Eukaryotic translation initiation (Homo sapiens)

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24, 5, 20, 21, 23...12, 15, 267, 9, 15, 23, 24, 2918172583, 166, 9, 13, 23, 2412, 1514, 19, 23, 241910143, 169, 23, 241714, 2811cytosolRPL9 RPS8 Met-tRNAi GTP Met-tRNAi EIF3B RPS17 GTP RPS27L RPL11 EIF2B2 RPS28 EIF3D RPS28 RPS9 EIF4G1 EIF3D RPS5 RPL38 EIF4E RPS24 EIF4E GTP EIF3J RPL22 RPLP0 RPS5 Ceruloplasmin mRNA RPS19 EIF3A RPS19 RPLP0 RPL26L1 RPS14 EIF5B RPS10 RPS28 RPS27 RPS14 RPS24 RPL27 RPS25 PABPC1 EIF3A RPS4Y1 28S rRNA RPS9 18S rRNA RPS4Y2 EIF3C EIF2B1 EIF3H RPL13 RPL21 RPL31 RPS27A(77-156) RPS28 RPL4 18S rRNA RPS3A RPL7 43S complexEIF2B1 RPS3A EIF2S3 RPS15A RPL37A RPS3A RPL10L RPS4Y2 RPL10L EIF2B4 RPL39 RPS3 eIF2B subunitscomplexEIF3E eIF1RPL10A RPL23 RPL30 RPS27 EIF3F RPS4X Met-tRNAi RPL14 EIF3K RPS27L EIF2S2 RPS6 RPS29 18S rRNA RPL21 RPL35A RPS13 RPS25 RPL18A RPS27 RPS23 RPL28 RPL3L RPS8 RPS11 RPS8 RPL32 EIF4A1 Ceruloplasmin mRNA RPL27A 5.8S rRNA RPL37 RPL10L RPL10A RPL14 RPS15A RPS9 RPS27A(77-156) RPS28 RPL18A EIF4A2 RPS3 RPS11 RPS20 EIF2B3 EIF2S1 EIF3C RPS3A RPL37A RPL38 RPL22 RPS15A RPS20 RPL39 RPS27A(77-156) RPS9 RPS23 EIF4B RPL21 RPS2 RPL3 RPL26 RPS21 FAU RPL7 RPS27L RPS19 RPL23A 5S rRNA 40S:Met-tRNAi:mRNARPS26 RPL7 GTP GTP 43S:mRNA:eIF4F:eIF4B:eIF4HRPL32 RPL11 RPL36A RPL36A RPS9 eIF5B:GTPEIF2S1:EIF2S2:EIF2S3RPL3 RPS6 EIF4B RPS20 EIF4A2 RPS19 RPL17 ATPRPL22 RPL9 RPS19 EIF3H RPL36 EIF4G1 5S rRNA RPS16 RPS27L EIF2S2 RPS15 RPS4X RPS28 EIF5B EIF4A2 RPS15A RPS23 RPL7A RPS27A(77-156) RPL3L RPL24 RPL23 RPL15 RPS8 EIF1AX RPS19 RPL6 RPLP0 EIF2B5 RPL15 RPS24 RPS8 RPS13 RPS16 RPS17 RPL34 RPS2 RPL8 RPS24 RPS4Y1 RPS24 5S rRNA L13a kinaseRPLP0 RPS21 EIF4A2 RPL28 RPSA EIF3G RPS15A 18S rRNA FAU RPS3 RPS16 EIF3K RPS4Y2 RPL21 RPS28 RPLP1 RPL3L EIF2S2 RPL37A EIF5FAU RPS17 EIF3B GTPRPS7 EIF3E eIF2:GDP: eIF2BRPL12 RPL23 EIF2S2 RPS6 RPL34 RPS4X RPL27 EIF3K RNA-binding protein in RNP (ribonucleoprotein) complexes 40S:eIF3:eIF1ARPS6 RPS2 EIF3E Ceruloplasmin mRNA RPS14 EIF3A RPS21 RPS4Y1 EIF3L RPL39L 40S ribosomalcomplexEIF2S1 RPS27 RPS23 EIF3D FAU RPL39 RPS29 RPS4Y1 RPS5 eIF3 subunitscomplexRPS2 Met-tRNAiEIF1AXADPEIF3C RPS14 EIF4H RPL37 RPS24 RPS15A RPS10 RPSA RPS24 RPS27 RPL30 RPS3A RPL36A 18S rRNA 80S ribosome60S ribosomalcomplexEIF5RPS7 mRNPRPS26 RPS21 RPL15 RPS24 EIF4A1 PiRPS4X EIF3J RPSA RPL35 EIF2S3 RPL24 RPS9 RPS26 RPS13 RPS4X RPS17 RPL13A eIF2:GTPRPL23 RPL40 RPL7A EIF3I EIF3I RPS26 RPL11 Met-tRNAi RPL39 EIF3E RPS4Y1 RPS3 RPL12 EIF2S3 EIF3B RPS7 RPL27 EIF4A2 RPLP1 RPS2 RPS4Y1 RPSA EIF4B RPS15A RPL4 RPL9 RPL32 RPS16 EIF4E RPL23A RPS2 RPLP2 EIF4H RPL34 RPS16 EIF4A2 EIF3F RPL41 EIF4A2 RPS10 RPS23 RPS23 RPS2 RPL10A RPS5 RPL10 EIF4H Met-tRNAi EIF3C RPS19 RPL5 RPL31 RPS8 RPS9 RPS25 EIF4A1 RPL24 RPL8 EIF2S2 EIF2S3 RPL31 RPS25 RPS12 RPS5 RPL27A RPS26 EIF3H EIF4A1 RPS23 RPS26 RPS17 Ceruloplasmin mRNA RPS14 RPL5 EIF2S1 EIF3J EIF3C RPS15 EIF3G RPS4X RPL9 RPS16 RPL36AL EIF3B RPS4Y2 RPS5 RPL24 RPL6 EIF4H RPL36AL RPL35 EIF4H RPL26 RPL35A RPL6 RPS14 RPS8 RPL14 RPL29 GTP RPS29 RPL31 RPS12 EIF3J EIF4E EIF3M EIF3G RPL12 RPS20 RPS4Y2 18S rRNA RPL27A RPL4 RPS15A EIF4BRPS13 ATPRPL41 RPS6 RPL13 RPS14 RPL40 RPSA 43S:CeruloplasminmRNA:eIF4F:eIF4B:eIF4H:PABPRPS27 RPL12 RPL26L1 RPS20 RPL36A RPS3A RPS18 RPL26 RPS27A(77-156) EIF4B RPS9 EIF4B RPS3A RPL7A EIF3I RPL19 EIF3L EIF2S1 RPL18A RPS9 EIF3F RPS7 RPS11 RPS7 RPL28 RPS29 eIF4F:mRNPRPL34 RPS27 EIF3F Ceruloplasmin mRNA RPS16 EIF2S2 RPS15 EIF4G1 RPL39 Ceruloplasmin mRNA RPS17 RPS6 RPL19 RPS3A EIF4H RPL39L EIF2S3 RPS4X RPS27L RPL39L 18S rRNA EIF3K