Class I MHC mediated antigen processing and presentation (Homo sapiens)

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14, 19, 45, 50, 110...9, 46, 76, 112113, 1276, 29, 84, 12747, 5646, 76, 11217, 33, 42, 105, 121...84, 898, 44, 70, 8831, 36, 129, 13312835, 63, 71, 72, 83...37, 117, 13261, 1289347, 12740, 12240, 12270, 97, 1006712818, 85, 10840, 1224, 49, 13921, 13428, 43, 54, 99, 12013128, 43, 54, 99, 12046, 76, 112, 11540, 73, 12246, 76, 11265, 923, 12, 38, 79, 91...11, 64, 8913, 25, 26, 67, 96...1218, 24, 30, 58, 74...3, 12, 90, 119, 12540, 70, 1226152, 10722, 61, 7834, 47, 5659, 80, 9877, 97, 100, 104recycling endosomecytosolendoplasmic reticulum lumenearly endosomeCOPII-coated ER to Golgi transport vesicleERGICclathrin-coated endocytic vesiclephagocytic vesicleGolgi lumenphagolysosomeendoplasmic reticulum-Golgi intermediate compartmentLRR1 class I MHC B67 K48polyUb-antigenic substrate HLA class I histocompatibility antigen, A-3 alpha chain precursor HLA class I histocompatibility antigen, A-29 alpha chain HLA class I histocompatibility antigen, A-69 alpha chain UBE2G1 RNF41 HLA class I histocompatibility antigen, Cw-8 alpha chain KCTD6 HLA class I histocompatibility antigen, Cw-15 alpha chain PSMA3 TRIM39 class I MHC B35 PDIA3 TRIM4 UBC(457-532) UBE4A ANAPC13 antigenic substrate UBB(77-152) class I MHC B53 CCNF class I MHC B42 STUB1 HLA class I histocompatibility antigen, A-33 alpha chain HLA class I histocompatibility antigen, Cw-1 alpha chain CDC26 4xPalmC-CD36 ZNRF1 class I MHC B51 HLA class I histocompatibility antigen, A-3 alpha chain precursor PSMD1 KBTBD7 HLA class I histocompatibility antigen, A-74 alpha chain class I MHC B82 HLA class I histocompatibility antigen, A-66 alpha chain UBC(609-684) ASB9 SEC24D class I MHC B50 HLA class I histocompatibility antigen, A-3 alpha chain precursor HLA class I histocompatibility antigen, Cw-16 alpha chain HLA class I histocompatibility antigen, E alpha chain precursor class I MHC B45 class I MHC B18 Antigen peptideclass I MHC B35 class I MHC B49 UBAC1 B2M(21-119) HLA class I histocompatibility antigen, A-24 alpha chain ELOC HLA class I histocompatibility antigen, A-43 alpha chain FBXO32 HLA class I histocompatibility antigen, A-66 alpha chain RBX1 HLA class I histocompatibility antigen, Cw-18 alpha chain class I MHC B54 VAMP8,VAMP3HLA class I histocompatibility antigen, Cw-17 alpha chain KBTBD7 Antigen peptide PSMC3 UBE2E3 HLA class I histocompatibility antigen, A-30 alpha chain Particulate Ag:DCreceptorsHLA class I histocompatibility antigen, Cw-7 alpha chain precursor HLA class I histocompatibility antigen, Cw-3 alpha chain precursor HLA class I histocompatibility antigen, alpha chain F precursor HLA class I histocompatibility antigen, Cw-17 alpha chain class I MHC B57 class I MHC B81 UBOX5 SEC24A HECW2 SEC23AFBXW4 HLA class I histocompatibility antigen, A-69 alpha chain class I MHC B50 HLA class I histocompatibility antigen, A-43 alpha chain TRIM50 Major outer membrane protein P class I MHC B47 class I MHC B49 FBXL21 HLA class I histocompatibility antigen, alpha chain G precursor CTSL2 class I MHC B59 class I MHC B35 PSME1 HLA class I histocompatibility antigen, alpha chain F precursor BTRC SPSB1 HLA class I histocompatibility antigen, A-26 alpha chain SMURF1 HLA-C PSMA8 Unknown hydrolasePSME1 HLA class I histocompatibility antigen, Cw-18 alpha chain HLA-H HLA class I histocompatibility antigen, A-74 alpha chain RNF41 RNF34 class I MHC B27 FBXO17 CDC27 MEX3C PSMD5 FBXL20 ASB7 class I MHC B35 HECTD1 class I MHC B57 PSMC1 HLA class I histocompatibility antigen, A-31 alpha chain PSMB2 HLA class I histocompatibility antigen, A-34 alpha chain HLA class I histocompatibility antigen, A-11 alpha chain MKRN1 UBE2Z TAPBPHLA class I histocompatibility antigen, A-31 alpha chain class I MHC B50 Sar1p:GTP:Sec23p:Sec24p:Ag bound MHC class Iclass I MHC B55 class I MHC B40 HLA class I histocompatibility antigen, A-23 alpha chain UBR2 HLA class I histocompatibility antigen, A-31 alpha chain HLA class I histocompatibility antigen, A-2 alpha chain class I MHC B53 FBXO4 class I MHC B56 FBXO21 HLA class I histocompatibility antigen, A-80 alpha chain HLA class I histocompatibility antigen, Cw-17 alpha chain UBR1 HLA class I histocompatibility antigen, A-2 alpha chain HLA class I histocompatibility antigen, A-29 alpha chain Exogenous solubleantigenclass I MHC B53 class I MHC B49 UBE2R2 PSME2 class I MHC B7 class I MHC B81 UBR4 PSMB7 LONRF1 HECTD2 class I MHC B50 B2M(21-119) HLA class I histocompatibility antigen, A-1 alpha chain precursor class I MHC B44 UBE2L6 UBE2J2 class I MHC B49 class I MHC B38 HLA class I histocompatibility antigen, alpha chain F precursor UBE2E1 ZNRF1 UBE3B HLA class I histocompatibility antigen, Cw-16 alpha chain HLA class I histocompatibility antigen, Cw-18 alpha chain class I MHC B59 FBXW5 UBC(533-608) BAP31 oligomer HLA class I histocompatibility antigen, A-30 alpha chain PSMD14 RNF114 AREL1 class I MHC B40 Antigenicpeptide:MHC:B2Mpeptide loadingcomplexGLMN HLA class I histocompatibility antigen, Cw-7 alpha chain precursor HLA class I histocompatibility antigen, E alpha chain precursor HLA class I histocompatibility antigen, Cw-4 alpha chain precursor SEC31A HLA-H HLA class I histocompatibility antigen, A-1 alpha chain precursor HLA class I histocompatibility antigen, A-34 alpha chain class I MHC B53 HLA class I histocompatibility antigen, alpha chain G precursor DZIP3 oligo-MyD88:Mal:BTK:activated TLRclass I MHC B57 KLHL22 class I MHC B81 NEDD4 HLA class I histocompatibility antigen, A-25 alpha chain PSMD6 B2M(21-119) PSMC3 HLA class I histocompatibility antigen, Cw-8 alpha chain class I MHC B14 CUL3 ASB3 UBB(1-76) HLA class I histocompatibility antigen, Cw-15 alpha chain HLA class I histocompatibility antigen, A-24 alpha chain BTBD6 HLA class I histocompatibility antigen, Cw-12 alpha chain class I MHC B81 HLA class I histocompatibility antigen, Cw-8 alpha chain NEDD4 NEDD4 RNF41 PSMB5 TRIM4 TRIM36 HLA class I histocompatibility antigen, E alpha chain precursor HLA class I histocompatibility antigen, Cw-2 alpha chain HLA class I histocompatibility antigen, A-24 alpha chain class I MHC B14 class I MHC B73 HLA class I histocompatibility antigen, A-43 alpha chain HLA class I histocompatibility antigen, A-26 alpha chain class I MHC B49 UBC(533-608) HLA class I histocompatibility antigen, Cw-14 alpha chain class I MHC B27 PSMB10 HLA class I histocompatibility antigen, alpha chain G precursor MRC1 SMURF2 PSMA1 HLA class I histocompatibility antigen, Cw-2 alpha chain class I MHC B82 FBXW12 class I MHC B47 HLA class I histocompatibility antigen, A-3 alpha chain precursor HLA class I histocompatibility antigen, Cw-15 alpha chain MIB2 KLHL20 HLA class I histocompatibility antigen, A-66 alpha chain HLA-H class I MHC B46 class I MHC B35 class I MHC B59 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor HLA class I histocompatibility antigen, Cw-14 alpha chain HLA class I histocompatibility antigen, A-34 alpha chain PiRCHY1 HLA class I histocompatibility antigen, alpha chain F precursor FBXW12 HLA class I histocompatibility antigen, Cw-18 alpha chain HLA class I histocompatibility antigen, Cw-6 alpha chain precursor UBC(1-76) HLA class I histocompatibility antigen, A-29 alpha chain CALRCDC23 PSMA7 UBE2B HLA class I histocompatibility antigen, alpha chain G precursor UBC(1-76) B2M(21-119) class I MHC B45 class I MHC B41 CTSS-like proteinsHLA class I histocompatibility antigen, Cw-2 alpha chain FBXO9 ATG7 ASB10 HLA class I histocompatibility antigen, A-1 alpha chain precursor class I MHC B45 class I MHC B42 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor HLA class I histocompatibility antigen, A-66 alpha chain HLA class I histocompatibility antigen, A-34 alpha chain class I MHC B38 class I MHC B37 HLA class I histocompatibility antigen, A-74 alpha chain VHL UBR2 KLHL11 LRRC41 ASB8 HLA class I histocompatibility antigen, A-11 alpha chain TRIM37 HLA class I histocompatibility antigen, A-32 alpha chain class I MHC B45 TRIM63 CHUK HLA class I histocompatibility antigen, E alpha chain precursor TRIM63 BTK UBE2A PSMD5 HLA class I histocompatibility antigen, A-66 alpha chain BAP31 oligomer Antigen peptide PSMA4 FZR1 CUL3 PSMD6 HLA class I histocompatibility antigen, A-2 alpha chain HLA class I histocompatibility antigen, Cw-7 alpha chain precursor PSME3 UBE2K UBE4A MYLIP class I MHC B52 ANAPC10 HLA class I histocompatibility antigen, A-32 alpha chain HLA class I histocompatibility antigen, Cw-3 alpha chain precursor HLA class I histocompatibility antigen, Cw-6 alpha chain precursor class I MHC B41 FBXL4 class I MHC B45 HLA class I histocompatibility antigen, Cw-16 alpha chain CUL5 HLA class I histocompatibility antigen, A-2 alpha chain HLA class I histocompatibility antigen, A-30 alpha chain class I MHC B46 UFL1 Exogenous solubleantigenclass I MHC B54 UBB(77-152) KCTD7 class I MHC B59 class I MHC B67 CUL1 HLA class I histocompatibility antigen, Cw-2 alpha chain RPS27A(1-76) FBXO10 oligopeptidefragmentclass I MHC B40 MYLIP RNF19B ATG7 class I MHC B35 SEC61A2 class I MHC B47 HLA class I histocompatibility antigen, A-11 alpha chain HLA class I histocompatibility antigen, A-68 alpha chain UBC(305-380) HLA class I histocompatibility antigen, A-1 alpha chain precursor BAP31 oligomer class I MHC B44 TRIM69 CCNF class I MHC B51 WSB1 HLA class I histocompatibility antigen, Cw-12 alpha chain UBC(381-456) ASB9 ANAPC11 CHUK:IKBKB:IKBKGSPSB2 ASB5 RLIM HLA class I histocompatibility antigen, A-30 alpha chain HLA class I histocompatibility antigen, A-26 alpha chain class I MHC B41 VAMP8 class I MHC B55 ASB15 UBB(153-228) adenosine5'-monophosphateHERC6 TAPBP class I MHC B45 PSME3 HLA class I histocompatibility antigen, A-11 alpha chain RNF7 (RBX2) TransloconHLA class I histocompatibility antigen, A-2 alpha chain UBE3B TAP1 HLA class I histocompatibility antigen, A-31 alpha chain SEC24D HLA class I histocompatibility antigen, A-30 alpha chain HLA class I histocompatibility antigen, A-68 alpha chain class I MHC B27 class I MHC B67 class I MHC B42 PSMB8 class I MHC B78 HERC4 class I MHC B52 HLA class I histocompatibility antigen, A-68 alpha chain HLA class I histocompatibility antigen, A-69 alpha chain HLA class I histocompatibility antigen, A-3 alpha chain precursor CBLB PSME4 FBXO22 class I MHC B42 class I MHC B82 class I MHC B82 HLA class I histocompatibility antigen, A-3 alpha chain precursor HLA class I histocompatibility antigen, A-29 alpha chain UBA6 class I MHC B8 HLA class I histocompatibility antigen, Cw-15 alpha chain UBE2G2 class I MHC B81 SPSB2 PSMA1 FBXL14 class I MHC B7 LNX1 class I MHC B8 ZNRF2 ASB14 SOCS1 class I MHC B38 SIAH1 class I MHC B47 FBXO40 class I MHC B59 HLA class I histocompatibility antigen, Cw-16 alpha chain HLA class I histocompatibility antigen, A-23 alpha chain class I MHC B7 ITCH HLA class I histocompatibility antigen, A-32 alpha chain MEX3C SAR1B HLA class I histocompatibility antigen, A-36 alpha chain SEC24D ZNRF2 B2M(21-119) L-amino acidSKP2 Antigen peptide HLA class I histocompatibility antigen, A-34 alpha chain FBXL13 FBXO4 class I MHC B73 UBE2J1 class I MHC B58 ANAPC10 class I MHC B67 HLA class I histocompatibility antigen, A-31 alpha chain TAPBPFBXL21 HLA class I histocompatibility antigen, A-69 alpha chain HACE1 HLA class I histocompatibility antigen, A-36 alpha chain LTN1 SIAH2 SOCS3 PSMB2 class I MHC B14 ASB7 RNF123 UFL1 class I MHC B18 class I MHC B73 CANX HLA class I histocompatibility antigen, A-26 alpha chain ELOB HLA class I histocompatibility antigen, A-74 alpha chain FBXO15 class I MHC B59 HLA class I histocompatibility antigen, alpha chain F precursor HLA class I histocompatibility antigen, Cw-5 alpha chain precursor class I MHC B14 HLA class I histocompatibility antigen, Cw-7 alpha chain precursor SEC61B HLA class I histocompatibility antigen, alpha chain F precursor Class I MHCHC:B2M:Erp57HLA class I histocompatibility antigen, A-66 alpha chain ANAPC13 HLA class I histocompatibility antigen, A-66 alpha chain HLA class I histocompatibility antigen, E alpha chain precursor HLA class I histocompatibility antigen, Cw-17 alpha chain HLA class I histocompatibility antigen, A-25 alpha chain class I MHC B8 class I MHC B50 class I MHC B52 HERC2 HLA class I histocompatibility antigen, A-36 alpha chain class I MHC B41 class I MHC B46 class I MHC B78 CUL3 SEC13 HLA class I histocompatibility antigen, Cw-1 alpha chain ASB13 HLA class I histocompatibility antigen, alpha chain F precursor HLA class I histocompatibility antigen, Cw-4 alpha chain precursor DET1 class I MHC B38 HLA class I histocompatibility antigen, Cw-2 alpha chain CDC34 UBE2A PDIA3 SEC22B (Glc)1 (GlcNAc)2 (Man)9 HLA class I histocompatibility antigen, alpha chain G precursor HLA class I histocompatibility antigen, A-2 alpha chain UBE2N KLHL13 CANX HLA class I histocompatibility antigen, A-69 alpha chain HLA class I histocompatibility antigen, A-11 alpha chain class I MHC B78 HLA class I histocompatibility antigen, A-68 alpha chain HLA class I histocompatibility antigen, Cw-1 alpha chain class I MHC B18 class I MHC B46 HLA class I histocompatibility antigen, A-2 alpha chain UBE2J1 HLA class I histocompatibility antigen, A-74 alpha chain LPS HECW2 UBE2R2 SIAH1 HLA-B HLA class I histocompatibility antigen, Cw-14 alpha chain HLA class I histocompatibility antigen, A-33 alpha chain GTP class I MHC B44 HLA class I histocompatibility antigen, A-34 alpha chain Antigen peptide KBTBD7 HLA class I histocompatibility antigen, A-23 alpha chain KLHL42 LTN1 HLA class I histocompatibility antigen, alpha chain G precursor UBE2Q1 KLHL5 class I MHC B7 SEC24C HLA class I histocompatibility antigen, A-74 alpha chain class I MHC B52 class I MHC B52 TAP2 CUL1 class I MHC B27 SEC24D UBE3D PPiclass I MHC B82 class I MHC B67 (Glc)1 (GlcNAc)2 (Man)9 HLA class I histocompatibility antigen, A-36 alpha chain CD14(20-345) HLA class I histocompatibility antigen, alpha chain G precursor HLA class I histocompatibility antigen, A-68 alpha chain HLA class I histocompatibility antigen, Cw-16 alpha chain class I MHC B53 oligopeptidefragment (3-7aa)class I MHC B41 FBXO6 class I MHC B50 HLA class I histocompatibility antigen, Cw-7 alpha chain precursor KLHL2 KLHL13 HLA class I histocompatibility antigen, A-3 alpha chain precursor MYLIP class I MHC B15 HLA class I histocompatibility antigen, A-32 alpha chain class I MHC B53 ASB2 UFL1 HLA class I histocompatibility antigen, A-33 alpha chain HLA class I histocompatibility antigen, A-2 alpha chain HLA class I histocompatibility antigen, A-36 alpha chain HLA class I histocompatibility antigen, A-25 alpha chain SPSB1 HECTD2 HLA class I histocompatibility antigen, Cw-1 alpha chain HERC2 class I MHC B59 HLA class I histocompatibility antigen, alpha chain F precursor PSMD12 class I MHC B73 HLA class I histocompatibility antigen, A-2 alpha chain RNF111 class I MHC B15 HLA class I histocompatibility antigen, A-80 alpha chain PSMD13 TRAF7 TRIM63 Antigen peptidebound class I MHCHLA class I histocompatibility antigen, A-23 alpha chain ASB16 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor class I MHC B51 HLA class I histocompatibility antigen, A-1 alpha chain precursor HLA class I histocompatibility antigen, Cw-7 alpha chain precursor class I MHC B27 HLA class I histocompatibility antigen, Cw-7 alpha chain precursor STX4ANAPC10 UBE2E2 MHC:B2M peptideloading complexclass I MHC B39 HLA class I histocompatibility antigen, A-74 alpha chain FBXO40 class I MHC B54 class I MHC B13 UBE2J2 ANAPC7 class I MHC B44 class I MHC B7 class I MHC B15 HLA class I histocompatibility antigen, A-29 alpha chain class I MHC B45 UBC(153-228) HLA class I histocompatibility antigen, Cw-5 alpha chain precursor RBBP6 HLA class I histocompatibility antigen, A-25 alpha chain CCNF TRIM41 HLA-B VAMP3 class I MHC B55 CDC27 HLA class I histocompatibility antigen, A-24 alpha chain UBC(153-228) Antigen peptidebound class I MHCclass I MHC B57 Class I MHC:B2MHLA class I histocompatibility antigen, Cw-14 alpha chain TRIM50 MHC HC:B2M:Erp57UBC(77-152) FBXL14 KBTBD8 class I MHC B38 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor HLA class I histocompatibility antigen, A-25 alpha chain HLA class I histocompatibility antigen, Cw-4 alpha chain precursor class I MHC B40 HLA class I histocompatibility antigen, alpha chain G precursor UBC(229-304) class I MHC B15 UBR2 HECW2 HLA-B ASB12 FBXO21 class I MHC B53 class I MHC B41 HLA-H VPRBP LRR1 E2Ubiquitin-conjugating enzymeclass I MHC B56 AREL1 RNF25 TRIM71 class I MHC B38 HLA class I histocompatibility antigen, A-3 alpha chain precursor HECTD2 TRIM11 TRIM21 PSMD7 HLA class I histocompatibility antigen, A-34 alpha chain PSMB1 RNF182 HLA class I histocompatibility antigen, alpha chain F precursor UBE2L3 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor class I MHC B73 TLR6 PSMC6 class I MHC B51 FBXL12 class I MHC B45 HLA class I histocompatibility antigen, A-29 alpha chain UBE3C class I MHC B44 UBC(305-380) UBC(381-456) TAPUBE2D2 class I MHC B57 HLA-B HLA class I histocompatibility antigen, A-43 alpha chain class I MHC B51 class I MHC B18 class I MHC B14 RNF123 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor HLA class I histocompatibility antigen, alpha chain G precursor HLA class I histocompatibility antigen, A-31 alpha chain CD207 RNF213 HLA class I histocompatibility antigen, Cw-14 alpha chain KLHL25 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor HLA class I histocompatibility antigen, A-36 alpha chain RNF14 class I MHC B59 class I MHC B41 class I MHC B8 SEC61A1 LRSAM1 HLA class I histocompatibility antigen, Cw-2 alpha chain FZR1 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor class I MHC B50 class I MHC B50 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor LNX1 FBXL16 class I MHC B45 FBXW12 H2OPSMD10 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor partially digestedAgHLA class I histocompatibility antigen, Cw-7 alpha chain precursor KLHL5 TAP1 TLR2 UBA1 class I MHC B54 