Sterol regulatory element-binding proteins (SREBP) signaling (Homo sapiens)

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ERNucleus13301228, 444046, 47Lipogenic enzymesCOPII coated vesicleGolgi 1Transcription-TranslationPositive effectstimulation CleavageNegative effectLegendCatalysisUp regulationExact mechanism unknownCholesterol synthesisSRECholesterol effluxAMPKCofactorInhibition26gp78SCAPPRKAB1SREBP2miRNA33bPKAOxysterolsPUFAsCAMPCDK8UFAsmTORC1PRKAG1importin betaHMGCRRBP4PRKAA1INSIG1GlucoseSIRT1CholesterolAKTNFYInsulinGSK3ATF6GlutamineFGF21LPIN1PRKAB2PRKAG3nSREBPTRC8PRKAG2 S1PPI3KLXRmiRNA33aPRKAA239141110, 1973132, 3833353516, 224369212917SCAP45435, 232, 8, 3720SCAPINSIG2INSIG1INSIG2SREBP1a,-c27, 34SREBP2SREBP1a,-cSREBP2SREBP1a,-cSAR1ASCAPSREBP2SREBP1a,-cSAR1BSAR1ASAR1BSEC23ASEC23BSEC24ASEC24BSEC24CSEC24DSEC13SEC31ASEC31BSEC13SEC23ASEC23BSEC24ASEC24BSEC24CSEC24DSAR1ASCAPSREBF2SREBP1a,-cSAR1BSEC31ASEC31BS2P25SCAPSREBP2SREBP1a,-cnSREBP1a,-cGeneSREnSREBP2GeneCholesterogenic enzymesLipoprotein metabolismCholesterol uptakeCofactorCREBSP118NFYCREBSP1YY136, 42YY1PGC-1betaARC10541ARC10524LSSHMGCSMVDIDIFDPSFDFTSQLECYP51A1LPLLDLRSCARB1ACACAGPAFASNDBIACLYMDHPPARGACSSCDFatty aciddegradationFatty acid synthesisSIRT115INSIG1INSIG2SREBP2SREBP1a,-c


Description

Sterol regulatory element-binding proteins (SREBPs) are membrane-bound proteins that act as transcription factors. They regulate lipid, especially cholesterol, biosynthesis and uptake at a transcriptional level to maintain cellular lipid homeostasis. In addition, SREBP appears to be involved in a variety of other cellular processes. This pathway of SREBP focusses on the regulation of lipid metabolism by SREBP. The data on which this pathway is based, is derived from a variety of in vitro and in vivo studies using different species, including mouse, rat, hamster and human.

This pathway served as the basis for a review about SREBP that was published in Genes and Nutrition: PubMed.

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal.

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Ontology Terms

 

Bibliography

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  3. Li Y, Xu S, Mihaylova MM, Zheng B, Hou X, Jiang B, Park O, Luo Z, Lefai E, Shyy JY, Gao B, Wierzbicki M, Verbeuren TJ, Shaw RJ, Cohen RA, Zang M; ''AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice.''; Cell Metab, 2011 PubMed Europe PMC Scholia
  4. Yellaturu CR, Deng X, Park EA, Raghow R, Elam MB; ''Insulin enhances the biogenesis of nuclear sterol regulatory element-binding protein (SREBP)-1c by posttranscriptional down-regulation of Insig-2A and its dissociation from SREBP cleavage-activating protein (SCAP).SREBP-1c complex.''; J Biol Chem, 2009 PubMed Europe PMC Scholia
  5. Brown MS, Goldstein JL; ''A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood.''; Proc Natl Acad Sci U S A, 1999 PubMed Europe PMC Scholia
  6. Peterson TR, Sengupta SS, Harris TE, Carmack AE, Kang SA, Balderas E, Guertin DA, Madden KL, Carpenter AE, Finck BN, Sabatini DM; ''mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway.''; Cell, 2011 PubMed Europe PMC Scholia
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History