RPL14 EIF3M EIF3A RPS12 RPS3 RPL22 PiRPS13 RPL40 RPS7 FAU RPL6 RPS15 RPS14 RPS6 RPS16 RPS21 RPL8 RPS23 FAU RPL10L RPS13 5.8S rRNA EIF2S1 ternary complexRPS13 RPS18 EIF2S1 5.8S rRNA RPL18A RPS18 RPL23A EIF3L EIF3H RPL22L1 RPL40 EIF2S2 RPL35 EIF3A EIF3M RPS12 RNA-binding protein in RNP (ribonucleoprotein) complexes RPS21 RPL36AL RPL22L1 RPS27A(77-156) EIF2S3 RPL23 RPS12 RPS18 RPS27L eIF4FRPS28 EIF3C RPS13 RPL10 EIF1AX RPL3 RPS6 RPL5 RPS6 RPS12 RPS18 EIF3I RPS4Y1 RPS4Y1 RPS14 PABPC1GTPEIF3A EIF3D EIF3M RPSA RPL40 RPLP1 RPL19 p-RPL13A5.8S rRNA RPS25 RPL39L EIF3L EIF3A RPL29 RPL8 RPS10 RPS4Y2 RPS15 EIF3J EIF3E RPL14 RPL5 RPS4X RPS7 RPS15 EIF2B3 RPS3 RPL41 RPL13A 5.8S rRNA RPL17 RPL18 RPL13A RPS25 RPL11 FAU RPS15A RPS26 EIF3K EIF3B EIF1AXRPL30 EIF3K RPS2 eIF2:GTPRPL36 Met-tRNAi RPL28 RPS20 EIF3J RPS11 RPL4 RPS11 EIF3E RPS15A RPL13 RPL24 EIF3G RPL3L RPSA RPSA RPS9 RPS4Y2 RPL36 RPS17 EIF3F RPS2 RPLP1 RPSA RPS6 RPS4Y1 EIF2S1 EIF3K EIF1AX RPS21 EIF4A1 EIF4E PiEIF4A2 RPS20 RPL38 EIF3G RPL38 EIF3M RPL26 RPS12 EIF4A1 RPL10 RPS18 RPS4X RPL8 RPS3 EIF4G1 eIF1EIF4G1PiEIF1AX FAU RPS11 RPL18A 18S rRNA EIF2B4 RPS18 RPL27A RPL17 EIF4A1 RPL19 RPL9 EIF3M RPS5 RPS15 RPS14 RPS27L EIF2B5 RPS27 RPS12 RPS21 RPS17 RPS10 RPL34 80S:Met-tRNAi:mRNA:eIF5B:GTP5S rRNA 28S rRNA RNA-binding proteinin RNP(ribonucleoprotein)complexesEIF4EBP1 RPLP1 Ceruloplasmin mRNA RPS24 EIF3M RPL19 18S rRNA RPS26 RPL39L GTP GTP RPL7 EIF4E EIF2S2 RPS19 EIF4G1 RPS15 RPS5 RPS8 RPL35A RPS24 RPLP0 Ceruloplasmin mRNA EIF4B RPL5 RPL35A RPS11 EIF4E EIF2S3 RPS13 RPS21 RPS12 EIF4A2 RPSA RPL6 RPS23 RPL22 EIF4A1 RPS7 RPL13 RPS3 EIF1AXRPL18 RPS21 Met-tRNAi RPS16 RPS15A EIF3L RPL7A EIF1AX RPL36 EIF3F RPS10 EIF3I RPS27 RPL22L1 RPS19 RPS8 GDP RPS5 GTP RPS3A EIF1AXEIF3L 5S rRNA EIF3C RPS8 RPS25 FAU RPL29 RPL41 RPL23A eIF4E:4E-BPRPS20 RPLP2 RPS4Y1 EIF2S1 RPS7 EIF3D RPS11 RPL13A RPS17 RPL36 RPL31 RPS26 RPL37 EIF2S3 RPS28 RPL18 p-RPL13A EIF2S1 RPS25 RPS4Y2 CeruloplasminmRNA:eIF4F:eIF4B:eIF4HEIF4E RPL35 RPS27L RPS10 EIF3J RPS4Y1 RPS26 60s ribosomalcomplex lackingL13a subunitRPS24 eIF2:GDPRPS17 RPL4 RPS29 RPS23 RPS12 RPL3 EIF1AX EIF4E EIF2S2 RPS29 ATPRPS5 RPL37A RPS12 RPS29 RPS4Y2 RPS23 RPL36AL RPL36AL RPL29 PABPC1 RPS19 Ceruloplasmin mRNA RPS25 EIF3G RPL26L1 EIF3I RPS3 RPL18 Met-tRNAi RPL28 RPS18 EIF3H RPL32 FAU RPL13ACeruloplasmin mRNA RPL26L1 ADPRPS3 RPS26 RPS15 EIF3H RPS4Y2 RPS18 RPLP2 EIF4HRPS10 EIF4EBP1RPL41 RPL30 RPL10L RPL35 GTP RPS7 EIF5EIF4G1 RPLP2 RPS29 EIF4G1 RPS9 EIF3F EIF4ERPS8 GDP EIF3H EIF2S2 GDPRPL38 RPL10A RPS27A(77-156) RPL37 RPL29 EIF2S3 RPL30 EIF3E EIF3D RPS11 RPS28 RPS20 RPS27A(77-156) RPL22L1 RPS29 28S rRNA RPS3A FAU RPS16 Ceruloplasmin mRNA RPS27L mRNA:eIF4F:eIF4B:eIF4HEIF3I RPL7A RPS20 RPS13 EIF2S3 RPS18 RPS27A(77-156) RPL17 18S rRNA EIF2S3 RPS3 GDP RPS10 EIF2B2 EIF5B EIF2S3 EIF2S1 EIF2S1 RPS29 RPL22L1 RPS28 RPL10 RPS14 RPS11 RPL26 80S:Met-tRNAi:mRNARPS6 RPS29 EIF3B RPL3 RPL26L1 EIF4G1 RPLP2 RPS2 RPL11 RPL10A RPS18 EIF3L EIF3D RPSA RPS27A(77-156) RPL21 RPS4X EIF2S2 48S complex28S rRNA phospho-L13aassociated wth the 3' UTR GAIT elementof ceruloplasminmRNA within thetranslationinitiation complexRPS4Y2 18S rRNA RPS15 RPL15 RPS13 RPS27L RPL17 EIF3B EIF4A1 eIF5B:GDPRPL36A RPS19 RPS7 RPL15 RPS16 RPS25 RPL37 EIF3G RPS27 RPS11 RPS25 RPL10 RPS10 EIF2S1 RPS27A(77-156) RPS21 eIF4A subunitscomplexRPS4X RPS3A RPL32 RPL18 RPL35A RPS27 RPL23A RPL12 RPL27A EIF2S2 RPS17 RPS20 RPL13 RPS10 RPS15 RPL3L RPL27 28S rRNA Met-tRNAi RPS5 RPL37A EIF2S1:EIF2S2:EIF2S3RPS27L RPS2 RPL7 RPL27 1, 22271, 221, 221, 221, 221, 221, 221, 221, 221, 22