UBE2D4 HLA class I histocompatibility antigen, A-80 alpha chain PSME4 p-S95-SNAP23 RNF19B class I MHC B15 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor CYBA HLA class I histocompatibility antigen, E alpha chain precursor TRIM11 UBC(77-152) MRC2 B2M(21-119) class I MHC B18 class I MHC B39 SHFM1 SHFM1 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor class I MHC B15 TRIM50 class I MHC B73 SAR1B HLA class I histocompatibility antigen, A-68 alpha chain HLA class I histocompatibility antigen, A-69 alpha chain Mg2+class I MHC B81 CDC34 class I MHC B27 RNF7 (RBX2) Exogenous solubleantigenHLA class I histocompatibility antigen, A-31 alpha chain HERC1 HLA class I histocompatibility antigen, A-25 alpha chain B2M(21-119) FBXW7 ARIH2 class I MHC B40 HLA class I histocompatibility antigen, A-69 alpha chain HLA class I histocompatibility antigen, A-74 alpha chain DTX3L HLA class I histocompatibility antigen, Cw-2 alpha chain ANAPC5 ASB11 HLA class I histocompatibility antigen, A-1 alpha chain precursor RLIM class I MHC B14 RNF19A p-T233-NCF2 class I MHC B41 HLA class I histocompatibility antigen, Cw-14 alpha chain Antigen peptidebound class I MHCclass I MHC B52 class I MHC B55 TRAF7 HLA class I histocompatibility antigen, alpha chain F precursor PSMD14 ADPHLA class I histocompatibility antigen, Cw-18 alpha chain RBX1 UBE2F class I MHC B41 class I MHC B81 GTP PSMB6 HLA class I histocompatibility antigen, Cw-18 alpha chain PSMC4 HLA class I histocompatibility antigen, A-30 alpha chain LRSAM1 class I MHC B35 class I MHC B59 HLA class I histocompatibility antigen, A-80 alpha chain B2M(21-119) ANAPC5 class I MHC B42 HLA class I histocompatibility antigen, A-26 alpha chain ELOC class I MHC B51 HLA class I histocompatibility antigen, A-23 alpha chain HLA class I histocompatibility antigen, A-32 alpha chain HLA class I histocompatibility antigen, A-36 alpha chain HLA-H GAN UBE2G1 HLA class I histocompatibility antigen, Cw-8 alpha chain WSB1 VPRBP FBXO2 B2M(21-119) HLA class I histocompatibility antigen, A-2 alpha chain ASB13 class I MHC B49 UBA1 class I MHC B67 HLA class I histocompatibility antigen, Cw-15 alpha chain class I MHC B37 HLA class I histocompatibility antigen, Cw-17 alpha chain HSPA5 class I MHC B37 ASB12 class I MHC B45 HLA class I histocompatibility antigen, Cw-15 alpha chain class I MHC B13 (Glc)1 (GlcNAc)2 (Man)9 PSMD11 class I MHC B37 class I MHC B56 ASB17 FBXO17 HLA class I histocompatibility antigen, Cw-18 alpha chain HLA class I histocompatibility antigen, Cw-2 alpha chain WWP1 ADPHLA-B FBXW7 class I MHC B73 precursor peptidefragment (>16 aa)SIAH2 HLA class I histocompatibility antigen, A-25 alpha chain HERC2 FBXW7 class I MHC B27 HLA class I histocompatibility antigen, A-74 alpha chain class I MHC B55 HLA class I histocompatibility antigen, A-11 alpha chain class I MHC B13 HLA class I histocompatibility antigen, A-34 alpha chain RNF14 HLA class I histocompatibility antigen, A-29 alpha chain monoglucosylated MHCclass I HCHERC5 class I MHC B42 HLA class I histocompatibility antigen, Cw-1 alpha chain HLA class I histocompatibility antigen, A-34 alpha chain UBE2U FBXO4 CALR ANAPC13 HLA class I histocompatibility antigen, Cw-7 alpha chain precursor TRIM36 FBXO10 ATPclass I MHC B50 class I MHC B49 SIAH2 PSMA6 RNF220 HLA class I histocompatibility antigen, Cw-7 alpha chain precursor HLA class I histocompatibility antigen, A-25 alpha chain ANAPC11 class I MHC B14 TRIP12 class I MHC B73 ASB17 FBXO4 TRIM9 PSMB4 RNF213 HLA class I histocompatibility antigen, A-31 alpha chain class I MHC B50 FBXL5 class I MHC B81 class I MHC B35 E1 bound ubiquitinHLA class I histocompatibility antigen, A-68 alpha chain CDC20 class I MHC B35 HLA class I histocompatibility antigen, E alpha chain precursor class I MHC B52 HLA class I histocompatibility antigen, A-74 alpha chain class I MHC B40 ANAPC1 class I MHC B53 PSMD4 HLA class I histocompatibility antigen, A-69 alpha chain HLA class I histocompatibility antigen, A-66 alpha chain PSMB5 adenosine5'-monophosphateUBE2C HLA class I histocompatibility antigen, A-43 alpha chain UBE2V2 HLA class I histocompatibility antigen, Cw-1 alpha chain HLA-B KBTBD8 UBB(77-152) UBE2Q2 MGRN1 KCTD6 HLA class I histocompatibility antigen, A-32 alpha chain UBA52(1-76) SOCS1 SEC23A class I MHC B8 HLA class I histocompatibility antigen, A-25 alpha chain class I MHC B55 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor class I MHC B56 CDC26 class I MHC B46 HLA class I histocompatibility antigen, A-32 alpha chain class I MHC B47 FBXO27 class I MHC B78 class I MHC B49 ELOB HLA class I histocompatibility antigen, Cw-16 alpha chain PSMA2 HERC4 ZNF645 class I MHC B41 class I MHC B53 SEC23A class I MHC B47 class I MHC B18 PSMD9 RLIM UNKL FBXO2 UBC(77-152) PSMB8 Antigen peptidebound class I MHCHLA class I histocompatibility antigen, A-43 alpha chain class I MHC B47 HLA class I histocompatibility antigen, A-36 alpha chain SAR1B HLA-C PSMA4 class I MHC B54 SAR1B class I MHC B44 MEX3C FBXW9 TRIM69 SEC31Aclass I MHC B47 class I MHC B42 UBE2A HLA-H HLA class I histocompatibility antigen, Cw-16 alpha chain TAPB2M(21-119) class I MHC B35 class I MHC B13 HLA class I histocompatibility antigen, E alpha chain precursor CDC26 class I MHC B46 PSMB1 HLA class I histocompatibility antigen, E alpha chain precursor TPP2 HLA-H PSMD6 PSMB8 class I MHC B67 PARK2 VPRBP class I MHC B42 SEC24C PSMB11 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor HLA class I histocompatibility antigen, A-69 alpha chain COPIIFCGR class I MHC B8 PJA1 HLA class I histocompatibility antigen, A-34 alpha chain HLA class I histocompatibility antigen, Cw-5 alpha chain precursor class I MHC B39 RNF182 HLA class I histocompatibility antigen, A-26 alpha chain SEC23A TAP2 SEC23:SEC24HLA class I histocompatibility antigen, alpha chain G precursor HLA class I histocompatibility antigen, Cw-6 alpha chain precursor FBXL7 class I MHC B58 HLA class I histocompatibility antigen, Cw-12 alpha chain PSMD10 HLA class I histocompatibility antigen, A-30 alpha chain HLA class I histocompatibility antigen, Cw-1 alpha chain class I MHC B46 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor PSMD9 class I MHC B47 SEC22BUBA52(1-76) ASB2 ANAPC2 class I MHC B73 class I MHC B45 class I MHC B78 HLA class I histocompatibility antigen, A-11 alpha chain FBXO40 PDIA3 class I MHC B58 UBE2W HERC6 KLHL42 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor MRC1 class I MHC B52 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor FBXO10 HLA class I histocompatibility antigen, A-1 alpha chain precursor HLA class I histocompatibility antigen, Cw-16 alpha chain RBBP6 UBC(457-532) ASB16 HLA class I histocompatibility antigen, A-43 alpha chain class I MHC B81 MKRN1 HLA class I histocompatibility antigen, Cw-17 alpha chain HLA class I histocompatibility antigen, A-32 alpha chain RNF19A PSMB2 RNF14 HLA class I histocompatibility antigen, A-68 alpha chain TRIM36 HLA class I histocompatibility antigen, B-48 alpha chain ASB1 FBXL3 RNF111 UBAC1 KLHL11 MRC1 RNF144B class I MHC B18 HLA class I histocompatibility antigen, A-24 alpha chain PSMD2 HLA class I histocompatibility antigen, A-30 alpha chain PDIA3 ANAPC4 HLA-H UBE2Q1 KLHL11 HLA class I histocompatibility antigen, A-32 alpha chain KLHL42 class I MHC B35 HLA class I histocompatibility antigen, A-36 alpha chain class I MHC B82 Exogenous soluble antigen FBXO10 UBR4 class I MHC B7 FBXW5 FBXL8 UBC(1-76) class I MHC B82 partially digestedAgFBXO44 ASB6 DTX3L CDC26 CBLB class I MHC B44 KLHL22 WSB1 UBE2E2 HLA class I histocompatibility antigen, A-43 alpha chain MRC2 UBE2O FBXW9 UBC(153-228) ASB13 class I MHC B73 FBXO11 UBE2R2 UBE2Z CUL7 HLA class I histocompatibility antigen, Cw-14 alpha chain B2M(21-119) KLHL20 HLA-B class I MHC B67 SEC24A UBC(533-608) class I MHC B39 FBXO15 SEC31A FBXL13 HLA class I histocompatibility antigen, Cw-14 alpha chain class I MHC B78 class I MHC B14 FBXL8 class I MHC B51 HLA class I histocompatibility antigen, A-3 alpha chain precursor HLA class I histocompatibility antigen, Cw-4 alpha chain precursor HLA class I histocompatibility antigen, A-31 alpha chain TRIM36 class I MHC B51 HLA class I histocompatibility antigen, Cw-1 alpha chain HLA class I histocompatibility antigen, Cw-14 alpha chain MR/other probablereceptorsclass I MHC B57 RNF213 class I MHC B44 CBLB class I MHC B41 class I MHC B54 class I MHC B51 DTX3L class I MHC B58 ITGB5 UBC(153-228) HLA class I histocompatibility antigen, A-33 alpha chain UBB(153-228) HACE1 FBXO41 HLA class I histocompatibility antigen, Cw-12 alpha chain class I MHC B41 class I MHC B53 HLA class I histocompatibility antigen, E alpha chain precursor HLA class I histocompatibility antigen, A-69 alpha chain SAR1B:GTPFBXL15 class I MHC B57 class I MHC B50 LNPEP HLA class I histocompatibility antigen, A-1 alpha chain precursor ITCH class I MHC B50 class I MHC B18 UBB(1-76) CALRclass I MHC B44 KLHL22 ASB16 PSMD10 ASB16 O2HLA class I histocompatibility antigen, Cw-2 alpha chain class I MHC B78 class I MHC B37 TAP2 HLA class I histocompatibility antigen, Cw-1 alpha chain RPS27A(1-76) L-amino acidBTBD6 class I MHC B7 WWP1 HLA class I histocompatibility antigen, A-3 alpha chain precursor HLA class I histocompatibility antigen, A-26 alpha chain PSMC5 TRAIP HLA class I histocompatibility antigen, Cw-14 alpha chain KCTD7 HLA class I histocompatibility antigen, Cw-7 alpha chain precursor class I MHC B15 SEC24B class I MHC B7 HLA class I histocompatibility antigen, A-68 alpha chain GDPERAP1 UBE2S class I MHC B54 class I MHC B18 HLA-H HLA class I histocompatibility antigen, A-31 alpha chain TRIM41 class I MHC B47 SKP1 FBXO27 HLA class I histocompatibility antigen, Cw-7 alpha chain precursor KLHL5 LRSAM1 MR:soluble antigenHLA class I histocompatibility antigen, Cw-15 alpha chain HLA class I histocompatibility antigen, Cw-16 alpha chain HLA class I histocompatibility antigen, A-32 alpha chain RNF138 HLA class I histocompatibility antigen, A-3 alpha chain precursor ATPRNF144B class I MHC B27 class I MHC B8 HECTD3 UBA52(1-76) HLA-H SEC24C BTBD6 MEX3C AREL1 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor class I MHC B81 HLA class I histocompatibility antigen, Cw-12 alpha chain MGRN1 HLA class I histocompatibility antigen, A-1 alpha chain precursor RNF138 UBR1 MGRN1 PSMA8 B2M(21-119)Exogenous Particulate antigen (Ag) KLHL13 HLA class I histocompatibility antigen, A-36 alpha chain class I MHC B37 PSMC3 HLA class I histocompatibility antigen, A-3 alpha chain precursor HLA class I histocompatibility antigen, A-74 alpha chain CDC20 class I MHC B42 PSMD11 CALR:SEC22B:STX4:TAP:TAPBPclass I MHC B67 HLA-H class I MHC B78 HLA class I histocompatibility antigen, A-11 alpha chain class I MHC B59 HLA class I histocompatibility antigen, A-43 alpha chain class I MHC B73 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor UBC(229-304) HLA class I histocompatibility antigen, A-33 alpha chain class I MHC B52 class I MHC B7 class I MHC B7 GDP STUB1 HLA class I histocompatibility antigen, Cw-17 alpha chain UBC(153-228) HLA-H IRAP in complex withMHC class IFBXL18 UBE2C class I MHC B82 CUL2 H+class I MHC B41 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor FBXO21 (Glc)1 (GlcNAc)2 (Man)9 SHFM1 class I MHC B13 GAN ASB7 HLA class I histocompatibility antigen, A-23 alpha chain FBXW2 RNF19B HLA class I histocompatibility antigen, Cw-12 alpha chain HLA class I histocompatibility antigen, Cw-4 alpha chain precursor HECTD3 UBC(305-380) MIB2 class I MHC B57 HLA class I histocompatibility antigen, A-32 alpha chain class I MHC B73 HLA class I histocompatibility antigen, Cw-14 alpha chain class I MHC B38 (Glc)1 (GlcNAc)2 (Man)9 FBXL18 HLA-H TRIM37 UBE2H UBA52(1-76) class I MHC B35 SEC24C FBXW4 MRC1 HLA class I histocompatibility antigen, A-33 alpha chain HLA-B class I MHC B67 class I MHC B42 class I MHC B82 KLHL9 HLA class I histocompatibility antigen, A-26 alpha chain UBC(457-532) class I MHC B46 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor UBR4 oligopeptidefragment (8-16aa)HLA class I histocompatibility antigen, E alpha chain precursor class I MHC B39 HLA class I histocompatibility antigen, Cw-2 alpha chain HLA class I histocompatibility antigen, Cw-7 alpha chain precursor UBE2W class I MHC B67 BLMH class I MHC B81 class I MHC B52 HLA class I histocompatibility antigen, A-66 alpha chain HERC4 HLA class I histocompatibility antigen, A-68 alpha chain HLA class I histocompatibility antigen, Cw-3 alpha chain precursor class I MHC B54 E3:Ub:substrateclass I MHC B38 HLA class I histocompatibility antigen, Cw-17 alpha chain HLA class I histocompatibility antigen, Cw-1 alpha chain DTX3L FBXO41 class I MHC B44 PSMB9 FBXO27 FBXW5 B2M(21-119) HLA class I histocompatibility antigen, A-33 alpha chain UBC(381-456) class I MHC B50 KLHL2 HLA class I histocompatibility antigen, A-69 alpha chain class I MHC B42 HLA class I histocompatibility antigen, A-34 alpha chain class I MHC B56 HLA class I histocompatibility antigen, A-33 alpha chain KBTBD13 UBR1 HLA class I histocompatibility antigen, Cw-18 alpha chain HLA class I histocompatibility antigen, alpha chain F precursor SIAH2 HLA class I histocompatibility antigen, Cw-12 alpha chain UBB(77-152) TRIP12 class I MHC B41 class I MHC B37 HLA class I histocompatibility antigen, Cw-8 alpha chain HLA class I histocompatibility antigen, A-80 alpha chain class I MHC B39 PSMD2 HERC3 FBXO32 class I MHC B52 class I MHC B78 HLA class I histocompatibility antigen, A-74 alpha chain HLA class I histocompatibility antigen, A-2 alpha chain ASB6 PSMA7 FBXO9 class I MHC B56 PSMD2 TAP2 HLA class I histocompatibility antigen, Cw-17 alpha chain HLA class I histocompatibility antigen, Cw-14 alpha chain class I MHC B47 HLA class I histocompatibility antigen, A-30 alpha chain class I MHC B49 UBAC1 THOP1RBCK1 class I MHC B27 class I MHC B15 FBXO6 FBXO31 ASB15 class I MHC B52 HLA class I histocompatibility antigen, A-36 alpha chain Antigen peptide HLA class I histocompatibility antigen, Cw-6 alpha chain precursor class I MHC B56 class I MHC B42 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor HLA class I histocompatibility antigen, A-34 alpha chain RNF34 HLA class I histocompatibility antigen, A-26 alpha chain HLA class I histocompatibility antigen, A-80 alpha chain UBC(229-304) HLA class I histocompatibility antigen, A-80 alpha chain FBXL20 DZIP3 HLA class I histocompatibility antigen, A-80 alpha chain class I MHC B49 class I MHC B59 HLA-H HLA class I histocompatibility antigen, Cw-7 alpha chain precursor class I MHC B45 HLA class I histocompatibility antigen, A-36 alpha chain RNF6 class I MHC B7 HLA class I histocompatibility antigen, A-43 alpha chain class I MHC B59 MR/other probablereceptorsHLA class I histocompatibility antigen, alpha chain F precursor HLA class I histocompatibility antigen, A-23 alpha chain FBXL12 COPII vesicle withMHC class IHLA class I histocompatibility antigen, A-24 alpha chain class I MHC B59 RNF115 class I MHC B18 CUL5 class I MHC B55 HLA class I histocompatibility antigen, A-31 alpha chain ELOB class I MHC B81 class I MHC B54 KLHL20 UBE2J2 HLA class I histocompatibility antigen, A-80 alpha chain RNF6 FBXO30 class I MHC B39 HLA class I histocompatibility antigen, A-25 alpha chain TRIM41 class I MHC B58 class I MHC B35 class I MHC B58 HLA class I histocompatibility antigen, A-1 alpha chain precursor class I MHC B37 HLA class I histocompatibility antigen, A-80 alpha chain HLA class I histocompatibility antigen, Cw-15 alpha chain antigenic substrateHLA class I histocompatibility antigen, A-36 alpha chain FBXW2 class I MHC B40 class I MHC B49 SMURF1 HLA-B class I MHC B15 UBE2S UBR4 HLA class I histocompatibility antigen, A-29 alpha chain UbRCHY1 TRIM39 UBC(229-304) SMURF2 UBB(1-76) class I MHC B45 CD207 PSMB4 FBXO22 KLHL21 HLA class I histocompatibility antigen, Cw-14 alpha chain class I MHC B15 class I MHC B8 SKP1 PSMB10 RNF25 HLA class I histocompatibility antigen, Cw-2 alpha chain HLA class I histocompatibility antigen, alpha chain F precursor SOCS1 HLA class I histocompatibility antigen, A-69 alpha chain TRIM11 PJA2 ITGB5 FBXL21 HLA-B precursor peptidefragment (>16 aa)UBE2L6 FBXL16 class I MHC B56 ASB2 NADPHRNF115 RNF14 RNF41 class I MHC B50 class I MHC B15 TRIM4 TAPHLA class I histocompatibility antigen, Cw-8 alpha chain class I MHC B55 FBXO7 PSMC2 LMO7 ATPLNX1 UBB(153-228) H2OGTP UBE2L3 class I MHC B57 ANAPC2 HLA class I histocompatibility antigen, A-1 alpha chain precursor class I MHC B40 SEC24B KLHL41 CDC20 4xPalmC-CD36 PSMC6 class I MHC B8 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor FBXO27 HACE1 HLA class I histocompatibility antigen, A-68 alpha chain ASB11 HLA class I histocompatibility antigen, Cw-15 alpha chain class I MHC B14 HLA class I histocompatibility antigen, Cw-16 alpha chain HLA class I histocompatibility antigen, alpha chain G precursor ITCH UBE2U MIB2 UBC(305-380) HLA class I histocompatibility antigen, A-26 alpha chain MGRN1 class I MHC B52 HERC4 HLA-H class I MHC B38 FBXO32 FBXL5 class I MHC B18 UBE2B ASB18 ASB3 class I MHC B52 class I MHC B46 HLA class I histocompatibility antigen, A-1 alpha chain precursor class I MHC B67 UBE2G1 TRIM9 HLA class I histocompatibility antigen, A-33 alpha chain HLA class I histocompatibility antigen, Cw-4 alpha chain precursor PSMD13 class I MHC B54 SEC23A TRIM21 class I MHC B50 HLA class I histocompatibility antigen, A-24 alpha chain HLA class I histocompatibility antigen, A-24 alpha chain FBXL5 class I MHC B38 HLA class I histocompatibility antigen, A-24 alpha chain UBE2V2 SEC23A HLA class I histocompatibility antigen, Cw-4 alpha chain precursor class I MHC B37 HLA class I histocompatibility antigen, Cw-14 alpha chain FBXW8 HLA class I histocompatibility antigen, A-11 alpha chain FBXO41 class I MHC B44 UBE2O class I MHC B53 FBXL20 HLA class I histocompatibility antigen, A-36 alpha chain PSMA5 PSMA6 B2M(21-119) class I MHC B56 class I MHC B47 HLA class I histocompatibility antigen, Cw-1 alpha chain Exogenous soluble antigen KBTBD13 UBE2U TRIM9 PSME2 ASB14 RNF130 CDC16 UBA6 PSMD9 PSMB6 HERC1 HLA class I histocompatibility antigen, A-24 alpha chain HLA class I histocompatibility antigen, A-1 alpha chain precursor UBE2Z PSME2 TRAIP SEC24B ANAPC4 HLA class I histocompatibility antigen, A-74 alpha chain RNF19A HERC5 class I MHC B38 HLA class I histocompatibility antigen, A-33 alpha chain class I MHC B57 PSMC1 HLA class I histocompatibility antigen, A-34 alpha chain SEC24D TAP2 PSMA3 class I MHC B8 SEC13ELOC HLA class I histocompatibility antigen, A-34 alpha chain class I MHC B55 FBXO40 HLA class I histocompatibility antigen, Cw-16 alpha chain HLA class I histocompatibility antigen, A-32 alpha chain FBXO7 class I MHC B38 26S proteasomeclass I MHC B15 FBXO15 VHL PSMB11 class I MHC B35 ELOB HLA class I histocompatibility antigen, Cw-12 alpha chain HLA class I histocompatibility antigen, A-68 alpha chain ASB9 HLA class I histocompatibility antigen, Cw-15 alpha chain PSMC5 HLA class I histocompatibility antigen, A-68 alpha chain HLA class I histocompatibility antigen, Cw-5 alpha chain precursor KLHL21 class I MHC B14 HLA class I histocompatibility antigen, A-23 alpha chain HLA class I histocompatibility antigen, A-24 alpha chain UBE3A RNF6 B2M(21-119) ELOC class I MHC B58 HLA class I histocompatibility antigen, A-1 alpha chain precursor L-amino acidHLA class I histocompatibility antigen, Cw-3 alpha chain precursor HLA class I histocompatibility antigen, Cw-6 alpha chain precursor FCGR ANAPC10 HLA class I histocompatibility antigen, alpha chain G precursor FZR1 FBXL13 FBXO9 TRIM69 HECTD1 class I MHC B40 IFN gamma stimulatedaminopeptidasesPSMB5 HLA class I histocompatibility antigen, A-33 alpha chain Chaperonescalnexin/BiPclass I MHC B37 HLA class I histocompatibility antigen, Cw-14 alpha chain HECTD1 ARIH2 ZNF645 HLA class I histocompatibility antigen, A-26 alpha chain class I MHC B45 HLA class I histocompatibility antigen, A-43 alpha chain class I MHC B82 FBXO22 NADP+CDC16 HLA class I histocompatibility antigen, Cw-12 alpha chain PSMC6 HLA class I histocompatibility antigen, Cw-15 alpha chain KLHL25 PSMB3 class I MHC B56 HLA class I histocompatibility antigen, A-11 alpha chain HLA class I histocompatibility antigen, A-66 alpha chain HERC1 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor HLA class I histocompatibility antigen, A-29 alpha chain ASB4 class I MHC B57 ANAPC1 UBR1 class I MHC B44 UBB(1-76) class I MHC B58 O2.