLA class I histocompatibility antigen, A-3 alpha chain precursor HLA class I histocompatibility antigen, Cw-6 alpha chain precursor HLA class I histocompatibility antigen, Cw-7 alpha chain precursor ATPclass I MHC B51 CANX UBC(229-304) ZNRF1 PSMF1 class I MHC B56 NPEPPS PJA2 VPRBP HLA class I histocompatibility antigen, Cw-2 alpha chain HLA class I histocompatibility antigen, A-74 alpha chain class I MHC B15 UBC(609-684) class I MHC B78 SEC23A class I MHC B46 H2Oclass I MHC B18 PSME2 UBR1 class I MHC B18 class I MHC B59 HERC6 class I MHC B13 IRAP in complex withMHC class IUBE3D SAR1B ExogenousParticulate antigen(Ag)PSMA2 HACE1 LNPEP UBB(153-228) TRAF7 class I MHC B27 RNF25 class I MHC B41 RNF41 class I MHC B40 class I MHC B18 HLA class I histocompatibility antigen, A-68 alpha chain HLA class I histocompatibility antigen, A-80 alpha chain class I MHC B55 HLA class I histocompatibility antigen, Cw-17 alpha chain class I MHC B38 HLA class I histocompatibility antigen, alpha chain F precursor class I MHC B53 HLA-H UBE2C TRIM4 FBXL16 HLA-H HLA class I histocompatibility antigen, A-74 alpha chain HLA-B class I MHC B41 PSMD7 FBXO15 UBC(457-532) HLA class I histocompatibility antigen, Cw-8 alpha chain KLHL21 RNF114 class I MHC B38 HLA class I histocompatibility antigen, Cw-1 alpha chain p-T233-NCF2 HLA class I histocompatibility antigen, A-36 alpha chain class I MHC B51 KEAP1 B2M(21-119)PSMD9 PSMB5 class I MHC B58 class I MHC B73 oligopeptide fragment class I MHC B53 ARIH2 FBXL16 HLA class I histocompatibility antigen, A-3 alpha chain precursor HSPA5 class I MHC B54 LTN1 SH3RF1 HLA class I histocompatibility antigen, Cw-17 alpha chain MEX3C ZNRF1 UBE2D2 HLA class I histocompatibility antigen, alpha chain G precursor HLA class I histocompatibility antigen, Cw-1 alpha chain HLA class I histocompatibility antigen, Cw-15 alpha chain HLA class I histocompatibility antigen, A-24 alpha chain class I MHC B53 class I MHC B78 HLA class I histocompatibility antigen, A-36 alpha chain TAPHLA class I histocompatibility antigen, alpha chain G precursor class I MHC B81 UBC(381-456) HLA class I histocompatibility antigen, Cw-12 alpha chain HLA class I histocompatibility antigen, A-32 alpha chain class I MHC B51 class I MHC B7 ADPclass I MHC B55 class I MHC B14 MHC:B2M peptideloading complexclass I MHC B52 class I MHC B8 HLA class I histocompatibility antigen, A-30 alpha chain HLA class I histocompatibility antigen, alpha chain F precursor ASB15 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor HLA class I histocompatibility antigen, A-23 alpha chain HLA class I histocompatibility antigen, A-43 alpha chain SEC24D ELOC SIAH2 PSMB2 KLHL22 TAPUBE2G1 HLA class I histocompatibility antigen, alpha chain F precursor PSMC5 B2M(21-119) UBB(77-152) HLA class I histocompatibility antigen, A-2 alpha chain class I MHC B78 class I MHC B82 HLA class I histocompatibility antigen, A-31 alpha chain class I MHC B35 HLA class I histocompatibility antigen, A-2 alpha chain HLA class I histocompatibility antigen, Cw-8 alpha chain RNF182 UBE2Q2 HLA class I histocompatibility antigen, A-32 alpha chain class I MHC B67 HLA class I histocompatibility antigen, alpha chain F precursor PSMC3 CDC16 HLA class I histocompatibility antigen, A-66 alpha chain HLA class I histocompatibility antigen, Cw-3 alpha chain precursor UBE2D2 CDC20 UBE2D3 PSMA8 HLA class I histocompatibility antigen, Cw-7 alpha chain precursor HLA class I histocompatibility antigen, A-31 alpha chain HLA class I histocompatibility antigen, A-68 alpha chain FBXW7 LMO7 RNF111 UBE2E1 HLA class I histocompatibility antigen, Cw-7 alpha chain precursor class I MHC B45 HLA class I histocompatibility antigen, A-31 alpha chain HLA class I histocompatibility antigen, A-3 alpha chain precursor MYLIP HLA class I histocompatibility antigen, A-66 alpha chain class I MHC B45 HLA class I histocompatibility antigen, A-66 alpha chain class I MHC B8 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor HLA class I histocompatibility antigen, Cw-14 alpha chain HLA class I histocompatibility antigen, A-31 alpha chain HLA class I histocompatibility antigen, Cw-12 alpha chain HLA class I histocompatibility antigen, A-33 alpha chain HLA class I histocompatibility antigen, A-80 alpha chain HLA class I histocompatibility antigen, A-29 alpha chain HLA class I histocompatibility antigen, E alpha chain precursor class I MHC B18 FBXO30 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor SOCS1 HLA class I histocompatibility antigen, A-3 alpha chain precursor HLA class I histocompatibility antigen, Cw-8 alpha chain FBXO6 HLA class I histocompatibility antigen, A-11 alpha chain PARK2 TRIM37 HLA class I histocompatibility antigen, A-25 alpha chain (Glc)1 (GlcNAc)2 (Man)9 DTX3L class I MHC B44 UBE2E1 HLA class I histocompatibility antigen, Cw-12 alpha chain HLA class I histocompatibility antigen, Cw-15 alpha chain CD207 PSMF1 SOCS1 HLA class I histocompatibility antigen, E alpha chain precursor LMO7 Ubiquitin activatingE1 enzymesHLA class I histocompatibility antigen, A-30 alpha chain UBB(153-228) HLA class I histocompatibility antigen, alpha chain G precursor KLHL5 class I MHC B52 ASB14 HLA class I histocompatibility antigen, Cw-2 alpha chain class I MHC B46 PSMD14 HLA class I histocompatibility antigen, Cw-17 alpha chain PSMC4 Exogenous solubleantigenKLHL22 class I MHC B58 HLA class I histocompatibility antigen, Cw-17 alpha chain class I MHC B54 UBE2Q2 class I MHC B54 class I MHC B73 FBXL4 HLA class I histocompatibility antigen, A-26 alpha chain class I MHC B51 HLA class I histocompatibility antigen, A-30 alpha chain class I MHC B38 HLA class I histocompatibility antigen, A-33 alpha chain class I MHC B56 class I MHC B56 class I MHC B8 HLA class I histocompatibility antigen, A-1 alpha chain precursor HERC6 GTP ASB12 PSMB9 class I MHC B55 HLA class I histocompatibility antigen, A-66 alpha chain ExogenousParticulate antigen(Ag)SEC23ASEC22Bclass I MHC B82 class I MHC B82 HERC3 CUL7 class I MHC B57 RLIM UBE3A class I MHC B40 PSMC4 HECW2 TRIM71 GLMN class I MHC B47 class I MHC B51 class I MHC B50 HLA class I histocompatibility antigen, A-2 alpha chain HLA class I histocompatibility antigen, Cw-1 alpha chain FBXL19 SEC24A CALRHLA class I histocompatibility antigen, A-80 alpha chain RNF111 antigenic substrateSMURF1 B2M(21-119) UBC(305-380) class I MHC B54 HLA class I histocompatibility antigen, Cw-17 alpha chain class I MHC B57 class I MHC B39 Antigen peptidebound class I MHCUBE2R2 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor H+HLA class I histocompatibility antigen, Cw-4 alpha chain precursor HLA class I histocompatibility antigen, Cw-5 alpha chain precursor Chaperonescalnexin/BiPclass I MHC B59 class I MHC B46 UBE2H class I MHC B35 HLA class I histocompatibility antigen, A-24 alpha chain (Glc)1 (GlcNAc)2 (Man)9 UBA52(1-76) HLA class I histocompatibility antigen, A-43 alpha chain HLA class I histocompatibility antigen, alpha chain F precursor class I MHC B13 class I MHC B51 FBXO27 PSMD1 HECTD1 HLA class I histocompatibility antigen, A-30 alpha chain class I MHC B45 HLA class I histocompatibility antigen, A-29 alpha chain HLA class I histocompatibility antigen, A-69 alpha chain LONRF1 WSB1 KLHL5 AMPHLA class I histocompatibility antigen, alpha chain F precursor RNF213 class I MHC B78 MR:soluble antigenSTX4 CDC26 AMPUBA7 class I MHC B39 PSMD3 FBXL15 class I MHC B54 HLA class I histocompatibility antigen, A-43 alpha chain HLA class I histocompatibility antigen, A-69 alpha chain HLA class I histocompatibility antigen, A-3 alpha chain precursor HLA class I histocompatibility antigen, Cw-6 alpha chain precursor UBE4A HLA class I histocompatibility antigen, Cw-2 alpha chain class I MHC B67 class I MHC B7 ANAPC11 Antigen peptideclass I MHC B49 CDC26 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor PSMD11 class I MHC B35 class I MHC B58 FBXL19 HLA class I histocompatibility antigen, E alpha chain precursor UBC(153-228) LNX1 HLA class I histocompatibility antigen, alpha chain F precursor UBE2G1 HLA-B RNF138 UBC(533-608) FBXO21 HLA class I histocompatibility antigen, Cw-7 alpha chain precursor HLA class I histocompatibility antigen, A-3 alpha chain precursor SMURF1 ANAPC5 class I MHC B47 class I MHC B59 UBC(77-152) HERC5 class I MHC B51 HLA class I histocompatibility antigen, Cw-1 alpha chain HLA-H HLA class I histocompatibility antigen, A-32 alpha chain class I MHC B81 class I MHC B14 MRC1 NEDD4 class I MHC B15 HLA class I histocompatibility antigen, A-25 alpha chain WWP1 class I MHC B41 class I MHC B44 class I MHC B57 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor class I MHC B54 class I MHC B8 HLA class I histocompatibility antigen, A-69 alpha chain HUWE1 class I MHC B73 MGRN1 HLA class I histocompatibility antigen, A-43 alpha chain class I MHC B13 class I MHC B73 HLA class I histocompatibility antigen, A-69 alpha chain HLA class I histocompatibility antigen, A-26 alpha chain HERC4 class I MHC B8 KLHL21 UBE2C UBE2U CDC16 HLA class I histocompatibility antigen, A-30 alpha chain HLA class I histocompatibility antigen, A-11 alpha chain class I MHC B38 B2M(21-119) HLA class I histocompatibility antigen, A-34 alpha chain SOCS1 PJA1 UBR2 class I MHC B35 CBLB HLA class I histocompatibility antigen, A-31 alpha chain (Glc)1 (GlcNAc)2 (Man)9 HLA-H BTRC FBXW5 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor KLHL5 class I MHC B46 UBE2R2 class I MHC B13 E3:Ub:substrateFBXW4 HLA-B RCHY1 SAR1B:GDPHLA class I histocompatibility antigen, E alpha chain precursor class I MHC B35 class I MHC B81 PSMD2 HLA class I histocompatibility antigen, alpha chain G precursor HLA class I histocompatibility antigen, A-24 alpha chain HLA-B PSMA5 class I MHC B44 class I MHC B39 class I MHC B56 class I MHC B44 HLA class I histocompatibility antigen, A-32 alpha chain KLHL21 GDPHLA class I histocompatibility antigen, A-25 alpha chain Major outer membrane protein P ANAPC7 class I MHC B42 HLA class I histocompatibility antigen, A-3 alpha chain precursor ASB17 HLA class I histocompatibility antigen, B-48 alpha chain GTP Ag-substrate:E3:E2:UbFBXL8 UBB(153-228) HLA class I histocompatibility antigen, E alpha chain precursor class I MHC B38 FBXO32 PSMD4 HLA class I histocompatibility antigen, E alpha chain precursor RNF213 class I MHC B14 RNF217 class I MHC B82 precursor peptidefragment (>16 aa)UBE2E1 class I MHC B18 UBA1 SEC24D UBE2E3 E3 ligases inproteasomaldegradationHLA class I histocompatibility antigen, A-69 alpha chain NEDD4 UBE2D3 ASB8 HLA class I histocompatibility antigen, A-1 alpha chain precursor class I MHC B47 class I MHC B49 UBE2J1 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor UBE2A KLHL22 CUL1 class I MHC B49 FBXW4 class I MHC B51 HLA class I histocompatibility antigen, Cw-15 alpha chain HECTD3 UBB(77-152) class I MHC B81 class I MHC B52 HLA class I histocompatibility antigen, A-29 alpha chain ASB3 SPSB2 class I MHC B81 class I MHC B7 UBE2U class I MHC B57 HLA class I histocompatibility antigen, A-2 alpha chain HLA class I histocompatibility antigen, A-36 alpha chain HLA-C UBE2V2 class I MHC B55 HLA class I histocompatibility antigen, A-30 alpha chain TAPBPclass I MHC B44 MKRN1 RNF144B PSMA8 HLA class I histocompatibility antigen, Cw-15 alpha chain class I MHC B52 class I MHC B39 class I MHC B7 class I MHC B49 HLA class I histocompatibility antigen, A-11 alpha chain PSMD2 DET1 SEC23A class I MHC B54 HLA class I histocompatibility antigen, A-31 alpha chain TRIM36 HLA class I histocompatibility antigen, Cw-16 alpha chain HLA class I histocompatibility antigen, Cw-4 alpha chain precursor class I MHC B54 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor Exogenous solubleantigenPSMD8 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor PDIA3 HLA class I histocompatibility antigen, A-34 alpha chain HLA class I histocompatibility antigen, Cw-4 alpha chain precursor CDC23 precursor peptidefragment (>16 aa)Class I MHC:B2Mclass I MHC B81 class I MHC B42 PSMB3 Exogenous soluble antigen BAP31 oligomer HLA class I histocompatibility antigen, Cw-1 alpha chain MYLIP class I MHC B57 HLA class I histocompatibility antigen, A-23 alpha chain HLA class I histocompatibility antigen, A-31 alpha chain ASB5 FBXO30 ASB4 ASB14 CD207 HLA class I histocompatibility antigen, A-43 alpha chain HLA class I histocompatibility antigen, A-33 alpha chain HLA class I histocompatibility antigen, alpha chain F precursor CUL1 RBBP6 class I MHC B39 HLA class I histocompatibility antigen, A-24 alpha chain HLA class I histocompatibility antigen, A-66 alpha chain FBXW11 HLA class I histocompatibility antigen, E alpha chain precursor PSMD12 oligopeptidefragmentHLA class I histocompatibility antigen, A-32 alpha chain class I MHC B81 HLA class I histocompatibility antigen, B-48 alpha chain class I MHC B38 ZNRF2 B2M(21-119) ANAPC7 SEC22B FBXW9 MRC2 p-S95-SNAP23:VAMP8,VAMP3SEC24A class I MHC B53 TRIM69 HLA class I histocompatibility antigen, A-25 alpha chain HLA class I histocompatibility antigen, A-29 alpha chain class I MHC B49 class I MHC B44 HLA class I histocompatibility antigen, A-68 alpha chain UBC(229-304) HLA class I histocompatibility antigen, A-80 alpha chain TRIM36 HLA class I histocompatibility antigen, A-1 alpha chain precursor HLA class I histocompatibility antigen, Cw-1 alpha chain class I MHC B40 VPRBP class I MHC B13 TLR2 PSME2 AMPSEC13HLA-C class I MHC B7 PARK2 FBXW12 PDIA3 class I MHC B39 ASB7 class I MHC B40 CBLB SOCS3 HLA class I histocompatibility antigen, E alpha chain precursor TRIM32 class I MHC B50 FBXO10 HLA class I histocompatibility antigen, A-29 alpha chain HLA class I histocompatibility antigen, A-26 alpha chain FBXL7 AREL1 FBXO9 ITCH class I MHC B15 class I MHC B82 UBE3B FBXW5 HLA class I histocompatibility antigen, alpha chain F precursor Exogenous solubleantigenHLA class I histocompatibility antigen, Cw-2 alpha chain oligopeptidefragmentHERC2 FBXO21 class I MHC B38 class I MHC B57 ASB12 HLA class I histocompatibility antigen, A-33 alpha chain class I MHC B40 class I MHC B18 class I MHC B41 class I MHC B37 ANAPC10 HLA class I histocompatibility antigen, A-23 alpha chain HLA class I histocompatibility antigen, Cw-12 alpha chain HLA class I histocompatibility antigen, A-23 alpha chain HLA class I histocompatibility antigen, Cw-4 alpha chain precursor class I MHC B56 CCNF HLA class I histocompatibility antigen, A-66 alpha chain FBXW7 UBB(1-76) class I MHC B51 class I MHC B35 class I MHC B51 UBE2M HLA class I histocompatibility antigen, Cw-18 alpha chain class I MHC B55 RNF115 class I MHC B78 class I MHC B46 FBXL7 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor PSMC6 HLA class I histocompatibility antigen, alpha chain F precursor HLA class I histocompatibility