Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation (Homo sapiens)

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111111111111111111111111111151111111111111111111111111111111111611111111cell junctioncytosolnucleoplasmmitochondrial matrixcytoplasmic vesicle membraneazurophil granule membraneendoplasmic reticulum membranesecretory granule lumenextracellular exosomeSERPINB1HNRNPFGSTO1 geneSERPINB2 geneMTAPSERPINB2CDC42HNRNPF genePPIA genePITPNATCP1RALAANXA2 geneLMNB1IFNGAIP geneLCP1BOLA2BOLA2 geneCFL1 geneTALDO1 geneHNRNPDL geneANXA2TALDO1RAPB1 geneARF1HNRNPDLCAPZA1ARF1 geneRPLP0MSN genePSME2PDCD4 geneSOD2IL10CDC42 geneRALA genePSME2 geneHNRNPA2B1 geneGSTO1GSTA2 geneSOD1 genePPIAHNRNPA2B1RPLP0 geneLCP1 geneRAP1BGSTA2CFL1CNN2HSPA9SNRPA1p-S43,S173,S294,S325-FOXO3MIF geneCNN2 geneAIPSNRPA1 geneMIFLMNB1 geneY963-STAT4 dimerSOD1IL10 genePAK2 geneTCP1 geneSOD2 genePDCD4CAPZA1 geneIFNG genePITPNA genep-Y693-STAT4 HSP9 geneCA1CA1 genePAK2MSNMTAP gene11101011129, 1134, 71112, 13148


Description

Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). 
The identified upregulated proteins are:  BOLA2, PSME2,  MTAP, CA1,  GSTA2,  RALA,  CNN2,  CFL1,  TCP1,  HNRNPDL,  MIF,  AIP,  SOD1, PPIA and  PDCD4.
And the identified downregulated proteins are:
ANXA2, RPLP0, CAPZA1, SOD2, SNRPA1, LMNB1, LCP1, HSPA9, SERPINB2, HNRNPF, TALDO1, PAK2, TCP1, HNRNPA2B1, MSN, PITPNA, ARF1, SOD2, ANXA2, CDC42, RAP1B and GSTO1.
View original pathway at:Reactome.

Comments

Reactome-Converter 
Pathway is converted from Reactome ID: 8950505
Reactome-version 
Reactome version: 62
Reactome Author 
Reactome Author: Duenas, Corina