-HLA class I histocompatibility antigen, A-80 alpha chain HLA class I histocompatibility antigen, A-80 alpha chain class I MHC B47 PSMD3 Exogenous soluble antigen HLA class I histocompatibility antigen, A-23 alpha chain B2M(21-119) HLA-B HLA class I histocompatibility antigen, alpha chain G precursor TAP1 class I MHC B15 ASB18 HLA class I histocompatibility antigen, A-26 alpha chain class I MHC B56 UBE2M class I MHC B78 FBXL22 FBXO22 class I MHC B7 TRIM69 class I MHC B52 class I MHC B78 HLA class I histocompatibility antigen, A-30 alpha chain HLA class I histocompatibility antigen, A-26 alpha chain ASB14 TAPBPHLA class I histocompatibility antigen, A-24 alpha chain class I MHC B58 TAP1 UBE2E1 UBE3A class I MHC B56 UBE2E3 UBE4A class I MHC B54 PSMA2 class I MHC B82 class I MHC B51 HLA class I histocompatibility antigen, A-29 alpha chain PJA2 class I MHC B81 SPSB2 HUWE1 HUWE1 HLA class I histocompatibility antigen, A-11 alpha chain HLA class I histocompatibility antigen, Cw-3 alpha chain precursor class I MHC B39 class I MHC B56 WWP1 HLA class I histocompatibility antigen, alpha chain G precursor class I MHC B42 HLA class I histocompatibility antigen, A-32 alpha chain class I MHC B27 class I MHC B38 class I MHC B41 UBE2D3 SEC24A PSMA4 CTSS KLHL41 class I MHC B13 KLHL9 class I MHC B13 RBBP6 class I MHC B54 HLA class I histocompatibility antigen, A-74 alpha chain Ag-substrate:E3:E2:UbDC receptorsrecognizingapoptotic cellsRNF182 HLA class I histocompatibility antigen, A-24 alpha chain UBE2L3 Antigen peptidebound class IMHC:BAP31 oligomerSEC24B HLA class I histocompatibility antigen, A-80 alpha chain UBC(533-608) HLA class I histocompatibility antigen, Cw-15 alpha chain class I MHC B41 class I MHC B14 CUL7 HECTD1 class I MHC B18 UBC(609-684) DET1 class I MHC B44 oligopeptide fragment HSPA5 PSMB9 LONRF1 HLA class I histocompatibility antigen, A-2 alpha chain HLA class I histocompatibility antigen, A-34 alpha chain class I MHC B47 Ubiquitin:E2conjugating enzymesPSMD7 HLA class I histocompatibility antigen, A-36 alpha chain HLA class I histocompatibility antigen, A-3 alpha chain precursor HLA class I histocompatibility antigen, A-68 alpha chain RCHY1 class I MHC B58 HLA class I histocompatibility antigen, Cw-8 alpha chain class I MHC B55 class I MHC B51 class I MHC B44 class I MHC B13 class I MHC B78 class I MHC B8 PSMA5 HLA class I histocompatibility antigen, A-23 alpha chain class I MHC B15 UBC(533-608) HLA class I histocompatibility antigen, Cw-8 alpha chain ASB17 CD36 HLA class I histocompatibility antigen, A-31 alpha chain SH3RF1 class I MHC B50 UBE2M class I MHC B7 FBXL16 KBTBD6 HLA class I histocompatibility antigen, Cw-18 alpha chain HLA-H HLA class I histocompatibility antigen, Cw-17 alpha chain ANAPC7 HLA class I histocompatibility antigen, A-23 alpha chain HLA class I histocompatibility antigen, A-11 alpha chain HUWE1 UBE2E3 RNF123 class I MHC B58 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor PSMC1 class I MHC B53 HLA class I histocompatibility antigen, A-23 alpha chain HLA class I histocompatibility antigen, A-31 alpha chain HLA class I histocompatibility antigen, A-23 alpha chain HLA class I histocompatibility antigen, A-36 alpha chain class I MHC B8 HLA class I histocompatibility antigen, A-30 alpha chain HLA class I histocompatibility antigen, Cw-15 alpha chain class I MHC B39 RNF111 ASB9 ANAPC2 HLA class I histocompatibility antigen, A-26 alpha chain class I MHC B55 RNF213 UBA7 CUL5 PSMD3 class I MHC B37 PSMD8 class I MHC B8 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor TRAIP HLA class I histocompatibility antigen, A-69 alpha chain class I MHC B8 PPiMR:soluble antigenclass I MHC B56 HLA class I histocompatibility antigen, Cw-1 alpha chain class I MHC B57 HACE1 HLA class I histocompatibility antigen, A-29 alpha chain HLA class I histocompatibility antigen, A-43 alpha chain PDIA3 class I MHC B18 PSMF1 class I MHC B14 HLA class I histocompatibility antigen, A-24 alpha chain FBXL22 HLA class I histocompatibility antigen, Cw-2 alpha chain HLA class I histocompatibility antigen, A-34 alpha chain ASB15 KLHL3 class I MHC B41 class I MHC B57 class I MHC B81 HLA class I histocompatibility antigen, A-29 alpha chain PI(4,5)P2 class I MHC B59 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor KLHL41 class I MHC B82 SMURF1 class I MHC B57 HLA class I histocompatibility antigen, E alpha chain precursor CCNF class I MHC B58 class I MHC B55 HLA class I histocompatibility antigen, A-33 alpha chain MRC2 HLA class I histocompatibility antigen, A-80 alpha chain E3 ligases inproteasomaldegradationUBC(381-456) HLA class I histocompatibility antigen, Cw-1 alpha chain class I MHC B78 FBXL13 E3:K48-polyubiquitinated substrateHLA class I histocompatibility antigen, A-29 alpha chain TRIM71 HLA class I histocompatibility antigen, Cw-18 alpha chain UBE3D HLA class I histocompatibility antigen, Cw-18 alpha chain UBOX5 FBXL12 HLA class I histocompatibility antigen, A-31 alpha chain HLA class I histocompatibility antigen, A-24 alpha chain HLA class I histocompatibility antigen, Cw-12 alpha chain FBXL8 HLA class I histocompatibility antigen, A-2 alpha chain GTP HLA class I histocompatibility antigen, A-31 alpha chain FBXO17 UBA7 HLA class I histocompatibility antigen, A-29 alpha chain HLA class I histocompatibility antigen, A-30 alpha chain class I MHC B27 HLA-H TRAF7 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor class I MHC B52 HLA class I histocompatibility antigen, A-25 alpha chain HLA class I histocompatibility antigen, A-2 alpha chain ITGAV(31-1048) class I MHC B82 RNF144B HLA class I histocompatibility antigen, A-25 alpha chain HLA class I histocompatibility antigen, Cw-2 alpha chain SIAH1 SEC23A class I MHC B55 HLA class I histocompatibility antigen, Cw-12 alpha chain UBE2O class I MHC B47 DZIP3 class I MHC B58 SPSB4 ANAPC13 TAPBP class I MHC B39 HERC5 PSME3 class I MHC B42 PSMB9 HLA class I histocompatibility antigen, A-29 alpha chain RNF114 class I MHC B41 FBXL21 Antigen peptide HLA class I histocompatibility antigen, A-33 alpha chain WSB1 ARIH2 class I MHC B78 HLA class I histocompatibility antigen, A-68 alpha chain class I MHC B47 CUL2 PSMD8 FBXW9 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor class I MHC B51 BAP31 oligomerCD207 class I MHC B53 UBC(609-684) LMO7 class I MHC B81 HLA class I histocompatibility antigen, alpha chain F precursor RNF220 RNF7 (RBX2) HLA class I histocompatibility antigen, alpha chain G precursor class I MHC B82 HLA class I histocompatibility antigen, Cw-12 alpha chain MRC2 HLA class I histocompatibility antigen, Cw-14 alpha chain GAN class I MHC B67 class I MHC B37 SKP2 TAPBPUBC(457-532) CYBB HLA class I histocompatibility antigen, E alpha chain precursor HUWE1 HLA class I histocompatibility antigen, alpha chain G precursor HLA class I histocompatibility antigen, A-30 alpha chain FBXL15 class I MHC B40 HLA class I histocompatibility antigen, Cw-18 alpha chain UBR2 PSMB10 HLA class I histocompatibility antigen, A-2 alpha chain KLHL20 ExogenousParticulate antigen(Ag)HLA class I histocompatibility antigen, A-36 alpha chain HLA class I histocompatibility antigen, A-11 alpha chain class I MHC B40 HLA class I histocompatibility antigen, A-24 alpha chain KLHL22 FBXO2 FCGR FBXW11 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor HLA class I histocompatibility antigen, Cw-12 alpha chain HLA class I histocompatibility antigen, alpha chain G precursor class I MHC B27 LRRC41 class I MHC B55 class I MHC B15 SPSB4 K48polyUb-partiallydigested Agclass I MHC B46 class I MHC B55 KEAP1 TRIM41 FBXW5 ASB5 class I MHC B37 KLHL21 2xN4GlycoAsn-TLR4 HLA class I histocompatibility antigen, Cw-7 alpha chain precursor class I MHC B35 UBC(77-152) class I MHC B13 class I MHC B40 UBE2L6 STX4 class I MHC B59 FBXO11 HLA class I histocompatibility antigen, A-1 alpha chain precursor (Glc)1 (GlcNAc)2 (Man)9 class I MHC B51 class I MHC B7 UBE2H HLA-H CALR MHCclassIHC:Calnexin/BiP:Erp57HLA class I histocompatibility antigen, alpha chain F precursor RBBP6 LRRC41 IKBKG ZBTB16 UBE2S class I MHC B35 class I MHC B42 HLA class I histocompatibility antigen, A-33 alpha chain HLA class I histocompatibility antigen, E alpha chain precursor PJA2 KCTD7 HLA-B HLA class I histocompatibility antigen, Cw-8 alpha chain class I MHC B82 CALR UBC(229-304) KBTBD6 FBXL3 class I MHC B73 PSMA3 GPIN-CD14(20-345) UBC(1-76) UFL1 HLA class I histocompatibility antigen, Cw-8 alpha chain HLA class I histocompatibility antigen, A-26 alpha chain class I MHC B40 SAR1B HLA class I histocompatibility antigen, A-3 alpha chain precursor HLA class I histocompatibility antigen, A-30 alpha chain adenosine5'-monophosphateclass I MHC B27 class I MHC B18 class I MHC B49 FBXL22 ASB12 CDC34 HLA class I histocompatibility antigen, Cw-18 alpha chain LRR1 HLA class I histocompatibility antigen, A-30 alpha chain class I MHC B18 UBAC1 HLA class I histocompatibility antigen, Cw-18 alpha chain 4xPalmC-CD36 HLA class I histocompatibility antigen, Cw-18 alpha chain RNF138 CDC23 class I MHC B46 class I MHC B39 HLA class I histocompatibility antigen, A-2 alpha chain UBC(609-684) SMURF2 HLA class I histocompatibility antigen, A-29 alpha chain RBX1 RNF6 HLA class I histocompatibility antigen, A-33 alpha chain ADPSEC24A class I MHC B38 HLA class I histocompatibility antigen, Cw-7 alpha chain precursor TAP1 p-S95-SNAP23:VAMP8,VAMP3class I MHC B44 class I MHC B14 ASB4 ATPHLA class I histocompatibility antigen, Cw-8 alpha chain FBXL19 class I MHC B13 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor class I MHC B40 SPSB4 SOCS1 CDC27 HLA class I histocompatibility antigen, Cw-1 alpha chain class I MHC B58 ZBTB16 class I MHC B50 UBE2V1 HLA class I histocompatibility antigen, A-43 alpha chain class I MHC B42 RNF7 (RBX2) NEDD4L HLA class I histocompatibility antigen, Cw-18 alpha chain HLA class I histocompatibility antigen, Cw-8 alpha chain PSMF1 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor HLA class I histocompatibility antigen, A-1 alpha chain precursor HLA class I histocompatibility antigen, alpha chain G precursor RBCK1 class I MHC B39 NEDD4L HLA class I histocompatibility antigen, E alpha chain precursor (Glc)1 (GlcNAc)2 (Man)9 HLA class I histocompatibility antigen, A-29 alpha chain HERC6 HLA-B FBXL7 Diacyl lipopeptide class I MHC B37 PSMD7 class I MHC B82 HLA class I histocompatibility antigen, A-74 alpha chain HLA class I histocompatibility antigen, Cw-16 alpha chain Antigen peptideFBXL16 PSMD1 CUL5 UBC(153-228) class I MHC B15 HLA class I histocompatibility antigen, A-33 alpha chain B2M(21-119) SEC24C HLA class I histocompatibility antigen, A-34 alpha chain MRC2 HSPA5 ASB10 class I MHC B42 PARK2 UBE2G2 PSMC2 class I MHC B49 class I MHC B56 p-T154,S315-NCF4 HLA class I histocompatibility antigen, A-68 alpha chain PARK2 PJA2 ASB14 class I MHC B56 HLA class I histocompatibility antigen, Cw-17 alpha chain HLA class I histocompatibility antigen, A-26 alpha chain class I MHC B54 HLA class I histocompatibility antigen, A-29 alpha chain UBE2W HLA class I histocompatibility antigen, Cw-8 alpha chain TAPRPS27A(1-76) SKP2 TRIM39 PiHLA class I histocompatibility antigen, A-69 alpha chain precursor peptidefragment (>16 aa)PSMC5 class I MHC B18 class I MHC B47 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor class I MHC B14 class I MHC B15 (Glc)1 (GlcNAc)2 (Man)9 RNF4 class I MHC B15 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor HLA class I histocompatibility antigen, Cw-17 alpha chain class I MHC B13 HLA class I histocompatibility antigen, A-23 alpha chain class I MHC B44 class I MHC B53 ZBTB16 PSMD11 HLA class I histocompatibility antigen, Cw-1 alpha chain HLA class I histocompatibility antigen, Cw-16 alpha chain class I MHC B55 SPSB2 HLA class I histocompatibility antigen, alpha chain F precursor class I MHC B49 HLA class I histocompatibility antigen, alpha chain G precursor SEC24C class I MHC B15 HLA class I histocompatibility antigen, Cw-18 alpha chain LRR1 class I MHC B53 SEC24D RLIM ANAPC11 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor HLA class I histocompatibility antigen, A-23 alpha chain class I MHC B40 FBXO2 LTN1 class I MHC B52 FBXL18 RNF217 class I MHC B38 class I MHC B49 class I MHC B59 HLA class I histocompatibility antigen, A-26 alpha chain FBXO44 UBE3D HLA class I histocompatibility antigen, E alpha chain precursor CUL2 SMURF2 ANAPC11 HLA class I histocompatibility antigen, Cw-12 alpha chain class I MHC B27 HLA class I histocompatibility antigen, A-33 alpha chain ZNF645 HLA class I histocompatibility antigen, Cw-15 alpha chain L-amino acidRNF111 TRIM32 HLA class I histocompatibility antigen, A-24 alpha chain class I MHC B18 SKP1 class I MHC B44 class I MHC B55 KBTBD13 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor HLA class I histocompatibility antigen, A-25 alpha chain HLA class I histocompatibility antigen, A-3 alpha chain precursor HLA class I histocompatibility antigen, Cw-2 alpha chain HLA class I histocompatibility antigen, A-24 alpha chain RNF126 LRSAM1 PSMB7 ASB11 class I MHC B46 PDIA3HLA class I histocompatibility antigen, Cw-1 alpha chain HLA class I histocompatibility antigen, A-66 alpha chain BTRC class I MHC B49 HLA class I histocompatibility antigen, Cw-8 alpha chain DET1 SEC24A RNF19B ANAPC1 PSME1 HLA class I histocompatibility antigen, A-66 alpha chain HLA class I histocompatibility antigen, Cw-2 alpha chain class I MHC B27 HLA class I histocompatibility antigen, A-34 alpha chain HLA class I histocompatibility antigen, A-26 alpha chain class I MHC B45 HLA class I histocompatibility antigen, A-33 alpha chain 26S proteasomeHLA class I histocompatibility antigen, A-3 alpha chain precursor TAP1 FBXW4 HLA class I histocompatibility antigen, Cw-12 alpha chain H2OKLHL2 KLHL2 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor class I MHC B54 class I MHC B78 RNF114 HLA-B CUL2 UBE2D1 CDC27 UBE2D2 MKRN1 CALRclass I MHC B51 HLA class I histocompatibility antigen, Cw-18 alpha chain FBXL19 class I MHC B59 class I MHC B54 TRAF7 HLA class I histocompatibility antigen, A-23 alpha chain HLA class I histocompatibility antigen, A-1 alpha chain precursor Triacyl lipopeptide ASB15 RNF114 DET1 GTP HLA class I histocompatibility antigen, Cw-12 alpha chain UBE2N ANAPC7 HLA class I histocompatibility antigen, Cw-15 alpha chain class I MHC B82 class I MHC B51 HLA class I histocompatibility antigen, A-43 alpha chain class I MHC B41 TRIM32 class I MHC B38 HLA class I histocompatibility antigen, E alpha chain precursor HLA class I histocompatibility antigen, A-26 alpha chain TRIM21 DC receptorsrecognizingapoptotic cellsFBXL22 HLA class I histocompatibility antigen, Cw-1 alpha chain HLA class I histocompatibility antigen, A-74 alpha chain BTRC ASB7 class I MHC B54 HLA class I histocompatibility antigen, A-34 alpha chain STX4 ASB13 UBE2Q2 Ubclass I MHC B46 HLA class I histocompatibility antigen, A-68 alpha chain class I MHC B81 HLA class I histocompatibility antigen, Cw-15 alpha chain HLA class I histocompatibility antigen, A-30 alpha chain UBA5 class I MHC B51 PSMA6 FBXL14 HLA class I histocompatibility antigen, Cw-18 alpha chain HECTD3 HLA class I histocompatibility antigen, A-69 alpha chain HLA class I histocompatibility antigen, A-32 alpha chain CALRRNF126 class I MHC B14 FBXW10 UBC(381-456) UBE2B HLA class I histocompatibility antigen, A-31 alpha chain ASB8 SAR1B SEC24B Antigen peptide class I MHC B13 KBTBD7 VPRBP HLA class I histocompatibility antigen, E alpha chain precursor HLA class I histocompatibility antigen, Cw-7 alpha chain precursor class I MHC B50 class I MHC B35 HLA class