antigen, Cw-6 alpha chain precursor UBB(77-152) UFL1 class I MHC B73 class I MHC B37 MRC2 UBC(1-76) HLA class I histocompatibility antigen, Cw-4 alpha chain precursor ITCH HLA class I histocompatibility antigen, A-33 alpha chain class I MHC B46 HLA class I histocompatibility antigen, A-69 alpha chain class I MHC B53 HLA class I histocompatibility antigen, Cw-18 alpha chain SIAH1 class I MHC B15 MIB2 SEC24B class I MHC B59 class I MHC B40 UBE2D1 HLA class I histocompatibility antigen, A-11 alpha chain TRIM69 FBXW2 PSMB2 class I MHC B18 Antigen peptide ELOB class I MHC B39 VHL HLA class I histocompatibility antigen, A-24 alpha chain LTN1 class I MHC B73 class I MHC B49 HLA class I histocompatibility antigen, E alpha chain precursor class I MHC B53 UBE2F class I MHC B14 class I MHC B82 class I MHC B8 class I MHC B56 HLA class I histocompatibility antigen, Cw-16 alpha chain UBE2M class I MHC B27 HLA class I histocompatibility antigen, Cw-16 alpha chain SPSB2 FBXO22 HLA class I histocompatibility antigen, A-29 alpha chain HLA class I histocompatibility antigen, Cw-7 alpha chain precursor FBXL12 HLA-B HLA class I histocompatibility antigen, Cw-3 alpha chain precursor RNF130 HLA-H GAN class I MHC B51 class I MHC B15 HLA class I histocompatibility antigen, A-24 alpha chain RNF220 UBE2K HLA class I histocompatibility antigen, Cw-1 alpha chain UBE3A TAP2 PSMB7 B2M(21-119) ASB2 PSMA1 class I MHC B53 class I MHC B37 ANAPC13 class I MHC B8 CD207 UBA7 HLA class I histocompatibility antigen, A-74 alpha chain FBXO31 TRIM11 FBXL15 HLA class I histocompatibility antigen, alpha chain F precursor HLA class I histocompatibility antigen, Cw-16 alpha chain class I MHC B55 MGRN1 ASB18 class I MHC B82 TAPHLA class I histocompatibility antigen, A-43 alpha chain HLA class I histocompatibility antigen, A-34 alpha chain HLA class I histocompatibility antigen, Cw-8 alpha chain SEC24C UBC(457-532) HLA class I histocompatibility antigen, A-34 alpha chain FZR1 class I MHC B8 KLHL25 TRIM32 UBR1 KLHL3 class I MHC B59 class I MHC B18 UBC(381-456) K48polyUb-antigenic substrate ASB9 class I MHC B44 TRIM21 Antigen peptideHLA class I histocompatibility antigen, A-34 alpha chain class I MHC B13 MIB2 ASB17 class I MHC B46 DET1 UBA3 DZIP3 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor TRIM36 TRAIP CD207 KLHL3 CDC16 HLA class I histocompatibility antigen, A-3 alpha chain precursor FBXO9 HLA-H class I MHC B67 SHFM1 partially digestedAgHLA class I histocompatibility antigen, A-69 alpha chain SKP1 class I MHC B55 FBXO40 ASB5 PSMB10 class I MHC B50 HLA class I histocompatibility antigen, alpha chain G precursor LRSAM1 class I MHC B42 HLA class I histocompatibility antigen, A-25 alpha chain class I MHC B42 class I MHC B52 PSMD11 AREL1 HLA class I histocompatibility antigen, A-80 alpha chain HLA class I histocompatibility antigen, A-23 alpha chain CDC27 class I MHC B47 class I MHC B82 UBA52(1-76) K48polyUb-antigenicsubstrateUbiquitin:E2conjugating enzymesCALR TAP1 class I MHC B50 UBE2Z HLA class I histocompatibility antigen, A-2 alpha chain class I MHC B35 class I MHC B67 class I MHC B40 HLA class I histocompatibility antigen, A-31 alpha chain oligo-MyD88:Mal:BTK:activated TLRHLA-B HLA class I histocompatibility antigen, E alpha chain precursor FCGRA KLHL9 FBXL22 class I MHC B50 class I MHC B81 class I MHC B13 FBXL7 class I MHC B18 RNF41 HLA class I histocompatibility antigen, A-2 alpha chain UBE2L6 HLA class I histocompatibility antigen, A-32 alpha chain PSMB1 ELOC ASB2 SEC61A2 KBTBD13 ASB14 HLA class I histocompatibility antigen, A-2 alpha chain ITGB5 class I MHC B45 SAR1B class I MHC B81 (Glc)1 (GlcNAc)2 (Man)9 class I MHC B18 FBXO11 HLA class I histocompatibility antigen, A-25 alpha chain FCGR HERC3 SMURF2 HLA class I histocompatibility antigen, A-29 alpha chain HLA class I histocompatibility antigen, Cw-4 alpha chain precursor UBC(229-304) TRIM21 class I MHC B52 HLA class I histocompatibility antigen, A-30 alpha chain SMURF2 HLA class I histocompatibility antigen, Cw-2 alpha chain ASB6 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor class I MHC B57 FBXL19 PSMD2 TAP2 FBXL13 UBE2D4 RNF7 (RBX2) HLA class I histocompatibility antigen, Cw-14 alpha chain UBE2Z L-amino acidclass I MHC B44 HLA class I histocompatibility antigen, A-26 alpha chain class I MHC B39 class I MHC B54 PSMA6 FBXO6 HLA class I histocompatibility antigen, Cw-1 alpha chain class I MHC B59 HLA class I histocompatibility antigen, A-36 alpha chain UBC(229-304) FBXO27 class I MHC B8 HLA class I histocompatibility antigen, A-34 alpha chain class I MHC B53 ANAPC13 HLA class I histocompatibility antigen, A-69 alpha chain HLA class I histocompatibility antigen, Cw-17 alpha chain HLA class I histocompatibility antigen, A-31 alpha chain MR/other probablereceptorsMRC2 TRIM63 ITGB5 HLA class I histocompatibility antigen, Cw-18 alpha chain HLA class I histocompatibility antigen, Cw-16 alpha chain KBTBD6 HLA class I histocompatibility antigen, Cw-2 alpha chain class I MHC B39 RNF213 HLA class I histocompatibility antigen, A-74 alpha chain GAN HERC5 UBB(1-76) class I MHC B45 class I MHC B56 UBC(1-76) HLA class I histocompatibility antigen, Cw-2 alpha chain UBB(77-152) class I MHC B13 HLA class I histocompatibility antigen, A-74 alpha chain UbHLA class I histocompatibility antigen, Cw-16 alpha chain CUL2 class I MHC B27 HLA class I histocompatibility antigen, Cw-18 alpha chain KLHL13 SEC22B HLA class I histocompatibility antigen, A-36 alpha chain class I MHC B14 HLA class I histocompatibility antigen, alpha chain G precursor PSMC6 HLA class I histocompatibility antigen, A-43 alpha chain ZNRF1 SEC22Bclass I MHC B81 FBXL5 UBC(1-76) HERC4 RNF6 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor HUWE1 PSME1 FBXL22 RNF25 LRR1 KBTBD6 class I MHC B46 class I MHC B37 HLA class I histocompatibility antigen, Cw-14 alpha chain FBXL4 HLA class I histocompatibility antigen, alpha chain G precursor UBB(1-76) TRIM41 HLA class I histocompatibility antigen, A-68 alpha chain RNF213 class I MHC B52 HLA class I histocompatibility antigen, E alpha chain precursor RNF217 HERC1 SKP1 HLA class I histocompatibility antigen, A-36 alpha chain FBXO32 monoglucosylated MHCclass I HCASB4 class I MHC B57 SEC24A HLA class I histocompatibility antigen, A-33 alpha chain class I MHC B56 HECTD2 FBXO10 class I MHC B46 CUL7 HLA class I histocompatibility antigen, A-29 alpha chain class I MHC B82 HERC5 HLA class I histocompatibility antigen, A-31 alpha chain HLA class I histocompatibility antigen, A-43 alpha chain class I MHC B40 RNF138 (Glc)1 (GlcNAc)2 (Man)9 FBXW12 Antigenicpeptide:MHC:B2Mpeptide loadingcomplexHLA class I histocompatibility antigen, A-80 alpha chain HLA class I histocompatibility antigen, A-23 alpha chain class I MHC B42 HLA class I histocompatibility antigen, E alpha chain precursor CUL1 HLA class I histocompatibility antigen, Cw-18 alpha chain class I MHC B44 SKP1 HLA class I histocompatibility antigen, A-23 alpha chain class I MHC B51 SIAH1 ASB8 TRAF7 B2M(21-119) class I MHC B46 ASB10 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor Clostridial peptidoglycan class I MHC B55 class I MHC B13 class I MHC B7 KLHL41 FBXL21 class I MHC B37 PDIA3 class I MHC B47 HLA class I histocompatibility antigen, Cw-16 alpha chain FBXL20 class I MHC B45 HLA class I histocompatibility antigen, Cw-14 alpha chain HLA class I histocompatibility antigen, Cw-7 alpha chain precursor class I MHC B82 FBXL8 class I MHC B7 class I MHC B45 HLA class I histocompatibility antigen, A-33 alpha chain KLHL2 class I MHC B58 HLA class I histocompatibility antigen, Cw-1 alpha chain FBXL21 HLA class I histocompatibility antigen, A-1 alpha chain precursor SEC24A LNX1 RNF25 RBCK1 ZNF645 UBE2V1 BTBD1 UBE2V1 HLA class I histocompatibility antigen, A-69 alpha chain PJA1 class I MHC B58 HLA class I histocompatibility antigen, A-25 alpha chain RNF126 FBXL5 HLA class I histocompatibility antigen, Cw-14 alpha chain LONRF1 class I MHC B50 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor UBB(153-228) HLA class I histocompatibility antigen, alpha chain F precursor UBE2E2 PSMB8 class I MHC B54 PDIA3 HLA class I histocompatibility antigen, A-2 alpha chain B2M(21-119) HLA class I histocompatibility antigen, A-32 alpha chain FBXL3 FBXL13 class I MHC B46 class I MHC B27 AREL1 class I MHC B78 class I MHC B56 HLA class I histocompatibility antigen, A-66 alpha chain p-6S-NCF1 SH3RF1 UBC(533-608) PSMB7 PSMB7 class I MHC B46 class I MHC B46 class I MHC B47 NOX2 complexPSMC1 IKBKB HLA class I histocompatibility antigen, Cw-17 alpha chain HLA class I histocompatibility antigen, A-25 alpha chain class I MHC B15 FBXL13 class I MHC B37 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor HLA class I histocompatibility antigen, A-33 alpha chain HLA class I histocompatibility antigen, A-30 alpha chain HLA class I histocompatibility antigen, Cw-12 alpha chain Class I MHCHC:B2M:Erp57class I MHC B35 PSMD1 FBXO32 HLA class I histocompatibility antigen, A-30 alpha chain class I MHC B47 Antigen peptide DTX3L HLA class I histocompatibility antigen, Cw-5 alpha chain precursor UBC(153-228) p-T154,S315-NCF4 UBAC1 FBXO44 class I MHC B50 HLA class I histocompatibility antigen, A-29 alpha chain HLA class I histocompatibility antigen, Cw-4 alpha chain precursor HLA class I histocompatibility antigen, Cw-4 alpha chain precursor HLA class I histocompatibility antigen, Cw-1 alpha chain HLA class I histocompatibility antigen, A-68 alpha chain GAN HLA-H HLA class I histocompatibility antigen, Cw-18 alpha chain FBXO32 Ag peptide boundclass I MHCHLA class I histocompatibility antigen, Cw-6 alpha chain precursor class I MHC B78 BLMH HLA class I histocompatibility antigen, A-31 alpha chain class I MHC B59 HLA class I histocompatibility antigen, A-32 alpha chain HLA class I histocompatibility antigen, Cw-17 alpha chain class I MHC B55 class I MHC B82 FBXO44 FBXL20 UBB(1-76) COPII vesicle withMHC class IHLA-H HLA-B HLA class I histocompatibility antigen, Cw-5 alpha chain precursor class I MHC B40 class I MHC B51 FBXL13 UNKL GDP HLA class I histocompatibility antigen, E alpha chain precursor HLA class I histocompatibility antigen, A-11 alpha chain UBA5 UBE2B PSMD7 HLA class I histocompatibility antigen, Cw-7 alpha chain precursor class I MHC B41 RCHY1 HLA class I histocompatibility antigen, alpha chain F precursor HERC1 class I MHC B78 HLA class I histocompatibility antigen, A-29 alpha chain UBE2J2 FBXO11 ANAPC11 class I MHC B40 HLA class I histocompatibility antigen, A-2 alpha chain UBE3D class I MHC B38 HLA class I histocompatibility antigen, A-69 alpha chain HLA class I histocompatibility antigen, Cw-4 alpha chain precursor CDC27 LPS Sar1p:GTP:Sec23p:Sec24p:Ag bound MHC class Iclass I MHC B58 HLA class I histocompatibility antigen, Cw-7 alpha chain precursor class I MHC B27 ANAPC4 ASB6 class I MHC B59 STUB1 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor RNF34 class I MHC B82 class I MHC B45 class I MHC B13 class I MHC B56 HLA class I histocompatibility antigen, A-1 alpha chain precursor HLA class I histocompatibility antigen, A-74 alpha chain class I MHC B27 class I MHC B35 class I MHC B14 class I MHC B52 SOCS3 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor HLA class I histocompatibility antigen, Cw-17 alpha chain ITGAV(31-1048) Antigen HERC2 class I MHC B53 HLA class I histocompatibility antigen, A-3 alpha chain precursor HLA class I histocompatibility antigen, Cw-14 alpha chain class I MHC B49 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor PSMC5 HLA class I histocompatibility antigen, A-3 alpha chain precursor class I MHC B67 HLA class I histocompatibility antigen, Cw-2 alpha chain HLA class I histocompatibility antigen, A-1 alpha chain precursor FBXO27 class I MHC B46 SEC24D FBXO41 class I MHC B58 RNF14 HLA class I histocompatibility antigen, A-24 alpha chain class I MHC B38 class I MHC B41 LRSAM1 HLA class I histocompatibility antigen, A-25 alpha chain HLA class I histocompatibility antigen, Cw-17 alpha chain UBE2N ANAPC4 HLA-B BTRC HLA class I histocompatibility antigen, A-69 alpha chain FBXO4 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor KLHL21 GTP PSMD9 FBXW9 class I MHC B42 class I MHC B50 HLA class I histocompatibility antigen, Cw-1 alpha chain class I MHC B38 HLA class I histocompatibility antigen, A-36 alpha chain HLA class I histocompatibility antigen, Cw-17 alpha chain HLA class I histocompatibility antigen, A-26 alpha chain HLA class I histocompatibility antigen, E alpha chain precursor HLA class I histocompatibility antigen, Cw-3 alpha chain precursor RNF144B ATPRPS27A(1-76) HLA class I histocompatibility antigen, A-25 alpha chain class I MHC B82 Antigen peptidebound class I MHCUBE2L3 HLA class I histocompatibility antigen, alpha chain G precursor class I MHC B82 class I MHC B39 4xPalmC-CD36 RNF114 PSMB4 SHFM1 TRIP12 UBC(609-684) KLHL13 class I MHC B58 HLA class I histocompatibility antigen, Cw-8 alpha chain ANAPC1 class I MHC B47 KBTBD7 HLA class I histocompatibility antigen, A-1 alpha chain precursor TLR6 HLA class I histocompatibility antigen, A-66 alpha chain class I MHC B78 UBE2G1 PSMA1 PSMB6 HLA class I histocompatibility antigen, A-3 alpha chain precursor ASB7 BAP31 oligomerHLA class I histocompatibility antigen, Cw-4 alpha chain precursor HLA class I histocompatibility antigen, A-68 alpha chain class I MHC B15 PSMD1 HLA class I histocompatibility antigen, Cw-1 alpha chain HLA class I histocompatibility antigen, Cw-3 alpha chain precursor HLA class I histocompatibility antigen, Cw-1 alpha chain class I MHC B67 HLA class I histocompatibility antigen, Cw-1 alpha chain HLA class I histocompatibility antigen, Cw-5 alpha chain precursor TLR1 HLA class I histocompatibility antigen, Cw-12 alpha chain HLA class I histocompatibility antigen, A-32 alpha chain HLA class I histocompatibility antigen, A-24 alpha chain KBTBD13 class I MHC B53 class I MHC B41 UBC(1-76) class I MHC B49 UBE2A HLA class I histocompatibility antigen, A-34 alpha chain GTP class I MHC B7 FBXO11 RNF7 (RBX2) CDC27 PSMD13 class I MHC B40 HLA class I histocompatibility antigen, Cw-1 alpha chain class I MHC B47 RNF14 HLA class I histocompatibility antigen, Cw-12 alpha chain HLA class I histocompatibility antigen, E alpha chain precursor TRIM9 class I MHC B35 HLA class I histocompatibility antigen, Cw-2 alpha chain HERC6 class I MHC B45 SPSB1 ASB1 UBE2D2 PPiHLA class I histocompatibility antigen, A-30 alpha chain HLA class I histocompatibility antigen, A-29 alpha chain HLA class I histocompatibility antigen, alpha chain F precursor class I MHC B81 RNF14 PSMB9 SMURF2 class I MHC B82 KEAP1 KLHL42 UBE2J1 FBXO2 FBXL5 E2Ubiquitin-conjugating enzymeclass I MHC B8 UBE2S class I MHC B59 class I MHC