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CompareRevisionActionTimeUserComment
135870view04:21, 20 November 2024EweitzIncrease font size
135869view04:15, 20 November 2024EweitzRefine legend
135868view04:10, 20 November 2024EweitzEconomize layout
127880view02:01, 6 January 2024EweitzModified description
116442view09:47, 7 May 2021EweitzModified title
110111view12:30, 17 April 2020FehrhartConnected lines and converted graphical lines
106704view13:13, 17 September 2019MaintBotHMDB identifier normalization
105824view23:03, 15 August 2019KhanspersModified description
90425view18:38, 13 November 2016EgonwAdded two references about the cholesterol-SCAP interaction.
90350view13:37, 6 November 2016EgonwFixed weird chars in several references.
86074view08:50, 29 June 2016MirellaKalafatiModified title
79943view09:38, 28 April 2015Zariadded anotation for AMPK
78494view10:28, 7 January 2015MaintBotadded missing graphIds
73382view05:26, 25 January 2014MaintBotremoved newlines from datanode labels
71987view11:08, 24 October 2013MkutmonChanged Unknown -> RNA for miRNA33a
71698view19:46, 17 October 2013MaintBotUpdated UniProt/TrEMBL data source
68403view09:40, 5 July 2013EveloModified description
68402view09:39, 5 July 2013EveloModified description
68401view09:32, 5 July 2013EveloAdded reference for review paper.
67653view11:44, 26 June 2013DdiglesOntology Term : 'sterol regulatory element-binding protein signaling pathway' added !
63160view20:19, 8 May 2013MaintBotUpdating gpml version
59430view09:37, 27 February 2013SabinedaemenModified description
59171view18:35, 22 February 2013MaintBotUpdated Ensembl data source
58748view12:15, 20 February 2013Sabinedaemenannotations
58745view09:56, 20 February 2013Sabinedaemenannotations
58744view09:52, 20 February 2013Sabinedaemenannotations
58743view09:01, 20 February 2013Sabinedaemenannotations
58578view10:43, 16 February 2013SabinedaemenModified description
58567view16:25, 15 February 2013Sabinedaemenliterature added
58566view16:21, 15 February 2013Sabinedaemenupdate
58565view10:58, 15 February 2013SabinedaemenRBP4
58564view08:59, 15 February 2013SabinedaemenFGF21
55311view15:16, 13 December 2012SabinedaemenUpdate
55303view15:07, 13 December 2012SabinedaemenPeriodical save, work in progress
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External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACACAGeneProductENSG00000278540 (Ensembl)
ACLYGeneProductENSG00000131473 (Ensembl)
ACSGeneProductENSG00000154930 (Ensembl)
AKTGeneProductENSG00000142208 (Ensembl)
ARC105GeneProductENSG00000099917 (Ensembl) activator recruited cofactor (ARC)-mediator activator complex
ATF6GeneProductENSG00000118217 (Ensembl)
CAMPGeneProductENSG00000164047 (Ensembl)
CDK8GeneProductENSG00000132964 (Ensembl)
CREBGeneProductENSG00000118260 (Ensembl)
CYP51A1GeneProductENSG00000001630 (Ensembl)
CholesterolMetaboliteHMDB00067 (HMDB)
DBIGeneProductENSG00000155368 (Ensembl)
FASNGeneProductENSG00000169710 (Ensembl)