I histocompatibility antigen, Cw-17 alpha chain FCGRA HLA class I histocompatibility antigen, Cw-16 alpha chain KCTD6 PSMD13 HLA class I histocompatibility antigen, Cw-7 alpha chain precursor HLA class I histocompatibility antigen, A-80 alpha chain Ubiquitin activatingE1 enzymesHLA class I histocompatibility antigen, Cw-17 alpha chain HLA class I histocompatibility antigen, alpha chain F precursor 2xN4GlycoAsn-LY96 HLA class I histocompatibility antigen, Cw-7 alpha chain precursor class I MHC B27 FBXO44 FBXW2 p-S95-SNAP23HLA class I histocompatibility antigen, A-31 alpha chain class I MHC B39 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor BTBD1 CUL1 class I MHC B78 HLA-B CANX SEC13 UBC(229-304) HLA class I histocompatibility antigen, Cw-6 alpha chain precursor SH3RF1 class I MHC B38 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor class I MHC B14 TRIM71 class I MHC B42 HLA class I histocompatibility antigen, A-74 alpha chain HLA class I histocompatibility antigen, A-74 alpha chain PSMB6 HLA class I histocompatibility antigen, A-32 alpha chain class I MHC B73 class I MHC B46 class I MHC B57 HLA class I histocompatibility antigen, A-43 alpha chain SOCS3 Antigen peptidebound class I MHCUBE3B ANAPC5 HLA class I histocompatibility antigen, Cw-17 alpha chain class I MHC B40 class I MHC B59 FBXL5 FBXL3 class I MHC B45 HLA class I histocompatibility antigen, A-43 alpha chain class I MHC B8 class I MHC B54 HLA class I histocompatibility antigen, A-25 alpha chain FBXO7 ANAPC4 FBXL8 PSMB4 RNF144B SPSB1 class I MHC B81 RNF4 UBE2E1 FBXW12 UBE2F HLA class I histocompatibility antigen, A-25 alpha chain (Glc)1 (GlcNAc)2 (Man)9 class I MHC B78 UBE3C class I MHC B42 class I MHC B41 class I MHC B57 HLA class I histocompatibility antigen, A-32 alpha chain CDC20 p-4Y-TIRAP class I MHC B82 HLA class I histocompatibility antigen, Cw-8 alpha chain RNF25 UBE2Q1 UBE2D1 PSMD4 ANAPC5 class I MHC B51 class I MHC B67 class I MHC B57 class I MHC B44 FBXW11 ASB11 UBE2D4 HLA class I histocompatibility antigen, A-32 alpha chain HLA class I histocompatibility antigen, Cw-2 alpha chain CD207 PSMD3 UBA52(1-76) class I MHC B37 class I MHC B67 class I MHC B42 LNPEP LTN1 PSMB3 KLHL21 Ag peptide boundclass I MHCclass I MHC B38 HLA class I histocompatibility antigen, A-1 alpha chain precursor class I MHC B44 class I MHC B42 HLA class I histocompatibility antigen, A-66 alpha chain class I MHC B13 HLA class I histocompatibility antigen, A-2 alpha chain KLHL11 SKP2 HLA class I histocompatibility antigen, A-43 alpha chain UBA7 class I MHC B78 class I MHC B14 UBC(457-532) class I MHC B13 SMURF1 IKBKB SAR1B HLA class I histocompatibility antigen, Cw-8 alpha chain ASB2 HLA class I histocompatibility antigen, Cw-14 alpha chain SEC24B HLA class I histocompatibility antigen, A-66 alpha chain KEAP1 CUL1 UBE2D2 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor class I MHC B54 HLA class I histocompatibility antigen, Cw-18 alpha chain UBB(153-228) PSMD12 TRIM4 TRAIP class I MHC B45 HLA class I histocompatibility antigen, A-2 alpha chain CUL7 VHL HLA class I histocompatibility antigen, A-3 alpha chain precursor CUL3 class I MHC B18 class I MHC B39 class I MHC B45 class I MHC B46 HLA class I histocompatibility antigen, Cw-17 alpha chain class I MHC B55 HLA class I histocompatibility antigen, A-34 alpha chain class I MHC B57 HLA class I histocompatibility antigen, A-68 alpha chain HLA class I histocompatibility antigen, B-48 alpha chain class I MHC B45 ASB3 class I MHC B49 HLA class I histocompatibility antigen, Cw-16 alpha chain HLA class I histocompatibility antigen, A-66 alpha chain UBE2V1 class I MHC B51 HLA class I histocompatibility antigen, A-69 alpha chain GLMN KLHL5 HLA class I histocompatibility antigen, A-80 alpha chain KLHL42 FBXO41 class I MHC B52 HLA-H TAP2 RNF220 class I MHC B78 class I MHC B51 class I MHC B58 class I MHC B67 class I MHC B73 HLA class I histocompatibility antigen, A-31 alpha chain TRIM71 HLA class I histocompatibility antigen, A-11 alpha chain HLA class I histocompatibility antigen, Cw-3 alpha chain precursor class I MHC B50 class I MHC B82 LMO7 HLA class I histocompatibility antigen, A-30 alpha chain HLA class I histocompatibility antigen, A-66 alpha chain UBC(457-532) DZIP3 class I MHC B53 MYD88 ITGAV(31-1048) class I MHC B47 KLHL41 UBC(305-380) UBE2N class I MHC B15 class I MHC B47 (Glc)1 (GlcNAc)2 (Man)9 RNF130 SNAP23HLA class I histocompatibility antigen, Cw-14 alpha chain HLA class I histocompatibility antigen, A-69 alpha chain HLA class I histocompatibility antigen, A-80 alpha chain RNF130 ZNRF2 class I MHC B82 RNF126 KLHL9 class I MHC B67 UBB(1-76) UBE2D1 class I MHC B27 KBTBD13 HERC5 class I MHC B39 HLA class I histocompatibility antigen, A-43 alpha chain SEC22B:STX4HLA class I histocompatibility antigen, A-25 alpha chain LNX1 HLA class I histocompatibility antigen, Cw-12 alpha chain FBXO31 class I MHC B39 UBC(533-608) HLA class I histocompatibility antigen, A-25 alpha chain class I MHC B27 ARIH2 class I MHC B46 CD207 class I MHC B55 CDC23 KLHL3 HLA class I histocompatibility antigen, A-32 alpha chain class I MHC B50 BTBD1 class I MHC B52 p-6S-NCF1 FBXW9 class I MHC B54 UBE2Q2 LRRC41 PSMA7 class I MHC B47 CDC16 ASB5 HLA class I histocompatibility antigen, Cw-1 alpha chain UBB(1-76) HLA class I histocompatibility antigen, A-26 alpha chain CUL7 HLA class I histocompatibility antigen, A-11 alpha chain FBXW11 VAMP3 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor HLA class I histocompatibility antigen, Cw-6 alpha chain precursor class I MHC B73 HLA class I histocompatibility antigen, A-36 alpha chain PSMB7 class I MHC B39 CTSL1(114-288) PSMB1 FBXW4 HLA class I histocompatibility antigen, A-11 alpha chain HLA class I histocompatibility antigen, Cw-12 alpha chain HLA class I histocompatibility antigen, A-66 alpha chain FBXL4 RCHY1 FBXO6 RNF123 UBE2V2 GTPClostridial peptidoglycan PSMD5 class I MHC B41 HLA class I histocompatibility antigen, A-11 alpha chain HLA class I histocompatibility antigen, A-66 alpha chain HLA class I histocompatibility antigen, A-66 alpha chain TRIM39 HLA class I histocompatibility antigen, A-74 alpha chain PSMA5 UBC(1-76) HLA class I histocompatibility antigen, A-34 alpha chain HLA class I histocompatibility antigen, Cw-12 alpha chain class I MHC B46 HLA class I histocompatibility antigen, A-32 alpha chain class I MHC B15 FBXL7 class I MHC B37 HERC6 FBXL4 HLA class I histocompatibility antigen, A-30 alpha chain class I MHC B81 HLA class I histocompatibility antigen, A-68 alpha chain class I MHC B37 RNF115 class I MHC B81 TRIM32 class I MHC B18 MRC1 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor TLR1 RNF115 SEC22B HLA class I histocompatibility antigen, Cw-15 alpha chain ASB8 TRIP12 HLA class I histocompatibility antigen, A-1 alpha chain precursor class I MHC B7 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor ITCH HLA class I histocompatibility antigen, A-80 alpha chain UBB(77-152) FBXO11 TAP1 class I MHC B59 class I MHC B7 UBE2M HERC3 HLA class I histocompatibility antigen, Cw-14 alpha chain FBXO30 HLA class I histocompatibility antigen, A-30 alpha chain HLA class I histocompatibility antigen, Cw-17 alpha chain PJA1 ZNRF1 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor RBX1 ASB8 HLA class I histocompatibility antigen, Cw-2 alpha chain UBE2D3 UBE2J1 UBE2G2 (Glc)1 (GlcNAc)2 (Man)9 class I MHC B8 (Glc)1 (GlcNAc)2 (Man)9 class I MHC B46 UBC(77-152) UBC(609-684) UBE2K FBXW10 UBA3 class I MHC B57 class I MHC B8 ANAPC2 class I MHC B46 FBXW10 ASB18 FZR1 PSMA1 class I MHC B78 GLMN PSMB3 HLA class I histocompatibility antigen, A-23 alpha chain PSME4 class I MHC B39 HLA class I histocompatibility antigen, A-66 alpha chain FBXO11 FBXO30 class I MHC B46 HLA class I histocompatibility antigen, Cw-14 alpha chain HECTD2 TRIM32 FBXO15 KEAP1 class I MHC B58 FBXW10 SEC24A SPSB4 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor HLA class I histocompatibility antigen, A-3 alpha chain precursor class I MHC B38 Antigen Class I MHCHC:B2M:Erp57FCGRA RNF4 class I MHC B37 FBXL4 class I MHC B73 UBE3C ERAP1/2ASB10 UBC(305-380) HLA class I histocompatibility antigen, Cw-12 alpha chain HLA class I histocompatibility antigen, Cw-3 alpha chain precursor RNF130 PSMA8 HLA class I histocompatibility antigen, alpha chain G precursor class I MHC B49 HLA-B HLA class I histocompatibility antigen, A-23 alpha chain UBE2D3 HLA class I histocompatibility antigen, A-36 alpha chain class I MHC B56 TRIM11 ASB1 Antigen SAR1B:GDPSTUB1 HLA class I histocompatibility antigen, A-32 alpha chain HLA class I histocompatibility antigen, A-23 alpha chain UBE2F CDC16 COPII vesicle withMHC class IRNF25 class I MHC B58 HLA class I histocompatibility antigen, A-69 alpha chain class I MHC B53 FBXO44 Antigen peptide UBE2K PSMA2 UBC(77-152) RPS27A(1-76) FBXL15 PJA1 HLA-B SEC24B HLA class I histocompatibility antigen, Cw-16 alpha chain ATPUBA5 SIAH1 class I MHC B47 FBXW7 SAR1B:GTP:SEC23:SEC24PSMB11 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor ASB5 26S proteasomeHLA class I histocompatibility antigen, Cw-2 alpha chain KCTD6 class I MHC B44 class I MHC B53 HLA class I histocompatibility antigen, A-33 alpha chain HLA class I histocompatibility antigen, A-68 alpha chain class I MHC B54 class I MHC B67 SEC61G HLA class I histocompatibility antigen, A-74 alpha chain class I MHC B55 UBE3B HLA class I histocompatibility antigen, Cw-3 alpha chain precursor UBOX5 HLA class I histocompatibility antigen, Cw-12 alpha chain MR:soluble antigenPSMC4 HECW2 HLA class I histocompatibility antigen, A-30 alpha chain SEC22BKBTBD8 class I MHC B45 class I MHC B73 HLA class I histocompatibility antigen, A-43 alpha chain PSMF1 class I MHC B39 HLA class I histocompatibility antigen, A-2 alpha chain ANAPC7 NEDD4L class I MHC B39 HLA class I histocompatibility antigen, A-25 alpha chain HLA class I histocompatibility antigen, Cw-17 alpha chain oligopeptidefragment (8-16aa)HLA class I histocompatibility antigen, Cw-16 alpha chain class I MHC B59 class I MHC B58 HLA class I histocompatibility antigen, Cw-8 alpha chain HLA class I histocompatibility antigen, Cw-5 alpha chain precursor KEAP1 class I MHC B46 TAP2 PSMC4 HLA class I histocompatibility antigen, A-43 alpha chain UBE2V1 UBE2D4 KLHL9 class I MHC B81 UBA52(1-76) ASB18 HLA class I histocompatibility antigen, A-80 alpha chain ITGB5 UNKL ANAPC1 class I MHC B53 SEC24FBXO9 HLA class I histocompatibility antigen, Cw-14 alpha chain HLA class I histocompatibility antigen, Cw-8 alpha chain PPiHLA class I histocompatibility antigen, A-3 alpha chain precursor KLHL25 RNF34 UBE3D class I MHC B13 class I MHC B40 SEC24A class I MHC B18 NPEPPS class I MHC B67 class I MHC B7 FBXL19 FBXO7 oligopeptidefragmentHLA class I histocompatibility antigen, A-69 alpha chain RNF126 class I MHC B56 class I MHC B35 TRIM37 ExogenousParticulate antigen(Ag)HLA class I histocompatibility antigen, A-11 alpha chain HLA class I histocompatibility antigen, A-25 alpha chain HLA class I histocompatibility antigen, Cw-1 alpha chain HLA class I histocompatibility antigen, A-11 alpha chain class I MHC B8 class I MHC B51 class I MHC B58 HLA class I histocompatibility antigen, A-11 alpha chain HLA class I histocompatibility antigen, Cw-18 alpha chain HLA class I histocompatibility antigen, Cw-1 alpha chain RNF217 RNF217 ASB1 class I MHC B57 HLA class I histocompatibility antigen, A-23 alpha chain B2M(21-119) RNF34 class I MHC B40 UBC(1-76) PSMD1 class I MHC B56 UNKL HECTD3 TRIM50 HERC1 HLA class I histocompatibility antigen, Cw-16 alpha chain HLA class I histocompatibility antigen, alpha chain G precursor class I MHC B38 ERAP2 class I MHC B7 KLHL13 HLA class I histocompatibility antigen, A-1 alpha chain precursor class I MHC B56 L-amino acidHLA class I histocompatibility antigen, Cw-2 alpha chain class I MHC B73 HLA class I histocompatibility antigen, A-2 alpha chain FBXW11 class I MHC B14 HLA class I histocompatibility antigen, A-1 alpha chain precursor ZBTB16 HLA class I histocompatibility antigen, A-24 alpha chain RNF220 monoglucosylated MHCclass IHC:Calnexin/BiPKCTD7 HLA class I histocompatibility antigen, A-25 alpha chain class I MHC B59 RBCK1 KBTBD6 ASB4 class I MHC B37 HLA class I histocompatibility antigen, A-80 alpha chain KLHL3 FBXW8 HLA class I histocompatibility antigen, A-23 alpha chain SH3RF1 class I MHC B13 HLA class I histocompatibility antigen, Cw-1 alpha chain SPSB1 HLA class I histocompatibility antigen, alpha chain F precursor HLA class I histocompatibility antigen, Cw-17 alpha chain UBC(381-456) class I MHC B8 class I MHC B7 ASB17 UBE3A class I MHC B73 ASB12 class I MHC B53 HLA class I histocompatibility antigen, A-31 alpha chain HLA class I histocompatibility antigen, Cw-16 alpha chain FBXL12 FBXO31 class I MHC B38 UNKL PSMD8 class I MHC B67 FBXO21 class I MHC B73 HLA class I histocompatibility antigen, A-80 alpha chain HLA class I histocompatibility antigen, A-24 alpha chain class I MHC B49 ASB6 HLA-H UBA7 HLA class I histocompatibility antigen, Cw-15 alpha chain UBE2C WWP1 class I MHC B55 HLA class I histocompatibility antigen, E alpha chain precursor TRIP12 RBCK1 HLA-H FBXL18 HLA class I histocompatibility antigen, A-30 alpha chain LMO7 UBOX5 NOX2 complexHLA class I histocompatibility antigen, Cw-3 alpha chain precursor class I MHC B44 FBXO17 class I MHC B40 FBXW8 HLA class I histocompatibility antigen, Cw-15 alpha chain UBE3C SKP1 HLA class I histocompatibility antigen, E alpha chain precursor UBE3A RNF4 class I MHC B13 HLA class I histocompatibility antigen, A-33 alpha chain class I MHC B27 FBXO32 BTRC HLA class I histocompatibility antigen, Cw-4 alpha chain precursor HLA-B BTBD6 TAPBP TRIM37 ZNRF1 Antigen peptidebound class I MHCHLA class I histocompatibility antigen, Cw-8 alpha chain ASB3 class I MHC B50 class I MHC B14 VAMP8 UBB(153-228) MYLIP HLA class I histocompatibility antigen, A-32 alpha chain class I MHC B54 ASB4 HLA class I histocompatibility antigen, A-68 alpha chain PSMD12 HLA class I histocompatibility antigen, A-43 alpha chain UBC(609-684) FBXO6 LONRF1 GAN HLA class I histocompatibility antigen, Cw-16 alpha chain class I MHC B53 ExogenousParticulate antigen(Ag)BTBD1 HLA class I histocompatibility antigen, Cw-2 alpha chain PDIA3 PSMC2 class I MHC B49 HLA class I histocompatibility antigen, Cw-16 alpha chain STUB1 class I MHC B13 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor HERC2 K48polyUb-antigenicsubstrateHLA-B class I MHC B37 FBXL19 KLHL3 ZNF645 class I MHC B51 class I MHC B58 BTBD1 L-amino acidGLMN RNF138 class I MHC B52 PSMD14 HLA class I histocompatibility antigen, Cw-15 alpha chain class I MHC B35 ATPITGAV(31-1048) HLA class I histocompatibility antigen, A-33 alpha chain HLA class I histocompatibility antigen, Cw-4 alpha chain precursor class I MHC B57 class I MHC B13 antigenic substrate HLA class I histocompatibility antigen, Cw-3 alpha chain precursor FBXW8 class I MHC B56 ASB1 HLA class I histocompatibility antigen, A-3 alpha chain precursor UBE2H HLA class I histocompatibility antigen, E alpha chain precursor MIB2 class I MHC B14 HERC3 LONRF1 HLA class I histocompatibility antigen, Cw-15 alpha chain RPS27A(1-76) HLA class I histocompatibility antigen, Cw-17 alpha chain class I MHC B35 PJA1 class I MHC B35 ANAPC4 SEC24D FBXL7 HLA class I histocompatibility antigen, A-11 alpha chain FBXL3 AREL1 class I MHC B67 HLA class I histocompatibility antigen, A-26 alpha chain Lipoteichoic acid TRIM21 TRIM63 UBA3 class I MHC B45 UBB(77-152) HLA class I histocompatibility antigen, A-69 alpha chain HLA class I histocompatibility antigen, A-74 alpha chain class I MHC B7 HERC3 class I MHC B8 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor SEC31A SEC13 CDC23 class I MHC B14 SH3RF1 MKRN1 PSMD4 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor class I MHC B39 HLA class I histocompatibility antigen, A-29 alpha chain HLA class I histocompatibility antigen, A-31 alpha chain CBLB RNF217 UBE4A RPS27A(1-76) RNF19A PARK2 ASB10 (Glc)1 (GlcNAc)2 (Man)9 HLA class I histocompatibility antigen, Cw-2 alpha chain class I MHC B7 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor class I MHC B49 class I MHC B18 HLA class I histocompatibility antigen, Cw-17 alpha chain HLA class I histocompatibility antigen, A-69 alpha chain ASB6 class I MHC B27 class I MHC B82 Antigen peptide UBB(153-228) VHL ZNRF2 NEDD4 HLA class I histocompatibility antigen, A-29 alpha chain FBXL20 class I MHC B27 class I MHC B37 HLA class I histocompatibility antigen, A-31 alpha chain SOCS3 HLA class I histocompatibility antigen, A-3 alpha chain precursor HLA class I histocompatibility antigen, Cw-8 alpha chain HLA class I histocompatibility antigen, Cw-8 alpha chain KBTBD6 class I MHC B52 class I MHC B13 TRIM9 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor FBXW2 FBXO30 class I MHC B40 HLA class I histocompatibility antigen, A-36 alpha chain KLHL25 HLA class I histocompatibility antigen, A-66 alpha chain HLA class I histocompatibility antigen, A-36 alpha chain FBXO31 class I MHC B8 FBXL15 class I MHC B58 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor class I MHC B78 HLA class I histocompatibility antigen, A-25 alpha chain SEC24C UBE2E2 SOCS3 HLA class I histocompatibility antigen, alpha chain F precursor class I MHC B13 FBXL14 HLA class I histocompatibility antigen, A-29 alpha chain RNF182 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor UBA7 KBTBD8 HLA class I histocompatibility antigen, alpha chain F precursor class I MHC B40 HLA class I histocompatibility antigen, A-24 alpha chain NEDD4L HLA class I histocompatibility antigen, alpha chain F precursor B2M(21-119) class I MHC B81 HLA class I histocompatibility antigen, A-2 alpha chain 1181184210660486239102667, 94, 11627, 124207, 94, 11613810136118101, 13069, 114161381660817, 94, 1165339531011, 9, 15, 23, 41...603960392, 75, 140101, 130392069, 11439661021363913810214111820483213669, 114165311869, 11466, 68481385310210610681101, 1305720321639171248110111832136815, 3448101017, 94, 11610666, 68