B42 HLA class I histocompatibility antigen, Cw-17 alpha chain HLA-H class I MHC B67 SAR1B HLA class I histocompatibility antigen, A-11 alpha chain HLA class I histocompatibility antigen, A-23 alpha chain SEC31A TRIM50 KLHL42 HLA class I histocompatibility antigen, A-36 alpha chain UBB(77-152) KLHL9 TAP2 HLA class I histocompatibility antigen, A-2 alpha chain class I MHC B58 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor MRC1 FBXL22 TRIM32 HLA class I histocompatibility antigen, A-24 alpha chain FBXW10 RNF41 HACE1 class I MHC B58 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor ANAPC13 FBXL21 B2M(21-119) HLA class I histocompatibility antigen, Cw-16 alpha chain class I MHC B67 class I MHC B7 class I MHC B44 HLA class I histocompatibility antigen, Cw-1 alpha chain class I MHC B81 HLA class I histocompatibility antigen, Cw-8 alpha chain HLA class I histocompatibility antigen, A-80 alpha chain HLA class I histocompatibility antigen, Cw-17 alpha chain SEC24C HLA class I histocompatibility antigen, Cw-8 alpha chain L-amino acidclass I MHC B59 RNF115 SEC24C ANAPC2 HLA class I histocompatibility antigen, A-24 alpha chain class I MHC B49 HLA class I histocompatibility antigen, Cw-12 alpha chain ZBTB16 Exogenous soluble antigen UBC(305-380) class I MHC B14 HLA class I histocompatibility antigen, A-23 alpha chain HLA class I histocompatibility antigen, A-32 alpha chain RNF114 HLA-B HERC3 ASB16 HLA class I histocompatibility antigen, Cw-12 alpha chain class I MHC B54 FBXO2 FZR1 RBX1 PSMB2 class I MHC B50 HERC2 RNF220 PJA2 UBE2Q1 FBXO17 class I MHC B44 WSB1 class I MHC B18 UBR2 FBXW7 class I MHC B78 class I MHC B49 ITGAV(31-1048) UBC(77-152) HLA class I histocompatibility antigen, A-74 alpha chain class I MHC B35 class I MHC B40 KLHL3 RNF114 HLA class I histocompatibility antigen, Cw-16 alpha chain HLA class I histocompatibility antigen, A-11 alpha chain class I MHC B78 SEC24D PSMA2 HLA class I histocompatibility antigen, A-33 alpha chain HLA class I histocompatibility antigen, Cw-12 alpha chain HLA class I histocompatibility antigen, Cw-14 alpha chain FBXW10 class I MHC B35 HLA class I histocompatibility antigen, Cw-14 alpha chain CHUK PSME4 RNF6 HLA class I histocompatibility antigen, A-23 alpha chain class I MHC B58 DC receptorsrecognizingapoptotic cellsHLA class I histocompatibility antigen, A-68 alpha chain TRIM21 class I MHC B73 class I MHC B67 GTPKLHL42 CDC16 class I MHC B13 HLA class I histocompatibility antigen, A-34 alpha chain class I MHC B39 HLA class I histocompatibility antigen, A-80 alpha chain HLA class I histocompatibility antigen, A-36 alpha chain NEDD4L class I MHC B7 VAMP8 FBXO6 RNF4 TRIP12 class I MHC B51 FBXW11 class I MHC B39 class I MHC B18 HLA class I histocompatibility antigen, A-80 alpha chain PSMD10 HLA class I histocompatibility antigen, Cw-1 alpha chain HLA class I histocompatibility antigen, Cw-6 alpha chain precursor class I MHC B56 HLA class I histocompatibility antigen, A-11 alpha chain FBXW8 HLA class I histocompatibility antigen, Cw-15 alpha chain UBB(153-228) HLA class I histocompatibility antigen, A-2 alpha chain HLA class I histocompatibility antigen, Cw-15 alpha chain ANAPC10 UBE2O UBE2E2 class I MHC B67 LNX1 class I MHC B73 class I MHC B53 FBXO41 FBXL12 Triacyl lipopeptide class I MHC B44 HLA class I histocompatibility antigen, A-31 alpha chain PSMA7 class I MHC B57 p-S95-SNAP23 UBE2N ASB2 UFL1 ASB11 PARK2 FCGR HLA class I histocompatibility antigen, A-68 alpha chain TRIM4 PSME1 HLA class I histocompatibility antigen, A-74 alpha chain MEX3C UBE2B E1 bound ubiquitinHECW2 HLA class I histocompatibility antigen, Cw-12 alpha chain HLA class I histocompatibility antigen, Cw-12 alpha chain PSMB1 UBE2O HLA class I histocompatibility antigen, A-74 alpha chain UBE3A class I MHC B78 HLA class I histocompatibility antigen, A-3 alpha chain precursor CUL7 PSMD8 TRIM63 ASB18 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor UBC(457-532) TRIM37 HLA class I histocompatibility antigen, Cw-12 alpha chain UBC(457-532) class I MHC B27 ERAP2 FBXW2 CCNF class I MHC B42 class I MHC B37 UFL1 VHL HLA class I histocompatibility antigen, A-36 alpha chain class I MHC B78 HLA class I histocompatibility antigen, A-31 alpha chain class I MHC B52 RNF220 UBE3C 4xPalmC-CD36 class I MHC B41 FBXL14 FBXO41 VAMP3 HLA class I histocompatibility antigen, A-26 alpha chain HLA class I histocompatibility antigen, A-74 alpha chain HLA class I histocompatibility antigen, Cw-18 alpha chain BTBD6 TAPHLA class I histocompatibility antigen, A-43 alpha chain UBE2L3 ASB8 HLA class I histocompatibility antigen, A-1 alpha chain precursor SAR1B FBXW9 RBBP6 HLA class I histocompatibility antigen, A-30 alpha chain HLA class I histocompatibility antigen, A-32 alpha chain UBE2L3 HLA class I histocompatibility antigen, Cw-16 alpha chain UBE2W HLA class I histocompatibility antigen, A-11 alpha chain UBE2K HLA class I histocompatibility antigen, Cw-15 alpha chain HLA class I histocompatibility antigen, Cw-18 alpha chain FBXL8 class I MHC B38 UBE2J1 CUL2 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor PSMB1 HLA class I histocompatibility antigen, Cw-2 alpha chain class I MHC B42 class I MHC B57 class I MHC B57 ZBTB16 HLA class I histocompatibility antigen, A-1 alpha chain precursor UBE2M CUL5 CUL7 HLA class I histocompatibility antigen, A-33 alpha chain HLA class I histocompatibility antigen, A-26 alpha chain HLA class I histocompatibility antigen, A-31 alpha chain SEC61G class I MHC B41 class I MHC B27 RNF182 UBE2U VHL RNF130 HECTD3 ZNRF2 PSMB5 class I MHC B49 WSB1 UBE2Z class I MHC B55 class I MHC B27 TRIM63 ASB15 class I MHC B54 HLA class I histocompatibility antigen, A-74 alpha chain HLA class I histocompatibility antigen, Cw-5 alpha chain precursor ANAPC4 RNF217 HLA class I histocompatibility antigen, A-69 alpha chain HLA class I histocompatibility antigen, A-2 alpha chain HLA class I histocompatibility antigen, A-66 alpha chain UBC(533-608) PSME1 RNF182 class I MHC B45 HLA class I histocompatibility antigen, A-24 alpha chain class I MHC B67 class I MHC B35 HLA class I histocompatibility antigen, A-30 alpha chain HLA class I histocompatibility antigen, Cw-7 alpha chain precursor HLA class I histocompatibility antigen, A-66 alpha chain PSMA2 HLA class I histocompatibility antigen, A-69 alpha chain UBR2 ASB13 class I MHC B50 PSMD6 class I MHC B45 HLA class I histocompatibility antigen, Cw-14 alpha chain antigenic substrate TRIM39 FBXO21 FBXO22 UBC(1-76) FBXO10 HLA class I histocompatibility antigen, A-31 alpha chain ANAPC11 MRC2 SPSB4 CDC34 class I MHC B67 class I MHC B51 FBXW11 class I MHC B8 class I MHC B52 class I MHC B27 HLA class I histocompatibility antigen, A-32 alpha chain HLA class I histocompatibility antigen, A-1 alpha chain precursor KBTBD6 class I MHC B14 UBE2O HLA class I histocompatibility antigen, Cw-16 alpha chain LRRC41 HLA class I histocompatibility antigen, A-33 alpha chain RNF115 class I MHC B44 MRC2 ANAPC10 LNPEP HLA class I histocompatibility antigen, A-31 alpha chain WSB1 ASB13 SEC24B GAN RNF123 class I MHC B81 MRC1 class I MHC B41 UBE2E3 DZIP3 HLA class I histocompatibility antigen, A-11 alpha chain MKRN1 class I MHC B56 PSMD6 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor HLA class I histocompatibility antigen, alpha chain F precursor class I MHC B38 HLA class I histocompatibility antigen, A-32 alpha chain CHUK:IKBKB:IKBKGUBC(77-152) RNF126 ASB4 class I MHC B81 L-amino acidHERC1 RNF111 HLA class I histocompatibility antigen, A-74 alpha chain SPSB4 TRIM69 TAP1 KLHL22 HLA class I histocompatibility antigen, A-30 alpha chain RNF14 ASB17 UBC(305-380) (Glc)1 (GlcNAc)2 (Man)9 UBC(381-456) HLA class I histocompatibility antigen, A-43 alpha chain HLA class I histocompatibility antigen, A-23 alpha chain p-4Y-TIRAP class I MHC B38 class I MHC B41 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor NEDD4L class I MHC B37 FBXL18 FBXW12 PSMB11 HLA class I histocompatibility antigen, A-11 alpha chain HLA class I histocompatibility antigen, A-3 alpha chain precursor class I MHC B73 HLA class I histocompatibility antigen, A-34 alpha chain class I MHC B57 HLA class I histocompatibility antigen, A-66 alpha chain HLA class I histocompatibility antigen, A-80 alpha chain SOCS1 UBR1 class I MHC B52 MR:soluble antigenSEC61A1 class I MHC B44 Antigen peptide TRIM41 class I MHC B55 class I MHC B39 ANAPC1 HLA class I histocompatibility antigen, A-25 alpha chain class I MHC B44 class I MHC B46 HLA class I histocompatibility antigen, A-66 alpha chain UBE2J2 HLA class I histocompatibility antigen, alpha chain G precursor HLA class I histocompatibility antigen, Cw-16 alpha chain KLHL20 ASB8 VPRBP RNF19B KCTD6 HLA class I histocompatibility antigen, A-43 alpha chain class I MHC B82 HSPA5 class I MHC B40 class I MHC B45 HLA class I histocompatibility antigen, Cw-8 alpha chain class I MHC B58 SAR1B:GTPUBE2S HLA class I histocompatibility antigen, A-68 alpha chain KLHL13 class I MHC B58 HLA class I histocompatibility antigen, A-1 alpha chain precursor class I MHC B35 TRIM41 ASB18 HLA class I histocompatibility antigen, A-23 alpha chain HLA class I histocompatibility antigen, A-1 alpha chain precursor ANAPC2 class I MHC B47 class I MHC B8 HLA class I histocompatibility antigen, Cw-15 alpha chain CDC20 PSMD5 UBE2E3 UBC(153-228) KEAP1 HLA class I histocompatibility antigen, A-30 alpha chain ASB11 HLA class I histocompatibility antigen, A-2 alpha chain class I MHC B54 class I MHC B78 FBXL12 HLA class I histocompatibility antigen, Cw-15 alpha chain class I MHC B15 Antigen peptidebound class I MHCHLA class I histocompatibility antigen, Cw-2 alpha chain HLA class I histocompatibility antigen, A-34 alpha chain PSMA3 class I MHC B13 CYBA MYLIP PSMB5 FBXO4 FBXO17 UBAC1 HLA class I histocompatibility antigen, Cw-12 alpha chain DTX3L TAP1 HLA class I histocompatibility antigen, Cw-18 alpha chain HLA class I histocompatibility antigen, A-3 alpha chain precursor class I MHC B39 class I MHC B18 class I MHC B81 TAPBPFBXO21 class I MHC B37 class I MHC B8 HLA class I histocompatibility antigen, A-33 alpha chain FBXW8 HLA class I histocompatibility antigen, Cw-16 alpha chain class I MHC B52 LRRC41 class I MHC B42 RCHY1 PSMB3 HLA class I histocompatibility antigen, Cw-14 alpha chain RNF144B SEC13 FBXL3 UBC(305-380) FBXL3 ZBTB16 HLA class I histocompatibility antigen, Cw-12 alpha chain HLA class I histocompatibility antigen, A-23 alpha chain AREL1 SKP2 ELOC ASB13 class I MHC B81 KLHL9 UBC(533-608) HLA class I histocompatibility antigen, Cw-18 alpha chain KLHL5 UBE3C B2M(21-119) TAP2 IFN gamma stimulatedaminopeptidasesRPS27A(1-76) HLA class I histocompatibility antigen, A-31 alpha chain TRIM11 class I MHC B18 class I MHC B39 UBOX5 class I MHC B45 UBE3C FBXL7 class I MHC B41 class I MHC B82 RBCK1 HLA class I histocompatibility antigen, Cw-18 alpha chain TRIM11 PSMD7 class I MHC B27 PSMB6 UBC(609-684) class I MHC B14 class I MHC B53 FBXL5 CUL3 TRIM32 UBC(153-228) UBE2D4 class I MHC B59 TRIM39 PSMB9 class I MHC B13 class I MHC B67 KLHL41 BTRC MKRN1 TRIM71 class I MHC B57 class I MHC B55 HLA-H HLA class I histocompatibility antigen, A-74 alpha chain CALR FBXO40 Antigen peptide PSMA5 UBC(533-608) HLA class I histocompatibility antigen, Cw-12 alpha chain class I MHC B7 class I MHC B49 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor PSMD10 E3:K48-polyubiquitinated substrateSEC23A class I MHC B37 BTK HLA class I histocompatibility antigen, Cw-15 alpha chain HLA-B UBA1 class I MHC B40 HLA class I histocompatibility antigen, A-23 alpha chain SIAH2 FBXO7 HLA class I histocompatibility antigen, A-80 alpha chain SPSB4 HLA class I histocompatibility antigen, A-68 alpha chain SEC24C UBE3B UBOX5 UBE2R2 KLHL41 class I MHC B35 FBXL15 class I MHC B18 WWP1 class I MHC B57 UBE2G2 UBA3 HLA class I histocompatibility antigen, Cw-2 alpha chain FBXW8 HLA class I histocompatibility antigen, A-32 alpha chain UBE2W UBC(457-532) UBE4A HLA class I histocompatibility antigen, Cw-8 alpha chain HLA class I histocompatibility antigen, A-43 alpha chain KBTBD6 HLA class I histocompatibility antigen, A-24 alpha chain HLA class I histocompatibility antigen, Cw-16 alpha chain class I MHC B57 TRIM37 FBXO30 KLHL2 FBXW10 HLA class I histocompatibility antigen, A-24 alpha chain Piclass I MHC B51 HLA-H class I MHC B13 UBE2D3 ZNRF1 UBE3B HLA class I histocompatibility antigen, A-43 alpha chain HLA class I histocompatibility antigen, A-68 alpha chain class I MHC B57 HLA-B SEC31Aoligopeptidefragment (8-16aa)class I MHC B82 HLA class I histocompatibility antigen, A-26 alpha chain HLA class I histocompatibility antigen, E alpha chain precursor HLA class I histocompatibility antigen, Cw-8 alpha chain PSMD8 ASB6 class I MHC B27 UBE4A class I MHC B73 MR:soluble antigenTAP2 HLA class I histocompatibility antigen, A-36 alpha chain IKBKG MRC1 class I MHC B50 class I MHC B47 STX4FBXO4 HLA-H HLA class I histocompatibility antigen, Cw-2 alpha chain class I MHC B14 B2M(21-119) HLA class I histocompatibility antigen, A-80 alpha chain class I MHC B39 precursor peptidefragment (>16 aa)HLA class I histocompatibility antigen, Cw-6 alpha chain precursor class I MHC B57 HLA class I histocompatibility antigen, A-43 alpha chain class I MHC B41 UBE2D1 VHL UBC(381-456) HLA class I histocompatibility antigen, A-34 alpha chain HLA class I histocompatibility antigen, Cw-8 alpha chain HLA class I histocompatibility antigen, A-31 alpha chain class I MHC B53 HLA class I histocompatibility antigen, A-1 alpha chain precursor HLA class I histocompatibility antigen, A-29 alpha chain ADPELOB FBXW7 class I MHC B8 ELOB UBOX5 PSMA5 PJA1 RNF138 RNF4 TRIP12 MEX3C class I MHC B46 HLA class I histocompatibility antigen, A-1 alpha chain precursor RNF6 HLA class I histocompatibility antigen, Cw-16 alpha chain HLA class I histocompatibility antigen, A-66 alpha chain TAPBPPSMD10 HLA class I histocompatibility antigen, A-11 alpha chain class I MHC B14 PSMD12 TRAF7 class I MHC B59 class I MHC B47 HLA class I histocompatibility antigen, A-2 alpha chain class I MHC B73 LONRF1 class I MHC B73 TAP1 class I MHC B27 KLHL2 class I MHC B59 HLA class I histocompatibility antigen, A-33 alpha chain class I MHC B78 HLA class I histocompatibility antigen, A-34 alpha chain MR/other probablereceptorsCDC26 Particulate Ag:DCreceptorsHLA class I histocompatibility antigen, A-1 alpha chain precursor HLA class I histocompatibility antigen, Cw-4 alpha chain precursor PDIA388932, 1411265452588112117, 22, 24, 32, 64...651125113735, 82, 981348810891211081125149131562565, 12019, 72, 12510891335191085814919, 72, 125936612152, 902, 1465, 12013325682, 1413312113365, 12019, 72, 12595168561336549, 14025133815, 7713181126813151205149, 14093133931312, 148819, 72, 1258888168133