Description

Initiation of translation in the majority of eukaryotic cellular mRNAs depends on the 5'-cap (m7GpppN) and involves ribosomal scanning of the 5' untranslated region (5'-UTR) for an initiating AUG start codon. Therefore, this mechanism is often called cap-dependent translation initiation. Proximity to the cap, as well as the nucleotides surrounding an AUG codon, influence the efficiency of the start site recognition during the scanning process. However, if the recognition site is poor enough, scanning ribosomal subunits will ignore and skip potential starting AUGs, a phenomenon called leaky scanning. Leaky scanning allows a single mRNA to encode several proteins that differ in their amino-termini. Merrick (2010) provides an overview of this process and hghlights several features of it that remain incompletely understood.

Several eukaryotic cell and viral mRNAs initiate translation by an alternative mechanism that involves internal initiation rather than ribosomal scanning. These mRNAs contain complex nucleotide sequences, called internal ribosomal entry sites, where ribosomes bind in a cap-independent manner and start translation at the closest downstream AUG codon.

Initiation on several viral and cellular mRNAs is cap-independent and is mediated by binding of the ribosome to internal ribosome entry site (IRES) elements. These elements are often found in characteristically long structured regions on the 5'-UTR of an mRNA that may or may not have regulatory upstream open reading frames (uORFs). Both of these features on the 5'-end of the mRNA hinder ribosomal scanning, and thus promote a cap-independent translation initiation mechanism. IRESs act as specific translational enhancers that allow translation initiation to occur in response to specific stimuli and under the control of different trans-acting factors, as for example when cap-dependent protein synthesis is shut off during viral infection. Such regulatory elements have been identified in the mRNAs of growth factors, protooncogenes, angiogenesis factors, and apoptosis regulators, which are translated under a variety of stress conditions, including hypoxia, serum deprivation, irradiation and apoptosis. Thus, cap-independent translational control might have evolved to regulate cellular responses in acute but transient stress conditions that would otherwise lead to cell death, while the same mechanism is of major importance for viral mRNAs to bypass the shutting-off of host protein synthesis after infection. Encephalomyocarditis virus (EMCV) and hepatitis C virus exemplify two distinct mechanisms of IRES-mediated initiation. In contrast to cap-dependent initiation, the eIF4A and eIF4G subunits of eIF4F bind immediately upstream of the EMCV initiation codon and promote binding of a 43S complex. Accordingly, EMCV initiation does not involve scanning and does not require eIF1, eIF1A, and the eIF4E subunit of eIF4F. Nonetheless, initiation on some EMCV-like IRESs requires additional non-canonical initiation factors, which alter IRES conformation and promote binding of eIF4A/eIF4G. Initiation on the hepatitis C virus IRES is simpler: a 43S complex containing only eIF2 and eIF3 binds directly to the initiation codon as a result of specific interaction of the IRES and the 40S subunit.

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Comments

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Pathway is converted from Reactome ID: 72613
Reactome-version 
Reactome version: 62

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Ontology Terms

 