Description

Major histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular bacteria or tumor-associated antigens. They bind peptide fragments of these proteins and presenting them to CD8+ T cells at the cell surface. This enables cytotoxic T cells to identify and eliminate cells that are synthesizing abnormal or foreign proteins. MHC class I is a trimeric complex composed of a polymorphic heavy chain (HC or alpha chain) and an invariable light chain, known as beta2-microglobulin (B2M) plus an 8-10 residue peptide ligand. Represented here are the events in the biosynthesis of MHC class I molecules, including generation of antigenic peptides by the ubiquitin/26S-proteasome system, delivery of these peptides to the endoplasmic reticulum (ER), loading of peptides to MHC class I molecules and display of MHC class I complexes on the cell surface. View original pathway at:Reactome.

Comments

Reactome-Converter 
Pathway is converted from Reactome ID: 983169
Reactome-version 
Reactome version: 65
Reactome Author 
Reactome Author: Garapati, Phani Vijay

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Bibliography

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  24. Putilina T, Jaworski C, Gentleman S, McDonald B, Kadiri M, Wong P.; ''Analysis of a human cDNA containing a tissue-specific alternatively spliced LIM domain.''; PubMed Europe PMC Scholia
  25. Kleijmeer MJ, Escola JM, UytdeHaag FG, Jakobson E, Griffith JM, Osterhaus AD, Stoorvogel W, Melief CJ, Rabouille C, Geuze HJ.; ''Antigen loading of MHC class I molecules in the endocytic tract.''; PubMed Europe PMC Scholia
  26. Cebrian I, Visentin G, Blanchard N, Jouve M, Bobard A, Moita C, Enninga J, Moita LF, Amigorena S, Savina A.; ''Sec22b regulates phagosomal maturation and antigen crosspresentation by dendritic cells.''; PubMed Europe PMC Scholia
  27. Kuang Z, Lewis RS, Curtis JM, Zhan Y, Saunders BM, Babon JJ, Kolesnik TB, Low A, Masters SL, Willson TA, Kedzierski L, Yao S, Handman E, Norton RS, Nicholson SE.; ''The SPRY domain-containing SOCS box protein SPSB2 targets iNOS for proteasomal degradation.''; PubMed Europe PMC Scholia
  28. Wearsch PA, Cresswell P.; ''The quality control of MHC class I peptide loading.''; PubMed Europe PMC Scholia
  29. Kawai T, Akira S.; ''TLR signaling.''; PubMed Europe PMC Scholia
  30. Lee PC, Sowa ME, Gygi SP, Harper JW.; ''Alternative ubiquitin activation/conjugation cascades interact with N-end rule ubiquitin ligases to control degradation of RGS proteins.''; PubMed Europe PMC Scholia
  31. Simone LC, Wang X, Solheim JC.; ''A transmembrane tail: interaction of tapasin with TAP and the MHC class I molecule.''; PubMed Europe PMC Scholia
  32. Koch J, Tampé R.; ''The macromolecular peptide-loading complex in MHC class I-dependent antigen presentation.''; PubMed Europe PMC Scholia
  33. Spiliotis ET, Manley H, Osorio M, Zúñiga MC, Edidin M.; ''Selective export of MHC class I molecules from the ER after their dissociation from TAP.''; PubMed Europe PMC Scholia
  34. Schulman BA, Harper JW.; ''Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways.''; PubMed Europe PMC Scholia
  35. Schölz C, Tampé R.; ''The peptide-loading complex--antigen translocation and MHC class I loading.''; PubMed Europe PMC Scholia
  36. Krappmann D, Hatada EN, Tegethoff S, Li J, Klippel A, Giese K, Baeuerle PA, Scheidereit C.; ''The I kappa B kinase (IKK) complex is tripartite and contains IKK gamma but not IKAP as a regular component.''; PubMed Europe PMC Scholia
  37. Jackson CL.; ''Mechanisms of transport through the Golgi complex.''; PubMed Europe PMC Scholia
  38. Saric T, Chang SC, Hattori A, York IA, Markant S, Rock KL, Tsujimoto M, Goldberg AL.; ''An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides.''; PubMed Europe PMC Scholia
  39. Rock KL, York IA, Goldberg AL.; ''Post-proteasomal antigen processing for major histocompatibility complex class I presentation.''; PubMed Europe PMC Scholia
  40. Nair-Gupta P, Baccarini A, Tung N, Seyffer F, Florey O, Huang Y, Banerjee M, Overholtzer M, Roche PA, Tampé R, Brown BD, Amsen D, Whiteheart SW, Blander JM.; ''TLR signals induce phagosomal MHC-I delivery from the endosomal recycling compartment to allow cross-presentation.''; PubMed Europe PMC Scholia
  41. Suzuki K, Verma IM.; ''Phosphorylation of SNAP-23 by IkappaB kinase 2 regulates mast cell degranulation.''; PubMed Europe PMC Scholia
  42. Dong G, Wearsch PA, Peaper DR, Cresswell P, Reinisch KM.; ''Insights into MHC class I peptide loading from the structure of the tapasin-ERp57 thiol oxidoreductase heterodimer.''; PubMed Europe PMC Scholia
  43. Watanabe K, Yumimoto K, Nakayama KI.; ''FBXO21 mediates the ubiquitylation and proteasomal degradation of EID1.''; PubMed Europe PMC Scholia
  44. Kim DT, Mitchell DJ, Brockstedt DG, Fong L, Nolan GP, Fathman CG, Engleman EG, Rothbard JB.; ''Introduction of soluble proteins into the MHC class I pathway by conjugation to an HIV tat peptide.''; PubMed Europe PMC Scholia
  45. Vyas JM, Van der Veen AG, Ploegh HL.; ''The known unknowns of antigen processing and presentation.''; PubMed Europe PMC Scholia
  46. Costoya JA, Hobbs RM, Pandolfi PP.; ''Cyclin-dependent kinase antagonizes promyelocytic leukemia zinc-finger through phosphorylation.''; PubMed Europe PMC Scholia
  47. Motshwene PG, Moncrieffe MC, Grossmann JG, Kao C, Ayaluru M, Sandercock AM, Robinson CV, Latz E, Gay NJ.; ''An oligomeric signaling platform formed by the Toll-like receptor signal transducers MyD88 and IRAK-4.''; PubMed Europe PMC Scholia
  48. York IA, Bhutani N, Zendzian S, Goldberg AL, Rock KL.; ''Tripeptidyl peptidase II is the major peptidase needed to trim long antigenic precursors, but is not required for most MHC class I antigen presentation.''; PubMed Europe PMC Scholia
  49. Kovacsovics-Bankowski M, Rock KL.; ''A phagosome-to-cytosol pathway for exogenous antigens presented on MHC class I molecules.''; PubMed Europe PMC Scholia
  50. Segura E, Albiston AL, Wicks IP, Chai SY, Villadangos JA.; ''Different cross-presentation pathways in steady-state and inflammatory dendritic cells.''; PubMed Europe PMC Scholia
  51. Park Y, Yoon SK, Yoon JB.; ''TRIP12 functions as an E3 ubiquitin ligase of APP-BP1.''; PubMed Europe PMC Scholia
  52. Rodriguez-Boulan E, Müsch A.; ''Protein sorting in the Golgi complex: shifting paradigms.''; PubMed Europe PMC Scholia
  53. Tan MK, Lim HJ, Bennett EJ, Shi Y, Harper JW.; ''Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover.''; PubMed Europe PMC Scholia
  54. Hewitt EW, Lehner PJ.; ''The ABC-transporter signature motif is required for peptide translocation but not peptide binding by TAP.''; PubMed Europe PMC Scholia
  55. Kanaseki T, Blanchard N, Hammer GE, Gonzalez F, Shastri N.; ''ERAAP synergizes with MHC class I molecules to make the final cut in the antigenic peptide precursors in the endoplasmic reticulum.''; PubMed Europe PMC Scholia
  56. el Benna J, Faust LP, Babior BM.; ''The phosphorylation of the respiratory burst oxidase component p47phox during neutrophil activation. Phosphorylation of sites recognized by protein kinase C and by proline-directed kinases.''; PubMed Europe PMC Scholia
  57. Starostina NG, Simpliciano JM, McGuirk MA, Kipreos ET.; ''CRL2(LRR-1) targets a CDK inhibitor for cell cycle control in C. elegans and actin-based motility regulation in human cells.''; PubMed Europe PMC Scholia
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  62. Hammond AT, Glick BS.; ''Dynamics of transitional endoplasmic reticulum sites in vertebrate cells.''; PubMed Europe PMC Scholia
  63. Ding W, Li C, Hu T, Graves-Deal R, Fotia AB, Weissman AM, Coffey RJ.; ''EGF receptor-independent action of TGF-alpha protects Naked2 from AO7-mediated ubiquitylation and proteasomal degradation.''; PubMed Europe PMC Scholia
  64. Winchester JF, Salsberg JA, Levin NW.; ''Beta-2 microglobulin in ESRD: an in-depth review.''; PubMed Europe PMC Scholia
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  66. Voges D, Zwickl P, Baumeister W.; ''The 26S proteasome: a molecular machine designed for controlled proteolysis.''; PubMed Europe PMC Scholia
  67. Rogers LD, Foster LJ.; ''Contributions of proteomics to understanding phagosome maturation.''; PubMed Europe PMC Scholia
  68. Grenfell SJ, Trausch-Azar JS, Handley-Gearhart PM, Ciechanover A, Schwartz AL.; ''Nuclear localization of the ubiquitin-activating enzyme, E1, is cell-cycle-dependent.''; PubMed Europe PMC Scholia
  69. Neumann L, Tampé R.; ''Kinetic analysis of peptide binding to the TAP transport complex: evidence for structural rearrangements induced by substrate binding.''; PubMed Europe PMC Scholia
  70. Wei SJ, Williams JG, Dang H, Darden TA, Betz BL, Humble MM, Chang FM, Trempus CS, Johnson K, Cannon RE, Tennant RW.; ''Identification of a specific motif of the DSS1 protein required for proteasome interaction and p53 protein degradation.''; PubMed Europe PMC Scholia
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History

View all...
CompareRevisionActionTimeUserComment
117684view12:08, 22 May 2021EweitzModified title
114758view16:24, 25 January 2021ReactomeTeamReactome version 75
113202view11:26, 2 November 2020ReactomeTeamReactome version 74
112427view15:37, 9 October 2020ReactomeTeamReactome version 73
101331view11:21, 1 November 2018ReactomeTeamreactome version 66
100869view20:55, 31 October 2018ReactomeTeamreactome version 65
100410view19:28, 31 October 2018ReactomeTeamreactome version 64
99959view16:13, 31 October 2018ReactomeTeamreactome version 63
99514view14:45, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99156view12:41, 31 October 2018ReactomeTeamreactome version 62
94507view09:31, 14 September 2017Mkutmonreactome version 61
87162view19:18, 18 July 2016MkutmonOntology Term : 'adaptive immune response pathway' added !
87068view11:35, 18 July 2016ReactomeTeamReactome version 56
83467view12:31, 18 November 2015ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(Glc)1 (GlcNAc)2 (Man)9 MetaboliteCHEBI:59080 (ChEBI)
26S proteasomeComplexR-HSA-68819 (Reactome)
2xN4GlycoAsn-LY96 ProteinQ9Y6Y9 (Uniprot-TrEMBL)
2xN4GlycoAsn-TLR4 ProteinO00206 (Uniprot-TrEMBL)
4xPalmC-CD36 ProteinP16671 (Uniprot-TrEMBL)
ADPMetaboliteCHEBI:16761 (ChEBI)
ANAPC1 ProteinQ9H1A4 (Uniprot-TrEMBL)
ANAPC10 ProteinQ9UM13 (Uniprot-TrEMBL)
ANAPC11 ProteinQ9NYG5 (Uniprot-TrEMBL)
ANAPC13 ProteinQ9BS18 (Uniprot-TrEMBL)
ANAPC2 ProteinQ9UJX6 (Uniprot-TrEMBL)
ANAPC4 ProteinQ9UJX5 (Uniprot-TrEMBL)
ANAPC5 ProteinQ9UJX4 (Uniprot-TrEMBL)
ANAPC7 ProteinQ9UJX3 (Uniprot-TrEMBL)
AREL1 ProteinO15033 (Uniprot-TrEMBL)
ARIH2 ProteinO95376 (Uniprot-TrEMBL)
ASB1 ProteinQ9Y576 (Uniprot-TrEMBL)
ASB10 ProteinQ8WXI3 (Uniprot-TrEMBL)
ASB11 ProteinQ8WXH4 (Uniprot-TrEMBL)
ASB12 ProteinQ8WXK4 (Uniprot-TrEMBL)
ASB13 ProteinQ8WXK3 (Uniprot-TrEMBL)
ASB14 ProteinA6NK59 (Uniprot-TrEMBL)
ASB15 ProteinQ8WXK1 (Uniprot-TrEMBL)
ASB16 ProteinQ96NS5 (Uniprot-TrEMBL)
ASB17 ProteinQ8WXJ9 (Uniprot-TrEMBL)
ASB18 ProteinQ6ZVZ8 (Uniprot-TrEMBL)
ASB2 ProteinQ96Q27 (Uniprot-TrEMBL)
ASB3 ProteinQ9Y575 (Uniprot-TrEMBL)
ASB4 ProteinQ9Y574 (Uniprot-TrEMBL)
ASB5 ProteinQ8WWX0 (Uniprot-TrEMBL)
ASB6 ProteinQ9NWX5 (Uniprot-TrEMBL)
ASB7 ProteinQ9H672 (Uniprot-TrEMBL)
ASB8 ProteinQ9H765 (Uniprot-TrEMBL)
ASB9 ProteinQ96DX5 (Uniprot-TrEMBL)
ATG7 ProteinO95352 (Uniprot-TrEMBL)
ATPMetaboliteCHEBI:15422 (ChEBI)
Ag peptide bound class I MHCComplexR-HSA-1236931 (Reactome)
Ag-substrate:E3:E2:UbComplexR-HSA-983126 (Reactome)
Antigen R-ALL-173548 (Reactome)
Antigen peptide

bound class I

MHC:BAP31 oligomer		ComplexR-HSA-983132 (Reactome)
Antigen peptide bound class I MHCComplexR-HSA-1236934 (Reactome)
Antigen peptide bound class I MHCComplexR-HSA-198904 (Reactome)
Antigen peptide bound class I MHCComplexR-HSA-983114 (Reactome)
Antigen peptide bound class I MHCComplexR-HSA-983412 (Reactome)
Antigen peptide bound class I MHCComplexR-HSA-983416 (Reactome)
Antigen peptide MetaboliteCHEBI:25676 (ChEBI)
Antigen peptide R-ALL-983324 (Reactome)
Antigen peptide R-ALL-983326 (Reactome)
Antigen peptideMetaboliteCHEBI:25676 (ChEBI)
Antigenic

peptide:MHC:B2M peptide loading

complex		ComplexR-HSA-8951496 (Reactome)
B2M(21-119) ProteinP61769 (Uniprot-TrEMBL)
B2M(21-119)ProteinP61769 (Uniprot-TrEMBL)
BAP31 oligomer R-HSA-983323 (Reactome)
BAP31 oligomerR-HSA-983323 (Reactome)
BLMH ProteinQ13867 (Uniprot-TrEMBL)
BTBD1 ProteinQ9H0C5 (Uniprot-TrEMBL)
BTBD6 ProteinQ96KE9 (Uniprot-TrEMBL)
BTK ProteinQ06187 (Uniprot-TrEMBL)
BTRC ProteinQ9Y297 (Uniprot-TrEMBL)
CALR ProteinP27797 (Uniprot-TrEMBL)
CALR:SEC22B:STX4:TAP:TAPBPComplexR-HSA-8951594 (Reactome)
CALRProteinP27797 (Uniprot-TrEMBL)
CANX ProteinP27824 (Uniprot-TrEMBL)
CBLB ProteinQ13191 (Uniprot-TrEMBL)
CCNF ProteinP41002 (Uniprot-TrEMBL)
CD14(20-345) ProteinP08571 (Uniprot-TrEMBL)
CD207 ProteinQ9UJ71 (Uniprot-TrEMBL)
CD36 ProteinP16671 (Uniprot-TrEMBL)
CDC16 ProteinQ13042 (Uniprot-TrEMBL)
CDC20 ProteinQ12834 (Uniprot-TrEMBL)
CDC23 ProteinQ9UJX2 (Uniprot-TrEMBL)
CDC26 ProteinQ8NHZ8 (Uniprot-TrEMBL)
CDC27 ProteinP30260 (Uniprot-TrEMBL)
CDC34 ProteinP49427 (Uniprot-TrEMBL)
CHUK ProteinO15111 (Uniprot-TrEMBL)
CHUK:IKBKB:IKBKGComplexR-HSA-168113 (Reactome) Co-immunoprecipitation studies and size exclusion chromatography analysis indicate that the high molecular weight (around 700 to 900 kDa) IKK complex is composed of two kinase subunits (IKK1/CHUK/IKBKA and/or IKK2/IKBKB/IKKB) bound to a regulatory gamma subunit (IKBKG/NEMO) (Rothwarf DMet al. 1998; Krappmann D et al. 2000; Miller BS & Zandi E 2001). Variants of the IKK complex containing IKBKA or IKBKB homodimers associated with NEMO may also exist. Crystallographic and quantitative analyses of the binding interactions between N-terminal NEMO and C-terminal IKBKB fragments showed that IKBKB dimers would interact with NEMO dimers resulting in 2:2 stoichiometry (Rushe M et al. 2008). Chemical cross-linking and equilibrium sedimentation analyses of IKBKG (NEMO) suggest a tetrameric oligomerization (dimers of dimers) (Tegethoff S et al. 2003). The tetrameric NEMO could sequester four kinase molecules, yielding an 2xIKBKA:2xIKBKB:4xNEMO stoichiometry (Tegethoff S et al. 2003). The above data suggest that the core IKK complex consists of an IKBKA:IKBKB heterodimer associated with an IKBKG dimer or higher oligomeric assemblies. However, the exact stoichiometry of the IKK complex remains unclear.
COPII vesicle with MHC class IComplexR-HSA-983414 (Reactome)
COPII vesicle with MHC class IComplexR-HSA-983418 (Reactome)
COPIIComplexR-HSA-204019 (Reactome)
CTSL1(114-288) ProteinP07711 (Uniprot-TrEMBL)
CTSL2 ProteinO60911 (Uniprot-TrEMBL)
CTSS ProteinP25774 (Uniprot-TrEMBL)
CTSS-like proteinsComplexR-HSA-4127472 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
CUL1 ProteinQ13616 (Uniprot-TrEMBL)
CUL2 ProteinQ13617 (Uniprot-TrEMBL)
CUL3 ProteinQ13618 (Uniprot-TrEMBL)
CUL5 ProteinQ93034 (Uniprot-TrEMBL)
CUL7 ProteinQ14999 (Uniprot-TrEMBL)
CYBA ProteinP13498 (Uniprot-TrEMBL)
CYBB ProteinP04839 (Uniprot-TrEMBL)
Chaperones calnexin/BiPComplexR-HSA-983129 (Reactome)
Class I MHC HC:B2M:Erp57ComplexR-HSA-1236922 (Reactome)
Class I MHC HC:B2M:Erp57ComplexR-HSA-8863933 (Reactome)
Class I MHC:B2MComplexR-HSA-1236930 (Reactome)
Clostridial peptidoglycan MetaboliteCHEBI:8005 (ChEBI)
DC receptors

recognizing

apoptotic cells		ComplexR-HSA-1236899 (Reactome)
DC receptors

recognizing

apoptotic cells		ComplexR-HSA-1236904 (Reactome)
DET1 ProteinQ7L5Y6 (Uniprot-TrEMBL)
DTX3L ProteinQ8TDB6 (Uniprot-TrEMBL)
DZIP3 ProteinQ86Y13 (Uniprot-TrEMBL)
Diacyl lipopeptide MetaboliteCHEBI:46896 (ChEBI)
E1 bound ubiquitinComplexR-HSA-976164 (Reactome)
E2 Ubiquitin-conjugating enzymeComplexR-HSA-947628 (Reactome)
E3 ligases in

proteasomal

degradation		ComplexR-HSA-976075 (Reactome)
E3:K48-polyubiquitinated substrateComplexR-HSA-983134 (Reactome)
E3:Ub:substrateComplexR-HSA-983131 (Reactome)
ELOB ProteinQ15370 (Uniprot-TrEMBL)
ELOC ProteinQ15369 (Uniprot-TrEMBL)
ERAP1 ProteinQ9NZ08 (Uniprot-TrEMBL)
ERAP1/2ComplexR-HSA-983125 (Reactome)
ERAP2 ProteinQ6P179 (Uniprot-TrEMBL)
Exogenous

Particulate antigen

(Ag)		R-ALL-1236714 (Reactome)
Exogenous

Particulate antigen

(Ag)		R-ALL-1236716 (Reactome)
Exogenous

Particulate antigen

(Ag)		R-ALL-1236726 (Reactome)
Exogenous Particulate antigen (Ag) R-ALL-1236726 (Reactome)
Exogenous soluble antigenMetaboliteCHEBI:16670 (ChEBI)
Exogenous soluble antigen MetaboliteCHEBI:16670 (ChEBI)
FBXL12 ProteinQ9NXK8 (Uniprot-TrEMBL)
FBXL13 ProteinQ8NEE6 (Uniprot-TrEMBL)
FBXL14 ProteinQ8N1E6 (Uniprot-TrEMBL)
FBXL15 ProteinQ9H469 (Uniprot-TrEMBL)
FBXL16 ProteinQ8N461 (Uniprot-TrEMBL)
FBXL18 ProteinQ96ME1 (Uniprot-TrEMBL)
FBXL19 ProteinQ6PCT2 (Uniprot-TrEMBL)
FBXL20 ProteinQ96IG2 (Uniprot-TrEMBL)
FBXL21 ProteinQ9UKT6 (Uniprot-TrEMBL)
FBXL22 ProteinQ6P050 (Uniprot-TrEMBL)
FBXL3 ProteinQ9UKT7 (Uniprot-TrEMBL)
FBXL4 ProteinQ9UKA2 (Uniprot-TrEMBL)
FBXL5 ProteinQ9UKA1 (Uniprot-TrEMBL)
FBXL7 ProteinQ9UJT9 (Uniprot-TrEMBL)
FBXL8 ProteinQ96CD0 (Uniprot-TrEMBL)
FBXO10 ProteinQ9UK96 (Uniprot-TrEMBL)
FBXO11 ProteinQ86XK2 (Uniprot-TrEMBL)
FBXO15 ProteinQ8NCQ5 (Uniprot-TrEMBL)
FBXO17 ProteinQ96EF6 (Uniprot-TrEMBL)
FBXO2 ProteinQ9UK22 (Uniprot-TrEMBL)
FBXO21 ProteinO94952 (Uniprot-TrEMBL)
FBXO22 ProteinQ8NEZ5 (Uniprot-TrEMBL)
FBXO27 ProteinQ8NI29 (Uniprot-TrEMBL)
FBXO30 ProteinQ8TB52 (Uniprot-TrEMBL)
FBXO31 ProteinQ5XUX0 (Uniprot-TrEMBL)
FBXO32 ProteinQ969P5 (Uniprot-TrEMBL)
FBXO4 ProteinQ9UKT5 (Uniprot-TrEMBL)
FBXO40 ProteinQ9UH90 (Uniprot-TrEMBL)
FBXO41 ProteinQ8TF61 (Uniprot-TrEMBL)
FBXO44 ProteinQ9H4M3 (Uniprot-TrEMBL)
FBXO6 ProteinQ9NRD1 (Uniprot-TrEMBL)
FBXO7 ProteinQ9Y3I1 (Uniprot-TrEMBL)
FBXO9 ProteinQ9UK97 (Uniprot-TrEMBL)
FBXW10 ProteinQ5XX13 (Uniprot-TrEMBL)
FBXW11 ProteinQ9UKB1 (Uniprot-TrEMBL)
FBXW12 ProteinQ6X9E4 (Uniprot-TrEMBL)
FBXW2 ProteinQ9UKT8 (Uniprot-TrEMBL)
FBXW4 ProteinP57775 (Uniprot-TrEMBL)
FBXW5 ProteinQ969U6 (Uniprot-TrEMBL)
FBXW7 ProteinQ969H0 (Uniprot-TrEMBL)
FBXW8 ProteinQ8N3Y1 (Uniprot-TrEMBL)
FBXW9 ProteinQ5XUX1 (Uniprot-TrEMBL)
FCGR R-HSA-1236898 (Reactome)
FCGR R-HSA-1236905 (Reactome)
FCGRA R-HSA-1031694 (Reactome)
FZR1 ProteinQ9UM11 (Uniprot-TrEMBL)
GAN ProteinQ9H2C0 (Uniprot-TrEMBL)
GDP MetaboliteCHEBI:17552 (ChEBI)
GDPMetaboliteCHEBI:17552 (ChEBI)
GLMN ProteinQ92990 (Uniprot-TrEMBL)
GPIN-CD14(20-345) ProteinP08571 (Uniprot-TrEMBL)
GTP MetaboliteCHEBI:15996 (ChEBI)
GTPMetaboliteCHEBI:15996 (ChEBI)
H+MetaboliteCHEBI:15378 (ChEBI)
H2OMetaboliteCHEBI:15377 (ChEBI)
HACE1 ProteinQ8IYU2 (Uniprot-TrEMBL)
HECTD1 ProteinQ9ULT8 (Uniprot-TrEMBL)
HECTD2 ProteinQ5U5R9 (Uniprot-TrEMBL)
HECTD3 ProteinQ5T447 (Uniprot-TrEMBL)
HECW2 ProteinQ9P2P5 (Uniprot-TrEMBL)
HERC1 ProteinQ15751 (Uniprot-TrEMBL)
HERC2 ProteinO95714 (Uniprot-TrEMBL)
HERC3 ProteinQ15034 (Uniprot-TrEMBL)
HERC4 ProteinQ5GLZ8 (Uniprot-TrEMBL)
HERC5 ProteinQ9UII4 (Uniprot-TrEMBL)
HERC6 ProteinQ8IVU3 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-1 alpha chain precursor ProteinP30443 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-11 alpha chain ProteinP13746 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-2 alpha chain ProteinP01892 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-23 alpha chain ProteinP30447 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-24 alpha chain ProteinP05534 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-25 alpha chain ProteinP18462 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-26 alpha chain ProteinP30450 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-29 alpha chain ProteinP30512 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-3 alpha chain precursor ProteinP04439 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-30 alpha chain ProteinP16188 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-31 alpha chain ProteinP16189 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-32 alpha chain ProteinP10314 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-33 alpha chain ProteinP16190 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-34 alpha chain ProteinP30453 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-36 alpha chain ProteinP30455 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-43 alpha chain ProteinP30456 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-66 alpha chain ProteinP30457 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-68 alpha chain ProteinP01891 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-69 alpha chain ProteinP10316 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-74 alpha chain ProteinP30459 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-80 alpha chain ProteinQ09160 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, B-48 alpha chain ProteinP30486 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-1 alpha chain ProteinP30499 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-12 alpha chain ProteinP30508 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-14 alpha chain ProteinP30510 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-15 alpha chain ProteinQ07000 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-16 alpha chain ProteinQ29960 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-17 alpha chain ProteinQ95604 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-18 alpha chain ProteinQ29865 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-2 alpha chain ProteinP30501 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-3 alpha chain precursor ProteinP04222 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-4 alpha chain precursor ProteinP30504 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-5 alpha chain precursor ProteinQ9TNN7 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-6 alpha chain precursor ProteinQ29963 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-7 alpha chain precursor ProteinP10321 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-8 alpha chain ProteinP30505 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, E alpha chain precursor ProteinP13747 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, alpha chain F precursor ProteinP30511 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, alpha chain G precursor ProteinP17693 (Uniprot-TrEMBL)
HLA-B ProteinP30486 (Uniprot-TrEMBL)
HLA-C ProteinP10321 (Uniprot-TrEMBL)
HLA-H ProteinP01893 (Uniprot-TrEMBL)
HSPA5 ProteinP11021 (Uniprot-TrEMBL)
HUWE1 ProteinQ7Z6Z7 (Uniprot-TrEMBL)
IFN gamma stimulated aminopeptidasesComplexR-HSA-983128 (Reactome)
IKBKB ProteinO14920 (Uniprot-TrEMBL)
IKBKG ProteinQ9Y6K9 (Uniprot-TrEMBL)
IRAP in complex with MHC class IComplexR-HSA-1236916 (Reactome)
ITCH ProteinQ96J02 (Uniprot-TrEMBL)
ITGAV(31-1048) ProteinP06756 (Uniprot-TrEMBL)
ITGB5 ProteinP18084 (Uniprot-TrEMBL)
K48polyUb-antigenic substrateR-ALL-983123 (Reactome)
K48polyUb-antigenic substrate R-ALL-983123 (Reactome)
K48polyUb-partially digested AgR-ALL-1236918 (Reactome)
KBTBD13 ProteinC9JR72 (Uniprot-TrEMBL)
KBTBD6 ProteinQ86V97 (Uniprot-TrEMBL)
KBTBD7 ProteinQ8WVZ9 (Uniprot-TrEMBL)
KBTBD8 ProteinQ8NFY9 (Uniprot-TrEMBL)
KCTD6 ProteinQ8NC69 (Uniprot-TrEMBL)
KCTD7 ProteinQ96MP8 (Uniprot-TrEMBL)
KEAP1 ProteinQ14145 (Uniprot-TrEMBL)
KLHL11 ProteinQ9NVR0 (Uniprot-TrEMBL)
KLHL13 ProteinQ9P2N7 (Uniprot-TrEMBL)
KLHL2 ProteinO95198 (Uniprot-TrEMBL)
KLHL20 ProteinQ9Y2M5 (Uniprot-TrEMBL)
KLHL21 ProteinQ9UJP4 (Uniprot-TrEMBL)
KLHL22 ProteinQ53GT1 (Uniprot-TrEMBL)
KLHL25 ProteinQ9H0H3 (Uniprot-TrEMBL)
KLHL3 ProteinQ9UH77 (Uniprot-TrEMBL)
KLHL41 ProteinO60662 (Uniprot-TrEMBL)
KLHL42 ProteinQ9P2K6 (Uniprot-TrEMBL)
KLHL5 ProteinQ96PQ7 (Uniprot-TrEMBL)
KLHL9 ProteinQ9P2J3 (Uniprot-TrEMBL)
L-amino acidMetaboliteCHEBI:59869 (ChEBI)
LMO7 ProteinQ8WWI1 (Uniprot-TrEMBL)
LNPEP ProteinQ9UIQ6 (Uniprot-TrEMBL)
LNX1 ProteinQ8TBB1 (Uniprot-TrEMBL)
LONRF1 ProteinQ17RB8 (Uniprot-TrEMBL)
LPS MetaboliteCHEBI:16412 (ChEBI)
LRR1 ProteinQ96L50 (Uniprot-TrEMBL)
LRRC41 ProteinQ15345 (Uniprot-TrEMBL)
LRSAM1 ProteinQ6UWE0 (Uniprot-TrEMBL)
LTN1 ProteinO94822 (Uniprot-TrEMBL)
Lipoteichoic acid MetaboliteCHEBI:28640 (ChEBI)
MEX3C ProteinQ5U5Q3 (Uniprot-TrEMBL)
MGRN1 ProteinO60291 (Uniprot-TrEMBL)
MHC