Description

Major histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular bacteria or tumor-associated antigens. They bind peptide fragments of these proteins and presenting them to CD8+ T cells at the cell surface. This enables cytotoxic T cells to identify and eliminate cells that are synthesizing abnormal or foreign proteins. MHC class I is a trimeric complex composed of a polymorphic heavy chain (HC or alpha chain) and an invariable light chain, known as beta2-microglobulin (B2M) plus an 8-10 residue peptide ligand. Represented here are the events in the biosynthesis of MHC class I molecules, including generation of antigenic peptides by the ubiquitin/26S-proteasome system, delivery of these peptides to the endoplasmic reticulum (ER), loading of peptides to MHC class I molecules and display of MHC class I complexes on the cell surface. View original pathway at:Reactome.

Comments

Reactome-Converter 
Pathway is converted from Reactome ID: 983169
Reactome-version 
Reactome version: 62
Reactome Author 
Reactome Author: Garapati, Phani Vijay

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Bibliography

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  28. Wearsch PA, Cresswell P.; ''The quality control of MHC class I peptide loading.''; PubMed Europe PMC Scholia
  29. Kawai T, Akira S.; ''TLR signaling.''; PubMed Europe PMC Scholia
  30. Lee PC, Sowa ME, Gygi SP, Harper JW.; ''Alternative ubiquitin activation/conjugation cascades interact with N-end rule ubiquitin ligases to control degradation of RGS proteins.''; PubMed Europe PMC Scholia
  31. Simone LC, Wang X, Solheim JC.; ''A transmembrane tail: interaction of tapasin with TAP and the MHC class I molecule.''; PubMed Europe PMC Scholia
  32. Koch J, Tampé R.; ''The macromolecular peptide-loading complex in MHC class I-dependent antigen presentation.''; PubMed Europe PMC Scholia
  33. Spiliotis ET, Manley H, Osorio M, Zúñiga MC, Edidin M.; ''Selective export of MHC class I molecules from the ER after their dissociation from TAP.''; PubMed Europe PMC Scholia
  34. Schulman BA, Harper JW.; ''Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways.''; PubMed Europe PMC Scholia
  35. Schölz C, Tampé R.; ''The peptide-loading complex--antigen translocation and MHC class I loading.''; PubMed Europe PMC Scholia
  36. Krappmann D, Hatada EN, Tegethoff S, Li J, Klippel A, Giese K, Baeuerle PA, Scheidereit C.; ''The I kappa B kinase (IKK) complex is tripartite and contains IKK gamma but not IKAP as a regular component.''; PubMed Europe PMC Scholia
  37. Jackson CL.; ''Mechanisms of transport through the Golgi complex.''; PubMed Europe PMC Scholia
  38. Saric T, Chang SC, Hattori A, York IA, Markant S, Rock KL, Tsujimoto M, Goldberg AL.; ''An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides.''; PubMed Europe PMC Scholia
  39. Rock KL, York IA, Goldberg AL.; ''Post-proteasomal antigen processing for major histocompatibility complex class I presentation.''; PubMed Europe PMC Scholia
  40. Nair-Gupta P, Baccarini A, Tung N, Seyffer F, Florey O, Huang Y, Banerjee M, Overholtzer M, Roche PA, Tampé R, Brown BD, Amsen D, Whiteheart SW, Blander JM.; ''TLR signals induce phagosomal MHC-I delivery from the endosomal recycling compartment to allow cross-presentation.''; PubMed Europe PMC Scholia
  41. Suzuki K, Verma IM.; ''Phosphorylation of SNAP-23 by IkappaB kinase 2 regulates mast cell degranulation.''; PubMed Europe PMC Scholia
  42. Dong G, Wearsch PA, Peaper DR, Cresswell P, Reinisch KM.; ''Insights into MHC class I peptide loading from the structure of the tapasin-ERp57 thiol oxidoreductase heterodimer.''; PubMed Europe PMC Scholia
  43. Watanabe K, Yumimoto K, Nakayama KI.; ''FBXO21 mediates the ubiquitylation and proteasomal degradation of EID1.''; PubMed Europe PMC Scholia
  44. Kim DT, Mitchell DJ, Brockstedt DG, Fong L, Nolan GP, Fathman CG, Engleman EG, Rothbard JB.; ''Introduction of soluble proteins into the MHC class I pathway by conjugation to an HIV tat peptide.''; PubMed Europe PMC Scholia
  45. Vyas JM, Van der Veen AG, Ploegh HL.; ''The known unknowns of antigen processing and presentation.''; PubMed Europe PMC Scholia
  46. Costoya JA, Hobbs RM, Pandolfi PP.; ''Cyclin-dependent kinase antagonizes promyelocytic leukemia zinc-finger through phosphorylation.''; PubMed Europe PMC Scholia
  47. Motshwene PG, Moncrieffe MC, Grossmann JG, Kao C, Ayaluru M, Sandercock AM, Robinson CV, Latz E, Gay NJ.; ''An oligomeric signaling platform formed by the Toll-like receptor signal transducers MyD88 and IRAK-4.''; PubMed Europe PMC Scholia
  48. York IA, Bhutani N, Zendzian S, Goldberg AL, Rock KL.; ''Tripeptidyl peptidase II is the major peptidase needed to trim long antigenic precursors, but is not required for most MHC class I antigen presentation.''; PubMed Europe PMC Scholia
  49. Kovacsovics-Bankowski M, Rock KL.; ''A phagosome-to-cytosol pathway for exogenous antigens presented on MHC class I molecules.''; PubMed Europe PMC Scholia
  50. Segura E, Albiston AL, Wicks IP, Chai SY, Villadangos JA.; ''Different cross-presentation pathways in steady-state and inflammatory dendritic cells.''; PubMed Europe PMC Scholia
  51. Park Y, Yoon SK, Yoon JB.; ''TRIP12 functions as an E3 ubiquitin ligase of APP-BP1.''; PubMed Europe PMC Scholia
  52. Rodriguez-Boulan E, Müsch A.; ''Protein sorting in the Golgi complex: shifting paradigms.''; PubMed Europe PMC Scholia
  53. Tan MK, Lim HJ, Bennett EJ, Shi Y, Harper JW.; ''Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover.''; PubMed Europe PMC Scholia
  54. Hewitt EW, Lehner PJ.; ''The ABC-transporter signature motif is required for peptide translocation but not peptide binding by TAP.''; PubMed Europe PMC Scholia
  55. Kanaseki T, Blanchard N, Hammer GE, Gonzalez F, Shastri N.; ''ERAAP synergizes with MHC class I molecules to make the final cut in the antigenic peptide precursors in the endoplasmic reticulum.''; PubMed Europe PMC Scholia
  56. el Benna J, Faust LP, Babior BM.; ''The phosphorylation of the respiratory burst oxidase component p47phox during neutrophil activation. Phosphorylation of sites recognized by protein kinase C and by proline-directed kinases.''; PubMed Europe PMC Scholia
  57. Starostina NG, Simpliciano JM, McGuirk MA, Kipreos ET.; ''CRL2(LRR-1) targets a CDK inhibitor for cell cycle control in C. elegans and actin-based motility regulation in human cells.''; PubMed Europe PMC Scholia
  58. Saveanu L, Carroll O, Weimershaus M, Guermonprez P, Firat E, Lindo V, Greer F, Davoust J, Kratzer R, Keller SR, Niedermann G, van Endert P.; ''IRAP identifies an endosomal compartment required for MHC class I cross-presentation.''; PubMed Europe PMC Scholia
  59. Amigorena S, Savina A.; ''Intracellular mechanisms of antigen cross presentation in dendritic cells.''; PubMed Europe PMC Scholia
  60. Mantegazza AR, Savina A, Vermeulen M, Pérez L, Geffner J, Hermine O, Rosenzweig SD, Faure F, Amigorena S.; ''NADPH oxidase controls phagosomal pH and antigen cross-presentation in human dendritic cells.''; PubMed Europe PMC Scholia
  61. Nillegoda NB, Theodoraki MA, Mandal AK, Mayo KJ, Ren HY, Sultana R, Wu K, Johnson J, Cyr DM, Caplan AJ.; ''Ubr1 and Ubr2 function in a quality control pathway for degradation of unfolded cytosolic proteins.''; PubMed Europe PMC Scholia
  62. Hammond AT, Glick BS.; ''Dynamics of transitional endoplasmic reticulum sites in vertebrate cells.''; PubMed Europe PMC Scholia
  63. Ding W, Li C, Hu T, Graves-Deal R, Fotia AB, Weissman AM, Coffey RJ.; ''EGF receptor-independent action of TGF-alpha protects Naked2 from AO7-mediated ubiquitylation and proteasomal degradation.''; PubMed Europe PMC Scholia
  64. Winchester JF, Salsberg JA, Levin NW.; ''Beta-2 microglobulin in ESRD: an in-depth review.''; PubMed Europe PMC Scholia
  65. Basha G, Lizée G, Reinicke AT, Seipp RP, Omilusik KD, Jefferies WA.; ''MHC class I endosomal and lysosomal trafficking coincides with exogenous antigen loading in dendritic cells.''; PubMed Europe PMC Scholia
  66. Voges D, Zwickl P, Baumeister W.; ''The 26S proteasome: a molecular machine designed for controlled proteolysis.''; PubMed Europe PMC Scholia
  67. Rogers LD, Foster LJ.; ''Contributions of proteomics to understanding phagosome maturation.''; PubMed Europe PMC Scholia
  68. Grenfell SJ, Trausch-Azar JS, Handley-Gearhart PM, Ciechanover A, Schwartz AL.; ''Nuclear localization of the ubiquitin-activating enzyme, E1, is cell-cycle-dependent.''; PubMed Europe PMC Scholia
  69. Neumann L, Tampé R.; ''Kinetic analysis of peptide binding to the TAP transport complex: evidence for structural rearrangements induced by substrate binding.''; PubMed Europe PMC Scholia
  70. Wei SJ, Williams JG, Dang H, Darden TA, Betz BL, Humble MM, Chang FM, Trempus CS, Johnson K, Cannon RE, Tennant RW.; ''Identification of a specific motif of the DSS1 protein required for proteasome interaction and p53 protein degradation.''; PubMed Europe PMC Scholia
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  73. Hu Q, Guo C, Li Y, Aronow BJ, Zhang J.; ''LMO7 mediates cell-specific activation of the Rho-myocardin-related transcription factor-serum response factor pathway and plays an important role in breast cancer cell migration.''; PubMed Europe PMC Scholia
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  141. Sato K, Nakano A.; ''Mechanisms of COPII vesicle formation and protein sorting.''; PubMed Europe PMC Scholia
  142. Kallijärvi J, Lahtinen U, Hämäläinen R, Lipsanen-Nyman M, Palvimo JJ, Lehesjoki AE.; ''TRIM37 defective in mulibrey nanism is a novel RING finger ubiquitin E3 ligase.''; PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117684view12:08, 22 May 2021EweitzModified title
114758view16:24, 25 January 2021ReactomeTeamReactome version 75
113202view11:26, 2 November 2020ReactomeTeamReactome version 74
112427view15:37, 9 October 2020ReactomeTeamReactome version 73
101331view11:21, 1 November 2018ReactomeTeamreactome version 66
100869view20:55, 31 October 2018ReactomeTeamreactome version 65
100410view19:28, 31 October 2018ReactomeTeamreactome version 64
99959view16:13, 31 October 2018ReactomeTeamreactome version 63
99514view14:45, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99156view12:41, 31 October 2018ReactomeTeamreactome version 62
94507view09:31, 14 September 2017Mkutmonreactome version 61
87162view19:18, 18 July 2016MkutmonOntology Term : 'adaptive immune response pathway' added !
87068view11:35, 18 July 2016ReactomeTeamReactome version 56
83467view12:31, 18 November 2015ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(Glc)1 (GlcNAc)2 (Man)9 MetaboliteCHEBI:59080 (ChEBI)
26S proteasomeComplexR-HSA-68819 (Reactome)
2xN4GlycoAsn-LY96 ProteinQ9Y6Y9 (Uniprot-TrEMBL)
2xN4GlycoAsn-TLR4 ProteinO00206 (Uniprot-TrEMBL)
4xPalmC-CD36 ProteinP16671 (Uniprot-TrEMBL)
ADPMetaboliteCHEBI:16761 (ChEBI)
AMPMetaboliteCHEBI:16027 (ChEBI)
ANAPC1 ProteinQ9H1A4 (Uniprot-TrEMBL)
ANAPC10 ProteinQ9UM13 (Uniprot-TrEMBL)
ANAPC11 ProteinQ9NYG5 (Uniprot-TrEMBL)
ANAPC13 ProteinQ9BS18 (Uniprot-TrEMBL)
ANAPC2 ProteinQ9UJX6 (Uniprot-TrEMBL)
ANAPC4 ProteinQ9UJX5 (Uniprot-TrEMBL)
ANAPC5 ProteinQ9UJX4 (Uniprot-TrEMBL)
ANAPC7 ProteinQ9UJX3 (Uniprot-TrEMBL)
AREL1 ProteinO15033 (Uniprot-TrEMBL)
ARIH2 ProteinO95376 (Uniprot-TrEMBL)
ASB1 ProteinQ9Y576 (Uniprot-TrEMBL)
ASB10 ProteinQ8WXI3 (Uniprot-TrEMBL)
ASB11 ProteinQ8WXH4 (Uniprot-TrEMBL)
ASB12 ProteinQ8WXK4 (Uniprot-TrEMBL)
ASB13 ProteinQ8WXK3 (Uniprot-TrEMBL)
ASB14 ProteinA6NK59 (Uniprot-TrEMBL)
ASB15 ProteinQ8WXK1 (Uniprot-TrEMBL)
ASB16 ProteinQ96NS5 (Uniprot-TrEMBL)
ASB17 ProteinQ8WXJ9 (Uniprot-TrEMBL)
ASB18 ProteinQ6ZVZ8 (Uniprot-TrEMBL)
ASB2 ProteinQ96Q27 (Uniprot-TrEMBL)
ASB3 ProteinQ9Y575 (Uniprot-TrEMBL)
ASB4 ProteinQ9Y574 (Uniprot-TrEMBL)
ASB5 ProteinQ8WWX0 (Uniprot-TrEMBL)
ASB6 ProteinQ9NWX5 (Uniprot-TrEMBL)
ASB7 ProteinQ9H672 (Uniprot-TrEMBL)
ASB8 ProteinQ9H765 (Uniprot-TrEMBL)
ASB9 ProteinQ96DX5 (Uniprot-TrEMBL)
ATG7 ProteinO95352 (Uniprot-TrEMBL)
ATPMetaboliteCHEBI:15422 (ChEBI)
Ag peptide bound class I MHCComplexR-HSA-1236931 (Reactome)
Ag-substrate:E3:E2:UbComplexR-HSA-983126 (Reactome)
Antigen R-ALL-173548 (Reactome)
Antigen peptide

bound class I

MHC:BAP31 oligomer		ComplexR-HSA-983132 (Reactome)
Antigen peptide bound class I MHCComplexR-HSA-1236934 (Reactome)
Antigen peptide bound class I MHCComplexR-HSA-198904 (Reactome)
Antigen peptide bound class I MHCComplexR-HSA-983114 (Reactome)
Antigen peptide bound class I MHCComplexR-HSA-983412 (Reactome)
Antigen peptide bound class I MHCComplexR-HSA-983416 (Reactome)
Antigen peptide MetaboliteCHEBI:25676 (ChEBI)
Antigen peptide R-ALL-983324 (Reactome)
Antigen peptide R-ALL-983326 (Reactome)
Antigen peptideMetaboliteCHEBI:25676 (ChEBI)
Antigenic

peptide:MHC:B2M peptide loading

complex		ComplexR-HSA-8951496 (Reactome)
B2M(21-119) ProteinP61769 (Uniprot-TrEMBL)
B2M(21-119)ProteinP61769 (Uniprot-TrEMBL)
BAP31 oligomer R-HSA-983323 (Reactome)
BAP31 oligomerR-HSA-983323 (Reactome)
BLMH ProteinQ13867 (Uniprot-TrEMBL)
BTBD1 ProteinQ9H0C5 (Uniprot-TrEMBL)
BTBD6 ProteinQ96KE9 (Uniprot-TrEMBL)
BTK ProteinQ06187 (Uniprot-TrEMBL)
BTRC ProteinQ9Y297 (Uniprot-TrEMBL)
CALR ProteinP27797 (Uniprot-TrEMBL)
CALR:SEC22B:STX4:TAP:TAPBPComplexR-HSA-8951594 (Reactome)
CALRProteinP27797 (Uniprot-TrEMBL)
CANX ProteinP27824 (Uniprot-TrEMBL)
CBLB ProteinQ13191 (Uniprot-TrEMBL)
CCNF ProteinP41002 (Uniprot-TrEMBL)
CD14(20-345) ProteinP08571 (Uniprot-TrEMBL)
CD207 ProteinQ9UJ71 (Uniprot-TrEMBL)
CD36 ProteinP16671 (Uniprot-TrEMBL)
CDC16 ProteinQ13042 (Uniprot-TrEMBL)
CDC20 ProteinQ12834 (Uniprot-TrEMBL)
CDC23 ProteinQ9UJX2 (Uniprot-TrEMBL)
CDC26 ProteinQ8NHZ8 (Uniprot-TrEMBL)
CDC27 ProteinP30260 (Uniprot-TrEMBL)
CDC34 ProteinP49427 (Uniprot-TrEMBL)
CHUK ProteinO15111 (Uniprot-TrEMBL)
CHUK:IKBKB:IKBKGComplexR-HSA-168113 (Reactome) Co-immunoprecipitation studies and size exclusion chromatography analysis indicate that the high molecular weight (around 700 to 900 kDa) IKK complex is composed of two kinase subunits (IKK1/CHUK/IKBKA and/or IKK2/IKBKB/IKKB) bound to a regulatory gamma subunit (IKBKG/NEMO) (Rothwarf DMet al. 1998; Krappmann D et al. 2000; Miller BS & Zandi E 2001). Variants of the IKK complex containing IKBKA or IKBKB homodimers associated with NEMO may also exist. Crystallographic and quantitative analyses of the binding interactions between N-terminal NEMO and C-terminal IKBKB fragments showed that IKBKB dimers would interact with NEMO dimers resulting in 2:2 stoichiometry (Rushe M et al. 2008). Chemical cross-linking and equilibrium sedimentation analyses of IKBKG (NEMO) suggest a tetrameric oligomerization (dimers of dimers) (Tegethoff S et al. 2003). The tetrameric NEMO could sequester four kinase molecules, yielding an 2xIKBKA:2xIKBKB:4xNEMO stoichiometry (Tegethoff S et al. 2003). The above data suggest that the core IKK complex consists of an IKBKA:IKBKB heterodimer associated with an IKBKG dimer or higher oligomeric assemblies. However, the exact stoichiometry of the IKK complex remains unclear.
COPII vesicle with MHC class IComplexR-HSA-983414 (Reactome)
COPII vesicle with MHC class IComplexR-HSA-983418 (Reactome)
COPIIComplexR-HSA-204019 (Reactome)
CTSL1(114-288) ProteinP07711 (Uniprot-TrEMBL)
CTSL2 ProteinO60911 (Uniprot-TrEMBL)
CTSS ProteinP25774 (Uniprot-TrEMBL)
CTSS-like proteinsComplexR-HSA-4127472 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
CUL1 ProteinQ13616 (Uniprot-TrEMBL)
CUL2 ProteinQ13617 (Uniprot-TrEMBL)
CUL3 ProteinQ13618 (Uniprot-TrEMBL)
CUL5 ProteinQ93034 (Uniprot-TrEMBL)
CUL7 ProteinQ14999 (Uniprot-TrEMBL)
CYBA ProteinP13498 (Uniprot-TrEMBL)
CYBB ProteinP04839 (Uniprot-TrEMBL)
Chaperones calnexin/BiPComplexR-HSA-983129 (Reactome)
Class I MHC HC:B2M:Erp57ComplexR-HSA-1236922 (Reactome)
Class I MHC HC:B2M:Erp57ComplexR-HSA-8863933 (Reactome)
Class I MHC:B2MComplexR-HSA-1236930 (Reactome)
Clostridial peptidoglycan MetaboliteCHEBI:8005 (ChEBI)
DC receptors

recognizing

apoptotic cells		ComplexR-HSA-1236899 (Reactome)
DC receptors

recognizing

apoptotic cells		ComplexR-HSA-1236904 (Reactome)
DET1 ProteinQ7L5Y6 (Uniprot-TrEMBL)
DTX3L ProteinQ8TDB6 (Uniprot-TrEMBL)
DZIP3 ProteinQ86Y13 (Uniprot-TrEMBL)
Diacyl lipopeptide MetaboliteCHEBI:46896 (ChEBI)
E1 bound ubiquitinComplexR-HSA-976164 (Reactome)
E2 Ubiquitin-conjugating enzymeComplexR-HSA-947628 (Reactome)
E3 ligases in

proteasomal

degradation		ComplexR-HSA-976075 (Reactome)
E3:K48-polyubiquitinated substrateComplexR-HSA-983134 (Reactome)
E3:Ub:substrateComplexR-HSA-983131 (Reactome)
ELOB ProteinQ15370 (Uniprot-TrEMBL)
ELOC ProteinQ15369 (Uniprot-TrEMBL)
ERAP1 ProteinQ9NZ08 (Uniprot-TrEMBL)
ERAP1/2ComplexR-HSA-983125 (Reactome)
ERAP2 ProteinQ6P179 (Uniprot-TrEMBL)
Exogenous

