Resistin as a regulator of inflammation (Homo sapiens)
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Description
Resistin induced intracellular signaling pathways. No receptor for resistin has yet been identified. Resistin induces NF-kB
activity. Resistin increases the cytosolic Ca concentration via both PLC activation, leading to the release of Ca from intracellular pools, such as the endoplasmic reticulum, and Ca influx from the extracellular environment. Activation of the abovementioned signaling pathways via resistin suggests that it has proinflammatory
potential.Quality Tags
Ontology Terms
Bibliography
- Gilmore TD; ''Introduction to NF-kappaB: players, pathways, perspectives.''; Oncogene, 2006 PubMed Europe PMC Scholia
- Filková M, HaluzÃk M, Gay S, Senolt L; ''The role of resistin as a regulator of inflammation: Implications for various human pathologies.''; Clin Immunol, 2009 PubMed Europe PMC Scholia
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Annotated Interactions
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