class I

HC:Calnexin/BiP:Erp57		ComplexR-HSA-983119 (Reactome)
MHC HC:B2M:Erp57ComplexR-HSA-983136 (Reactome)
MHC:B2M peptide loading complexComplexR-HSA-983121 (Reactome)
MIB2 ProteinQ96AX9 (Uniprot-TrEMBL)
MKRN1 ProteinQ9UHC7 (Uniprot-TrEMBL)
MR/other probable receptorsComplexR-HSA-1236909 (Reactome)
MR/other probable receptorsComplexR-HSA-1236911 (Reactome)
MR:soluble antigenComplexR-HSA-1236923 (Reactome)
MR:soluble antigenComplexR-HSA-1236926 (Reactome)
MR:soluble antigenComplexR-HSA-1236929 (Reactome)
MRC1 ProteinP22897 (Uniprot-TrEMBL)
MRC2 ProteinQ9UBG0 (Uniprot-TrEMBL)
MYD88 ProteinQ99836 (Uniprot-TrEMBL)
MYLIP ProteinQ8WY64 (Uniprot-TrEMBL)
Major outer membrane protein P ProteinP30690 (Uniprot-TrEMBL)
Mg2+MetaboliteCHEBI:18420 (ChEBI)
NADP+MetaboliteCHEBI:18009 (ChEBI)
NADPHMetaboliteCHEBI:16474 (ChEBI)
NEDD4 ProteinP46934 (Uniprot-TrEMBL)
NEDD4L ProteinQ96PU5 (Uniprot-TrEMBL)
NOX2 complexComplexR-HSA-1996217 (Reactome)
NPEPPS ProteinP55786 (Uniprot-TrEMBL)
O2.-MetaboliteCHEBI:18421 (ChEBI)
O2MetaboliteCHEBI:15379 (ChEBI)
PARK2 ProteinO60260 (Uniprot-TrEMBL)
PDIA3 ProteinP30101 (Uniprot-TrEMBL)
PDIA3ProteinP30101 (Uniprot-TrEMBL)
PI(4,5)P2 MetaboliteCHEBI:18348 (ChEBI)
PJA1 ProteinQ8NG27 (Uniprot-TrEMBL)
PJA2 ProteinO43164 (Uniprot-TrEMBL)
PPiMetaboliteCHEBI:29888 (ChEBI)
PSMA1 ProteinP25786 (Uniprot-TrEMBL)
PSMA2 ProteinP25787 (Uniprot-TrEMBL)
PSMA3 ProteinP25788 (Uniprot-TrEMBL)
PSMA4 ProteinP25789 (Uniprot-TrEMBL)
PSMA5 ProteinP28066 (Uniprot-TrEMBL)
PSMA6 ProteinP60900 (Uniprot-TrEMBL)
PSMA7 ProteinO14818 (Uniprot-TrEMBL)
PSMA8 ProteinQ8TAA3 (Uniprot-TrEMBL)
PSMB1 ProteinP20618 (Uniprot-TrEMBL)
PSMB10 ProteinP40306 (Uniprot-TrEMBL)
PSMB11 ProteinA5LHX3 (Uniprot-TrEMBL)
PSMB2 ProteinP49721 (Uniprot-TrEMBL)
PSMB3 ProteinP49720 (Uniprot-TrEMBL)
PSMB4 ProteinP28070 (Uniprot-TrEMBL)
PSMB5 ProteinP28074 (Uniprot-TrEMBL)
PSMB6 ProteinP28072 (Uniprot-TrEMBL)
PSMB7 ProteinQ99436 (Uniprot-TrEMBL)
PSMB8 ProteinP28062 (Uniprot-TrEMBL)
PSMB9 ProteinP28065 (Uniprot-TrEMBL)
PSMC1 ProteinP62191 (Uniprot-TrEMBL)
PSMC2 ProteinP35998 (Uniprot-TrEMBL)
PSMC3 ProteinP17980 (Uniprot-TrEMBL)
PSMC4 ProteinP43686 (Uniprot-TrEMBL)
PSMC5 ProteinP62195 (Uniprot-TrEMBL)
PSMC6 ProteinP62333 (Uniprot-TrEMBL)
PSMD1 ProteinQ99460 (Uniprot-TrEMBL)
PSMD10 ProteinO75832 (Uniprot-TrEMBL)
PSMD11 ProteinO00231 (Uniprot-TrEMBL)
PSMD12 ProteinO00232 (Uniprot-TrEMBL)
PSMD13 ProteinQ9UNM6 (Uniprot-TrEMBL)
PSMD14 ProteinO00487 (Uniprot-TrEMBL)
PSMD2 ProteinQ13200 (Uniprot-TrEMBL)
PSMD3 ProteinO43242 (Uniprot-TrEMBL)
PSMD4 ProteinP55036 (Uniprot-TrEMBL)
PSMD5 ProteinQ16401 (Uniprot-TrEMBL)
PSMD6 ProteinQ15008 (Uniprot-TrEMBL)
PSMD7 ProteinP51665 (Uniprot-TrEMBL)
PSMD8 ProteinP48556 (Uniprot-TrEMBL)
PSMD9 ProteinO00233 (Uniprot-TrEMBL)
PSME1 ProteinQ06323 (Uniprot-TrEMBL)
PSME2 ProteinQ9UL46 (Uniprot-TrEMBL)
PSME3 ProteinP61289 (Uniprot-TrEMBL)
PSME4 ProteinQ14997 (Uniprot-TrEMBL)
PSMF1 ProteinQ92530 (Uniprot-TrEMBL)
Particulate Ag:DC receptorsComplexR-HSA-1236920 (Reactome)
PiMetaboliteCHEBI:18367 (ChEBI)
RBBP6 ProteinQ7Z6E9 (Uniprot-TrEMBL)
RBCK1 ProteinQ9BYM8 (Uniprot-TrEMBL)
RBX1 ProteinP62877 (Uniprot-TrEMBL)
RCHY1 ProteinQ96PM5 (Uniprot-TrEMBL)
RLIM ProteinQ9NVW2 (Uniprot-TrEMBL)
RNF111 ProteinQ6ZNA4 (Uniprot-TrEMBL)
RNF114 ProteinQ9Y508 (Uniprot-TrEMBL)
RNF115 ProteinQ9Y4L5 (Uniprot-TrEMBL)
RNF123 ProteinQ5XPI4 (Uniprot-TrEMBL)
RNF126 ProteinQ9BV68 (Uniprot-TrEMBL)
RNF130 ProteinQ86XS8 (Uniprot-TrEMBL)
RNF138 ProteinQ8WVD3 (Uniprot-TrEMBL)
RNF14 ProteinQ9UBS8 (Uniprot-TrEMBL)
RNF144B ProteinQ7Z419 (Uniprot-TrEMBL)
RNF182 ProteinQ8N6D2 (Uniprot-TrEMBL)
RNF19A ProteinQ9NV58 (Uniprot-TrEMBL)
RNF19B ProteinQ6ZMZ0 (Uniprot-TrEMBL)
RNF213 ProteinQ63HN8 (Uniprot-TrEMBL)
RNF217 ProteinQ8TC41 (Uniprot-TrEMBL)
RNF220 ProteinQ5VTB9 (Uniprot-TrEMBL)
RNF25 ProteinQ96BH1 (Uniprot-TrEMBL)
RNF34 ProteinQ969K3 (Uniprot-TrEMBL)
RNF4 ProteinP78317 (Uniprot-TrEMBL)
RNF41 ProteinQ9H4P4 (Uniprot-TrEMBL)
RNF6 ProteinQ9Y252 (Uniprot-TrEMBL)
RNF7 (RBX2) ProteinQ9UBF6 (Uniprot-TrEMBL)
RPS27A(1-76) ProteinP62979 (Uniprot-TrEMBL)
SAR1B ProteinQ9Y6B6 (Uniprot-TrEMBL)
SAR1B:GDPComplexR-HSA-203989 (Reactome)
SAR1B:GTP:SEC23:SEC24ComplexR-HSA-203997 (Reactome)
SAR1B:GTPComplexR-HSA-204003 (Reactome)
SEC13 ProteinP55735 (Uniprot-TrEMBL)
SEC13ProteinP55735 (Uniprot-TrEMBL)
SEC22B ProteinO75396 (Uniprot-TrEMBL)
SEC22B:STX4ComplexR-HSA-8863847 (Reactome)
SEC22BProteinO75396 (Uniprot-TrEMBL)
SEC23:SEC24ComplexR-HSA-203975 (Reactome)
SEC23A ProteinQ15436 (Uniprot-TrEMBL)
SEC23AProteinQ15436 (Uniprot-TrEMBL)
SEC24A ProteinO95486 (Uniprot-TrEMBL)
SEC24B ProteinO95487 (Uniprot-TrEMBL)
SEC24C ProteinP53992 (Uniprot-TrEMBL)
SEC24D ProteinO94855 (Uniprot-TrEMBL)
SEC24ComplexR-HSA-203991 (Reactome)
SEC31A ProteinO94979 (Uniprot-TrEMBL)
SEC31AProteinO94979 (Uniprot-TrEMBL)
SEC61A1 ProteinP61619 (Uniprot-TrEMBL)
SEC61A2 ProteinQ9H9S3 (Uniprot-TrEMBL)
SEC61B ProteinP60468 (Uniprot-TrEMBL)
SEC61G ProteinP60059 (Uniprot-TrEMBL)
SH3RF1 ProteinQ7Z6J0 (Uniprot-TrEMBL)
SHFM1 ProteinP60896 (Uniprot-TrEMBL)
SIAH1 ProteinQ8IUQ4 (Uniprot-TrEMBL)
SIAH2 ProteinO43255 (Uniprot-TrEMBL)
SKP1 ProteinP63208 (Uniprot-TrEMBL)
SKP2 ProteinQ13309 (Uniprot-TrEMBL)
SMURF1 ProteinQ9HCE7 (Uniprot-TrEMBL)
SMURF2 ProteinQ9HAU4 (Uniprot-TrEMBL)
SNAP23ProteinO00161 (Uniprot-TrEMBL)
SOCS1 ProteinO15524 (Uniprot-TrEMBL)
SOCS3 ProteinO14543 (Uniprot-TrEMBL)
SPSB1 ProteinQ96BD6 (Uniprot-TrEMBL)
SPSB2 ProteinQ99619 (Uniprot-TrEMBL)
SPSB4 ProteinQ96A44 (Uniprot-TrEMBL)
STUB1 ProteinQ9UNE7 (Uniprot-TrEMBL)
STX4 ProteinQ12846 (Uniprot-TrEMBL)
STX4ProteinQ12846 (Uniprot-TrEMBL)
Sar1p:GTP:Sec23p:Sec24p:Ag bound MHC class IComplexR-HSA-983413 (Reactome)
TAP1 ProteinQ03518 (Uniprot-TrEMBL)
TAP2 ProteinQ03519 (Uniprot-TrEMBL)
TAPBP ProteinO15533 (Uniprot-TrEMBL)
TAPBPProteinO15533 (Uniprot-TrEMBL)
TAPComplexR-HSA-1236915 (Reactome)
TAPComplexR-HSA-8863936 (Reactome)
TAPComplexR-HSA-983113 (Reactome)
THOP1ProteinP52888 (Uniprot-TrEMBL)
TLR1 ProteinQ15399 (Uniprot-TrEMBL)
TLR2 ProteinO60603 (Uniprot-TrEMBL)
TLR6 ProteinQ9Y2C9 (Uniprot-TrEMBL)
TPP2 ProteinP29144 (Uniprot-TrEMBL)
TRAF7 ProteinQ6Q0C0 (Uniprot-TrEMBL)
TRAIP ProteinQ9BWF2 (Uniprot-TrEMBL)
TRIM11 ProteinQ96F44 (Uniprot-TrEMBL)
TRIM21 ProteinP19474 (Uniprot-TrEMBL)
TRIM32 ProteinQ13049 (Uniprot-TrEMBL)
TRIM36 ProteinQ9NQ86 (Uniprot-TrEMBL)
TRIM37 ProteinO94972 (Uniprot-TrEMBL)
TRIM39 ProteinQ9HCM9 (Uniprot-TrEMBL)
TRIM4 ProteinQ9C037 (Uniprot-TrEMBL)
TRIM41 ProteinQ8WV44 (Uniprot-TrEMBL)
TRIM50 ProteinQ86XT4 (Uniprot-TrEMBL)
TRIM63 ProteinQ969Q1 (Uniprot-TrEMBL)
TRIM69 ProteinQ86WT6 (Uniprot-TrEMBL)
TRIM71 ProteinQ2Q1W2 (Uniprot-TrEMBL)
TRIM9 ProteinQ9C026 (Uniprot-TrEMBL)
TRIP12 ProteinQ14669 (Uniprot-TrEMBL)
TransloconComplexR-HSA-1236927 (Reactome)
Triacyl lipopeptide MetaboliteCHEBI:60192 (ChEBI)
UBA1 ProteinP22314 (Uniprot-TrEMBL)
UBA3 ProteinQ8TBC4 (Uniprot-TrEMBL)
UBA5 ProteinQ9GZZ9 (Uniprot-TrEMBL)
UBA52(1-76) ProteinP62987 (Uniprot-TrEMBL)
UBA6 ProteinA0AVT1 (Uniprot-TrEMBL)
UBA7 ProteinP41226 (Uniprot-TrEMBL)
UBAC1 ProteinQ9BSL1 (Uniprot-TrEMBL)
UBB(1-76) ProteinP0CG47 (Uniprot-TrEMBL)
UBB(153-228) ProteinP0CG47 (Uniprot-TrEMBL)
UBB(77-152) ProteinP0CG47 (Uniprot-TrEMBL)
UBC(1-76) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(153-228) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(229-304) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(305-380) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(381-456) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(457-532) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(533-608) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(609-684) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(77-152) ProteinP0CG48 (Uniprot-TrEMBL)
UBE2A ProteinP49459 (Uniprot-TrEMBL)
UBE2B ProteinP63146 (Uniprot-TrEMBL)
UBE2C ProteinO00762 (Uniprot-TrEMBL)
UBE2D1 ProteinP51668 (Uniprot-TrEMBL)
UBE2D2 ProteinP62837 (Uniprot-TrEMBL)
UBE2D3 ProteinP61077 (Uniprot-TrEMBL)
UBE2D4 ProteinQ9Y2X8 (Uniprot-TrEMBL)
UBE2E1 ProteinP51965 (Uniprot-TrEMBL)
UBE2E2 ProteinQ96LR5 (Uniprot-TrEMBL)
UBE2E3 ProteinQ969T4 (Uniprot-TrEMBL)
UBE2F ProteinQ969M7 (Uniprot-TrEMBL)
UBE2G1 ProteinP62253 (Uniprot-TrEMBL)
UBE2G2 ProteinP60604 (Uniprot-TrEMBL)
UBE2H ProteinP62256 (Uniprot-TrEMBL)
UBE2J1 ProteinQ9Y385 (Uniprot-TrEMBL)
UBE2J2 ProteinQ8N2K1 (Uniprot-TrEMBL)
UBE2K ProteinP61086 (Uniprot-TrEMBL)
UBE2L3 ProteinP68036 (Uniprot-TrEMBL)
UBE2L6 ProteinO14933 (Uniprot-TrEMBL)
UBE2M ProteinP61081 (Uniprot-TrEMBL)
UBE2N ProteinP61088 (Uniprot-TrEMBL)
UBE2O ProteinQ9C0C9 (Uniprot-TrEMBL)
UBE2Q1 ProteinQ7Z7E8 (Uniprot-TrEMBL)
UBE2Q2 ProteinQ8WVN8 (Uniprot-TrEMBL)
UBE2R2 ProteinQ712K3 (Uniprot-TrEMBL)
UBE2S ProteinQ16763 (Uniprot-TrEMBL)
UBE2U ProteinQ5VVX9 (Uniprot-TrEMBL)
UBE2V1 ProteinQ13404 (Uniprot-TrEMBL)
UBE2V2 ProteinQ15819 (Uniprot-TrEMBL)
UBE2W ProteinQ96B02 (Uniprot-TrEMBL)
UBE2Z ProteinQ9H832 (Uniprot-TrEMBL)
UBE3A ProteinQ05086 (Uniprot-TrEMBL)
UBE3B ProteinQ7Z3V4 (Uniprot-TrEMBL)
UBE3C ProteinQ15386 (Uniprot-TrEMBL)
UBE3D ProteinQ7Z6J8 (Uniprot-TrEMBL)
UBE4A ProteinQ14139 (Uniprot-TrEMBL)
UBOX5 ProteinO94941 (Uniprot-TrEMBL)
UBR1 ProteinQ8IWV7 (Uniprot-TrEMBL)
UBR2 ProteinQ8IWV8 (Uniprot-TrEMBL)
UBR4 ProteinQ5T4S7 (Uniprot-TrEMBL)
UFL1 ProteinO94874 (Uniprot-TrEMBL)
UNKL ProteinQ9H9P5 (Uniprot-TrEMBL)
UbComplexR-HSA-113595 (Reactome)
Ubiquitin activating E1 enzymesComplexR-HSA-947695 (Reactome)
Ubiquitin:E2 conjugating enzymesComplexR-HSA-976165 (Reactome)
Unknown hydrolaseR-HSA-8939794 (Reactome)
VAMP3 ProteinQ15836 (Uniprot-TrEMBL)
VAMP8 ProteinQ9BV40 (Uniprot-TrEMBL)
VAMP8,VAMP3ComplexR-HSA-8863861 (Reactome)
VHL ProteinP40337 (Uniprot-TrEMBL)
VPRBP ProteinQ9Y4B6 (Uniprot-TrEMBL)
WSB1 ProteinQ9Y6I7 (Uniprot-TrEMBL)
WWP1 ProteinQ9H0M0 (Uniprot-TrEMBL)
ZBTB16 ProteinQ05516 (Uniprot-TrEMBL)
ZNF645 ProteinQ8N7E2 (Uniprot-TrEMBL)
ZNRF1 ProteinQ8ND25 (Uniprot-TrEMBL)
ZNRF2 ProteinQ8NHG8 (Uniprot-TrEMBL)
adenosine 5'-monophosphateMetaboliteCHEBI:16027 (ChEBI)
antigenic substrate R-ALL-983035 (Reactome)
antigenic substrateR-ALL-983035 (Reactome)
class I MHC B13 ProteinP30461 (Uniprot-TrEMBL)
class I MHC B14 ProteinP30462 (Uniprot-TrEMBL)
class I MHC B15 ProteinP30464 (Uniprot-TrEMBL)
class I MHC B18 ProteinP30466 (Uniprot-TrEMBL)
class I MHC B27 ProteinP03989 (Uniprot-TrEMBL)
class I MHC B35 ProteinP30685 (Uniprot-TrEMBL)
class I MHC B37 ProteinP18463 (Uniprot-TrEMBL)
class I MHC B38 ProteinQ95365 (Uniprot-TrEMBL)
class I MHC B39 ProteinP30475 (Uniprot-TrEMBL)
class I MHC B40 ProteinQ04826 (Uniprot-TrEMBL)
class I MHC B41 ProteinP30479 (Uniprot-TrEMBL)
class I MHC B42 ProteinP30480 (Uniprot-TrEMBL)
class I MHC B44 ProteinP30481 (Uniprot-TrEMBL)
class I MHC B45 ProteinP30483 (Uniprot-TrEMBL)
class I MHC B46 ProteinP30484 (Uniprot-TrEMBL)
class I MHC B47 ProteinP30485 (Uniprot-TrEMBL)
class I MHC B49 ProteinP30487 (Uniprot-TrEMBL)
class I MHC B50 ProteinP30488 (Uniprot-TrEMBL)
class I MHC B51 ProteinP18464 (Uniprot-TrEMBL)
class I MHC B52 ProteinP30490 (Uniprot-TrEMBL)
class I MHC B53 ProteinP30491 (Uniprot-TrEMBL)
class I MHC B54 ProteinP30492 (Uniprot-TrEMBL)
class I MHC B55 ProteinP30493 (Uniprot-TrEMBL)
class I MHC B56 ProteinP30495 (Uniprot-TrEMBL)
class I MHC B57 ProteinP18465 (Uniprot-TrEMBL)
class I MHC B58 ProteinP10319 (Uniprot-TrEMBL)
class I MHC B59 ProteinQ29940 (Uniprot-TrEMBL)
class I MHC B67 ProteinQ29836 (Uniprot-TrEMBL)
class I MHC B7 ProteinP01889 (Uniprot-TrEMBL)
class I MHC B73 ProteinQ31612 (Uniprot-TrEMBL)
class I MHC B78 ProteinP30498 (Uniprot-TrEMBL)
class I MHC B8 ProteinP30460 (Uniprot-TrEMBL)
class I MHC B81 ProteinQ31610 (Uniprot-TrEMBL)
class I MHC B82 ProteinQ29718 (Uniprot-TrEMBL)
monoglucosylated MHC