Particulate antigen

(Ag)		R-ALL-1236714 (Reactome)
Exogenous

Particulate antigen

(Ag)		R-ALL-1236716 (Reactome)
Exogenous

Particulate antigen

(Ag)		R-ALL-1236726 (Reactome)
Exogenous Particulate antigen (Ag) R-ALL-1236726 (Reactome)
Exogenous soluble antigenMetaboliteCHEBI:16670 (ChEBI)
Exogenous soluble antigen MetaboliteCHEBI:16670 (ChEBI)
FBXL12 ProteinQ9NXK8 (Uniprot-TrEMBL)
FBXL13 ProteinQ8NEE6 (Uniprot-TrEMBL)
FBXL14 ProteinQ8N1E6 (Uniprot-TrEMBL)
FBXL15 ProteinQ9H469 (Uniprot-TrEMBL)
FBXL16 ProteinQ8N461 (Uniprot-TrEMBL)
FBXL18 ProteinQ96ME1 (Uniprot-TrEMBL)
FBXL19 ProteinQ6PCT2 (Uniprot-TrEMBL)
FBXL20 ProteinQ96IG2 (Uniprot-TrEMBL)
FBXL21 ProteinQ9UKT6 (Uniprot-TrEMBL)
FBXL22 ProteinQ6P050 (Uniprot-TrEMBL)
FBXL3 ProteinQ9UKT7 (Uniprot-TrEMBL)
FBXL4 ProteinQ9UKA2 (Uniprot-TrEMBL)
FBXL5 ProteinQ9UKA1 (Uniprot-TrEMBL)
FBXL7 ProteinQ9UJT9 (Uniprot-TrEMBL)
FBXL8 ProteinQ96CD0 (Uniprot-TrEMBL)
FBXO10 ProteinQ9UK96 (Uniprot-TrEMBL)
FBXO11 ProteinQ86XK2 (Uniprot-TrEMBL)
FBXO15 ProteinQ8NCQ5 (Uniprot-TrEMBL)
FBXO17 ProteinQ96EF6 (Uniprot-TrEMBL)
FBXO2 ProteinQ9UK22 (Uniprot-TrEMBL)
FBXO21 ProteinO94952 (Uniprot-TrEMBL)
FBXO22 ProteinQ8NEZ5 (Uniprot-TrEMBL)
FBXO27 ProteinQ8NI29 (Uniprot-TrEMBL)
FBXO30 ProteinQ8TB52 (Uniprot-TrEMBL)
FBXO31 ProteinQ5XUX0 (Uniprot-TrEMBL)
FBXO32 ProteinQ969P5 (Uniprot-TrEMBL)
FBXO4 ProteinQ9UKT5 (Uniprot-TrEMBL)
FBXO40 ProteinQ9UH90 (Uniprot-TrEMBL)
FBXO41 ProteinQ8TF61 (Uniprot-TrEMBL)
FBXO44 ProteinQ9H4M3 (Uniprot-TrEMBL)
FBXO6 ProteinQ9NRD1 (Uniprot-TrEMBL)
FBXO7 ProteinQ9Y3I1 (Uniprot-TrEMBL)
FBXO9 ProteinQ9UK97 (Uniprot-TrEMBL)
FBXW10 ProteinQ5XX13 (Uniprot-TrEMBL)
FBXW11 ProteinQ9UKB1 (Uniprot-TrEMBL)
FBXW12 ProteinQ6X9E4 (Uniprot-TrEMBL)
FBXW2 ProteinQ9UKT8 (Uniprot-TrEMBL)
FBXW4 ProteinP57775 (Uniprot-TrEMBL)
FBXW5 ProteinQ969U6 (Uniprot-TrEMBL)
FBXW7 ProteinQ969H0 (Uniprot-TrEMBL)
FBXW8 ProteinQ8N3Y1 (Uniprot-TrEMBL)
FBXW9 ProteinQ5XUX1 (Uniprot-TrEMBL)
FCGR R-HSA-1236898 (Reactome)
FCGR R-HSA-1236905 (Reactome)
FCGRA R-HSA-1031694 (Reactome)
FZR1 ProteinQ9UM11 (Uniprot-TrEMBL)
GAN ProteinQ9H2C0 (Uniprot-TrEMBL)
GDP MetaboliteCHEBI:17552 (ChEBI)
GDPMetaboliteCHEBI:17552 (ChEBI)
GLMN ProteinQ92990 (Uniprot-TrEMBL)
GPIN-CD14(20-345) ProteinP08571 (Uniprot-TrEMBL)
GTP MetaboliteCHEBI:15996 (ChEBI)
GTPMetaboliteCHEBI:15996 (ChEBI)
H+MetaboliteCHEBI:15378 (ChEBI)
H2OMetaboliteCHEBI:15377 (ChEBI)
HACE1 ProteinQ8IYU2 (Uniprot-TrEMBL)
HECTD1 ProteinQ9ULT8 (Uniprot-TrEMBL)
HECTD2 ProteinQ5U5R9 (Uniprot-TrEMBL)
HECTD3 ProteinQ5T447 (Uniprot-TrEMBL)
HECW2 ProteinQ9P2P5 (Uniprot-TrEMBL)
HERC1 ProteinQ15751 (Uniprot-TrEMBL)
HERC2 ProteinO95714 (Uniprot-TrEMBL)
HERC3 ProteinQ15034 (Uniprot-TrEMBL)
HERC4 ProteinQ5GLZ8 (Uniprot-TrEMBL)
HERC5 ProteinQ9UII4 (Uniprot-TrEMBL)
HERC6 ProteinQ8IVU3 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-1 alpha chain precursor ProteinP30443 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-11 alpha chain ProteinP13746 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-2 alpha chain ProteinP01892 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-23 alpha chain ProteinP30447 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-24 alpha chain ProteinP05534 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-25 alpha chain ProteinP18462 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-26 alpha chain ProteinP30450 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-29 alpha chain ProteinP30512 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-3 alpha chain precursor ProteinP04439 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-30 alpha chain ProteinP16188 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-31 alpha chain ProteinP16189 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-32 alpha chain ProteinP10314 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-33 alpha chain ProteinP16190 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-34 alpha chain ProteinP30453 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-36 alpha chain ProteinP30455 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-43 alpha chain ProteinP30456 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-66 alpha chain ProteinP30457 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-68 alpha chain ProteinP01891 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-69 alpha chain ProteinP10316 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-74 alpha chain ProteinP30459 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-80 alpha chain ProteinQ09160 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, B-48 alpha chain ProteinP30486 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-1 alpha chain ProteinP30499 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-12 alpha chain ProteinP30508 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-14 alpha chain ProteinP30510 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-15 alpha chain ProteinQ07000 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-16 alpha chain ProteinQ29960 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-17 alpha chain ProteinQ95604 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-18 alpha chain ProteinQ29865 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-2 alpha chain ProteinP30501 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-3 alpha chain precursor ProteinP04222 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-4 alpha chain precursor ProteinP30504 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-5 alpha chain precursor ProteinQ9TNN7 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-6 alpha chain precursor ProteinQ29963 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-7 alpha chain precursor ProteinP10321 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-8 alpha chain ProteinP30505 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, E alpha chain precursor ProteinP13747 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, alpha chain F precursor ProteinP30511 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, alpha chain G precursor ProteinP17693 (Uniprot-TrEMBL)
HLA-B ProteinP30486 (Uniprot-TrEMBL)
HLA-C ProteinP10321 (Uniprot-TrEMBL)
HLA-H ProteinP01893 (Uniprot-TrEMBL)
HSPA5 ProteinP11021 (Uniprot-TrEMBL)
HUWE1 ProteinQ7Z6Z7 (Uniprot-TrEMBL)
IFN gamma stimulated aminopeptidasesComplexR-HSA-983128 (Reactome)
IKBKB ProteinO14920 (Uniprot-TrEMBL)
IKBKG ProteinQ9Y6K9 (Uniprot-TrEMBL)
IRAP in complex with MHC class IComplexR-HSA-1236916 (Reactome)
ITCH ProteinQ96J02 (Uniprot-TrEMBL)
ITGAV(31-1048) ProteinP06756 (Uniprot-TrEMBL)
ITGB5 ProteinP18084 (Uniprot-TrEMBL)
K48polyUb-antigenic substrateR-ALL-983123 (Reactome)
K48polyUb-antigenic substrate R-ALL-983123 (Reactome)
K48polyUb-partially digested AgR-ALL-1236918 (Reactome)
KBTBD13 ProteinC9JR72 (Uniprot-TrEMBL)
KBTBD6 ProteinQ86V97 (Uniprot-TrEMBL)
KBTBD7 ProteinQ8WVZ9 (Uniprot-TrEMBL)
KBTBD8 ProteinQ8NFY9 (Uniprot-TrEMBL)
KCTD6 ProteinQ8NC69 (Uniprot-TrEMBL)
KCTD7 ProteinQ96MP8 (Uniprot-TrEMBL)
KEAP1 ProteinQ14145 (Uniprot-TrEMBL)
KLHL11 ProteinQ9NVR0 (Uniprot-TrEMBL)
KLHL13 ProteinQ9P2N7 (Uniprot-TrEMBL)
KLHL2 ProteinO95198 (Uniprot-TrEMBL)
KLHL20 ProteinQ9Y2M5 (Uniprot-TrEMBL)
KLHL21 ProteinQ9UJP4 (Uniprot-TrEMBL)
KLHL22 ProteinQ53GT1 (Uniprot-TrEMBL)
KLHL25 ProteinQ9H0H3 (Uniprot-TrEMBL)
KLHL3 ProteinQ9UH77 (Uniprot-TrEMBL)
KLHL41 ProteinO60662 (Uniprot-TrEMBL)
KLHL42 ProteinQ9P2K6 (Uniprot-TrEMBL)
KLHL5 ProteinQ96PQ7 (Uniprot-TrEMBL)
KLHL9 ProteinQ9P2J3 (Uniprot-TrEMBL)
L-amino acidMetaboliteCHEBI:59869 (ChEBI)
LMO7 ProteinQ8WWI1 (Uniprot-TrEMBL)
LNPEP ProteinQ9UIQ6 (Uniprot-TrEMBL)
LNX1 ProteinQ8TBB1 (Uniprot-TrEMBL)
LONRF1 ProteinQ17RB8 (Uniprot-TrEMBL)
LPS MetaboliteCHEBI:16412 (ChEBI)
LRR1 ProteinQ96L50 (Uniprot-TrEMBL)
LRRC41 ProteinQ15345 (Uniprot-TrEMBL)
LRSAM1 ProteinQ6UWE0 (Uniprot-TrEMBL)
LTN1 ProteinO94822 (Uniprot-TrEMBL)
Lipoteichoic acid MetaboliteCHEBI:28640 (ChEBI)
MEX3C ProteinQ5U5Q3 (Uniprot-TrEMBL)
MGRN1 ProteinO60291 (Uniprot-TrEMBL)
MHC