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Bibliography

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  1. Verhoeven NM, Huck JH, Roos B, Struys EA, Salomons GS, Douwes AC, van der Knaap MS, Jakobs C.; ''Transaldolase deficiency: liver cirrhosis associated with a new inborn error in the pentose phosphate pathway.''; PubMed Europe PMC Scholia
  2. Wispé JR, Clark JC, Burhans MS, Kropp KE, Korfhagen TR, Whitsett JA.; ''Synthesis and processing of the precursor for human mangano-superoxide dismutase.''; PubMed Europe PMC Scholia
  3. Naeger LK, McKinney J, Salvekar A, Hoey T.; ''Identification of a STAT4 binding site in the interleukin-12 receptor required for signaling.''; PubMed Europe PMC Scholia
  4. Higgins CM, Jung C, Ding H, Xu Z.; ''Mutant Cu, Zn superoxide dismutase that causes motoneuron degeneration is present in mitochondria in the CNS.''; PubMed Europe PMC Scholia
  5. Rosengren AT, Nyman TA, Lahesmaa R.; ''Proteome profiling of interleukin-12 treated human T helper cells.''; PubMed Europe PMC Scholia
  6. Ono M, Yaguchi H, Ohkura N, Kitabayashi I, Nagamura Y, Nomura T, Miyachi Y, Tsukada T, Sakaguchi S.; ''Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1.''; PubMed Europe PMC Scholia
  7. Kienhöfer J, Häussler DJ, Ruckelshausen F, Muessig E, Weber K, Pimentel D, Ullrich V, Bürkle A, Bachschmid MM.; ''Association of mitochondrial antioxidant enzymes with mitochondrial DNA as integral nucleoid constituents.''; PubMed Europe PMC Scholia
  8. Principe S, Jones EE, Kim Y, Sinha A, Nyalwidhe JO, Brooks J, Semmes OJ, Troyer DA, Lance RS, Kislinger T, Drake RR.; ''In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.''; PubMed Europe PMC Scholia
  9. Banci L, Camponeschi F, Ciofi-Baffoni S, Muzzioli R.; ''Elucidating the Molecular Function of Human BOLA2 in GRX3-Dependent Anamorsin Maturation Pathway.''; PubMed Europe PMC Scholia
  10. Wabnitz GH, Köcher T, Lohneis P, Stober C, Konstandin MH, Funk B, Sester U, Wilm M, Klemke M, Samstag Y.; ''Costimulation induced phosphorylation of L-plastin facilitates surface transport of the T cell activation molecules CD69 and CD25.''; PubMed Europe PMC Scholia
  11. Zakharyan RA, Sampayo-Reyes A, Healy SM, Tsaprailis G, Board PG, Liebler DC, Aposhian HV.; ''Human monomethylarsonic acid (MMA(V)) reductase is a member of the glutathione-S-transferase superfamily.''; PubMed Europe PMC Scholia
  12. He C, Murthy S, McCormick ML, Spitz DR, Ryan AJ, Carter AB.; ''Mitochondrial Cu,Zn-superoxide dismutase mediates pulmonary fibrosis by augmenting H2O2 generation.''; PubMed Europe PMC Scholia
  13. Ghosh D, Lippert D, Krokhin O, Cortens JP, Wilkins JA.; ''Defining the membrane proteome of NK cells.''; PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
114696view16:17, 25 January 2021ReactomeTeamReactome version 75
113141view11:20, 2 November 2020ReactomeTeamReactome version 74
112371view15:30, 9 October 2020ReactomeTeamReactome version 73
101274view11:16, 1 November 2018ReactomeTeamreactome version 66
100812view20:46, 31 October 2018ReactomeTeamreactome version 65
100353view19:22, 31 October 2018ReactomeTeamreactome version 64
99898view16:05, 31 October 2018ReactomeTeamreactome version 63
99455view14:38, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99119view12:40, 31 October 2018ReactomeTeamreactome version 62