class I

HC:Calnexin/BiP		ComplexR-HSA-983116 (Reactome)
monoglucosylated MHC class I HCComplexR-HSA-983120 (Reactome)
oligo-MyD88:Mal:BTK:activated TLRComplexR-HSA-937033 (Reactome)
oligopeptide fragment (3-7aa)MetaboliteCHEBI:25676 (ChEBI)
oligopeptide fragment (8-16aa)MetaboliteCHEBI:25676 (ChEBI)
oligopeptide fragmentMetaboliteCHEBI:25676 (ChEBI)
oligopeptide fragmentR-ALL-1236721 (Reactome)
oligopeptide fragment R-ALL-1236721 (Reactome)
p-4Y-TIRAP ProteinP58753 (Uniprot-TrEMBL)
p-6S-NCF1 ProteinP14598 (Uniprot-TrEMBL)
p-S95-SNAP23 ProteinO00161 (Uniprot-TrEMBL)
p-S95-SNAP23:VAMP8,VAMP3ComplexR-HSA-8863972 (Reactome)
p-S95-SNAP23ProteinO00161 (Uniprot-TrEMBL)
p-T154,S315-NCF4 ProteinQ15080 (Uniprot-TrEMBL)
p-T233-NCF2 ProteinP19878 (Uniprot-TrEMBL)
partially digested AgR-ALL-1236713 (Reactome)
partially digested AgR-ALL-1236718 (Reactome)
precursor peptide fragment (>16 aa)MetaboliteCHEBI:25676 (ChEBI)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
26S proteasomemim-catalysisR-HSA-1236935 (Reactome)
26S proteasomemim-catalysisR-HSA-1236970 (Reactome)
26S proteasomemim-catalysisR-HSA-983150 (Reactome)
ADPArrowR-HSA-1236949 (Reactome)
ADPArrowR-HSA-8863895 (Reactome)
ADPArrowR-HSA-983144 (Reactome)
ATPR-HSA-1236949 (Reactome)
ATPR-HSA-8863895 (Reactome)
ATPR-HSA-983140 (Reactome)
ATPR-HSA-983144 (Reactome)
ATPR-HSA-983153 (Reactome)
ATPR-HSA-983156 (Reactome)
Ag peptide bound class I MHCArrowR-HSA-1236971 (Reactome)
Ag peptide bound class I MHCR-HSA-1236965 (Reactome)
Ag-substrate:E3:E2:UbArrowR-HSA-983157 (Reactome)
Ag-substrate:E3:E2:UbR-HSA-983140 (Reactome)
Antigen peptide

bound class I

MHC:BAP31 oligomer		ArrowR-HSA-983161 (Reactome)
Antigen peptide

bound class I

MHC:BAP31 oligomer		R-HSA-983138 (Reactome)
Antigen peptide bound class I MHCArrowR-HSA-1236943 (Reactome)
Antigen peptide bound class I MHCArrowR-HSA-1236964 (Reactome)
Antigen peptide bound class I MHCArrowR-HSA-1236965 (Reactome)
Antigen peptide bound class I MHCArrowR-HSA-983138 (Reactome)
Antigen peptide bound class I MHCArrowR-HSA-983421 (Reactome)
Antigen peptide bound class I MHCArrowR-HSA-983422 (Reactome)
Antigen peptide bound class I MHCArrowR-HSA-983427 (Reactome)
Antigen peptide bound class I MHCR-HSA-1236964 (Reactome)
Antigen peptide bound class I MHCR-HSA-983421 (Reactome)
Antigen peptide bound class I MHCR-HSA-983426 (Reactome)
Antigen peptide bound class I MHCR-HSA-983427 (Reactome)
Antigen peptideArrowR-HSA-1236954 (Reactome)
Antigen peptideArrowR-HSA-983158 (Reactome)
Antigen peptideR-HSA-1236943 (Reactome)
Antigen peptideR-HSA-8951499 (Reactome)
Antigenic

peptide:MHC:B2M peptide loading

complex		ArrowR-HSA-8951499 (Reactome)
Antigenic

peptide:MHC:B2M peptide loading

complex		R-HSA-983161 (Reactome)
B2M(21-119)R-HSA-983146 (Reactome)
BAP31 oligomerArrowR-HSA-983138 (Reactome)
BAP31 oligomerR-HSA-983142 (Reactome)
CALR:SEC22B:STX4:TAP:TAPBPArrowR-HSA-8863858 (Reactome)
CALR:SEC22B:STX4:TAP:TAPBPR-HSA-8951595 (Reactome)
CALRArrowR-HSA-8863914 (Reactome)
CALRArrowR-HSA-8951595 (Reactome)
CALRArrowR-HSA-983161 (Reactome)
CALRR-HSA-8863858 (Reactome)
CALRR-HSA-8863914 (Reactome)
CALRR-HSA-983142 (Reactome)
CHUK:IKBKB:IKBKGmim-catalysisR-HSA-8863895 (Reactome)
COPII vesicle with MHC class IArrowR-HSA-983424 (Reactome)
COPII vesicle with MHC class IArrowR-HSA-983425 (Reactome)
COPII vesicle with MHC class IR-HSA-983422 (Reactome)
COPII vesicle with MHC class IR-HSA-983424 (Reactome)
COPIImim-catalysisR-HSA-983422 (Reactome)
CTSS-like proteinsmim-catalysisR-HSA-1236948 (Reactome)
Chaperones calnexin/BiPArrowR-HSA-983146 (Reactome)
Chaperones calnexin/BiPR-HSA-983145 (Reactome)
Class I MHC HC:B2M:Erp57ArrowR-HSA-8863973 (Reactome)
Class I MHC HC:B2M:Erp57R-HSA-1236971 (Reactome)
Class I MHC HC:B2M:Erp57R-HSA-8863973 (Reactome)
Class I MHC:B2MR-HSA-1236943 (Reactome)
DC receptors

recognizing

apoptotic cells		ArrowR-HSA-1236956 (Reactome)
DC receptors

recognizing

apoptotic cells		R-HSA-1236958 (Reactome)
E1 bound ubiquitinArrowR-HSA-983153 (Reactome)
E1 bound ubiquitinR-HSA-983152 (Reactome)
E2 Ubiquitin-conjugating enzymeArrowR-HSA-983140 (Reactome)
E2 Ubiquitin-conjugating enzymeArrowR-HSA-983156 (Reactome)
E2 Ubiquitin-conjugating enzymeR-HSA-983152 (Reactome)
E2 Ubiquitin-conjugating enzymemim-catalysisR-HSA-983152 (Reactome)
E3 ligases in

proteasomal

degradation		ArrowR-HSA-983147 (Reactome)
E3 ligases in

proteasomal

degradation		R-HSA-983157 (Reactome)
E3 ligases in

proteasomal

degradation		mim-catalysisR-HSA-983140 (Reactome)
E3:K48-polyubiquitinated substrateArrowR-HSA-983156 (Reactome)
E3:K48-polyubiquitinated substrateR-HSA-983147 (Reactome)
E3:Ub:substrateArrowR-HSA-983140 (Reactome)
E3:Ub:substrateR-HSA-983156 (Reactome)
E3:Ub:substratemim-catalysisR-HSA-983156 (Reactome)
ERAP1/2mim-catalysisR-HSA-983158 (Reactome)
Exogenous

Particulate antigen

(Ag)		ArrowR-HSA-1236956 (Reactome)
Exogenous

Particulate antigen

(Ag)		ArrowR-HSA-1236963 (Reactome)
Exogenous

Particulate antigen

(Ag)		R-HSA-1236938 (Reactome)
Exogenous

Particulate antigen

(Ag)		R-HSA-1236958 (Reactome)
Exogenous

Particulate antigen

(Ag)		R-HSA-1236963 (Reactome)
Exogenous soluble antigenArrowR-HSA-1236940 (Reactome)
Exogenous soluble antigenArrowR-HSA-1236968 (Reactome)
Exogenous soluble antigenR-HSA-1236939 (Reactome)
Exogenous soluble antigenR-HSA-1236948 (Reactome)
Exogenous soluble antigenR-HSA-1236968 (Reactome)
Exogenous soluble antigenR-HSA-1236970 (Reactome)
GDPR-HSA-983422 (Reactome)
GTPArrowR-HSA-983422 (Reactome)
H+ArrowR-HSA-1236967 (Reactome)
H2OR-HSA-1236949 (Reactome)
H2OR-HSA-983144 (Reactome)
H2OR-HSA-983422 (Reactome)
IFN gamma stimulated aminopeptidasesmim-catalysisR-HSA-983162 (Reactome)
IRAP in complex with MHC class Imim-catalysisR-HSA-1236954 (Reactome)
K48polyUb-antigenic substrateArrowR-HSA-983147 (Reactome)
K48polyUb-antigenic substrateR-HSA-983150 (Reactome)
K48polyUb-partially digested AgR-HSA-1236935 (Reactome)
L-amino acidArrowR-HSA-1236935 (Reactome)
L-amino acidArrowR-HSA-1236948 (Reactome)
L-amino acidArrowR-HSA-1236954 (Reactome)
L-amino acidArrowR-HSA-1236970 (Reactome)
L-amino acidArrowR-HSA-983150 (Reactome)
L-amino acidArrowR-HSA-983158 (Reactome)
L-amino acidArrowR-HSA-983162 (Reactome)
MHC

class I

HC:Calnexin/BiP:Erp57		ArrowR-HSA-983148 (Reactome)
MHC

class I

HC:Calnexin/BiP:Erp57		R-HSA-983146 (Reactome)
MHC HC:B2M:Erp57ArrowR-HSA-983146 (Reactome)
MHC HC:B2M:Erp57R-HSA-983142 (Reactome)
MHC:B2M peptide loading complexArrowR-HSA-983142 (Reactome)
MHC:B2M peptide loading complexR-HSA-8951499 (Reactome)
MR/other probable receptorsArrowR-HSA-1236940 (Reactome)
MR/other probable receptorsR-HSA-1236939 (Reactome)
MR:soluble antigenArrowR-HSA-1236939 (Reactome)
MR:soluble antigenArrowR-HSA-1236941 (Reactome)
MR:soluble antigenArrowR-HSA-1236955 (Reactome)
MR:soluble antigenR-HSA-1236940 (Reactome)
MR:soluble antigenR-HSA-1236941 (Reactome)
MR:soluble antigenR-HSA-1236955 (Reactome)
Mg2+ArrowR-HSA-983153 (Reactome)
Mg2+R-HSA-983153 (Reactome)
NADP+ArrowR-HSA-1236967 (Reactome)
NADPHR-HSA-1236967 (Reactome)
NOX2 complexmim-catalysisR-HSA-1236967 (Reactome)
O2.-ArrowR-HSA-1236967 (Reactome)
O2R-HSA-1236967 (Reactome)
PDIA3ArrowR-HSA-983161 (Reactome)
PDIA3R-HSA-983148 (Reactome)
PPiArrowR-HSA-983140 (Reactome)
PPiArrowR-HSA-983153 (Reactome)
PPiArrowR-HSA-983156 (Reactome)
Particulate Ag:DC receptorsArrowR-HSA-1236958 (Reactome)
Particulate Ag:DC receptorsR-HSA-1236956 (Reactome)
PiArrowR-HSA-1236949 (Reactome)
PiArrowR-HSA-983144 (Reactome)
R-HSA-1236935 (Reactome) Proteasomes are usually localized to the cytoplasm but are also present in the nucleus and ER. Houde et al. (2003) investigated the distribution of proteasomes in J774 macrophages and observed them on phagosomes. The proteasomes present on phagosomes may not come directly from ER, but instead assemble on phagosomes to play a function at a precise point during phagolysosomal biogenesis. Houde et al. also observed polyubiquitinated proteins on the cytoplasmic side of phagosomes and highlighted the link between the ubiquitination process and proteasomal degradation; translocated peptides are ubiquitinated and processed by the proteasome complex assembled on the cytoplasmic side of phagosomes, leading to the generation of MHC class I binding peptides.
R-HSA-1236938 (Reactome) Phagocytosed particulate antigens are partially digested in the lumen of phagolysosomes by various lysosomal hydrolases.
R-HSA-1236939 (Reactome) Soluble antigens are presented to dendritic cells (DCs) in some cases by receptor mediated endocytosis or fluid-phase endocytosis. Burgdorf et al. (2008) suggest that there are two different endocytic compartments for antigen processing: one dedicated to MHC class I (early endosomes) and the other one for MHC class II presentation (lysosomes). Sorting of cargo into these different compartments occurs at the plasma membrane and is likely to depend on the type of endocytic receptor the cargo is interacting with (Burgdorf et al. 2008, Zhuang et al. 2006). The mannose receptor (MR) is the best studied receptor that targets soluble antigens to early endosomes but not to lysosomes (Burgdorf et al. 2006). Antigens taken up by the MR are targeted towards a mildly acidic stable early endosomal compartment for exclusive presentation on MHC I molecules (Burgdorf et al. 2008).
R-HSA-1236940 (Reactome) Within the endosome the receptor and cargo separate and the receptor recycles back to the cell surface. Soluble antigens are targeted into the stable early endosome lumen for efficient cross presentation. Early endosomes are mildly acidic and relatively poor in proteases.
R-HSA-1236941 (Reactome) Receptor-bound exogenous antigens in coated pits on the cell surface are internalized into clathrin-coated vesicles.
R-HSA-1236943 (Reactome) Peptides generated by Cathepsin S or IRAP-mediated proteolysis in the endosomes are loaded onto MHC class I molecules, which are internalized and transported to early and late endosomal compartments where antigenic peptides can be loaded. A fraction of the internalized cell surface class I molecules enter MHC class II compartments (MIICs) within endocytic vesicles (Gromme et al. 1999, Kleijmeer et al. 2001). Microscopic analysis has revealed that surface MHC-I molecules are internalized and transported to early and late endosomal compartments (Basha et al. 2008, Lizee et al. 2003). A tyrosine-based endocytic trafficking motif (YXXA) is required for the constitutive internalization of MHC-I molecules from the cell surface into early/late endosomes for peptide loading (Basha et al. 2008, Lizee et al. 2003). Upon entry in to these endosomal compartments the MHC class I complexes exchange their pre-bound peptides with exogenously derived antigenic peptides.
R-HSA-1236947 (Reactome) Fusion of the maturing phagosome with the ER mediates the exchange of materials resulting in the formation of a hybrid ER-phagosome compartment (Gagnon et al. 2002, Guermonprez et al. 2003, Houde et al. 2003, Ackerman et al. 2003, Blanchard et al. 2010). This hybrid contains the retrotranslocon factor Sec61 that mediates the access of proteasomes on the cytosolic surface of the phagosome. Using fluorescence imaging, Houde et al. (2003) provided evidence for the role of Sec61 in the retrotranslocation of internalized exogenous proteins from phagosomes to the cytoplasmic face of J774 macrophages. Sec61 factor is a heterotrimeric complex composed of alpha, beta and gamma subunits forming the core of the mammalian ER translocon (Greenfield et al. 1999). Oligomers of the Sec61 complex form a transmembrane channel involved in the retrotranslocation of misfolded proteins from ER to the cytosol for degradation, and thus it has been proposed that Sec61 might be involved in the translocation of proteins in phagosomes to the cytosol (Kasturi et al. 2008).
R-HSA-1236948 (Reactome) Endocytic compartments contain many cysteine proteases such as cathepsin S that can generate cross-presented peptides. Cathepsins may participate in the generation of MHC class II-presentated peptides (Villadangos et al. 1999). Shen et al. (2004) demonstrated that cathepsin S contributes to TAP-independent cross-presentation in vivo, showing that ovalbumin was cross-presented by denritic cells (DCs) through both TAP-dependent and TAP-independent pathways. The TAP-independent pathway was sensitive to the cystine protease inhibitor leupeptin, but not to proteasome inhibitors. Further experiments with knockout mice showed that cathepsin S contributed to cross-presentation. DCs lacking cathepsin S lack the TAP-independent pathway (Khor et al. 2008, Shen et al. 2004).
R-HSA-1236949 (Reactome) After processing by the proteasome, some of the oligopeptides could be reinternalized to the phagosome lumen of the same phagosome through the TAP complex probably acquired during ER-phagosome fusion. Guermonprez et al. (2003) tested this model and observed abundant TAP complex in early phagosomes and its reduction over time. Electron microscopy analysis of purified phagosomes also showed the insertion of TAP2 into the phagosomal membrane.
R-HSA-1236954 (Reactome) While it is established that cathepsin S is involved in antigen processing in endocytotic vesicles, it is less certain whether other proteases present in endocytic vesicles are also involved in generating the peptide fragments. Insulin regulated aminopeptidase (IRAP) is an epitope-trimming zinc-dependent aminopeptidase closely related to ERAP1 and ERAP2. IRAP may be involved in vacuolar processing of the peptide fragments within endosomes (Saveanu et al. 2009, Segura et al. 2009). IRAP is detected predominantly in the early and recycling endosome fractions. Saveanu et al. (2009) observed the physical association of IRAP with internalized class I MHC molecules and suggested that this may favour a direct linkage between peptide trimming and MHC class I loading. They also showed that IRAP-dependent processing of antigens requires active proteasome but not lysosomal proteases, which suggests that this pathway utilizes cytosolic degradation followed by peptide transport into IRAP-containing endosomes.
R-HSA-1236955 (Reactome) The antigen:receptor complex moves from clathrin-coated vesicles to the early endosome membrane.
R-HSA-1236956 (Reactome) After internalization, F-actin is depolymerized from the phagosome, and the newly denuded vacuole membrane becomes accessible to early endosomes (Aderem & Underhill. 1999).
R-HSA-1236958 (Reactome) Dendritic cells (DCs) and macrophages recognize and phagocytose apoptotic cells/invading microorganisms using a variety of receptors including lectins, Mannose receptor (MR) (Stahl & Ezekowitz. 1998), CD36 (Savill 1997), CD14 (Devitt et al. 1998), scavenger receptor A (SR-A) (Platt et al. 1996) and integrin alphaVbeta5 (Savill et al. 1992, Savilli et al. 1990), then cross-present cell-associated antigens to CD8+ T cells. Ligands on apoptotic cell like sugars, phosphatidylserine and surface-bound thrombospondin (TSP) are recognized by these receptors and induce rearrangements in the actin cytoskeleton that lead to the internalization of the particle.
R-HSA-1236963 (Reactome) Following fission of the phagosome vesicle from the plasma membrane, the phagosome undergoes maturation by a series of fusion and fission events, fusing with late endosomes and ultimately lysosomes, to form a phagolysosome.

fuses sequentially with sorting/early endosomes, late endosomes and finally lysosomes to acquire degradative capabilities. This process is referred to as phagosome maturation.
R-HSA-1236964 (Reactome) Peptide-loaded MHC class I complexes are transported by an undefined mechanism back to the cell surface for cross-presentation to T cells.
R-HSA-1236965 (Reactome) Exogenous antigen loaded class I MHC molecules in phagosomes may be delivered to the surface by membrane recycling machinery.
R-HSA-1236967 (Reactome) After the fusion of phagosome and lysosome lumen acidity rises and the activity of lysosomal proteases increases, conferring proteolytic ability. However antigens must be spared from complete proteolytic destruction. Dendritic cells (DCs) achieve this by regulating the level of proteolysis and phagosomal acidification. DCs recruit the NADPH oxidase NOX2 to the phagosome and mediate sustained production of low levels of reactive oxygen species (ROS), causing active alkalization of the phagosomal lumen (Savina et al. 2006, Ramachandra et al. 2009). NOX2 consumes oxygen and protons (pumped by V-ATPase or other H+ voltage-gated channels) to produce ROS and this lowers phagosome acidity. This apparently reduces antigen proteolysis to a level that allows processing but does not fully destroy the antigenic peptides, favouring increased MHC-I cross presentation (Ramachandra et al. 2009). Rab27a controls the recruitment of NOX2 to DC phagosomes (Savina et al. 2007).
R-HSA-1236968 (Reactome) Endocytosed antigens must leave the endocytic structure to enter into the MHC I pathway before exhaustive degradation within lysosomes. The canonical pathway is the transporter associated with antigen processing (TAP)-dependent cytosolic pathway, which involves the translocation of endocytosed antigens into the cytosol where they are degraded into antigenic peptides by the proteasome and transported to ER through TAP. This hypothesis comes from indirect evidences showing that proteasome inhibitors block cross presentation of certain antigens (Amigorena et al. 2010, Burgdorf et al. 2008) . According to this model antigens are translocated into the cytosol by an undefined mechanism.
There are less well-characterized mechanisms for the delivery of exogenous antigens into the cytosol. Certain peptides with highly positively charged sequences derived from HIV tat protein or the Antennapedia homeodomain (AntHD) protein seem to penetrate into the cytosol directly across the plasma membrane (Monu et al. 2007, Vendeville et al. 2004). It is also proposed that some exogenous antigens can be exchanged between neighboring cells through gap junctions, leading to cross presentation by the recipient cell (Monu et al. 2007, Neijssen et al. 2005).
Once internalized antigens are routed into the cytosol, they follow the conventional pathway of proteasome digestion and TAP mediated transport of peptides into the ER lumen.
R-HSA-1236970 (Reactome) Exogenous antigens are thought to be processed for cross-presentation in much the same manner as endogenous proteins once they enter the cytosolic pathway (Rock et al. 2010). Immunoproteasome components are the major proteases involved in generating the antigenic fragments. The precurssor peptides are further trimmed by cytosolic aminopeptidases and shuttled to ER through TAP for MHC class I loading.
R-HSA-1236971 (Reactome) Peptides translocated back into the phagosomal lumen are loaded onto MHC class I molecules. Guermonprez et al. (2003) detected the components of the peptide loading complex (TAP, tapasin, calreticulin and ERp57) together with MHC class I in purified early phagosomes. They observed peptide loading in the presence of ATP in purified phagosomes expressing HLA-A2, incubated with iodinated S-9-L peptide. From these experiments they concluded that TAP-imported peptides can be loaded on MHC class I molecules in the lumen of phagosomes. Houde et al. (2003) also observed OVA peptide SIINFEKL:MHC-I complex in the phagosome lumen.
R-HSA-1236972 (Reactome) Upon phagolysosomal proteolysis the phagocytosed proteins still need to gain access to the cytosol for proteasomal access, transport into the ER and loading onto MHC class I. The mechanism for this escape of phagocytosed antigens remain unknown.
R-HSA-203979 (Reactome) Sar1p-GTP recruits the cytoplasmic Sec23p-Sec24p complex. (Though not represented in the subsequent steps, Sec23p-Sec24p would bind to members of the p24 protein family of possible cargo receptors, and together with Sar1p bind the appropiate v-SNARE, and Rab-GTP.)