class I

HC:Calnexin/BiP:Erp57		ComplexR-HSA-983119 (Reactome)
MHC HC:B2M:Erp57ComplexR-HSA-983136 (Reactome)
MHC:B2M peptide loading complexComplexR-HSA-983121 (Reactome)
MIB2 ProteinQ96AX9 (Uniprot-TrEMBL)
MKRN1 ProteinQ9UHC7 (Uniprot-TrEMBL)
MR/other probable receptorsComplexR-HSA-1236909 (Reactome)
MR/other probable receptorsComplexR-HSA-1236911 (Reactome)
MR:soluble antigenComplexR-HSA-1236923 (Reactome)
MR:soluble antigenComplexR-HSA-1236926 (Reactome)
MR:soluble antigenComplexR-HSA-1236929 (Reactome)
MRC1 ProteinP22897 (Uniprot-TrEMBL)
MRC2 ProteinQ9UBG0 (Uniprot-TrEMBL)
MYD88 ProteinQ99836 (Uniprot-TrEMBL)
MYLIP ProteinQ8WY64 (Uniprot-TrEMBL)
Major outer membrane protein P ProteinP30690 (Uniprot-TrEMBL)
Mg2+MetaboliteCHEBI:18420 (ChEBI)
NADP+MetaboliteCHEBI:18009 (ChEBI)
NADPHMetaboliteCHEBI:16474 (ChEBI)
NEDD4 ProteinP46934 (Uniprot-TrEMBL)
NEDD4L ProteinQ96PU5 (Uniprot-TrEMBL)
NOX2 complexComplexR-HSA-1996217 (Reactome)
NPEPPS ProteinP55786 (Uniprot-TrEMBL)
O2.-MetaboliteCHEBI:18421 (ChEBI)
O2MetaboliteCHEBI:15379 (ChEBI)
PARK2 ProteinO60260 (Uniprot-TrEMBL)
PDIA3 ProteinP30101 (Uniprot-TrEMBL)
PDIA3ProteinP30101 (Uniprot-TrEMBL)
PI(4,5)P2 MetaboliteCHEBI:18348 (ChEBI)
PJA1 ProteinQ8NG27 (Uniprot-TrEMBL)
PJA2 ProteinO43164 (Uniprot-TrEMBL)
PPiMetaboliteCHEBI:29888 (ChEBI)
PSMA1 ProteinP25786 (Uniprot-TrEMBL)
PSMA2 ProteinP25787 (Uniprot-TrEMBL)
PSMA3 ProteinP25788 (Uniprot-TrEMBL)
PSMA4 ProteinP25789 (Uniprot-TrEMBL)
PSMA5 ProteinP28066 (Uniprot-TrEMBL)
PSMA6 ProteinP60900 (Uniprot-TrEMBL)
PSMA7 ProteinO14818 (Uniprot-TrEMBL)
PSMA8 ProteinQ8TAA3 (Uniprot-TrEMBL)
PSMB1 ProteinP20618 (Uniprot-TrEMBL)
PSMB10 ProteinP40306 (Uniprot-TrEMBL)
PSMB11 ProteinA5LHX3 (Uniprot-TrEMBL)
PSMB2 ProteinP49721 (Uniprot-TrEMBL)
PSMB3 ProteinP49720 (Uniprot-TrEMBL)
PSMB4 ProteinP28070 (Uniprot-TrEMBL)
PSMB5 ProteinP28074 (Uniprot-TrEMBL)
PSMB6 ProteinP28072 (Uniprot-TrEMBL)
PSMB7 ProteinQ99436 (Uniprot-TrEMBL)
PSMB8 ProteinP28062 (Uniprot-TrEMBL)
PSMB9 ProteinP28065 (Uniprot-TrEMBL)
PSMC1 ProteinP62191 (Uniprot-TrEMBL)
PSMC2 ProteinP35998 (Uniprot-TrEMBL)
PSMC3 ProteinP17980 (Uniprot-TrEMBL)
PSMC4 ProteinP43686 (Uniprot-TrEMBL)
PSMC5 ProteinP62195 (Uniprot-TrEMBL)
PSMC6 ProteinP62333 (Uniprot-TrEMBL)
PSMD1 ProteinQ99460 (Uniprot-TrEMBL)
PSMD10 ProteinO75832 (Uniprot-TrEMBL)
PSMD11 ProteinO00231 (Uniprot-TrEMBL)
PSMD12 ProteinO00232 (Uniprot-TrEMBL)
PSMD13 ProteinQ9UNM6 (Uniprot-TrEMBL)
PSMD14 ProteinO00487 (Uniprot-TrEMBL)
PSMD2 ProteinQ13200 (Uniprot-TrEMBL)
PSMD3 ProteinO43242 (Uniprot-TrEMBL)
PSMD4 ProteinP55036 (Uniprot-TrEMBL)
PSMD5 ProteinQ16401 (Uniprot-TrEMBL)
PSMD6 ProteinQ15008 (Uniprot-TrEMBL)
PSMD7 ProteinP51665 (Uniprot-TrEMBL)
PSMD8 ProteinP48556 (Uniprot-TrEMBL)
PSMD9 ProteinO00233 (Uniprot-TrEMBL)
PSME1 ProteinQ06323 (Uniprot-TrEMBL)
PSME2 ProteinQ9UL46 (Uniprot-TrEMBL)
PSME3 ProteinP61289 (Uniprot-TrEMBL)
PSME4 ProteinQ14997 (Uniprot-TrEMBL)
PSMF1 ProteinQ92530 (Uniprot-TrEMBL)
Particulate Ag:DC receptorsComplexR-HSA-1236920 (Reactome)
PiMetaboliteCHEBI:18367 (ChEBI)
RBBP6 ProteinQ7Z6E9 (Uniprot-TrEMBL)
RBCK1 ProteinQ9BYM8 (Uniprot-TrEMBL)
RBX1 ProteinP62877 (Uniprot-TrEMBL)
RCHY1 ProteinQ96PM5 (Uniprot-TrEMBL)
RLIM ProteinQ9NVW2 (Uniprot-TrEMBL)
RNF111 ProteinQ6ZNA4 (Uniprot-TrEMBL)
RNF114 ProteinQ9Y508 (Uniprot-TrEMBL)
RNF115 ProteinQ9Y4L5 (Uniprot-TrEMBL)
RNF123 ProteinQ5XPI4 (Uniprot-TrEMBL)
RNF126 ProteinQ9BV68 (Uniprot-TrEMBL)
RNF130 ProteinQ86XS8 (Uniprot-TrEMBL)
RNF138 ProteinQ8WVD3 (Uniprot-TrEMBL)
RNF14 ProteinQ9UBS8 (Uniprot-TrEMBL)
RNF144B ProteinQ7Z419 (Uniprot-TrEMBL)
RNF182 ProteinQ8N6D2 (Uniprot-TrEMBL)
RNF19A ProteinQ9NV58 (Uniprot-TrEMBL)
RNF19B ProteinQ6ZMZ0 (Uniprot-TrEMBL)
RNF213 ProteinQ63HN8 (Uniprot-TrEMBL)
RNF217 ProteinQ8TC41 (Uniprot-TrEMBL)
RNF220 ProteinQ5VTB9 (Uniprot-TrEMBL)
RNF25 ProteinQ96BH1 (Uniprot-TrEMBL)
RNF34 ProteinQ969K3 (Uniprot-TrEMBL)
RNF4 ProteinP78317 (Uniprot-TrEMBL)
RNF41 ProteinQ9H4P4 (Uniprot-TrEMBL)
RNF6 ProteinQ9Y252 (Uniprot-TrEMBL)
RNF7 (RBX2) ProteinQ9UBF6 (Uniprot-TrEMBL)
RPS27A(1-76) ProteinP62979 (Uniprot-TrEMBL)
SAR1B ProteinQ9Y6B6 (Uniprot-TrEMBL)
SAR1B:GDPComplexR-HSA-203989 (Reactome)
SAR1B:GTP:SEC23:SEC24ComplexR-HSA-203997 (Reactome)
SAR1B:GTPComplexR-HSA-204003 (Reactome)
SEC13 ProteinP55735 (Uniprot-TrEMBL)
SEC13ProteinP55735 (Uniprot-TrEMBL)
SEC22B ProteinO75396 (Uniprot-TrEMBL)
SEC22B:STX4ComplexR-HSA-8863847 (Reactome)
SEC22BProteinO75396 (Uniprot-TrEMBL)
SEC23:SEC24ComplexR-HSA-203975 (Reactome)
SEC23A ProteinQ15436 (Uniprot-TrEMBL)
SEC23AProteinQ15436 (Uniprot-TrEMBL)
SEC24A ProteinO95486 (Uniprot-TrEMBL)
SEC24B ProteinO95487 (Uniprot-TrEMBL)
SEC24C ProteinP53992 (Uniprot-TrEMBL)
SEC24D ProteinO94855 (Uniprot-TrEMBL)
SEC24ComplexR-HSA-203991 (Reactome)
SEC31A ProteinO94979 (Uniprot-TrEMBL)
SEC31AProteinO94979 (Uniprot-TrEMBL)
SEC61A1 ProteinP61619 (Uniprot-TrEMBL)
SEC61A2 ProteinQ9H9S3 (Uniprot-TrEMBL)
SEC61B ProteinP60468 (Uniprot-TrEMBL)
SEC61G ProteinP60059 (Uniprot-TrEMBL)
SH3RF1 ProteinQ7Z6J0 (Uniprot-TrEMBL)
SHFM1 ProteinP60896 (Uniprot-TrEMBL)
SIAH1 ProteinQ8IUQ4 (Uniprot-TrEMBL)
SIAH2 ProteinO43255 (Uniprot-TrEMBL)
SKP1 ProteinP63208 (Uniprot-TrEMBL)
SKP2 ProteinQ13309 (Uniprot-TrEMBL)
SMURF1 ProteinQ9HCE7 (Uniprot-TrEMBL)
SMURF2 ProteinQ9HAU4 (Uniprot-TrEMBL)
SNAP23ProteinO00161 (Uniprot-TrEMBL)
SOCS1 ProteinO15524 (Uniprot-TrEMBL)
SOCS3 ProteinO14543 (Uniprot-TrEMBL)
SPSB1 ProteinQ96BD6 (Uniprot-TrEMBL)
SPSB2 ProteinQ99619 (Uniprot-TrEMBL)
SPSB4 ProteinQ96A44 (Uniprot-TrEMBL)
STUB1 ProteinQ9UNE7 (Uniprot-TrEMBL)
STX4 ProteinQ12846 (Uniprot-TrEMBL)
STX4ProteinQ12846 (Uniprot-TrEMBL)
Sar1p:GTP:Sec23p:Sec24p:Ag bound MHC class IComplexR-HSA-983413 (Reactome)
TAP1 ProteinQ03518 (Uniprot-TrEMBL)
TAP2 ProteinQ03519 (Uniprot-TrEMBL)
TAPBP ProteinO15533 (Uniprot-TrEMBL)
TAPBPProteinO15533 (Uniprot-TrEMBL)
TAPComplexR-HSA-1236915 (Reactome)
TAPComplexR-HSA-8863936 (Reactome)
TAPComplexR-HSA-983113 (Reactome)
THOP1ProteinP52888 (Uniprot-TrEMBL)
TLR1 ProteinQ15399 (Uniprot-TrEMBL)
TLR2 ProteinO60603 (Uniprot-TrEMBL)
TLR6 ProteinQ9Y2C9 (Uniprot-TrEMBL)
TPP2 ProteinP29144 (Uniprot-TrEMBL)
TRAF7 ProteinQ6Q0C0 (Uniprot-TrEMBL)
TRAIP ProteinQ9BWF2 (Uniprot-TrEMBL)
TRIM11 ProteinQ96F44 (Uniprot-TrEMBL)
TRIM21 ProteinP19474 (Uniprot-TrEMBL)
TRIM32 ProteinQ13049 (Uniprot-TrEMBL)
TRIM36 ProteinQ9NQ86 (Uniprot-TrEMBL)
TRIM37 ProteinO94972 (Uniprot-TrEMBL)
TRIM39 ProteinQ9HCM9 (Uniprot-TrEMBL)
TRIM4 ProteinQ9C037 (Uniprot-TrEMBL)
TRIM41 ProteinQ8WV44 (Uniprot-TrEMBL)
TRIM50 ProteinQ86XT4 (Uniprot-TrEMBL)
TRIM63 ProteinQ969Q1 (Uniprot-TrEMBL)
TRIM69 ProteinQ86WT6 (Uniprot-TrEMBL)
TRIM71 ProteinQ2Q1W2 (Uniprot-TrEMBL)
TRIM9 ProteinQ9C026 (Uniprot-TrEMBL)
TRIP12 ProteinQ14669 (Uniprot-TrEMBL)
TransloconComplexR-HSA-1236927 (Reactome)
Triacyl lipopeptide MetaboliteCHEBI:60192 (ChEBI)
UBA1 ProteinP22314 (Uniprot-TrEMBL)
UBA3 ProteinQ8TBC4 (Uniprot-TrEMBL)
UBA5 ProteinQ9GZZ9 (Uniprot-TrEMBL)
UBA52(1-76) ProteinP62987 (Uniprot-TrEMBL)
UBA6 ProteinA0AVT1 (Uniprot-TrEMBL)
UBA7 ProteinP41226 (Uniprot-TrEMBL)
UBAC1 ProteinQ9BSL1 (Uniprot-TrEMBL)
UBB(1-76) ProteinP0CG47 (Uniprot-TrEMBL)
UBB(153-228) ProteinP0CG47 (Uniprot-TrEMBL)
UBB(77-152) ProteinP0CG47 (Uniprot-TrEMBL)
UBC(1-76) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(153-228) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(229-304) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(305-380) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(381-456) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(457-532) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(533-608) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(609-684) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(77-152) ProteinP0CG48 (Uniprot-TrEMBL)
UBE2A ProteinP49459 (Uniprot-TrEMBL)
UBE2B ProteinP63146 (Uniprot-TrEMBL)
UBE2C ProteinO00762 (Uniprot-TrEMBL)
UBE2D1 ProteinP51668 (Uniprot-TrEMBL)
UBE2D2 ProteinP62837 (Uniprot-TrEMBL)
UBE2D3 ProteinP61077 (Uniprot-TrEMBL)
UBE2D4 ProteinQ9Y2X8 (Uniprot-TrEMBL)
UBE2E1 ProteinP51965 (Uniprot-TrEMBL)
UBE2E2 ProteinQ96LR5 (Uniprot-TrEMBL)
UBE2E3 ProteinQ969T4 (Uniprot-TrEMBL)
UBE2F ProteinQ969M7 (Uniprot-TrEMBL)
UBE2G1 ProteinP62253 (Uniprot-TrEMBL)
UBE2G2 ProteinP60604 (Uniprot-TrEMBL)
UBE2H ProteinP62256 (Uniprot-TrEMBL)
UBE2J1 ProteinQ9Y385 (Uniprot-TrEMBL)
UBE2J2 ProteinQ8N2K1 (Uniprot-TrEMBL)
UBE2K ProteinP61086 (Uniprot-TrEMBL)
UBE2L3 ProteinP68036 (Uniprot-TrEMBL)
UBE2L6 ProteinO14933 (Uniprot-TrEMBL)
UBE2M ProteinP61081 (Uniprot-TrEMBL)
UBE2N ProteinP61088 (Uniprot-TrEMBL)
UBE2O ProteinQ9C0C9 (Uniprot-TrEMBL)
UBE2Q1 ProteinQ7Z7E8 (Uniprot-TrEMBL)
UBE2Q2 ProteinQ8WVN8 (Uniprot-TrEMBL)
UBE2R2 ProteinQ712K3 (Uniprot-TrEMBL)
UBE2S ProteinQ16763 (Uniprot-TrEMBL)
UBE2U ProteinQ5VVX9 (Uniprot-TrEMBL)
UBE2V1 ProteinQ13404 (Uniprot-TrEMBL)
UBE2V2 ProteinQ15819 (Uniprot-TrEMBL)
UBE2W ProteinQ96B02 (Uniprot-TrEMBL)
UBE2Z ProteinQ9H832 (Uniprot-TrEMBL)
UBE3A ProteinQ05086 (Uniprot-TrEMBL)
UBE3B ProteinQ7Z3V4 (Uniprot-TrEMBL)
UBE3C ProteinQ15386 (Uniprot-TrEMBL)
UBE3D ProteinQ7Z6J8 (Uniprot-TrEMBL)
UBE4A ProteinQ14139 (Uniprot-TrEMBL)
UBOX5 ProteinO94941 (Uniprot-TrEMBL)
UBR1 ProteinQ8IWV7 (Uniprot-TrEMBL)
UBR2 ProteinQ8IWV8 (Uniprot-TrEMBL)
UBR4 ProteinQ5T4S7 (Uniprot-TrEMBL)
UFL1 ProteinO94874 (Uniprot-TrEMBL)
UNKL ProteinQ9H9P5 (Uniprot-TrEMBL)
UbComplexR-HSA-113595 (Reactome)
Ubiquitin activating E1 enzymesComplexR-HSA-947695 (Reactome)
Ubiquitin:E2 conjugating enzymesComplexR-HSA-976165 (Reactome)
Unknown hydrolaseR-HSA-8939794 (Reactome)
VAMP3 ProteinQ15836 (Uniprot-TrEMBL)
VAMP8 ProteinQ9BV40 (Uniprot-TrEMBL)
VAMP8,VAMP3ComplexR-HSA-8863861 (Reactome)
VHL ProteinP40337 (Uniprot-TrEMBL)
VPRBP ProteinQ9Y4B6 (Uniprot-TrEMBL)
WSB1 ProteinQ9Y6I7 (Uniprot-TrEMBL)
WWP1 ProteinQ9H0M0 (Uniprot-TrEMBL)
ZBTB16 ProteinQ05516 (Uniprot-TrEMBL)
ZNF645 ProteinQ8N7E2 (Uniprot-TrEMBL)
ZNRF1 ProteinQ8ND25 (Uniprot-TrEMBL)
ZNRF2 ProteinQ8NHG8 (Uniprot-TrEMBL)
antigenic substrate R-ALL-983035 (Reactome)
antigenic substrateR-ALL-983035 (Reactome)
class I MHC B13 ProteinP30461 (Uniprot-TrEMBL)
class I MHC B14 ProteinP30462 (Uniprot-TrEMBL)
class I MHC B15 ProteinP30464 (Uniprot-TrEMBL)
class I MHC B18 ProteinP30466 (Uniprot-TrEMBL)
class I MHC B27 ProteinP03989 (Uniprot-TrEMBL)
class I MHC B35 ProteinP30685 (Uniprot-TrEMBL)
class I MHC B37 ProteinP18463 (Uniprot-TrEMBL)
class I MHC B38 ProteinQ95365 (Uniprot-TrEMBL)
class I MHC B39 ProteinP30475 (Uniprot-TrEMBL)
class I MHC B40 ProteinQ04826 (Uniprot-TrEMBL)
class I MHC B41 ProteinP30479 (Uniprot-TrEMBL)
class I MHC B42 ProteinP30480 (Uniprot-TrEMBL)
class I MHC B44 ProteinP30481 (Uniprot-TrEMBL)
class I MHC B45 ProteinP30483 (Uniprot-TrEMBL)
class I MHC B46 ProteinP30484 (Uniprot-TrEMBL)
class I MHC B47 ProteinP30485 (Uniprot-TrEMBL)
class I MHC B49 ProteinP30487 (Uniprot-TrEMBL)
class I MHC B50 ProteinP30488 (Uniprot-TrEMBL)
class I MHC B51 ProteinP18464 (Uniprot-TrEMBL)
class I MHC B52 ProteinP30490 (Uniprot-TrEMBL)
class I MHC B53 ProteinP30491 (Uniprot-TrEMBL)
class I MHC B54 ProteinP30492 (Uniprot-TrEMBL)
class I MHC B55 ProteinP30493 (Uniprot-TrEMBL)
class I MHC B56 ProteinP30495 (Uniprot-TrEMBL)
class I MHC B57 ProteinP18465 (Uniprot-TrEMBL)
class I MHC B58 ProteinP10319 (Uniprot-TrEMBL)
class I MHC B59 ProteinQ29940 (Uniprot-TrEMBL)
class I MHC B67 ProteinQ29836 (Uniprot-TrEMBL)
class I MHC B7 ProteinP01889 (Uniprot-TrEMBL)
class I MHC B73 ProteinQ31612 (Uniprot-TrEMBL)
class I MHC B78 ProteinP30498 (Uniprot-TrEMBL)
class I MHC B8 ProteinP30460 (Uniprot-TrEMBL)
class I MHC B81 ProteinQ31610 (Uniprot-TrEMBL)
class I MHC B82 ProteinQ29718 (Uniprot-TrEMBL)
monoglucosylated MHC

class I

HC:Calnexin/BiP		ComplexR-HSA-983116 (Reactome)
monoglucosylated MHC class I HCComplexR-HSA-983120 (Reactome)
oligo-MyD88:Mal:BTK:activated TLRComplexR-HSA-937033 (Reactome)
oligopeptide fragment (3-7aa)MetaboliteCHEBI:25676 (ChEBI)
oligopeptide fragment (8-16aa)MetaboliteCHEBI:25676 (ChEBI)
oligopeptide fragmentMetaboliteCHEBI:25676 (ChEBI)
oligopeptide fragmentR-ALL-1236721 (Reactome)
oligopeptide fragment R-ALL-1236721 (Reactome)
p-4Y-TIRAP ProteinP58753 (Uniprot-TrEMBL)
p-6S-NCF1 ProteinP14598 (Uniprot-TrEMBL)
p-S95-SNAP23 ProteinO00161 (Uniprot-TrEMBL)
p-S95-SNAP23:VAMP8,VAMP3ComplexR-HSA-8863972 (Reactome)
p-S95-SNAP23ProteinO00161 (Uniprot-TrEMBL)
p-T154,S315-NCF4 ProteinQ15080 (Uniprot-TrEMBL)
p-T233-NCF2 ProteinP19878 (Uniprot-TrEMBL)
partially digested AgR-ALL-1236713 (Reactome)
partially digested AgR-ALL-1236718 (Reactome)
precursor peptide fragment (>16 aa)MetaboliteCHEBI:25676 (ChEBI)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
26S proteasomemim-catalysisR-HSA-1236935 (Reactome)
26S proteasomemim-catalysisR-HSA-1236970 (Reactome)
26S proteasomemim-catalysisR-HSA-983150 (Reactome)
ADPArrowR-HSA-1236949 (Reactome)
ADPArrowR-HSA-8863895 (Reactome)
ADPArrowR-HSA-983144 (Reactome)
AMPArrowR-HSA-983140 (Reactome)
AMPArrowR-HSA-983153 (Reactome)
AMPArrowR-HSA-983156 (Reactome)
ATPR-HSA-1236949 (Reactome)
ATPR-HSA-8863895 (Reactome)
ATPR-HSA-983140 (Reactome)
ATPR-HSA-983144 (Reactome)
ATPR-HSA-983153 (Reactome)
ATPR-HSA-983156 (Reactome)
Ag peptide bound class I MHCArrowR-HSA-1236971 (Reactome)
Ag peptide bound class I MHCR-HSA-1236965 (Reactome)
Ag-substrate:E3:E2:UbArrowR-HSA-983157 (Reactome)
Ag-substrate:E3:E2:UbR-HSA-983140 (Reactome)
Antigen peptide

bound class I

MHC:BAP31 oligomer		ArrowR-HSA-983161 (Reactome)
Antigen peptide

bound class I

MHC:BAP31 oligomer		R-HSA-983138 (Reactome)
Antigen peptide bound class I MHCArrowR-HSA-1236943 (Reactome)
Antigen peptide bound class I MHCArrowR-HSA-1236964 (Reactome)
Antigen peptide bound class I MHCArrowR-HSA-1236965 (Reactome)
Antigen peptide bound class I MHCArrowR-HSA-983138 (Reactome)
Antigen peptide bound class I MHCArrowR-HSA-983421 (Reactome)
Antigen peptide bound class I MHCArrowR-HSA-983422 (Reactome)
Antigen peptide bound class I MHCArrowR-HSA-983427 (Reactome)
Antigen peptide bound class I MHCR-HSA-1236964 (Reactome)
Antigen peptide bound class I MHCR-HSA-983421 (Reactome)
Antigen peptide bound class I MHCR-HSA-983426 (Reactome)
Antigen peptide bound class I MHCR-HSA-983427 (Reactome)
Antigen peptideArrowR-HSA-1236954 (Reactome)
Antigen peptideArrowR-HSA-983158 (Reactome)
Antigen peptideR-HSA-1236943 (Reactome)
Antigen peptideR-HSA-8951499 (Reactome)
Antigenic

peptide:MHC:B2M peptide loading

complex		ArrowR-HSA-8951499 (Reactome)
Antigenic

peptide:MHC:B2M peptide loading

complex		R-HSA-983161 (Reactome)
B2M(21-119)R-HSA-983146 (Reactome)
BAP31 oligomerArrowR-HSA-983138 (Reactome)
BAP31 oligomerR-HSA-983142 (Reactome)
CALR:SEC22B:STX4:TAP:TAPBPArrowR-HSA-8863858 (Reactome)
CALR:SEC22B:STX4:TAP:TAPBPR-HSA-8951595 (Reactome)
CALRArrowR-HSA-8863914 (Reactome)
CALRArrowR-HSA-8951595 (Reactome)
CALRArrowR-HSA-983161 (Reactome)
CALRR-HSA-8863858 (Reactome)
CALRR-HSA-8863914 (Reactome)
CALRR-HSA-983142 (Reactome)
CHUK:IKBKB:IKBKGmim-catalysisR-HSA-8863895 (Reactome)
COPII vesicle with MHC class IArrowR-HSA-983424 (Reactome)
COPII vesicle with MHC class IArrowR-HSA-983425 (Reactome)
COPII vesicle with MHC class IR-HSA-983422 (Reactome)
COPII vesicle with MHC class IR-HSA-983424 (Reactome)
COPIImim-catalysisR-HSA-983422 (Reactome)
CTSS-like proteinsmim-catalysisR-HSA-1236948 (Reactome)
Chaperones calnexin/BiPArrowR-HSA-983146 (Reactome)
Chaperones calnexin/BiPR-HSA-983145 (Reactome)
Class I MHC HC:B2M:Erp57ArrowR-HSA-8863973 (Reactome)
Class I MHC HC:B2M:Erp57R-HSA-1236971 (Reactome)
Class I MHC HC:B2M:Erp57R-HSA-8863973 (Reactome)
Class I MHC:B2MR-HSA-1236943 (Reactome)
DC receptors

recognizing

apoptotic cells		ArrowR-HSA-1236956 (Reactome)
DC receptors

recognizing

apoptotic cells		R-HSA-1236958 (Reactome)
E1 bound ubiquitinArrowR-HSA-983153 (Reactome)
E1 bound ubiquitinR-HSA-983152 (Reactome)
E2 Ubiquitin-conjugating enzymeArrowR-HSA-983140 (Reactome)
E2 Ubiquitin-conjugating enzymeArrowR-HSA-983156 (Reactome)
E2 Ubiquitin-conjugating enzymeR-HSA-983152 (Reactome)
E2 Ubiquitin-conjugating enzymemim-catalysisR-HSA-983152 (Reactome)
E3 ligases in

proteasomal

degradation		ArrowR-HSA-983147 (Reactome)
E3 ligases in

proteasomal

degradation		R-HSA-983157 (Reactome)
E3 ligases in

proteasomal

degradation		mim-catalysisR-HSA-983140 (Reactome)
E3:K48-polyubiquitinated substrateArrowR-HSA-983156 (Reactome)
E3:K48-polyubiquitinated substrateR-HSA-983147 (Reactome)
E3:Ub:substrateArrowR-HSA-983140 (Reactome)
E3:Ub:substrateR-HSA-983156 (Reactome)
E3:Ub:substratemim-catalysisR-HSA-983156 (Reactome)
ERAP1/2mim-catalysisR-HSA-983158 (Reactome)
Exogenous