Bibliography

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  1. Pause A, Belsham GJ, Gingras AC, Donzé O, Lin TA, Lawrence JC, Sonenberg N.; ''Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function.''; PubMed Europe PMC Scholia
  2. Sampath P, Mazumder B, Seshadri V, Fox PL.; ''Transcript-selective translational silencing by gamma interferon is directed by a novel structural element in the ceruloplasmin mRNA 3' untranslated region.''; PubMed Europe PMC Scholia
  3. Pestova TV, Borukhov SI, Hellen CU.; ''Eukaryotic ribosomes require initiation factors 1 and 1A to locate initiation codons.''; PubMed Europe PMC Scholia
  4. Mazumder B, Sampath P, Seshadri V, Maitra RK, DiCorleto PE, Fox PL.; ''Regulated release of L13a from the 60S ribosomal subunit as a mechanism of transcript-specific translational control.''; PubMed Europe PMC Scholia
  5. Grifo JA, Tahara SM, Morgan MA, Shatkin AJ, Merrick WC.; ''New initiation factor activity required for globin mRNA translation.''; PubMed Europe PMC Scholia
  6. Safer B, Adams SL, Anderson WF, Merrick WC.; ''Binding of MET-TRNAf and GTP to homogeneous initiation factor MP.''; PubMed Europe PMC Scholia
  7. Pestova TV, Shatsky IN, Hellen CU.; ''Functional dissection of eukaryotic initiation factor 4F: the 4A subunit and the central domain of the 4G subunit are sufficient to mediate internal entry of 43S preinitiation complexes.''; PubMed Europe PMC Scholia
  8. Merrick WC.; ''Eukaryotic protein synthesis: still a mystery.''; PubMed Europe PMC Scholia
  9. Kozak M.; ''Evaluation of the "scanning model" for initiation of protein synthesis in eucaryotes.''; PubMed Europe PMC Scholia
  10. Chakrabarti A, Maitra U.; ''Function of eukaryotic initiation factor 5 in the formation of an 80 S ribosomal polypeptide chain initiation complex.''; PubMed Europe PMC Scholia
  11. Trachsel H, Erni B, Schreier MH, Staehelin T.; ''Initiation of mammalian protein synthesis. II. The assembly of the initiation complex with purified initiation factors.''; PubMed Europe PMC Scholia
  12. Rowlands AG, Panniers R, Henshaw EC.; ''The catalytic mechanism of guanine nucleotide exchange factor action and competitive inhibition by phosphorylated eukaryotic initiation factor 2.''; PubMed Europe PMC Scholia
  13. Iost I, Dreyfus M, Linder P.; ''Ded1p, a DEAD-box protein required for translation initiation in Saccharomyces cerevisiae, is an RNA helicase.''; PubMed Europe PMC Scholia
  14. Benne R, Hershey JW.; ''The mechanism of action of protein synthesis initiation factors from rabbit reticulocytes.''; PubMed Europe PMC Scholia
  15. Schreier MH, Erni B, Staehelin T.; ''Initiation of mammalian protein synthesis. I. Purification and characterization of seven initiation factors.''; PubMed Europe PMC Scholia
  16. Sonenberg N, Rupprecht KM, Hecht SM, Shatkin AJ.; ''Eukaryotic mRNA cap binding protein: purification by affinity chromatography on sepharose-coupled m7GDP.''; PubMed Europe PMC Scholia
  17. Dever TE, Wei CL, Benkowski LA, Browning K, Merrick WC, Hershey JW.; ''Determination of the amino acid sequence of rabbit, human, and wheat germ protein synthesis factor eIF-4C by cloning and chemical sequencing.''; PubMed Europe PMC Scholia
  18. Merrick WC, Kemper WM, Anderson WF.; ''Purification and characterization of homogeneous initiation factor M2A from rabbit reticulocytes.''; PubMed Europe PMC Scholia
  19. Asano K, Clayton J, Shalev A, Hinnebusch AG.; ''A multifactor complex of eukaryotic initiation factors, eIF1, eIF2, eIF3, eIF5, and initiator tRNA(Met) is an important translation initiation intermediate in vivo.''; PubMed Europe PMC Scholia
  20. Peterson DT, Merrick WC, Safer B.; ''Binding and release of radiolabeled eukaryotic initiation factors 2 and 3 during 80 S initiation complex formation.''; PubMed Europe PMC Scholia
  21. Goumans H, Thomas A, Verhoeven A, Voorma HO, Benne R.; ''The role of eIF-4C in protein synthesis initiation complex formation.''; PubMed Europe PMC Scholia
  22. Imataka H, Gradi A, Sonenberg N.; ''A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation.''; PubMed Europe PMC Scholia
  23. Chuang RY, Weaver PL, Liu Z, Chang TH.; ''Requirement of the DEAD-Box protein ded1p for messenger RNA translation.''; PubMed Europe PMC Scholia
  24. Lahn BT, Page DC.; ''Functional coherence of the human Y chromosome.''; PubMed Europe PMC Scholia
  25. Yoder-Hill J, Pause A, Sonenberg N, Merrick WC.; ''The p46 subunit of eukaryotic initiation factor (eIF)-4F exchanges with eIF-4A.''; PubMed Europe PMC Scholia
  26. Pestova TV, Lomakin IB, Lee JH, Choi SK, Dever TE, Hellen CU.; ''The joining of ribosomal subunits in eukaryotes requires eIF5B.''; PubMed Europe PMC Scholia
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  28. Majumdar R, Bandyopadhyay A, Maitra U.; ''Mammalian translation initiation factor eIF1 functions with eIF1A and eIF3 in the formation of a stable 40 S preinitiation complex.''; PubMed Europe PMC Scholia
  29. Dholakia JN, Wahba AJ.; ''Mechanism of the nucleotide exchange reaction in eukaryotic polypeptide chain initiation. Characterization of the guanine nucleotide exchange factor as a GTP-binding protein.''; PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
128373view17:49, 3 February 2024Ash iyerFixing error (check)
128372view17:45, 3 February 2024Ash iyeridentifier added
128371view17:43, 3 February 2024Ash iyereif1 identifier added.
128323view00:28, 1 February 2024EweitzOntology Term : 'translation pathway' added !
117720view12:33, 22 May 2021EweitzModified title
114979view16:50, 25 January 2021ReactomeTeamReactome version 75
113423view11:49, 2 November 2020ReactomeTeamReactome version 74
112625view16:00, 9 October 2020ReactomeTeamReactome version 73
101541view11:40, 1 November 2018ReactomeTeamreactome version 66
101076view21:23, 31 October 2018ReactomeTeamreactome version 65
100606view19:57, 31 October 2018ReactomeTeamreactome version 64
100157view16:42, 31 October 2018ReactomeTeamreactome version 63
99707view15:11, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99288view12:46, 31 October 2018ReactomeTeamreactome version 62
93969view13:48, 16 August 2017ReactomeTeamreactome version 61
93568view11:27, 9 August 2017ReactomeTeamreactome version 61
86670view09:23, 11 July 2016ReactomeTeamreactome version 56
83337view10:49, 18 November 2015ReactomeTeamVersion54
76969view08:25, 17 July 2014ReactomeTeamFixed remaining interactions
76674view12:04, 16 July 2014ReactomeTeamFixed remaining interactions
76136view13:23, 11 June 2014AnweshaRe-fixing comment source
75707view11:05, 10 June 2014ReactomeTeamReactome 48 Update
75062view13:57, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74706view08:46, 30 April 2014ReactomeTeamReactome46
45250view18:36, 7 October 2011AlexanderPicoOntology Term : 'translation initiation pathway' added !
42035view21:51, 4 March 2011MaintBotAutomatic update
39838view05:52, 21 January 2011MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
18S rRNA ProteinX03205 (EMBL)
28S rRNA ProteinM11167 (EMBL)
40S ribosomal complexComplexR-HSA-72392 (Reactome)
40S:Met-tRNAi:mRNAComplexR-HSA-72508 (Reactome)
40S:eIF3:eIF1AComplexR-HSA-72570 (Reactome)
43S complexComplexR-HSA-72571 (Reactome)
43S:

Ceruloplasmin

mRNA:eIF4F:eIF4B:eIF4H:PABP
ComplexR-HSA-156804 (Reactome)
43S:mRNA:eIF4F:eIF4B:eIF4HComplexR-HSA-72592 (Reactome)
48S complexComplexR-HSA-72594 (Reactome)
5.8S rRNA ProteinJ01866 (EMBL)
5S rRNA ProteinV00589 (EMBL)
60S ribosomal complexComplexR-HSA-72499 (Reactome)
60s ribosomal

complex lacking

L13a subunit
ComplexR-HSA-156817 (Reactome)
80S ribosomeComplexR-HSA-72500 (Reactome)
80S:Met-tRNAi:mRNA:eIF5B:GTPComplexR-HSA-72504 (Reactome)
80S:Met-tRNAi:mRNAComplexR-HSA-72505 (Reactome)
ADPMetaboliteCHEBI:16761 (ChEBI)
ATPMetaboliteCHEBI:15422 (ChEBI)
Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4HComplexR-HSA-156809 (Reactome)
Ceruloplasmin mRNA ProteinM13699 (EMBL)
EIF1AX ProteinP47813 (Uniprot-TrEMBL)
EIF1AXProteinP47813 (Uniprot-TrEMBL)
EIF2B1 ProteinQ14232 (Uniprot-TrEMBL)
EIF2B2 ProteinP49770 (Uniprot-TrEMBL)
EIF2B3 ProteinQ9NR50 (Uniprot-TrEMBL)
EIF2B4 ProteinQ9UI10 (Uniprot-TrEMBL)
EIF2B5 ProteinQ13144 (Uniprot-TrEMBL)
EIF2S1 ProteinP05198 (Uniprot-TrEMBL)
EIF2S1:EIF2S2:EIF2S3ComplexR-HSA-72515 (Reactome)
EIF2S2 ProteinP20042 (Uniprot-TrEMBL)
EIF2S3 ProteinP41091 (Uniprot-TrEMBL)
EIF3A ProteinQ14152 (Uniprot-TrEMBL)
EIF3B ProteinP55884 (Uniprot-TrEMBL)
EIF3C ProteinQ99613 (Uniprot-TrEMBL)
EIF3D ProteinO15371 (Uniprot-TrEMBL)
EIF3E ProteinP60228 (Uniprot-TrEMBL)
EIF3F ProteinO00303 (Uniprot-TrEMBL)
EIF3G ProteinO75821 (Uniprot-TrEMBL)
EIF3H ProteinO15372 (Uniprot-TrEMBL)
EIF3I ProteinQ13347 (Uniprot-TrEMBL)
EIF3J ProteinO75822 (Uniprot-TrEMBL)
EIF3K ProteinQ9UBQ5 (Uniprot-TrEMBL)
EIF3L ProteinQ9Y262 (Uniprot-TrEMBL)
EIF3M ProteinQ7L2H7 (Uniprot-TrEMBL)
EIF4A1 ProteinP60842 (Uniprot-TrEMBL)
EIF4A2 ProteinQ14240 (Uniprot-TrEMBL)
EIF4B ProteinP23588 (Uniprot-TrEMBL)
EIF4BProteinP23588 (Uniprot-TrEMBL)
EIF4E ProteinP06730 (Uniprot-TrEMBL)
EIF4EBP1 ProteinQ13541 (Uniprot-TrEMBL)
EIF4EBP1ProteinQ13541 (Uniprot-TrEMBL)
EIF4EProteinP06730 (Uniprot-TrEMBL)
EIF4G1 ProteinQ04637 (Uniprot-TrEMBL)
EIF4G1ProteinQ04637 (Uniprot-TrEMBL)
EIF4H ProteinQ15056 (Uniprot-TrEMBL)
EIF4HProteinQ15056 (Uniprot-TrEMBL)
EIF5B ProteinO60841 (Uniprot-TrEMBL)
EIF5ProteinP55010 (Uniprot-TrEMBL)
FAU ProteinP62861 (Uniprot-TrEMBL)
GDP MetaboliteCHEBI:17552 (ChEBI)
GDPMetaboliteCHEBI:17552 (ChEBI)
GTP MetaboliteCHEBI:15996 (ChEBI)
GTPMetaboliteCHEBI:15996 (ChEBI)
L13a kinaseR-HSA-170641 (Reactome)
Met-tRNAi R-ALL-72393 (Reactome)
Met-tRNAiR-ALL-72393 (Reactome)
PABPC1 ProteinP11940 (Uniprot-TrEMBL)
PABPC1ProteinP11940 (Uniprot-TrEMBL)
PiMetaboliteCHEBI:18367 (ChEBI)
RNA-binding protein

in RNP (ribonucleoprotein)

