Suppression of HMGB1-mediated inflammation by THBD (Homo sapiens)

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1, 2NucleusDNAProteolytic cleavageInflammationCytosolIκKγNFkBIκβαIκKαHMGB1IκKβRAGETHBDRELAHMGB1THBDHMGB1IκβαPRELANFkB


Description

THBD inhibition of HMGB1 mediated pro-inflammatory pathway via proteolytic cleavage of HMGB1.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Li YH, Kuo CH, Shi GY, Wu HL; ''The role of thrombomodulin lectin-like domain in inflammation.''; J Biomed Sci, 2012 PubMed Europe PMC Scholia
  2. Gilmore TD; ''Introduction to NF-kappaB: players, pathways, perspectives.''; Oncogene, 2006 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
129206view01:26, 16 March 2024EweitzModified title
129198view16:41, 15 March 2024EgonwOntology Term : 'signaling pathway' added !
121700view03:42, 26 February 2022EweitzFix graphics overlap, fix gene symbol
102253view10:41, 13 December 2018LaurentVisual aspects
102244view13:57, 12 December 2018LaurentUpdated collapse of genes due to allignment
102243view13:52, 12 December 2018LaurentUpdated pathway and visual aspects
102240view13:16, 12 December 2018LaurentUpdated visual aspects
102236view09:58, 12 December 2018Laurentchanged typo
102235view09:57, 12 December 2018LaurentModified description
102234view09:56, 12 December 2018LaurentUpdated literature reference
102233view09:54, 12 December 2018LaurentNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
HMGB1GeneProduct3146 (Entrez Gene)
IκKαGeneProduct1147 (Entrez Gene)
IκKβGeneProduct3551 (Entrez Gene)
IκKγGeneProduct8517 (Entrez Gene)
IκβαGeneProduct4792 (Entrez Gene)
NFkBGeneProduct4790 (Entrez Gene)
RAGEGeneProduct177 (Entrez Gene)
RELAGeneProduct5970 (Entrez Gene)
THBDGeneProduct7056 (Entrez Gene)

Annotated Interactions

No annotated interactions

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