Particulate antigen

(Ag)		ArrowR-HSA-1236956 (Reactome)
Exogenous

Particulate antigen

(Ag)		ArrowR-HSA-1236963 (Reactome)
Exogenous

Particulate antigen

(Ag)		R-HSA-1236938 (Reactome)
Exogenous

Particulate antigen

(Ag)		R-HSA-1236958 (Reactome)
Exogenous

Particulate antigen

(Ag)		R-HSA-1236963 (Reactome)
Exogenous soluble antigenArrowR-HSA-1236940 (Reactome)
Exogenous soluble antigenArrowR-HSA-1236968 (Reactome)
Exogenous soluble antigenR-HSA-1236939 (Reactome)
Exogenous soluble antigenR-HSA-1236948 (Reactome)
Exogenous soluble antigenR-HSA-1236968 (Reactome)
Exogenous soluble antigenR-HSA-1236970 (Reactome)
GDPR-HSA-983422 (Reactome)
GTPArrowR-HSA-983422 (Reactome)
H+ArrowR-HSA-1236967 (Reactome)
H2OR-HSA-1236949 (Reactome)
H2OR-HSA-983144 (Reactome)
H2OR-HSA-983422 (Reactome)
IFN gamma stimulated aminopeptidasesmim-catalysisR-HSA-983162 (Reactome)
IRAP in complex with MHC class Imim-catalysisR-HSA-1236954 (Reactome)
K48polyUb-antigenic substrateArrowR-HSA-983147 (Reactome)
K48polyUb-antigenic substrateR-HSA-983150 (Reactome)
K48polyUb-partially digested AgR-HSA-1236935 (Reactome)
L-amino acidArrowR-HSA-1236935 (Reactome)
L-amino acidArrowR-HSA-1236948 (Reactome)
L-amino acidArrowR-HSA-1236954 (Reactome)
L-amino acidArrowR-HSA-1236970 (Reactome)
L-amino acidArrowR-HSA-983150 (Reactome)
L-amino acidArrowR-HSA-983158 (Reactome)
L-amino acidArrowR-HSA-983162 (Reactome)
MHC

class I

HC:Calnexin/BiP:Erp57		ArrowR-HSA-983148 (Reactome)
MHC

class I

HC:Calnexin/BiP:Erp57		R-HSA-983146 (Reactome)
MHC HC:B2M:Erp57ArrowR-HSA-983146 (Reactome)
MHC HC:B2M:Erp57R-HSA-983142 (Reactome)
MHC:B2M peptide loading complexArrowR-HSA-983142 (Reactome)
MHC:B2M peptide loading complexR-HSA-8951499 (Reactome)
MR/other probable receptorsArrowR-HSA-1236940 (Reactome)
MR/other probable receptorsR-HSA-1236939 (Reactome)
MR:soluble antigenArrowR-HSA-1236939 (Reactome)
MR:soluble antigenArrowR-HSA-1236941 (Reactome)
MR:soluble antigenArrowR-HSA-1236955 (Reactome)
MR:soluble antigenR-HSA-1236940 (Reactome)
MR:soluble antigenR-HSA-1236941 (Reactome)
MR:soluble antigenR-HSA-1236955 (Reactome)
Mg2+ArrowR-HSA-983153 (Reactome)
Mg2+R-HSA-983153 (Reactome)
NADP+ArrowR-HSA-1236967 (Reactome)
NADPHR-HSA-1236967 (Reactome)
NOX2 complexmim-catalysisR-HSA-1236967 (Reactome)
O2.-ArrowR-HSA-1236967 (Reactome)
O2R-HSA-1236967 (Reactome)
PDIA3ArrowR-HSA-983161 (Reactome)
PDIA3R-HSA-983148 (Reactome)
PPiArrowR-HSA-983140 (Reactome)
PPiArrowR-HSA-983153 (Reactome)
PPiArrowR-HSA-983156 (Reactome)
Particulate Ag:DC receptorsArrowR-HSA-1236958 (Reactome)
Particulate Ag:DC receptorsR-HSA-1236956 (Reactome)
PiArrowR-HSA-1236949 (Reactome)
PiArrowR-HSA-983144 (Reactome)
R-HSA-1236935 (Reactome) Proteasomes are usually localized to the cytoplasm but are also present in the nucleus and ER. Houde et al. (2003) investigated the distribution of proteasomes in J774 macrophages and observed them on phagosomes. The proteasomes present on phagosomes may not come directly from ER, but instead assemble on phagosomes to play a function at a precise point during phagolysosomal biogenesis. Houde et al. also observed polyubiquitinated proteins on the cytoplasmic side of phagosomes and highlighted the link between the ubiquitination process and proteasomal degradation; translocated peptides are ubiquitinated and processed by the proteasome complex assembled on the cytoplasmic side of phagosomes, leading to the generation of MHC class I binding peptides.
R-HSA-1236938 (Reactome) Phagocytosed particulate antigens are partially digested in the lumen of phagolysosomes by various lysosomal hydrolases.
R-HSA-1236939 (Reactome) Soluble antigens are presented to dendritic cells (DCs) in some cases by receptor mediated endocytosis or fluid-phase endocytosis. Burgdorf et al. (2008) suggest that there are two different endocytic compartments for antigen processing: one dedicated to MHC class I (early endosomes) and the other one for MHC class II presentation (lysosomes). Sorting of cargo into these different compartments occurs at the plasma membrane and is likely to depend on the type of endocytic receptor the cargo is interacting with (Burgdorf et al. 2008, Zhuang et al. 2006). The mannose receptor (MR) is the best studied receptor that targets soluble antigens to early endosomes but not to lysosomes (Burgdorf et al. 2006). Antigens taken up by the MR are targeted towards a mildly acidic stable early endosomal compartment for exclusive presentation on MHC I molecules (Burgdorf et al. 2008).
R-HSA-1236940 (Reactome) Within the endosome the receptor and cargo separate and the receptor recycles back to the cell surface. Soluble antigens are targeted into the stable early endosome lumen for efficient cross presentation. Early endosomes are mildly acidic and relatively poor in proteases.
R-HSA-1236941 (Reactome) Receptor-bound exogenous antigens in coated pits on the cell surface are internalized into clathrin-coated vesicles.
R-HSA-1236943 (Reactome) Peptides generated by Cathepsin S or IRAP-mediated proteolysis in the endosomes are loaded onto MHC class I molecules, which are internalized and transported to early and late endosomal compartments where antigenic peptides can be loaded. A fraction of the internalized cell surface class I molecules enter MHC class II compartments (MIICs) within endocytic vesicles (Gromme et al. 1999, Kleijmeer et al. 2001). Microscopic analysis has revealed that surface MHC-I molecules are internalized and transported to early and late endosomal compartments (Basha et al. 2008, Lizee et al. 2003). A tyrosine-based endocytic trafficking motif (YXXA) is required for the constitutive internalization of MHC-I molecules from the cell surface into early/late endosomes for peptide loading (Basha et al. 2008, Lizee et al. 2003). Upon entry in to these endosomal compartments the MHC class I complexes exchange their pre-bound peptides with exogenously derived antigenic peptides.
R-HSA-1236947 (Reactome) Fusion of the maturing phagosome with the ER mediates the exchange of materials resulting in the formation of a hybrid ER-phagosome compartment (Gagnon et al. 2002, Guermonprez et al. 2003, Houde et al. 2003, Ackerman et al. 2003, Blanchard et al. 2010). This hybrid contains the retrotranslocon factor Sec61 that mediates the access of proteasomes on the cytosolic surface of the phagosome. Using fluorescence imaging, Houde et al. (2003) provided evidence for the role of Sec61 in the retrotranslocation of internalized exogenous proteins from phagosomes to the cytoplasmic face of J774 macrophages. Sec61 factor is a heterotrimeric complex composed of alpha, beta and gamma subunits forming the core of the mammalian ER translocon (Greenfield et al. 1999). Oligomers of the Sec61 complex form a transmembrane channel involved in the retrotranslocation of misfolded proteins from ER to the cytosol for degradation, and thus it has been proposed that Sec61 might be involved in the translocation of proteins in phagosomes to the cytosol (Kasturi et al. 2008).
R-HSA-1236948 (Reactome) Endocytic compartments contain many cysteine proteases such as cathepsin S that can generate cross-presented peptides. Cathepsins may participate in the generation of MHC class II-presentated peptides (Villadangos et al. 1999). Shen et al. (2004) demonstrated that cathepsin S contributes to TAP-independent cross-presentation in vivo, showing that ovalbumin was cross-presented by denritic cells (DCs) through both TAP-dependent and TAP-independent pathways. The TAP-independent pathway was sensitive to the cystine protease inhibitor leupeptin, but not to proteasome inhibitors. Further experiments with knockout mice showed that cathepsin S contributed to cross-presentation. DCs lacking cathepsin S lack the TAP-independent pathway (Khor et al. 2008, Shen et al. 2004).
R-HSA-1236949 (Reactome) After processing by the proteasome, some of the oligopeptides could be reinternalized to the phagosome lumen of the same phagosome through the TAP complex probably acquired during ER-phagosome fusion. Guermonprez et al. (2003) tested this model and observed abundant TAP complex in early phagosomes and its reduction over time. Electron microscopy analysis of purified phagosomes also showed the insertion of TAP2 into the phagosomal membrane.
R-HSA-1236954 (Reactome) While it is established that cathepsin S is involved in antigen processing in endocytotic vesicles, it is less certain whether other proteases present in endocytic vesicles are also involved in generating the peptide fragments. Insulin regulated aminopeptidase (IRAP) is an epitope-trimming zinc-dependent aminopeptidase closely related to ERAP1 and ERAP2. IRAP may be involved in vacuolar processing of the peptide fragments within endosomes (Saveanu et al. 2009, Segura et al. 2009). IRAP is detected predominantly in the early and recycling endosome fractions. Saveanu et al. (2009) observed the physical association of IRAP with internalized class I MHC molecules and suggested that this may favour a direct linkage between peptide trimming and MHC class I loading. They also showed that IRAP-dependent processing of antigens requires active proteasome but not lysosomal proteases, which suggests that this pathway utilizes cytosolic degradation followed by peptide transport into IRAP-containing endosomes.
R-HSA-1236955 (Reactome) The antigen:receptor complex moves from clathrin-coated vesicles to the early endosome membrane.
R-HSA-1236956 (Reactome) After internalization, F-actin is depolymerized from the phagosome, and the newly denuded vacuole membrane becomes accessible to early endosomes (Aderem & Underhill. 1999).
R-HSA-1236958 (Reactome) Dendritic cells (DCs) and macrophages recognize and phagocytose apoptotic cells/invading microorganisms using a variety of receptors including lectins, Mannose receptor (MR) (Stahl & Ezekowitz. 1998), CD36 (Savill 1997), CD14 (Devitt et al. 1998), scavenger receptor A (SR-A) (Platt et al. 1996) and integrin alphaVbeta5 (Savill et al. 1992, Savilli et al. 1990), then cross-present cell-associated antigens to CD8+ T cells. Ligands on apoptotic cell like sugars, phosphatidylserine and surface-bound thrombospondin (TSP) are recognized by these receptors and induce rearrangements in the actin cytoskeleton that lead to the internalization of the particle.
R-HSA-1236963 (Reactome) Following fission of the phagosome vesicle from the plasma membrane, the phagosome undergoes maturation by a series of fusion and fission events, fusing with late endosomes and ultimately lysosomes, to form a phagolysosome.

fuses sequentially with sorting/early endosomes, late endosomes and finally lysosomes to acquire degradative capabilities. This process is referred to as phagosome maturation.
R-HSA-1236964 (Reactome) Peptide-loaded MHC class I complexes are transported by an undefined mechanism back to the cell surface for cross-presentation to T cells.
R-HSA-1236965 (Reactome) Exogenous antigen loaded class I MHC molecules in phagosomes may be delivered to the surface by membrane recycling machinery.
R-HSA-1236967 (Reactome) After the fusion of phagosome and lysosome lumen acidity rises and the activity of lysosomal proteases increases, conferring proteolytic ability. However antigens must be spared from complete proteolytic destruction. Dendritic cells (DCs) achieve this by regulating the level of proteolysis and phagosomal acidification. DCs recruit the NADPH oxidase NOX2 to the phagosome and mediate sustained production of low levels of reactive oxygen species (ROS), causing active alkalization of the phagosomal lumen (Savina et al. 2006, Ramachandra et al. 2009). NOX2 consumes oxygen and protons (pumped by V-ATPase or other H+ voltage-gated channels) to produce ROS and this lowers phagosome acidity. This apparently reduces antigen proteolysis to a level that allows processing but does not fully destroy the antigenic peptides, favouring increased MHC-I cross presentation (Ramachandra et al. 2009). Rab27a controls the recruitment of NOX2 to DC phagosomes (Savina et al. 2007).
R-HSA-1236968 (Reactome) Endocytosed antigens must leave the endocytic structure to enter into the MHC I pathway before exhaustive degradation within lysosomes. The canonical pathway is the transporter associated with antigen processing (TAP)-dependent cytosolic pathway, which involves the translocation of endocytosed antigens into the cytosol where they are degraded into antigenic peptides by the proteasome and transported to ER through TAP. This hypothesis comes from indirect evidences showing that proteasome inhibitors block cross presentation of certain antigens (Amigorena et al. 2010, Burgdorf et al. 2008) . According to this model antigens are translocated into the cytosol by an undefined mechanism.
There are less well-characterized mechanisms for the delivery of exogenous antigens into the cytosol. Certain peptides with highly positively charged sequences derived from HIV tat protein or the Antennapedia homeodomain (AntHD) protein seem to penetrate into the cytosol directly across the plasma membrane (Monu et al. 2007, Vendeville et al. 2004). It is also proposed that some exogenous antigens can be exchanged between neighboring cells through gap junctions, leading to cross presentation by the recipient cell (Monu et al. 2007, Neijssen et al. 2005).
Once internalized antigens are routed into the cytosol, they follow the conventional pathway of proteasome digestion and TAP mediated transport of peptides into the ER lumen.
R-HSA-1236970 (Reactome) Exogenous antigens are thought to be processed for cross-presentation in much the same manner as endogenous proteins once they enter the cytosolic pathway (Rock et al. 2010). Immunoproteasome components are the major proteases involved in generating the antigenic fragments. The precurssor peptides are further trimmed by cytosolic aminopeptidases and shuttled to ER through TAP for MHC class I loading.
R-HSA-1236971 (Reactome) Peptides translocated back into the phagosomal lumen are loaded onto MHC class I molecules. Guermonprez et al. (2003) detected the components of the peptide loading complex (TAP, tapasin, calreticulin and ERp57) together with MHC class I in purified early phagosomes. They observed peptide loading in the presence of ATP in purified phagosomes expressing HLA-A2, incubated with iodinated S-9-L peptide. From these experiments they concluded that TAP-imported peptides can be loaded on MHC class I molecules in the lumen of phagosomes. Houde et al. (2003) also observed OVA peptide SIINFEKL:MHC-I complex in the phagosome lumen.
R-HSA-1236972 (Reactome) Upon phagolysosomal proteolysis the phagocytosed proteins still need to gain access to the cytosol for proteasomal access, transport into the ER and loading onto MHC class I. The mechanism for this escape of phagocytosed antigens remain unknown.
R-HSA-203979 (Reactome) Sar1p-GTP recruits the cytoplasmic Sec23p-Sec24p complex. (Though not represented in the subsequent steps, Sec23p-Sec24p would bind to members of the p24 protein family of possible cargo receptors, and together with Sar1p bind the appropiate v-SNARE, and Rab-GTP.)