93536view11:26, 9 August 2017ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AIP geneGeneProductENSG00000110711 (Ensembl)
AIPProteinO00170 (Uniprot-TrEMBL)
ANXA2 geneGeneProductENSG00000182718 (Ensembl)
ANXA2ProteinP07355 (Uniprot-TrEMBL)
ARF1 geneGeneProductENSG00000143761 (Ensembl)
ARF1ProteinP84077 (Uniprot-TrEMBL)
BOLA2 geneGeneProductENSG00000183336 (Ensembl)
BOLA2ProteinQ9H3K6 (Uniprot-TrEMBL)
CA1 geneGeneProductENSG00000133742 (Ensembl)
CA1ProteinP00915 (Uniprot-TrEMBL)
CAPZA1 geneGeneProductENSG00000116489 (Ensembl)
CAPZA1ProteinP52907 (Uniprot-TrEMBL)
CDC42 geneGeneProductENSG00000070831 (Ensembl)
CDC42ProteinP60953 (Uniprot-TrEMBL)
CFL1 geneGeneProductENSG00000172757 (Ensembl)
CFL1ProteinP23528 (Uniprot-TrEMBL)
CNN2 geneGeneProductENSG00000064666 (Ensembl)
CNN2ProteinQ99439 (Uniprot-TrEMBL)
GSTA2 geneGeneProductENSG00000244067 (Ensembl)
GSTA2ProteinP09210 (Uniprot-TrEMBL)
GSTO1 geneGeneProductENSG00000148834 (Ensembl)
GSTO1ProteinP78417 (Uniprot-TrEMBL)
HNRNPA2B1 geneGeneProductENSG00000122566 (Ensembl)
HNRNPA2B1ProteinP22626 (Uniprot-TrEMBL)
HNRNPDL geneGeneProductENSG00000152795 (Ensembl)
HNRNPDLProteinO14979 (Uniprot-TrEMBL)
HNRNPF geneGeneProductENSG00000169813 (Ensembl)
HNRNPFProteinP52597 (Uniprot-TrEMBL)
HSP9 geneGeneProductENSG00000113013 (Ensembl)
HSPA9ProteinP38646 (Uniprot-TrEMBL)
IFNG geneGeneProductENSG00000111537 (Ensembl)
IFNGProteinP01579 (Uniprot-TrEMBL)
IL10 geneGeneProductENSG00000136634 (Ensembl)
IL10ProteinP22301 (Uniprot-TrEMBL)
LCP1 geneGeneProductENSG00000136167 (Ensembl)
LCP1ProteinP13796 (Uniprot-TrEMBL)
LMNB1 geneGeneProductENSG00000113368 (Ensembl)
LMNB1ProteinP20700 (Uniprot-TrEMBL)
MIF geneGeneProductENSG00000240972 (Ensembl)
MIFProteinP14174 (Uniprot-TrEMBL)
MSN geneGeneProductENSG00000147065 (Ensembl)
MSNProteinP26038 (Uniprot-TrEMBL)
MTAP geneGeneProductENSG00000099810 (Ensembl)
MTAPProteinQ13126 (Uniprot-TrEMBL)
PAK2 geneGeneProductENSG00000180370 (Ensembl)
PAK2ProteinQ13177 (Uniprot-TrEMBL)
PDCD4 geneGeneProductENSG00000150593 (Ensembl)
PDCD4ProteinQ53EL6 (Uniprot-TrEMBL)
PITPNA geneGeneProductENSG00000174238 (Ensembl)
PITPNAProteinQ00169 (Uniprot-TrEMBL)
PPIA geneGeneProductENSG00000196262 (Ensembl)
PPIAProteinP62937 (Uniprot-TrEMBL)
PSME2 geneGeneProductENSG00000100911 (Ensembl)
PSME2ProteinQ9UL46 (Uniprot-TrEMBL)
RALA geneGeneProductENSG00000006451 (Ensembl)
RALAProteinP11233 (Uniprot-TrEMBL)
RAP1BProteinP61224 (Uniprot-TrEMBL)
RAPB1 geneGeneProductENSG00000127314 (Ensembl)
RPLP0 geneGeneProductENSG00000089157 (Ensembl)
RPLP0ProteinP05388 (Uniprot-TrEMBL)
SERPINB1ProteinP30740 (Uniprot-TrEMBL)
SERPINB2 geneGeneProductENSG00000197632 (Ensembl)
SERPINB2ProteinP05120 (Uniprot-TrEMBL)
SNRPA1 geneGeneProductENSG00000131876 (Ensembl)
SNRPA1ProteinP09661 (Uniprot-TrEMBL)
SOD1 geneGeneProductENSG00000142168 (Ensembl)
SOD1ProteinP00441 (Uniprot-TrEMBL)
SOD2 geneGeneProductENSG00000112096 (Ensembl)
SOD2ProteinP04179 (Uniprot-TrEMBL)
TALDO1 geneGeneProductENSG00000177156 (Ensembl)
TALDO1ProteinP37837 (Uniprot-TrEMBL)
TCP1 geneGeneProductENSG00000120438 (Ensembl)
TCP1ProteinP17987 (Uniprot-TrEMBL)
Y963-STAT4 dimerComplexR-HSA-8950759 (Reactome)
p-S43,S173,S294,S325-FOXO3ProteinO43524 (Uniprot-TrEMBL)
p-Y693-STAT4 ProteinQ14765 (Uniprot-TrEMBL)