complexes
R-ALL-72595 (Reactome)
RNA-binding protein in RNP (ribonucleoprotein) complexes R-ALL-72595 (Reactome)
RPL10 ProteinP27635 (Uniprot-TrEMBL)
RPL10A ProteinP62906 (Uniprot-TrEMBL)
RPL10L ProteinQ96L21 (Uniprot-TrEMBL)
RPL11 ProteinP62913 (Uniprot-TrEMBL)
RPL12 ProteinP30050 (Uniprot-TrEMBL)
RPL13 ProteinP26373 (Uniprot-TrEMBL)
RPL13A ProteinP40429 (Uniprot-TrEMBL)
RPL13AProteinP40429 (Uniprot-TrEMBL)
RPL14 ProteinP50914 (Uniprot-TrEMBL)
RPL15 ProteinP61313 (Uniprot-TrEMBL)
RPL17 ProteinP18621 (Uniprot-TrEMBL)
RPL18 ProteinQ07020 (Uniprot-TrEMBL)
RPL18A ProteinQ02543 (Uniprot-TrEMBL)
RPL19 ProteinP84098 (Uniprot-TrEMBL)
RPL21 ProteinP46778 (Uniprot-TrEMBL)
RPL22 ProteinP35268 (Uniprot-TrEMBL)
RPL22L1 ProteinQ6P5R6 (Uniprot-TrEMBL)
RPL23 ProteinP62829 (Uniprot-TrEMBL)
RPL23A ProteinP62750 (Uniprot-TrEMBL)
RPL24 ProteinP83731 (Uniprot-TrEMBL)
RPL26 ProteinP61254 (Uniprot-TrEMBL)
RPL26L1 ProteinQ9UNX3 (Uniprot-TrEMBL)
RPL27 ProteinP61353 (Uniprot-TrEMBL)
RPL27A ProteinP46776 (Uniprot-TrEMBL)
RPL28 ProteinP46779 (Uniprot-TrEMBL)
RPL29 ProteinP47914 (Uniprot-TrEMBL)
RPL3 ProteinP39023 (Uniprot-TrEMBL)
RPL30 ProteinP62888 (Uniprot-TrEMBL)
RPL31 ProteinP62899 (Uniprot-TrEMBL)
RPL32 ProteinP62910 (Uniprot-TrEMBL)
RPL34 ProteinP49207 (Uniprot-TrEMBL)
RPL35 ProteinP42766 (Uniprot-TrEMBL)
RPL35A ProteinP18077 (Uniprot-TrEMBL)
RPL36 ProteinQ9Y3U8 (Uniprot-TrEMBL)
RPL36A ProteinP83881 (Uniprot-TrEMBL)
RPL36AL ProteinQ969Q0 (Uniprot-TrEMBL)
RPL37 ProteinP61927 (Uniprot-TrEMBL)
RPL37A ProteinP61513 (Uniprot-TrEMBL)
RPL38 ProteinP63173 (Uniprot-TrEMBL)
RPL39 ProteinP62891 (Uniprot-TrEMBL)
RPL39L ProteinQ96EH5 (Uniprot-TrEMBL)
RPL3L ProteinQ92901 (Uniprot-TrEMBL)
RPL4 ProteinP36578 (Uniprot-TrEMBL)
RPL40 ProteinP62987 (Uniprot-TrEMBL)
RPL41 ProteinP62945 (Uniprot-TrEMBL)
RPL5 ProteinP46777 (Uniprot-TrEMBL)
RPL6 ProteinQ02878 (Uniprot-TrEMBL)
RPL7 ProteinP18124 (Uniprot-TrEMBL)
RPL7A ProteinP62424 (Uniprot-TrEMBL)
RPL8 ProteinP62917 (Uniprot-TrEMBL)
RPL9 ProteinP32969 (Uniprot-TrEMBL)
RPLP0 ProteinP05388 (Uniprot-TrEMBL)
RPLP1 ProteinP05386 (Uniprot-TrEMBL)
RPLP2 ProteinP05387 (Uniprot-TrEMBL)
RPS10 ProteinP46783 (Uniprot-TrEMBL)
RPS11 ProteinP62280 (Uniprot-TrEMBL)
RPS12 ProteinP25398 (Uniprot-TrEMBL)
RPS13 ProteinP62277 (Uniprot-TrEMBL)
RPS14 ProteinP62263 (Uniprot-TrEMBL)
RPS15 ProteinP62841 (Uniprot-TrEMBL)
RPS15A ProteinP62244 (Uniprot-TrEMBL)
RPS16 ProteinP62249 (Uniprot-TrEMBL)
RPS17 ProteinP08708 (Uniprot-TrEMBL)
RPS18 ProteinP62269 (Uniprot-TrEMBL)
RPS19 ProteinP39019 (Uniprot-TrEMBL)
RPS2 ProteinP15880 (Uniprot-TrEMBL)
RPS20 ProteinP60866 (Uniprot-TrEMBL)
RPS21 ProteinP63220 (Uniprot-TrEMBL)
RPS23 ProteinP62266 (Uniprot-TrEMBL)
RPS24 ProteinP62847 (Uniprot-TrEMBL)
RPS25 ProteinP62851 (Uniprot-TrEMBL)
RPS26 ProteinP62854 (Uniprot-TrEMBL)
RPS27 ProteinP42677 (Uniprot-TrEMBL)
RPS27A(77-156) ProteinP62979 (Uniprot-TrEMBL)
RPS27L ProteinQ71UM5 (Uniprot-TrEMBL)
RPS28 ProteinP62857 (Uniprot-TrEMBL)
RPS29 ProteinP62273 (Uniprot-TrEMBL)
RPS3 ProteinP23396 (Uniprot-TrEMBL)
RPS3A ProteinP61247 (Uniprot-TrEMBL)
RPS4X ProteinP62701 (Uniprot-TrEMBL)
RPS4Y1 ProteinP22090 (Uniprot-TrEMBL)
RPS4Y2 ProteinQ8TD47 (Uniprot-TrEMBL)
RPS5 ProteinP46782 (Uniprot-TrEMBL)
RPS6 ProteinP62753 (Uniprot-TrEMBL)
RPS7 ProteinP62081 (Uniprot-TrEMBL)
RPS8 ProteinP62241 (Uniprot-TrEMBL)
RPS9 ProteinP46781 (Uniprot-TrEMBL)
RPSA ProteinP08865 (Uniprot-TrEMBL)
eIF1R-ALL-72617 (Reactome)
eIF2:GDP: eIF2BComplexR-HSA-72529 (Reactome)
eIF2:GDPComplexR-HSA-72530 (Reactome)
eIF2:GTPComplexR-HSA-72531 (Reactome)
eIF2B subunits complexComplexR-HSA-72526 (Reactome)
eIF3 subunits complexComplexR-HSA-72555 (Reactome)
eIF4A subunits complexComplexR-HSA-72576 (Reactome)
eIF4E:4E-BPComplexR-HSA-72581 (Reactome)
eIF4F:mRNPComplexR-HSA-72597 (Reactome)
eIF4FComplexR-HSA-72587 (Reactome)
eIF5B:GDPComplexR-HSA-72502 (Reactome)
eIF5B:GTPComplexR-HSA-72503 (Reactome)
mRNA:eIF4F:eIF4B:eIF4HComplexR-HSA-72593 (Reactome)
mRNPComplexR-HSA-72596 (Reactome)
p-RPL13A ProteinP40429 (Uniprot-TrEMBL)
p-RPL13AProteinP40429 (Uniprot-TrEMBL)
phospho-L13a

associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation

initiation complex
ComplexR-HSA-156824 (Reactome)
ternary complexComplexR-HSA-72532 (Reactome)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
40S ribosomal complexArrowR-HSA-72673 (Reactome)
40S ribosomal complexR-HSA-72676 (Reactome)
40S:Met-tRNAi:mRNAArrowR-HSA-72619 (Reactome)
40S:Met-tRNAi:mRNAR-HSA-72672 (Reactome)
40S:eIF3:eIF1AArrowR-HSA-72676 (Reactome)
40S:eIF3:eIF1AR-HSA-72691 (Reactome)
43S complexArrowR-HSA-72691 (Reactome)
43S complexR-HSA-156808 (Reactome)
43S complexR-HSA-157849 (Reactome)
43S:

Ceruloplasmin

mRNA:eIF4F:eIF4B:eIF4H:PABP
ArrowR-HSA-156808 (Reactome)
43S:

Ceruloplasmin

mRNA:eIF4F:eIF4B:eIF4H:PABP
R-HSA-156823 (Reactome)
43S:mRNA:eIF4F:eIF4B:eIF4HArrowR-HSA-157849 (Reactome)
43S:mRNA:eIF4F:eIF4B:eIF4HR-HSA-72621 (Reactome)
48S complexArrowR-HSA-72621 (Reactome)
48S complexArrowR-HSA-72697 (Reactome)
48S complexR-HSA-72619 (Reactome)
48S complexR-HSA-72697 (Reactome)
60S ribosomal complexArrowR-HSA-72673 (Reactome)
60S ribosomal complexR-HSA-156826 (Reactome)
60S ribosomal complexR-HSA-72672 (Reactome)
60s ribosomal

complex lacking

L13a subunit
ArrowR-HSA-156826 (Reactome)
80S ribosomeR-HSA-72673 (Reactome)
80S:Met-tRNAi:mRNA:eIF5B:GTPArrowR-HSA-72672 (Reactome)
80S:Met-tRNAi:mRNA:eIF5B:GTPR-HSA-72671 (Reactome)
80S:Met-tRNAi:mRNAArrowR-HSA-72671 (Reactome)
ADPArrowR-HSA-72621 (Reactome)
ADPArrowR-HSA-72647 (Reactome)
ATPArrowR-HSA-72621 (Reactome)
ATPR-HSA-72621 (Reactome)
ATPR-HSA-72647 (Reactome)
Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4HR-HSA-156808 (Reactome)
EIF1AXArrowR-HSA-156808 (Reactome)
EIF1AXArrowR-HSA-157849 (Reactome)
EIF1AXArrowR-HSA-72619 (Reactome)
EIF1AXArrowR-HSA-72673 (Reactome)
EIF1AXArrowR-HSA-72697 (Reactome)
EIF1AXR-HSA-156808 (Reactome)
EIF1AXR-HSA-157849 (Reactome)
EIF1AXR-HSA-72673 (Reactome)
EIF1AXR-HSA-72676 (Reactome)
EIF1AXR-HSA-72697 (Reactome)
EIF2S1:EIF2S2:EIF2S3ArrowR-HSA-72697 (Reactome)
EIF2S1:EIF2S2:EIF2S3R-HSA-72663 (Reactome)
EIF2S1:EIF2S2:EIF2S3R-HSA-72697 (Reactome)
EIF4BArrowR-HSA-72619 (Reactome)
EIF4BR-HSA-72647 (Reactome)
EIF4Bmim-catalysisR-HSA-72647 (Reactome)
EIF4EArrowR-HSA-72619 (Reactome)
EIF4EArrowR-HSA-72622 (Reactome)
EIF4EBP1ArrowR-HSA-72622 (Reactome)
EIF4ER-HSA-72631 (Reactome)
EIF4G1ArrowR-HSA-72619 (Reactome)
EIF4G1R-HSA-72631 (Reactome)
EIF4HArrowR-HSA-72619 (Reactome)
EIF4HR-HSA-72647 (Reactome)
EIF4Hmim-catalysisR-HSA-72647 (Reactome)
EIF5ArrowR-HSA-72619 (Reactome)
EIF5ArrowR-HSA-72697 (Reactome)
EIF5R-HSA-72619 (Reactome)
EIF5R-HSA-72697 (Reactome)
GDPArrowR-HSA-72722 (Reactome)
GTPArrowR-HSA-72669 (Reactome)
GTPR-HSA-72663 (Reactome)
GTPR-HSA-72722 (Reactome)
L13a kinasemim-catalysisR-HSA-156832 (Reactome)
Met-tRNAiR-HSA-72669 (Reactome)
PABPC1R-HSA-156808 (Reactome)
PiArrowR-HSA-72619 (Reactome)
PiArrowR-HSA-72621 (Reactome)
PiArrowR-HSA-72647 (Reactome)
PiArrowR-HSA-72671 (Reactome)
R-HSA-156808 (Reactome) The precise order of events leading to the circularization of poly (A) mRNA during translation initiation is unknown. Here the association of PABP with the poly (A) mRNA and the association of PABP with eIF4F are represented as occuring simultaneously after formation of the initiation complex. However, it is also possible that these interactions occur during the formation of the translation initiation complex. The binding of eIF4F to the cap and binding of PABP to the poly (A) tail, for example, may occur at the same time. In fact, the eIF4G-PABP interaction helps eIF4F to bind tighter to the cap (Borman et al. 2000.) In addition, eIF4B and eIF4H bind more transiently to the mRNA and may not be part of an initial complex in which PABP has not yet touched eIF4G.
R-HSA-156823 (Reactome) Although the mechanism through which L13a prevents translation initiation has not been determined, Mazumder et al. (2003) have described four alternatives. L13a could (1) inhibit the function of eIF4F, (2) block the recruitment of the 43S preinitiation complex, (3) prevent scanning of the 43S complex to the initiation codon, or 4) interfere with joining of the 60S ribosomal subunit.
R-HSA-156826 (Reactome) The L13a subunit of the 60s ribosome is phosphorylated about 16 hours after INF gamma induction by an unknown kinase. At this time, L13a is also released from the 60s subunit (Mazumder et al.,2003). It is unclear, however, whether phosphorylation occurs before or after the release of L13a. Here, phosphorylation is shown as occurring after release.
R-HSA-156832 (Reactome) The L13a subunit of the 60s ribosome is phosphorylated about 16 hours after INF gamma induction by an unknown kinase. At this time, L13a is also released from the 60s subunit (Mazumder et al.,2003). It is unclear, however, whether phosphorylation occurs before or after the release of L13a. Here, phosphorylation is shown as occurring after release.
R-HSA-157849 (Reactome) The translation initiation complex forms when the 43S complex binds the mRNA that is associated with eIF4F, eIF4B and eIF4H. eIF4G in the eIF4F complex can directly contact eIF3 in the 43S complex. eIF1A is necessary for the formation of this complex.
R-HSA-72619 (Reactome) Once the Met-tRNAi has recognized the AUG, eIF2-bound GTP is hydrolyzed. The reaction is catalyzed by eIF5 (or eIF5B) and is thought to cause dissociation of all other initiation factors and allow joining of the large 60S ribosomal subunit. Release of the initiation factors from 40S leaves the Met-tRNAi in the ribosomal P-site base-paired to the start codon on the mRNA.
R-HSA-72621 (Reactome) The mRNA-bound ribosomal complex moves along the 5'-untranslated region (5'-UTR) of the mRNA from its initial site to the initiation codon to form a 48S complex, in which the initiation codon (AUG) is base paired to the anticodon of the Met-tRNAi. It is not known whether eIF4A (or another ATPase, such as DED1) facilitates scanning by melting mRNA secondary structures or by actively propelling the ribosome.
R-HSA-72622 (Reactome) eIF4E gets released from the inactive eIF4E:4EBP complex.
R-HSA-72631 (Reactome) eIF4A interacts with eIF4G, and eIF4E interacts with the amino-terminal domain of eIF4G to form the cap-binding complex eIF4F.
R-HSA-72635 (Reactome) The factor eIF4E within the eIF4F (cap-binding) complex directly binds the 5'-cap on eukaryotic mRNAs. Note that the mRNA is in complex with cytoplasmic proteins constituting an mRNP complex.
R-HSA-72647 (Reactome) The DEAD-box RNA helicase eIF4A, together with the RNA-binding proteins eIF4B or eIF4H, is thought to unwind RNA secondary structures near the 5'-end of the mRNA and in the presence of ATP.
R-HSA-72663 (Reactome) Activation of eIF2 through direct binding of GTP.
R-HSA-72669 (Reactome) The ternary complex forms upon binding of the initiator methionyl-tRNA to the active eIF2:GTP complex.
R-HSA-72670 (Reactome) Inactive eIF2:GDP binds eIF2B to form an eIF2:GDP:eIF2B intermediate.
R-HSA-72671 (Reactome) Once the 60S subunit joins the translation initiation complex, eIF5B hydrolyzes its GTP and is released from the now 80S monosome. The fully assembled 80s ribosome is now ready to start elongation of the polypeptide chain.
R-HSA-72672 (Reactome) Joining of the 60S subunit to form the 80S ribosome is catalyzed by the presence of GTP-bound eIF5B.
R-HSA-72673 (Reactome) 80S monosomes dissociate into 40S and 60S ribosomal subunits. eIF1A promotes this dissociation.
R-HSA-72676 (Reactome) eIF3 and eIF1A bind to the 40S ribosomal subunit.
R-HSA-72691 (Reactome) The ternary complex (Met-tRNAi:eIF2:GTP) binds to the complex formed by the 40S subunit, eIF3 and eIF1A, to form the 43S complex. eIF1A promotes binding of the ternary complex to the 40S subunit within 43S. The initiator methionyl-tRNA from the ternary complex is positioned at the ribosomal P site.
R-HSA-72697 (Reactome) The AUG initiation codon in the mRNA is recognized by base pairing with the anticodon of the Met-tRNAi. This reaction requires eIF1, eIF1A, eIF2 and eIF5.
R-HSA-72722 (Reactome) eIF2B is a guanine nucleotide releasing factor that is required to cause GDP release so that a new GTP molecule can bind and activate eIF2, so that it can be reused.
RNA-binding protein