R-HSA-8863858 (Reactome) The interaction between the two compartments could involve either direct fusion of ER stacks to phagosomes (Phgs) or vesicular intermediates. In both cases, a fusion event between the ER or ER-derived membrane vesicles and Phgs must occur. The SNARE SEC22B localizes to the ER-Golgi intermediate compartment (ERGIC) and interacts with SNARE syntaxin 4 (STX4) on phagosomes (Phgs), mediating the recruitment of subset of ER components including transporter associated with antigen processing (TAP), to phagosomes (Cebrian et al. 2011).
R-HSA-8863895 (Reactome) A major reserve of MHC-I in dendritic cells reside within the endocytic recycling compartments (ERC). MHC-I trafficking to the ERC is regulated by the activity of Rab11a and subsequent trafficking from ERC to phagosomes is controlled by TLR-MyD88-IKK2-dependent phosphorylation of phagosomal SNAP23. Toll-like receptor (TLR) signalling regulate cross-presentation as they regulate phagocytosis and phagolysosomal fusion (Nair et al. 2011). MHC-I bearing ERC are enriched with R-SNAREs like RAB11a, VAMP3, and VAMP8. These SNARE molecules can interact with Q-SNARE SNAP23 present on phagosomes and this mediates membrane fusion. This interaction of SNAP23 with R-SNAREs require phosphorylation of SNAP23 (on Ser-95) by IKK2, and IKK2 is activated by TLR signalling. SNAP23 phosphorylation may increase SNAP23 binding to SNAREs. It may also regulate platelet and mast cell secretion (Karim et al. 2013, Suziki & Verma 2008).
R-HSA-8863914 (Reactome) In DCs subset of ER proteins including MHC-I peptide loading complex (PLC) and transporter associated with antigen processing (TAP) transit to phagosomes via the intermediate compartment ER-Golgi intermediate compartment (ERGIC) (Cebrian et al. 2011). TAP exits the ER in COPII vesicles in association with MHC class I, and that peptide translocation by TAP and binding to class I can occur in post-ER compartments (Ghanem et al. 2010). SEC22B, an ER-resident SNARE is required for the transport of PLC from ERGIC (Cebrian et al. 2011), but this step does not deliver MHC-I (Nair-Gupta et al. 2014). Instead, MHC-I are recruited from an endosomal recycling compartment (ERC), which is marked by Rab11a, VAMP3/cellubrevin, and VAMP8/endobrevin that holds large reserves of MHC-I. This step is dependent on TLR signalling (Nair-Gupta et al. 2014).
R-HSA-8863973 (Reactome) Recycling endosome-localized R-SNARE protein like RAB11a, VAMP3, and VAMP8 dock with target phagosome membrane Q-SNARE protein SNAP23. MHC-I present on the recycling endosomes would be delivered to phagosomes during this process.
R-HSA-8940641 (Reactome) Thimet oligopeptidase (THOP1, EP24.15) is a zinc-dependent peptidase of the metallopeptidase M3 family (Pierotti et al. 1990). It was first described as a neuropeptide-degrading enzyme present in the soluble fraction of brain homogenates (Orlowski et al. 1983). However, its predominant location in the cytosol and nucleus suggests that extracellular degradation of neuropeptides and hormones is not its primary function (Fontenele-Neto et al. 2001). THOP1 can metabolize peptides within cells, thereby affecting antigen presentation and G protein-coupled receptor signal transduction. It was shown in vivo to participate in antigen presentation through MHC-I (Silva et al. 1999, Kim et al. 2003, Yorl et al. 2003) and in vitro to bind (Portaro et al. 1999) or degrade (Saric et al. 2001) some MHC-I associated peptides. THOP1 can degrade a broad range of intracellular peptides containing 5–17 amino acids (Oliveira et al. 2001, Berti et al. 2009). Substrate size is restricted because its catalytic center is located in a deep channel (Ray et al. 2004). THOP1 can both degrade existing peptides and generate new peptides, making it a versatile enzyme for regulating intracellular peptide function including antigen presentation (Berti et al. 2009, Russo et al. 2012).

Cytotoxic T lymphocytes (CTLs) recognize peptides presented by HLA class I molecules on the cell surface. The C terminus of these CTL epitopes is considered to be produced by the proteasome, but is complemented by THOP1 and other cytosolic endopeptidases such as Nardilysin (Kessler et al. 2011, Oliveira & van Hall 2015).
R-HSA-8951499 (Reactome) MHC class I heterodimers are only stable in peptide bound form and only as a trimer (with bound peptide) present on the cell surface. Class I MHC molecules prefer nonapeptides, and less frequently use octa- or deca-peptides. The peptide binding groove in MHC class I molecules is formed by the intimate association of the alpha1 and alpha2 domains of the heavy chain. Structural studies have revealed that the alpha1:alpha2 domains form a single peptide binding groove consisting of 2 parallel helices on a floor of 8 beta-strands. Hydrogen bonding networks are established in the binding groove with the antigenic peptide main chain and terminal atoms that enable largely sequence independent ligation. Upon peptide binding the class I MHC molecule releases from the peptide loading complex (PLC) and clusters at ER exit sites and is finally exported to the cell surface.
MHC I molecules bound to low-affinity peptides are not transferred to the cell surface and are instead cycled back to ER. They can proceed to the cell surface only when they become bound to high-affinity peptide (Howe et al, 2009; Garstka et al, 2007). Calreticulin binds to these low-affinity peptide bound class I molecules and mediate the retrieval from golgi apparatus to ER and for effcient presentation of a model antigen (Howe et al, 2009).
R-HSA-8951595 (Reactome) The interaction between the two compartments involves either direct fusion of ER stacks to phagosomes (Phgs) or vesicular intermediates. In both cases, a fusion event between the ER or ER-derived membrane vesicles and Phgs must occur. The SNARE SEC22B localizes to the ER-Golgi intermediate compartment (ERGIC) and interacts with SNARE syntaxin 4 (STX4) on phagosomes (Phgs), mediating the recruitment of subset of ER components including transporter associated with antigen processing (TAP), to phagosomes (Cebrian et al. 2011).
R-HSA-983138 (Reactome) When the loaded peptide is of a sufficiently high-affinity the trimeric complex is transported to a special ER exit site by a putative cargo receptor, B cell receptor-associated protein (BAP31), where it translocates to the cell surface, possibly by transport in COPII-coated vesicles.
R-HSA-983140 (Reactome) Interaction of E3 with both substrate and E2-Ub, brings them into proximity so that ubiquitin is transferred from E2 to the substrate. In most cases the transfer of ubiquitin is direct from E2 to substrate, but in a small subset of E3s, it occurs via a covalent E3-Ub thioester intermediate (Raymond et al. 2009).
R-HSA-983142 (Reactome) Upon interaction of Beta-2-microglobin (B2M) with MHC class I Heavy Chain (HC), calnexin is fully replaced by its soluble ortholog calreticulin (CRT) and this complex is incorporated into the peptide loading complex (PLC). PLC is a multiprotein complex that includes CRT, ERp57 and the additional components tapasin, transporter associated with antigen processing (TAP) and Bap31. The stoichometry of components in PLC remains unclear. The PLC loads antigenic peptides onto MHC class I molecules; components of the PLC cooperate to stabilize the MHC class I complex and optimally load peptides. Tapasin is a type I transmembrane protein that interacts directly with TAP and tethers the MHC complex to it. TAP facilitates the transport of peptides from the cytosol to the ER lumen. B cell receptor–associated protein (Bap31), a putative cargo receptor, associates with HC and acts as a retrograde transporter, carrying peptide-loaded class I MHC molecules.
R-HSA-983144 (Reactome) Ttransporter associated with antigen processing (TAP) is a heterodimeric complex, composed of TAP1 and TAP2 proteins, members of the ATP-binding cassette (ABC) superfamily. TAP consists of two transmembrane domains (TMDs) and two cytosolic nucleotide-binding domains. Peptide binding to the cytosolic-facing cavity formed by the TMDs causes it to undergo a conformational change that induces ATP hydrolysis, forcing the opening of a pore and translocation of the peptide into the ER lumen. TAP transports peptides in the range of 8-16 amino acids into the ER, which is the peptide length typically generated by the immunoproteasome.
R-HSA-983145 (Reactome) The newly synthesized MHC class I heavy chain (HC) translocates into the endoplasmic reticulum (ER) and binds rapidly to calnexin (CNX), a transmembrane calcium-dependent lectin with chaperone activity. CNX recognizes and binds to an N-linked monoglycosylated Glc1Man9GlcNAc2 carbohydrate group found attached to the conserved Asn-86 in the HC. Interaction of HC with CNX promotes the formation of intrachain disulfide bonds. Another candidate ER chaperon protein is immunoglobulin binding protein (BiP), found to associate with HC in the absence of CNX. These chaperones can cooperate in protein folding and prevention of aggregation.
R-HSA-983146 (Reactome) Interaction of calnexin (CNX) with MHC class I HC stabilizes it and facilitates the association of the beta2 microglobulin component (B2M). The two chains are linked noncovalently via interaction of B2M and the alpha3 domain of MHC HC. After formation of the HC:B2M heterodimer, the MHC complex dissociates from CNX.
R-HSA-983147 (Reactome) K48 polyubiquitinated substrate dissociates from E3 to become a substrate for a multicatalytic complex called the 26S proteasome.
R-HSA-983148 (Reactome) Endoplasmic reticulum resident protein 57 (ERp57), is a member of the protein disulphide isomerase (PDI) family of thiol oxidoreducatases. It associates with Calnexin (CNX), and its soluble homolog calreticulin (CRT) and is recruited to MHC Class I Heavy Chain (HC). ERp57 is involved in the formation of HC disulphide bonds.
R-HSA-983150 (Reactome) The 26S proteasome complex consists of the 20S catalytic core particle which harbours the proteolytically active sites and the regulatory 19S particle which is responsible for substrate interaction. This process generates a vast number (perhaps hundreds) of different peptides, depending on the length and sequence of the substrate protein. Only a small fraction of these peptides (nearly 10%) form the exact length to be presented by class I MHC; most (approximately 70%) are too short to bind. The remaining proteasome products (10-20%) are N-terminally extended precursors that require additional cleavage by cytosolic aminopeptidases for presentation by MHC class I molecules.
R-HSA-983152 (Reactome) Activated ubiquitin is transferred from E1 to the active site cystine of ubiquitin conjugating enzymes (E2s) via a trans-esterification reaction. E2s catalyze covalent attachment of ubiquitin to target proteins. They all share an active-site ubiquitin-binding cysteine residue and are distinguished by the presence of a ubiquitin-conjugating catalytic (UBC) fold required for binding of distinct ubiquitin ligases or E3s. Once conjugated to ubiquitin, the E2 molecule binds one of several E3s (Glickman et al. 2002).
R-HSA-983153 (Reactome) Ubiquitin is activated in an ATP-dependent manner, catalyzed by E1 ubiquitin-activating enzymes. In the first step of ubiquitin activation, the E1 enzyme binds ATP, Mg+2 and ubiquitin, and catalyses ubiquitin C-terminal acyl-adenylation (Ubiquitin-AMP). In the second step, the catalytic cystine in the E1 attacks the ubiquitin-adenylate (Ub-AMP) to form the activated ubiquitin-E1 thioester-bonded complex and an AMP leaving group. The intermediate reaction involving the formation of the ubiquitin-AMP complex is not represented here.
R-HSA-983156 (Reactome) Monoubiquitinated substrate acquires additional ubiquitin modifications in the form of multiple single attachments or a ubiquitin chain. Polyubiquitin chains added through K48 residue of ubiquitin typically targets the substrate for degradation (Raymond et al. 2009).
R-HSA-983157 (Reactome) Ubiquitin E3 ligases confer specificity to ubiquitination by recognizing target substrates and mediating transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to substrate (Raymond et al. 2009). E3 ligases includes a large, diverse set of proteins characterized by several defining motifs which include a HECT (homologous to E6-associated C-terminus), RING (Really Interesting New Gene) and U-box domains. The E3 ligases can be multisubunit complexes rather than a single polypeptide. Presently three different kinds of E3 complexes have been described called SCF, APC, and VHL. E3 ligases binds to both substrate and an E2 thioesterified with ubiquitin (E2-Ub).
R-HSA-983158 (Reactome) Transporter associated with antigen processing (TAP) prefers peptides 8-16 residues long, slightly longer than the canonical 8-10 residue peptides that fit into class I MHC binding sites. These longer peptides are further trimmed at their N-termini by the ER-associated aminopeptidase (ERAP). ERAP trims peptides to a length of 8-10 residues, suitable for loading into the MHC class I binding groove.
R-HSA-983161 (Reactome) Upon peptide binding the class I MHC molecule releases from the peptide loading complex (PLC) and clusters at ER exit sites and is finally exported to the cell surface.
MHC I molecules bound to low-affinity peptides are not transferred to the cell surface and are instead cycled back to ER. They can proceed to the cell surface only when they become bound to high-affinity peptide (Howe et al. 2009, Garstka et al. 2007). Calreticulin binds to these low-affinity peptide bound class I molecules and mediate the retrieval from golgi apparatus to ER and for effcient presentation of a model antigen (Howe et al. 2009).
R-HSA-983162 (Reactome) Some peptides generated by the 26S proteasome are too long to bind to MHC class I molecules. These N-terminal extended precursor peptides may be trimmed by cytosolic aminopeptidases, such as Tripeptidyl peptidase II (TPP2), puromycin-sensitive aminopeptidase (PSA), bleomycin hydrolase (BH), and leucine aminopeptidase (LAP).
R-HSA-983421 (Reactome) Cargo must pass through the various compartments of the Golgi complex to reach the plasma membrane. This may occur through either of the two well known models, cisternal maturation or vesicular transport (Refer to review articles Glick et al. 2009, Jackson 2009, Nakano et al. 2010).
R-HSA-983422 (Reactome) Before the cargo vesicle can fuse with target membrane, the COPII protein coat must be disassembled and its components released into cytosol. This uncoating is triggered by hydrolysis of the bound GTP to produce Sar1p-GDP, which has decreased affinity for the vesicle membrane. Disassociation of Sar1p-GDP from the membrane is followed by the release of the other COPII subunits.
R-HSA-983424 (Reactome) Once the entire COPII coat has been assembled, the bud is separated from the ER membrane in the form of a COPII coated vesicle.
R-HSA-983425 (Reactome) Sec13-Sec31 binds the prebudding complex and this Sec13-Sec31 heterotetramer forms the outer structural scaffold of the coat. Sec13-Sec31 is likely to crosslink the prebudding complexes generating COPII-coated vesicles.
R-HSA-983426 (Reactome) The cytoplasmic tails of MHC class I molecules do not possess any of the known ER export sequences. BAP31 acts as a cargo receptor by exporting peptide-loaded class I MHC molecules to the ER exit sites or ER/Golgi intermediate compartment. Sec24 of the Sec23-Sec24/Sar1-GTP complex catches cargo by direct contact, forming the prebudding complex. Sar1/Sec23-Sec24 can bring about curvature of the membrane in the formation of vesicle. The cargo (antigen-bound MHC) accumulates within the COPII vesicle by binding to the Sec24 polypeptide of the COPII coat.
R-HSA-983427 (Reactome) After passing through the Golgi complex, secretory cargo is packaged into post-Golgi transport intermediates (post-Golgi), which translocate plus-end directed along microtubules to the plasma membrane.
SAR1B:GDPArrowR-HSA-983422 (Reactome)
SAR1B:GTP:SEC23:SEC24ArrowR-HSA-203979 (Reactome)
SAR1B:GTP:SEC23:SEC24R-HSA-983426 (Reactome)
SAR1B:GTPR-HSA-203979 (Reactome)
SEC13ArrowR-HSA-983422 (Reactome)
SEC13R-HSA-983425 (Reactome)
SEC22B:STX4ArrowR-HSA-8951595 (Reactome)
SEC22BArrowR-HSA-8863914 (Reactome)
SEC22BR-HSA-8863858 (Reactome)
SEC22BR-HSA-8863914 (Reactome)
SEC23:SEC24R-HSA-203979 (Reactome)
SEC23AArrowR-HSA-983422 (Reactome)
SEC24ArrowR-HSA-983422 (Reactome)
SEC31AArrowR-HSA-983422 (Reactome)
SEC31AR-HSA-983425 (Reactome)
SNAP23R-HSA-8863895 (Reactome)
STX4R-HSA-8863858 (Reactome)
Sar1p:GTP:Sec23p:Sec24p:Ag bound MHC class IArrowR-HSA-983426 (Reactome)
Sar1p:GTP:Sec23p:Sec24p:Ag bound MHC class IR-HSA-983425 (Reactome)
TAPArrowR-HSA-8863914 (Reactome)
TAPArrowR-HSA-8951595 (Reactome)
TAPArrowR-HSA-983161 (Reactome)
TAPBPArrowR-HSA-8863914 (Reactome)
TAPBPArrowR-HSA-8951595 (Reactome)
TAPBPArrowR-HSA-983161 (Reactome)
TAPBPR-HSA-8863858 (Reactome)
TAPBPR-HSA-8863914 (Reactome)
TAPBPR-HSA-983142 (Reactome)
TAPR-HSA-8863858 (Reactome)
TAPR-HSA-8863914 (Reactome)
TAPR-HSA-983142 (Reactome)
TAPmim-catalysisR-HSA-1236949 (Reactome)
TAPmim-catalysisR-HSA-983144 (Reactome)
THOP1mim-catalysisR-HSA-8940641 (Reactome)
Transloconmim-catalysisR-HSA-1236947 (Reactome)
UbArrowR-HSA-1236935 (Reactome)
UbArrowR-HSA-983150 (Reactome)
UbR-HSA-983153 (Reactome)
Ubiquitin activating E1 enzymesArrowR-HSA-983152 (Reactome)
Ubiquitin activating E1 enzymesR-HSA-983153 (Reactome)
Ubiquitin activating E1 enzymesmim-catalysisR-HSA-983153 (Reactome)
Ubiquitin:E2 conjugating enzymesArrowR-HSA-983152 (Reactome)
Ubiquitin:E2 conjugating enzymesR-HSA-983156 (Reactome)
Ubiquitin:E2 conjugating enzymesR-HSA-983157 (Reactome)
Unknown hydrolasemim-catalysisR-HSA-1236938 (Reactome)
VAMP8,VAMP3R-HSA-8863973 (Reactome)
antigenic substrateR-HSA-983157 (Reactome)
monoglucosylated MHC

class I

HC:Calnexin/BiP		ArrowR-HSA-983145 (Reactome)
monoglucosylated MHC

class I

HC:Calnexin/BiP		R-HSA-983148 (Reactome)
monoglucosylated MHC class I HCR-HSA-983145 (Reactome)
oligo-MyD88:Mal:BTK:activated TLRArrowR-HSA-8863895 (Reactome)
oligopeptide fragment (3-7aa)ArrowR-HSA-8940641 (Reactome)
oligopeptide fragment (8-16aa)ArrowR-HSA-1236935 (Reactome)
oligopeptide fragment (8-16aa)ArrowR-HSA-983150 (Reactome)
oligopeptide fragment (8-16aa)ArrowR-HSA-983162 (Reactome)
oligopeptide fragment (8-16aa)R-HSA-1236949 (Reactome)
oligopeptide fragment (8-16aa)R-HSA-8940641 (Reactome)
oligopeptide fragment (8-16aa)R-HSA-983144 (Reactome)
oligopeptide fragmentArrowR-HSA-1236949 (Reactome)
oligopeptide fragmentArrowR-HSA-983144 (Reactome)
oligopeptide fragmentR-HSA-1236971 (Reactome)
oligopeptide fragmentR-HSA-983158 (Reactome)
p-S95-SNAP23:VAMP8,VAMP3ArrowR-HSA-8863973 (Reactome)
p-S95-SNAP23ArrowR-HSA-8863895 (Reactome)
p-S95-SNAP23R-HSA-8863973 (Reactome)
partially digested AgArrowR-HSA-1236938 (Reactome)
partially digested AgArrowR-HSA-1236947 (Reactome)
partially digested AgArrowR-HSA-1236972 (Reactome)
partially digested AgR-HSA-1236947 (Reactome)
partially digested AgR-HSA-1236972 (Reactome)
precursor peptide fragment (>16 aa)ArrowR-HSA-1236948 (Reactome)
precursor peptide fragment (>16 aa)ArrowR-HSA-1236970 (Reactome)
precursor peptide fragment (>16 aa)ArrowR-HSA-983150 (Reactome)
precursor peptide fragment (>16 aa)R-HSA-1236954 (Reactome)
precursor peptide fragment (>16 aa)R-HSA-983162 (Reactome)
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