Annotated Interactions

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SourceTargetTypeDatabase referenceComment
AIP geneR-HSA-8950201 (Reactome)
AIPArrowR-HSA-8950201 (Reactome)
ANXA2 geneR-HSA-8950480 (Reactome)
ANXA2ArrowR-HSA-8950480 (Reactome)
ARF1 geneR-HSA-8950173 (Reactome)
ARF1ArrowR-HSA-8950173 (Reactome)
BOLA2 geneR-HSA-8950344 (Reactome)
BOLA2ArrowR-HSA-8950344 (Reactome)
CA1 geneR-HSA-8950623 (Reactome)
CA1ArrowR-HSA-8950623 (Reactome)
CAPZA1 geneR-HSA-8950634 (Reactome)
CAPZA1ArrowR-HSA-8950634 (Reactome)
CDC42 geneR-HSA-8950637 (Reactome)
CDC42ArrowR-HSA-8950637 (Reactome)
CFL1 geneR-HSA-8950581 (Reactome)
CFL1ArrowR-HSA-8950581 (Reactome)
CNN2 geneR-HSA-8950314 (Reactome)
CNN2ArrowR-HSA-8950314 (Reactome)
GSTA2 geneR-HSA-8950586 (Reactome)
GSTA2ArrowR-HSA-8950586 (Reactome)
GSTO1 geneR-HSA-8950175 (Reactome)
GSTO1ArrowR-HSA-8950175 (Reactome)
HNRNPA2B1 geneR-HSA-8950292 (Reactome)
HNRNPA2B1ArrowR-HSA-8950292 (Reactome)
HNRNPDL geneR-HSA-8950684 (Reactome)
HNRNPDLArrowR-HSA-8950684 (Reactome)
HNRNPF geneR-HSA-8950415 (Reactome)
HNRNPFArrowR-HSA-8950415 (Reactome)
HSP9 geneR-HSA-8950389 (Reactome)
HSPA9ArrowR-HSA-8950389 (Reactome)
IFNG geneR-HSA-9006431 (Reactome)
IFNGArrowR-HSA-9006431 (Reactome)
IL10 geneR-HSA-8981073 (Reactome)
IL10ArrowR-HSA-8981073 (Reactome)
LCP1 geneR-HSA-8950426 (Reactome)
LCP1ArrowR-HSA-8950426 (Reactome)
LMNB1 geneR-HSA-8950681 (Reactome)
LMNB1ArrowR-HSA-8950681 (Reactome)
MIF geneR-HSA-8950732 (Reactome)
MIFArrowR-HSA-8950732 (Reactome)
MSN geneR-HSA-8950218 (Reactome)
MSNArrowR-HSA-8950218 (Reactome)
MTAP geneR-HSA-8950365 (Reactome)
MTAPArrowR-HSA-8950365 (Reactome)
PAK2 geneR-HSA-8950190 (Reactome)
PAK2ArrowR-HSA-8950190 (Reactome)
PDCD4 geneR-HSA-8950721 (Reactome)
PDCD4ArrowR-HSA-8950721 (Reactome)
PITPNA geneR-HSA-8950213 (Reactome)
PITPNAArrowR-HSA-8950213 (Reactome)
PPIA geneR-HSA-8950328 (Reactome)
PPIAArrowR-HSA-8950328 (Reactome)
PSME2 geneR-HSA-8950260 (Reactome)
PSME2ArrowR-HSA-8950260 (Reactome)
R-HSA-8870703 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the down-regulated proteins is :Superoxide dismutase [Mn], mitochondrial(SOD2).
R-HSA-8950173 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the down-regulated proteins is :ADP-ribosylation factor 1(ARF1).
R-HSA-8950175 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the up-regulated proteins is :Glutathione S-transferase omega-1(GSTO1)
R-HSA-8950190 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the down-regulated proteins is :Serine/threonine-protein kinase PAK 2(PAK2).
R-HSA-8950201 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the up-regulated proteins is :AH receptor-interacting protein(AIP).
R-HSA-8950213 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the up-regulated proteins is :Phosphatidylinositol transfer protein alpha isoform(PITPNA).
R-HSA-8950218 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the up-regulated proteins is :Moesin(MSN).
R-HSA-8950225 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the down-regulated proteins is :Ras-related protein Rap-1b(RAP1B).
R-HSA-8950260 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the up-regulated proteins is :Proteasome activator complex subunit 2(PSME2).
R-HSA-8950292 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the down-regulated proteins is :Heterogeneous nuclear ribonucleoproteins A2/B1(HNRNPA2B1).
R-HSA-8950314 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the up-regulated proteins is :Calponin-2(CNN2).
R-HSA-8950322 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the down-regulated proteins is :60S acidic ribosomal protein P0(RPLP0).