FDFTGeneProductENSG00000079459 (Ensembl)
FDPSGeneProductENSG00000160752 (Ensembl)
FGF21GeneProductENSG00000105550 (Ensembl)
GPAGeneProductENSG00000119927 (Ensembl)
GSK3GeneProductENSG00000105723 (Ensembl)
GlucoseMetaboliteHMDB00122 (HMDB)
GlutamineMetaboliteHMDB00641 (HMDB)
HMGCRGeneProductENSG00000113161 (Ensembl)
HMGCSGeneProductENSG00000112972 (Ensembl)
IDIGeneProductENSG00000067064 (Ensembl)
INSIG1GeneProductENSG00000186480 (Ensembl)
INSIG2GeneProductENSG00000125629 (Ensembl)
InsulinProteinP01308 (Uniprot-TrEMBL)
LDLRGeneProductENSG00000130164 (Ensembl)
LPIN1GeneProductENSG00000134324 (Ensembl)
LPLGeneProductENSG00000175445 (Ensembl)
LSSGeneProductENSG00000160285 (Ensembl)
LXRGeneProductENSG00000131408 (Ensembl)
MDHGeneProductENSG00000014641 (Ensembl)
MVDGeneProductENSG00000167508 (Ensembl)
NFYGeneProductENSG00000001167 (Ensembl)
OxysterolsMetaboliteCHEBI:53030 (ChEBI)
PGC-1betaGeneProductENSG00000155846 (Ensembl)
PI3KGeneProductENSG00000121879 (Ensembl)
PKAGeneProductENSG00000072062 (Ensembl)
PPARGGeneProductENSG00000132170 (Ensembl)
PRKAA1GeneProductENSG00000132356 (Ensembl)
PRKAA2GeneProductENSG00000162409 (Ensembl)
PRKAB1GeneProductENSG00000111725 (Ensembl)
PRKAB2GeneProductENSG00000131791 (Ensembl)
PRKAG1GeneProductENSG00000181929 (Ensembl)
PRKAG2 GeneProductENSG00000106617 (Ensembl)
PRKAG3GeneProductENSG00000115592 (Ensembl)
PUFAsMetaboliteCHEBI:26208 (ChEBI) Inhibition of SREBP1 processing
RBP4GeneProductENSG00000138207 (Ensembl)
S1PGeneProductENSG00000140943 (Ensembl)
S2PGeneProductENSG00000012174 (Ensembl)
SAR1AGeneProductENSG00000079332 (Ensembl)
SAR1BGeneProductENSG00000152700 (Ensembl)
SCAPGeneProductENSG00000114650 (Ensembl)
SCARB1GeneProductENSG00000073060 (Ensembl)
SCDGeneProductENSG00000099194 (Ensembl)
SEC13GeneProductENSG00000157020 (Ensembl)
SEC23AGeneProductENSG00000100934 (Ensembl)
SEC23BGeneProductENSG00000101310 (Ensembl)
SEC24AGeneProductENSG00000113615 (Ensembl)
SEC24BGeneProductENSG00000138802 (Ensembl)
SEC24CGeneProductENSG00000176986 (Ensembl)
SEC24DGeneProductENSG00000150961 (Ensembl)
SEC31AGeneProductENSG00000138674 (Ensembl)
SEC31BGeneProductENSG00000075826 (Ensembl)
SIRT1GeneProductENSG00000096717 (Ensembl)
SP1GeneProductENSG00000185591 (Ensembl)
SQLEGeneProductENSG00000104549 (Ensembl)
SREBF2GeneProductENSG00000198911 (Ensembl)
SREBP1a,-cGeneProductENSG00000072310 (Ensembl)
SREBP2GeneProductENSG00000198911 (Ensembl)
TRC8GeneProductENSG00000170881 (Ensembl)
UFAsMetaboliteCHEBI:26208 (ChEBI)
YY1GeneProductENSG00000100811 (Ensembl)
gp78GeneProductENSG00000159461 (Ensembl)
importin betaGeneProductENSG00000108424 (Ensembl)
mTORC1GeneProductENSG00000198793 (Ensembl)
miRNA33aRnaMI0000091 (miRBase Sequence)
miRNA33bRnaMI0003646 (miRBase Sequence)
nSREBP1a,-cGeneProductENSG00000072310 (Ensembl)
nSREBP2GeneProductENSG00000198911 (Ensembl)
nSREBPGeneProductENSG00000072310 (Ensembl)

Annotated Interactions

No annotated interactions

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