As inferred from mouse, RORA binds ROR elements (ROREs) in DNA and recruits the coactivators PPARGC1A (PGC-1alpha) and p300 (EP300, a histone acetylase) to activate transcription.
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Kawabe Y, Honda M, Wada Y, Yazaki Y, Suzuki T, Ohba Y, Nabata H, Endo A, Matsumoto A, Itakura H.; ''Sterol mediated regulation of SREBP-1a,1b,1c and SREBP-2 in cultured human cells.''; PubMedEurope PMCScholia
Wang X, Sato R, Brown MS, Hua X, Goldstein JL.; ''SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis.''; PubMedEurope PMCScholia
Juge-Aubry C, Pernin A, Favez T, Burger AG, Wahli W, Meier CA, Desvergne B.; ''DNA binding properties of peroxisome proliferator-activated receptor subtypes on various natural peroxisome proliferator response elements. Importance of the 5'-flanking region.''; PubMedEurope PMCScholia
Britton CH, Schultz RA, Zhang B, Esser V, Foster DW, McGarry JD.; ''Human liver mitochondrial carnitine palmitoyltransferase I: characterization of its cDNA and chromosomal localization and partial analysis of the gene.''; PubMedEurope PMCScholia
Shimomura I, Shimano H, Horton JD, Goldstein JL, Brown MS.; ''Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells.''; PubMedEurope PMCScholia
Johnson EF, Hsu MH, Savas U, Griffin KJ.; ''Regulation of P450 4A expression by peroxisome proliferator activated receptors.''; PubMedEurope PMCScholia
Rakhshandehroo M, Hooiveld G, Müller M, Kersten S.; ''Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human.''; PubMedEurope PMCScholia
Yokoyama C, Wang X, Briggs MR, Admon A, Wu J, Hua X, Goldstein JL, Brown MS.; ''SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene.''; PubMedEurope PMCScholia
MED1 is a component of each of the various Mediator complexes, that function as transcription co-activators. The MED1-containing compolexes include the DRIP, ARC, TRIP and CRSP compllexes.
Peroxisome proliferator receptor elements bind heterodimers containing a peroxisome proliferator receptor and a retinoic acid receptor. The consensus sequence is TGAMCTTTGNCCTAGWTYYG.
As inferred from mouse, RORA binds RRE DNA elements and recruits the coactivators PGC-1alpha (PPARGC1A) and p300 (EP300, a histone acetylase). As inferred from mouse, ROR-alpha binds the promoter of the CPT1A gene and, together with coactivators EP300 and PGC-1alpha, enhances transcription.
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