R-HSA-8950328 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the up-regulated proteins is :Peptidyl-prolyl cis-trans isomerase A(PPIA). This protein is found in four spots, which probably represent four different isoforms.
R-HSA-8950344 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005).Among the up-regulated proteins is :BolA-like protein 2(BOLA2).
R-HSA-8950365 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the up-regulated proteins is :S-methyl-5'-thioadenosine phosphorylase(MTAP).
R-HSA-8950367 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the down-regulated proteins is :Transaldolase(TALDO1).
R-HSA-8950389 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the down-regulated proteins is :HSPA9 protein(HSPA9).
R-HSA-8950415 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the down-regulated proteins is :Heterogeneous nuclear ribonucleoprotein F(HNRNPF).
R-HSA-8950426 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the down-regulated proteins is :Plastin-2(LCP1).
R-HSA-8950480 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the down-regulated proteins is :Annexin A2(ANXA2), which is present in two spots probably indicating two different isoforms
R-HSA-8950533 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the up-regulated proteins is :Ras-related protein Ral-A(RALA).
R-HSA-8950567 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the down-regulated proteins is :Plasminogen activator inhibitor 2(SERPINB2).
R-HSA-8950581 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the up-regulated proteins is :Cofilin-1(CFL1).
R-HSA-8950586 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the up-regulated proteins is :Glutathione S-transferase A2(GSTA2).
R-HSA-8950608 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the down-regulated proteins is :U2 small nuclear ribonucleoprotein A' (SNRPA1).
R-HSA-8950623 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the up-regulated proteins is :Carbonic anhydrase 1(CA1).
R-HSA-8950634 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the down-regulated proteins is :F-actin-capping protein subunit alpha-1(CAPZA1).
R-HSA-8950637 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the down-regulated proteins is :Cell division control protein 42 homolog(CDC42).
R-HSA-8950681 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the down-regulated proteins is :Lamin-B1(LMNB1).
R-HSA-8950684 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the up-regulated proteins is :Heterogeneous nuclear ribonucleoprotein D-like(HNRNPDL).
R-HSA-8950718 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the proteins that is identified in more than one spot, which probably is due to different isoforms, is T-complex protein 1 subunit alpha (TCP1), one isoform of this protein is upregulated, the other down-regulated.
R-HSA-8950721 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the up-regulated proteins is :Programmed cell death protein 4(PDCD4).
R-HSA-8950732 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the up-regulated proteins is :Macrophage migration inhibitory factor(MIF).
R-HSA-8950771 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the up-regulated proteins is :Superoxide dismutase [Cu-Zn](SOD1).
R-HSA-8981073 (Reactome) In response to IL-12 normal T cells produce interleukin-10 (IL10) (van de Vosse et al 2005).
R-HSA-9006431 (Reactome) The most important and most analysed IL-12-induced protein is Interferon-gamma (IFNG). In response to IL-12 normal T cells produce interferon-gamma (IFNG) (van de Vosse et al 2005). In PBMCs from subjects that lack the interleukin-12 receptor beta 2 subunit (IL12RB2) no interferon gamma is produced in response to IL-12, while in healthy subjects it is (de Jong et al 1998).