in RNP (ribonucleoprotein)

complexes
ArrowR-HSA-72647 (Reactome)
RPL13AArrowR-HSA-156826 (Reactome)
RPL13AR-HSA-156832 (Reactome)
eIF1ArrowR-HSA-72697 (Reactome)
eIF1R-HSA-72619 (Reactome)
eIF1R-HSA-72697 (Reactome)
eIF1mim-catalysisR-HSA-72621 (Reactome)
eIF1mim-catalysisR-HSA-72697 (Reactome)
eIF2:GDP: eIF2BArrowR-HSA-72670 (Reactome)
eIF2:GDP: eIF2BR-HSA-72722 (Reactome)
eIF2:GDPArrowR-HSA-72619 (Reactome)
eIF2:GDPR-HSA-72670 (Reactome)
eIF2:GTPArrowR-HSA-72663 (Reactome)
eIF2:GTPArrowR-HSA-72722 (Reactome)
eIF2:GTPR-HSA-72669 (Reactome)
eIF2B subunits complexArrowR-HSA-72722 (Reactome)
eIF2B subunits complexR-HSA-72670 (Reactome)
eIF2B subunits complexmim-catalysisR-HSA-72722 (Reactome)
eIF3 subunits complexArrowR-HSA-72619 (Reactome)
eIF3 subunits complexR-HSA-72676 (Reactome)
eIF4A subunits complexArrowR-HSA-72619 (Reactome)
eIF4A subunits complexArrowR-HSA-72647 (Reactome)
eIF4A subunits complexR-HSA-72631 (Reactome)
eIF4A subunits complexR-HSA-72647 (Reactome)
eIF4A subunits complexmim-catalysisR-HSA-72647 (Reactome)
eIF4E:4E-BPR-HSA-72622 (Reactome)
eIF4F:mRNPArrowR-HSA-72635 (Reactome)
eIF4F:mRNPR-HSA-72647 (Reactome)
eIF4FArrowR-HSA-72631 (Reactome)
eIF4FR-HSA-72635 (Reactome)
eIF5B:GDPArrowR-HSA-72671 (Reactome)
eIF5B:GTPR-HSA-72672 (Reactome)
mRNA:eIF4F:eIF4B:eIF4HArrowR-HSA-72647 (Reactome)
mRNA:eIF4F:eIF4B:eIF4HR-HSA-157849 (Reactome)
mRNPR-HSA-72635 (Reactome)
p-RPL13AArrowR-HSA-156832 (Reactome)
p-RPL13AR-HSA-156823 (Reactome)
phospho-L13a

associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation

initiation complex
ArrowR-HSA-156823 (Reactome)
ternary complexArrowR-HSA-72669 (Reactome)
ternary complexR-HSA-72691 (Reactome)

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