R-HSA-8863858 (Reactome) The interaction between the two compartments could involve either direct fusion of ER stacks to phagosomes (Phgs) or vesicular intermediates. In both cases, a fusion event between the ER or ER-derived membrane vesicles and Phgs must occur. The SNARE SEC22B localizes to the ER-Golgi intermediate compartment (ERGIC) and interacts with SNARE syntaxin 4 (STX4) on phagosomes (Phgs), mediating the recruitment of subset of ER components including transporter associated with antigen processing (TAP), to phagosomes (Cebrian et al. 2011).
R-HSA-8863895 (Reactome) A major reserve of MHC-I in dendritic cells reside within the endocytic recycling compartments (ERC). MHC-I trafficking to the ERC is regulated by the activity of Rab11a and subsequent trafficking from ERC to phagosomes is controlled by TLR-MyD88-IKK2-dependent phosphorylation of phagosomal SNAP23. Toll-like receptor (TLR) signalling regulate cross-presentation as they regulate phagocytosis and phagolysosomal fusion (Nair et al. 2011). MHC-I bearing ERC are enriched with R-SNAREs like RAB11a, VAMP3, and VAMP8. These SNARE molecules can interact with Q-SNARE SNAP23 present on phagosomes and this mediates membrane fusion. This interaction of SNAP23 with R-SNAREs require phosphorylation of SNAP23 (on Ser-95) by IKK2, and IKK2 is activated by TLR signalling. SNAP23 phosphorylation may increase SNAP23 binding to SNAREs. It may also regulate platelet and mast cell secretion (Karim et al. 2013, Suziki & Verma 2008).
R-HSA-8863914 (Reactome) In DCs subset of ER proteins including MHC-I peptide loading complex (PLC) and transporter associated with antigen processing (TAP) transit to phagosomes via the intermediate compartment ER-Golgi intermediate compartment (ERGIC) (Cebrian et al. 2011). TAP exits the ER in COPII vesicles in association with MHC class I, and that peptide translocation by TAP and binding to class I can occur in post-ER compartments (Ghanem et al. 2010). SEC22B, an ER-resident SNARE is required for the transport of PLC from ERGIC (Cebrian et al. 2011), but this step does not deliver MHC-I (Nair-Gupta et al. 2014). Instead, MHC-I are recruited from an endosomal recycling compartment (ERC), which is marked by Rab11a, VAMP3/cellubrevin, and VAMP8/endobrevin that holds large reserves of MHC-I. This step is dependent on TLR signalling (Nair-Gupta et al. 2014).
R-HSA-8863973 (Reactome) Recycling endosome-localized R-SNARE protein like RAB11a, VAMP3, and VAMP8 dock with target phagosome membrane Q-SNARE protein SNAP23. MHC-I present on the recycling endosomes would be delivered to phagosomes during this process.
R-HSA-8940641 (Reactome) Thimet oligopeptidase (THOP1, EP24.15) is a zinc-dependent peptidase of the metallopeptidase M3 family (Pierotti et al. 1990). It was first described as a neuropeptide-degrading enzyme present in the soluble fraction of brain homogenates (Orlowski et al. 1983). However, its predominant location in the cytosol and nucleus suggests that extracellular degradation of neuropeptides and hormones is not its primary function (Fontenele-Neto et al. 2001). THOP1 can metabolize peptides within cells, thereby affecting antigen presentation and G protein-coupled receptor signal transduction. It was shown in vivo to participate in antigen presentation through MHC-I (Silva et al. 1999, Kim et al. 2003, Yorl et al. 2003) and in vitro to bind (Portaro et al. 1999) or degrade (Saric et al. 2001) some MHC-I associated peptides. THOP1 can degrade a broad range of intracellular peptides containing 5–17 amino acids (Oliveira et al. 2001, Berti et al. 2009). Substrate size is restricted because its catalytic center is located in a deep channel (Ray et al. 2004). THOP1 can both degrade existing peptides and generate new peptides, making it a versatile enzyme for regulating intracellular peptide function including antigen presentation (Berti et al. 2009, Russo et al. 2012).

Cytotoxic T lymphocytes (CTLs) recognize peptides presented by HLA class I molecules on the cell surface. The C terminus of these CTL epitopes is considered to be produced by the proteasome, but is complemented by THOP1 and other cytosolic endopeptidases such as Nardilysin (Kessler et al. 2011, Oliveira & van Hall 2015).
R-HSA-8951499 (Reactome) MHC class I heterodimers are only stable in peptide bound form and only as a trimer (with bound peptide) present on the cell surface. Class I MHC molecules prefer nonapeptides, and less frequently use octa- or deca-peptides. The peptide binding groove in MHC class I molecules is formed by the intimate association of the alpha1 and alpha2 domains of the heavy chain. Structural studies have revealed that the alpha1:alpha2 domains form a single peptide binding groove consisting of 2 parallel helices on a floor of 8 beta-strands. Hydrogen bonding networks are established in the binding groove with the antigenic peptide main chain and terminal atoms that enable largely sequence independent ligation. Upon peptide binding the class I MHC molecule releases from the peptide loading complex (PLC) and clusters at ER exit sites and is finally exported to the cell surface.
MHC I molecules bound to low-affinity peptides are not transferred to the cell surface and are instead cycled back to ER. They can proceed to the cell surface only when they become bound to high-affinity peptide (Howe et al, 2009; Garstka et al, 2007). Calreticulin binds to these low-affinity peptide bound class I molecules and mediate the retrieval from golgi apparatus to ER and for effcient presentation of a model antigen (Howe et al, 2009).
R-HSA-8951595 (Reactome) The interaction between the two compartments involves either direct fusion of ER stacks to phagosomes (Phgs) or vesicular intermediates. In both cases, a fusion event between the ER or ER-derived membrane vesicles and Phgs must occur. The SNARE SEC22B localizes to the ER-Golgi intermediate compartment (ERGIC) and interacts with SNARE syntaxin 4 (STX4) on phagosomes (Phgs), mediating the recruitment of subset of ER components including transporter associated with antigen processing (TAP), to phagosomes (Cebrian et al. 2011).
R-HSA-983138 (Reactome) When the loaded peptide is of a sufficiently high-affinity the trimeric complex is transported to a special ER exit site by a putative cargo receptor, B cell receptor-associated protein (BAP31), where it translocates to the cell surface, possibly by transport in COPII-coated vesicles.
R-HSA-983140 (Reactome) Interaction of E3 with both substrate and E2-Ub, brings them into proximity so that ubiquitin is transferred from E2 to the substrate. In most cases the transfer of ubiquitin is direct from E2 to substrate, but in a small subset of E3s, it occurs via a covalent E3-Ub thioester intermediate (Raymond et al. 2009).
R-HSA-983142 (Reactome) Upon interaction of Beta-2-microglobin (B2M) with MHC class I Heavy Chain (HC), calnexin is fully replaced by its soluble ortholog calreticulin (CRT) and this complex is incorporated into the peptide loading complex (PLC). PLC is a multiprotein complex that includes CRT, ERp57 and the additional components tapasin, transporter associated with antigen processing (TAP) and Bap31. The stoichometry of components in PLC remains unclear. The PLC loads antigenic peptides onto MHC class I molecules; components of the PLC cooperate to stabilize the MHC class I complex and optimally load peptides. Tapasin is a type I transmembrane protein that interacts directly with TAP and tethers the MHC complex to it. TAP facilitates the transport of peptides from the cytosol to the ER lumen. B cell receptor–associated protein (Bap31), a putative cargo receptor, associates with HC and acts as a retrograde transporter, carrying peptide-loaded class I MHC molecules.
R-HSA-983144 (Reactome) Ttransporter associated with antigen processing (TAP) is a heterodimeric complex, composed of TAP1 and TAP2 proteins, members of the ATP-binding cassette (ABC) superfamily. TAP consists of two transmembrane domains (TMDs) and two cytosolic nucleotide-binding domains. Peptide binding to the cytosolic-facing cavity formed by the TMDs causes it to undergo a conformational change that induces ATP hydrolysis, forcing the opening of a pore and translocation of the peptide into the ER lumen. TAP transports peptides in the range of 8-16 amino acids into the ER, which is the peptide length typically generated by the immunoproteasome.
R-HSA-983145 (Reactome) The newly synthesized MHC class I heavy chain (HC) translocates into the endoplasmic reticulum (ER) and binds rapidly to calnexin (CNX), a transmembrane calcium-dependent lectin with chaperone activity. CNX recognizes and binds to an N-linked monoglycosylated Glc1Man9GlcNAc2 carbohydrate group found attached to the conserved Asn-86 in the HC. Interaction of HC with CNX promotes the formation of intrachain disulfide bonds. Another candidate ER chaperon protein is immunoglobulin binding protein (BiP), found to associate with HC in the absence of CNX. These chaperones can cooperate in protein folding and prevention of aggregation.
R-HSA-983146 (Reactome) Interaction of calnexin (CNX) with MHC class I HC stabilizes it and facilitates the association of the beta2 microglobulin component (B2M). The two chains are linked noncovalently via interaction of B2M and the alpha3 domain of MHC HC. After formation of the HC:B2M heterodimer, the MHC complex dissociates from CNX.
R-HSA-983147 (Reactome) K48 polyubiquitinated substrate dissociates from E3 to become a substrate for a multicatalytic complex called the 26S proteasome.
R-HSA-983148 (Reactome) Endoplasmic reticulum resident protein 57 (ERp57), is a member of the protein disulphide isomerase (PDI) family of thiol oxidoreducatases. It associates with Calnexin (CNX), and its soluble homolog calreticulin (CRT) and is recruited to MHC Class I Heavy Chain (HC). ERp57 is involved in the formation of HC disulphide bonds.
R-HSA-983150 (Reactome) The 26S proteasome complex consists of the 20S catalytic core particle which harbours the proteolytically active sites and the regulatory 19S particle which is responsible for substrate interaction. This process generates a vast number (perhaps hundreds) of different peptides, depending on the length and sequence of the substrate protein. Only a small fraction of these peptides (nearly 10%) form the exact length to be presented by class I MHC; most (approximately 70%) are too short to bind. The remaining proteasome products (10-20%) are N-terminally extended precursors that require additional cleavage by cytosolic aminopeptidases for presentation by MHC class I molecules.
R-HSA-983152 (Reactome) Activated ubiquitin is transferred from E1 to the active site cystine of ubiquitin conjugating enzymes (E2s) via a trans-esterification reaction. E2s catalyze covalent attachment of ubiquitin to target proteins. They all share an active-site ubiquitin-binding cysteine residue and are distinguished by the presence of a ubiquitin-conjugating catalytic (UBC) fold required for binding of distinct ubiquitin ligases or E3s. Once conjugated to ubiquitin, the E2 molecule binds one of several E3s (Glickman et al. 2002).
R-HSA-983153 (Reactome) Ubiquitin is activated in an ATP-dependent manner, catalyzed by E1 ubiquitin-activating enzymes. In the first step of ubiquitin activation, the E1 enzyme binds ATP, Mg+2 and ubiquitin, and catalyses ubiquitin C-terminal acyl-adenylation (Ubiquitin-AMP). In the second step, the catalytic cystine in the E1 attacks the ubiquitin-adenylate (Ub-AMP) to form the activated ubiquitin-E1 thioester-bonded complex and an AMP leaving group. The intermediate reaction involving the formation of the ubiquitin-AMP complex is not represented here.
R-HSA-983156 (Reactome) Monoubiquitinated substrate acquires additional ubiquitin modifications in the form of multiple single attachments or a ubiquitin chain. Polyubiquitin chains added through K48 residue of ubiquitin typically targets the substrate for degradation (Raymond et al. 2009).
R-HSA-983157 (Reactome) Ubiquitin E3 ligases confer specificity to ubiquitination by recognizing target substrates and mediating transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to substrate (Raymond et al. 2009). E3 ligases includes a large, diverse set of proteins characterized by several defining motifs which include a HECT (homologous to E6-associated C-terminus), RING (Really Interesting New Gene) and U-box domains. The E3 ligases can be multisubunit complexes rather than a single polypeptide. Presently three different kinds of E3 complexes have been described called SCF, APC, and VHL. E3 ligases binds to both substrate and an E2 thioesterified with ubiquitin (E2-Ub).
R-HSA-983158 (Reactome) Transporter associated with antigen processing (TAP) prefers peptides 8-16 residues long, slightly longer than the canonical 8-10 residue peptides that fit into class I MHC binding sites. These longer peptides are further trimmed at their N-termini by the ER-associated aminopeptidase (ERAP). ERAP trims peptides to a length of 8-10 residues, suitable for loading into the MHC class I binding groove.
R-HSA-983161 (Reactome) Upon peptide binding the class I MHC molecule releases from the peptide loading complex (PLC) and clusters at ER exit sites and is finally exported to the cell surface.
MHC I molecules bound to low-affinity peptides are not transferred to the cell surface and are instead cycled back to ER. They can proceed to the cell surface only when they become bound to high-affinity peptide (Howe et al. 2009, Garstka et al. 2007). Calreticulin binds to these low-affinity peptide bound class I molecules and mediate the retrieval from golgi apparatus to ER and for effcient presentation of a model antigen (Howe et al. 2009).
R-HSA-983162 (Reactome) Some peptides generated by the 26S proteasome are too long to bind to MHC class I molecules. These N-terminal extended precursor peptides may be trimmed by cytosolic aminopeptidases, such as Tripeptidyl peptidase II (TPP2), puromycin-sensitive aminopeptidase (PSA), bleomycin hydrolase (BH), and leucine aminopeptidase (LAP).
R-HSA-983421 (Reactome) Cargo must pass through the various compartments of the Golgi complex to reach the plasma membrane. This may occur through either of the two well known models, cisternal maturation or vesicular transport (Refer to review articles Glick et al. 2009, Jackson 2009, Nakano et al. 2010).
R-HSA-983422 (Reactome) Before the cargo vesicle can fuse with target membrane, the COPII protein coat must be disassembled and its components released into cytosol. This uncoating is triggered by hydrolysis of the bound GTP to produce Sar1p-GDP, which has decreased affinity for the vesicle membrane. Disassociation of Sar1p-GDP from the membrane is followed by the release of the other COPII subunits.
R-HSA-983424 (Reactome) Once the entire COPII coat has been assembled, the bud is separated from the ER membrane in the form of a COPII coated vesicle.
R-HSA-983425 (Reactome) Sec13-Sec31 binds the prebudding complex and this Sec13-Sec31 heterotetramer forms the outer structural scaffold of the coat. Sec13-Sec31 is likely to crosslink the prebudding complexes generating COPII-coated vesicles.
R-HSA-983426 (Reactome) The cytoplasmic tails of MHC class I molecules do not possess any of the known ER export sequences. BAP31 acts as a cargo receptor by exporting peptide-loaded class I MHC molecules to the ER exit sites or ER/Golgi intermediate compartment. Sec24 of the Sec23-Sec24/Sar1-GTP complex catches cargo by direct contact, forming the prebudding complex. Sar1/Sec23-Sec24 can bring about curvature of the membrane in the formation of vesicle. The cargo (antigen-bound MHC) accumulates within the COPII vesicle by binding to the Sec24 polypeptide of the COPII coat.
R-HSA-983427 (Reactome) After passing through the Golgi complex, secretory cargo is packaged into post-Golgi transport intermediates (post-Golgi), which translocate plus-end directed along microtubules to the plasma membrane.
SAR1B:GDPArrowR-HSA-983422 (Reactome)
SAR1B:GTP:SEC23:SEC24ArrowR-HSA-203979 (Reactome)
SAR1B:GTP:SEC23:SEC24R-HSA-983426 (Reactome)
SAR1B:GTPR-HSA-203979 (Reactome)
SEC13ArrowR-HSA-983422 (Reactome)
SEC13R-HSA-983425 (Reactome)
SEC22B:STX4ArrowR-HSA-8951595 (Reactome)
SEC22BArrowR-HSA-8863914 (Reactome)
SEC22BR-HSA-8863858 (Reactome)
SEC22BR-HSA-8863914 (Reactome)
SEC23:SEC24R-HSA-203979 (Reactome)
SEC23AArrowR-HSA-983422 (Reactome)
SEC24ArrowR-HSA-983422 (Reactome)
SEC31AArrowR-HSA-983422 (Reactome)
SEC31AR-HSA-983425 (Reactome)
SNAP23R-HSA-8863895 (Reactome)
STX4R-HSA-8863858 (Reactome)
Sar1p:GTP:Sec23p:Sec24p:Ag bound MHC class IArrowR-HSA-983426 (Reactome)
Sar1p:GTP:Sec23p:Sec24p:Ag bound MHC class IR-HSA-983425 (Reactome)
TAPArrowR-HSA-8863914 (Reactome)
TAPArrowR-HSA-8951595 (Reactome)
TAPArrowR-HSA-983161 (Reactome)
TAPBPArrowR-HSA-8863914 (Reactome)
TAPBPArrowR-HSA-8951595 (Reactome)
TAPBPArrowR-HSA-983161 (Reactome)
TAPBPR-HSA-8863858 (Reactome)
TAPBPR-HSA-8863914 (Reactome)
TAPBPR-HSA-983142 (Reactome)
TAPR-HSA-8863858 (Reactome)
TAPR-HSA-8863914 (Reactome)
TAPR-HSA-983142 (Reactome)
TAPmim-catalysisR-HSA-1236949 (Reactome)
TAPmim-catalysisR-HSA-983144 (Reactome)
THOP1mim-catalysisR-HSA-8940641 (Reactome)
Transloconmim-catalysisR-HSA-1236947 (Reactome)
UbArrowR-HSA-1236935 (Reactome)
UbArrowR-HSA-983150 (Reactome)
UbR-HSA-983153 (Reactome)
Ubiquitin activating E1 enzymesArrowR-HSA-983152 (Reactome)
Ubiquitin activating E1 enzymesR-HSA-983153 (Reactome)
Ubiquitin activating E1 enzymesmim-catalysisR-HSA-983153 (Reactome)
Ubiquitin:E2 conjugating enzymesArrowR-HSA-983152 (Reactome)
Ubiquitin:E2 conjugating enzymesR-HSA-983156 (Reactome)
Ubiquitin:E2 conjugating enzymesR-HSA-983157 (Reactome)
Unknown hydrolasemim-catalysisR-HSA-1236938 (Reactome)
VAMP8,VAMP3R-HSA-8863973 (Reactome)
adenosine 5'-monophosphateArrowR-HSA-983140 (Reactome)
adenosine 5'-monophosphateArrowR-HSA-983153 (Reactome)
adenosine 5'-monophosphateArrowR-HSA-983156 (Reactome)
antigenic substrateR-HSA-983157 (Reactome)
monoglucosylated MHC

class I

HC:Calnexin/BiP		ArrowR-HSA-983145 (Reactome)
monoglucosylated MHC

class I

HC:Calnexin/BiP		R-HSA-983148 (Reactome)
monoglucosylated MHC class I HCR-HSA-983145 (Reactome)
oligo-MyD88:Mal:BTK:activated TLRArrowR-HSA-8863895 (Reactome)
oligopeptide fragment (3-7aa)ArrowR-HSA-8940641 (Reactome)
oligopeptide fragment (8-16aa)ArrowR-HSA-1236935 (Reactome)
oligopeptide fragment (8-16aa)ArrowR-HSA-983150 (Reactome)
oligopeptide fragment (8-16aa)ArrowR-HSA-983162 (Reactome)
oligopeptide fragment (8-16aa)R-HSA-1236949 (Reactome)
oligopeptide fragment (8-16aa)R-HSA-8940641 (Reactome)
oligopeptide fragment (8-16aa)R-HSA-983144 (Reactome)
oligopeptide fragmentArrowR-HSA-1236949 (Reactome)
oligopeptide fragmentArrowR-HSA-983144 (Reactome)
oligopeptide fragmentR-HSA-1236971 (Reactome)
oligopeptide fragmentR-HSA-983158 (Reactome)
p-S95-SNAP23:VAMP8,VAMP3ArrowR-HSA-8863973 (Reactome)
p-S95-SNAP23ArrowR-HSA-8863895 (Reactome)
p-S95-SNAP23R-HSA-8863973 (Reactome)
partially digested AgArrowR-HSA-1236938 (Reactome)
partially digested AgArrowR-HSA-1236947 (Reactome)
partially digested AgArrowR-HSA-1236972 (Reactome)
partially digested AgR-HSA-1236947 (Reactome)
partially digested AgR-HSA-1236972 (Reactome)
precursor peptide fragment (>16 aa)ArrowR-HSA-1236948 (Reactome)
precursor peptide fragment (>16 aa)ArrowR-HSA-1236970 (Reactome)
precursor peptide fragment (>16 aa)ArrowR-HSA-983150 (Reactome)
precursor peptide fragment (>16 aa)R-HSA-1236954 (Reactome)
precursor peptide fragment (>16 aa)R-HSA-983162 (Reactome)
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