To identify genes induced by IL-12, microarray analysis of over 33.000 genes was conducted using human PBMC enriched for CD3 + T cells after stimulation for 6 h with IL-12. Approximately 90 genes were differentially induced by IL-12 stimulation, of which IFNG was upregulated 24-fold (Watford et al 2008). Expression of IL-12 induced genes was also analysed by a microarray containing 6000 human genes, in differentiated Th1 cells. In these cells IL-12 induced a 53-fold upregulation of IFNG (Rogge et al 2000)

Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005).
RALA geneR-HSA-8950533 (Reactome)
RALAArrowR-HSA-8950533 (Reactome)
RAP1BArrowR-HSA-8950225 (Reactome)
RAPB1 geneR-HSA-8950225 (Reactome)
RPLP0 geneR-HSA-8950322 (Reactome)
RPLP0ArrowR-HSA-8950322 (Reactome)
SERPINB2 geneR-HSA-8950567 (Reactome)
SERPINB2ArrowR-HSA-8950567 (Reactome)
SNRPA1 geneR-HSA-8950608 (Reactome)
SNRPA1ArrowR-HSA-8950608 (Reactome)
SOD1 geneR-HSA-8950771 (Reactome)
SOD1ArrowR-HSA-8950771 (Reactome)
SOD2 geneR-HSA-8870703 (Reactome)
SOD2ArrowR-HSA-8870703 (Reactome)
TALDO1 geneR-HSA-8950367 (Reactome)
TALDO1ArrowR-HSA-8950367 (Reactome)
TCP1 geneR-HSA-8950718 (Reactome)
TCP1ArrowR-HSA-8950718 (Reactome)
Y963-STAT4 dimerArrowR-HSA-8950201 (Reactome)
Y963-STAT4 dimerArrowR-HSA-8950260 (Reactome)
Y963-STAT4 dimerArrowR-HSA-8950314 (Reactome)
Y963-STAT4 dimerArrowR-HSA-8950328 (Reactome)
Y963-STAT4 dimerArrowR-HSA-8950344 (Reactome)
Y963-STAT4 dimerArrowR-HSA-8950365 (Reactome)
Y963-STAT4 dimerArrowR-HSA-8950533 (Reactome)
Y963-STAT4 dimerArrowR-HSA-8950581 (Reactome)
Y963-STAT4 dimerArrowR-HSA-8950586 (Reactome)
Y963-STAT4 dimerArrowR-HSA-8950623 (Reactome)
Y963-STAT4 dimerArrowR-HSA-8950684 (Reactome)
Y963-STAT4 dimerArrowR-HSA-8950718 (Reactome)
Y963-STAT4 dimerArrowR-HSA-8950721 (Reactome)
Y963-STAT4 dimerArrowR-HSA-8950732 (Reactome)
Y963-STAT4 dimerArrowR-HSA-8950771 (Reactome)
Y963-STAT4 dimerArrowR-HSA-8981073 (Reactome)
Y963-STAT4 dimerArrowR-HSA-9006431 (Reactome)
Y963-STAT4 dimerTBarR-HSA-8870703 (Reactome)
Y963-STAT4 dimerTBarR-HSA-8950173 (Reactome)
Y963-STAT4 dimerTBarR-HSA-8950175 (Reactome)
Y963-STAT4 dimerTBarR-HSA-8950190 (Reactome)
Y963-STAT4 dimerTBarR-HSA-8950213 (Reactome)
Y963-STAT4 dimerTBarR-HSA-8950218 (Reactome)
Y963-STAT4 dimerTBarR-HSA-8950225 (Reactome)
Y963-STAT4 dimerTBarR-HSA-8950292 (Reactome)
Y963-STAT4 dimerTBarR-HSA-8950322 (Reactome)
Y963-STAT4 dimerTBarR-HSA-8950367 (Reactome)
Y963-STAT4 dimerTBarR-HSA-8950389 (Reactome)
Y963-STAT4 dimerTBarR-HSA-8950415 (Reactome)
Y963-STAT4 dimerTBarR-HSA-8950426 (Reactome)
Y963-STAT4 dimerTBarR-HSA-8950480 (Reactome)
Y963-STAT4 dimerTBarR-HSA-8950567 (Reactome)
Y963-STAT4 dimerTBarR-HSA-8950608 (Reactome)
Y963-STAT4 dimerTBarR-HSA-8950634 (Reactome)
Y963-STAT4 dimerTBarR-HSA-8950637 (Reactome)
Y963-STAT4 dimerTBarR-HSA-8950681 (Reactome)
p-S43,S173,S294,S325-FOXO3ArrowR-HSA-8870703 (Reactome)
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