TGF-beta receptor signaling (Homo sapiens)
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Description
The Transforming growth factor beta (TGFβ) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions. In spite of the wide range of cellular processes that the TGFβ signaling pathway regulates, the process is relatively simple. TGFβ superfamily ligands bind to a type II receptor, which recruits and phosphorylates a type I receptor. The type I receptor then phosphorylates receptor-regulated SMADs (R-SMADs) which can now bind the coSMAD SMAD4. R-SMAD/coSMAD complexes accumulate in the nucleus where they act as transcription factors and participate in the regulation of target gene expression. (source: WikiPedia).
Also see: TGF-beta receptor signaling at the NCI-Nature pathway interaction database.
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Bibliography
- Massague J, Blain SW, Lo RS; ''TGFbeta signaling in growth control, cancer, and heritable disorders.''; Cell, 2000 PubMed Europe PMC Scholia
- Massague J; ''How cells read TGF-beta signals.''; Nat Rev Mol Cell Biol, 2000 PubMed Europe PMC Scholia
- Ivey KN, Srivastava D; ''MicroRNAs as regulators of differentiation and cell fate decisions.''; Cell Stem Cell, 2010 PubMed Europe PMC Scholia
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