Cancer immunotherapy by CTLA4 blockade (Homo sapiens)

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1, 75, 62-45, 68LegendAPCIL-2 expressionImmune ResponseAntagonistic bindingIpilimumabPPP2CAAkt SignalingTremelimumabPTPN6CD80CD86Tumor-associatedantigenMHC IIT cellNucleusCTLA4TRATRBCD28PTPN11PIK3CAPIK3R1PIK3R2PIK3CBPIK3CDPIK3R3


Description

Partially based on Thermo Fisher CTLA4 Signaling Pathway and figure 4B from the review by Pardoll.

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Podojil JR, Miller SD; ''Molecular mechanisms of T-cell receptor and costimulatory molecule ligation/blockade in autoimmune disease therapy.''; Immunol Rev, 2009 PubMed Europe PMC Scholia
  2. Walker LS, Sansom DM; ''The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses.''; Nat Rev Immunol, 2011 PubMed Europe PMC Scholia
  3. Ariyan CE, Brady MS, Siegelbaum RH, Hu J, Bello DM, Rand J, Fisher C, Lefkowitz RA, Panageas KS, Pulitzer M, Vignali M, Emerson R, Tipton C, Robins H, Merghoub T, Yuan J, Jungbluth A, Blando J, Sharma P, Rudensky AY, Wolchok JD, Allison JP; ''Robust Antitumor Responses Result from Local Chemotherapy and CTLA-4 Blockade.''; Cancer Immunol Res, 2018 PubMed Europe PMC Scholia
  4. Dustin ML, Depoil D; ''New insights into the T cell synapse from single molecule techniques.''; Nat Rev Immunol, 2011 PubMed Europe PMC Scholia
  5. Leach DR, Krummel MF, Allison JP; ''Enhancement of antitumor immunity by CTLA-4 blockade.''; Science, 1996 PubMed Europe PMC Scholia
  6. Trinca C, Bressler R, Walson P; ''The drug surveillance program at the Arizona Medical Center.''; Ariz Med, 1975 PubMed Europe PMC Scholia
  7. Teft WA, Kirchhof MG, Madrenas J; ''A molecular perspective of CTLA-4 function.''; Annu Rev Immunol, 2006 PubMed Europe PMC Scholia
  8. Sadreddini S, Baradaran B, Aghebati-Maleki A, Shanehbandi D, Fotouhi A, Aghebati-Maleki L; ''Immune checkpoint blockade opens a new way to cancer immunotherapy.''; J Cell Physiol, 2019 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
128136view14:42, 27 January 2024EweitzEconomize layout, standardize case
123435view04:36, 27 July 2022EgonwMade two pathways clickable
108125view10:27, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
104340view22:19, 17 May 2019KhanspersModified description
104339view22:15, 17 May 2019Khanspersupdated details
104107view19:21, 3 May 2019KhanspersModified description
104106view19:17, 3 May 2019KhanspersModified description
104105view18:55, 3 May 2019KhanspersOntology Term : 'adaptive immune response pathway' added !
104104view18:54, 3 May 2019KhanspersOntology Term : 'T cell' added !
104103view18:54, 3 May 2019Khanspersdecreased board size
104086view21:28, 2 May 2019KhanspersModified description
104085view21:23, 2 May 2019KhanspersOntology Term : 'professional antigen presenting cell' added !
104084view21:20, 2 May 2019KhanspersOntology Term : 'immune response pathway' added !
104083view21:20, 2 May 2019KhanspersOntology Term : 'cancer' added !
104082view21:18, 2 May 2019KhanspersNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
Akt SignalingPathwayWP4172 (WikiPathways)
CD28GeneProductENSG00000178562 (Ensembl)
CD80GeneProductENSG00000121594 (Ensembl)
CD86GeneProductENSG00000114013 (Ensembl)
CTLA4GeneProductENSG00000163599 (Ensembl)
IpilimumabMetaboliteQ2459042 (Wikidata)
MHC IIProteinD7RIH8 (Uniprot-TrEMBL)
PIK3CAGeneProductENSG00000121879 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18706
PIK3CBGeneProductENSG00000051382 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74769
PIK3CDGeneProductENSG00000171608 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18707
PIK3R1GeneProductENSG00000145675 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18708
PIK3R2GeneProductENSG00000105647 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18709
PIK3R3GeneProductENSG00000117461 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:75669
PPP2CAGeneProductENSG00000113575 (Ensembl)
PTPN11GeneProductENSG00000179295 (Ensembl)
PTPN6GeneProductENSG00000111679 (Ensembl)
TRAGeneProduct6955 (Entrez Gene)
TRBGeneProduct6957 (Entrez Gene)
TremelimumabMetaboliteQ7838098 (Wikidata)
Tumor-associated antigenGeneProduct

Annotated Interactions

No annotated interactions

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