Selenium micronutrient network (Bos taurus)

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79137, 185, 240, 25318529, 70, 82, 130, 160...36, 157931744, 79, 131, 201791146, 25770, 2301320254, 23519, 48, 212209235121, 154, 182, 20138Protein tyrosine nitrationOxidative stressStimulationLeukotriene metabolismMetabolitesBiomarker forNecessary stimulationNegative EffectGlycogenesisCofactorsSelenoproteinsMetabolic stressLipoprotein melabolismReactionLipid peroxidationCatalysisOther proteinsInhibitionProcess or metabolism involved in Se PathwayBindingis composed ofInflammation and immune responseOverarching processLEGENDStatusCleavageEnzymesConversionMicronutrientsSelenium statusCa++ metabolismFrom intracellular part to the plasmaTryptophan metabolismCofactor conversionProstaglandins metabolismTranscription factorIntracellularER protein foldingNAD+ metabolismGlutathione metabolismDNA oxidationFolate metabolismPlasmaEPALipoxin B4NFKB2PGD2DPAPGE2Lipoxin A4PTGS18-Isoprostaglandin F2aPGF2aThromboxane A2PGI2DHAPTGS2DPAPGG2F2-IsoprostaneLipoxin B4PGH2PGH3a-TocopherolF2-IsoprostaneArachidonic acidPGE1MDA8-Isoprostaglandin F2aLinoleic acidDGLAa-TocopherolPGI2PGE3ALAPGD2PGE1PGF2aThromboxane B2PGE2Arachidonic acidLinoleic acidRELAThromboxane B2Lipoxin A4DHANFKB1MDAALAEPA20, 158123135152110135, 17859, 715, 18720, 15815214, 17, 71, 110, 123...15259, 7113523020, 110, 123, 158, 24919159, 7114, 17, 123, 152152, 18855, 135, 191230129151, 183, 195, 215, 243...551351915, 187135, 207151, 183, 195, 215, 24311056, 13518718711014135129135129129110249Kynurenine54MTR93, 255TXNRD1CBS97, 255IodineIodine6060KMO5415-HETETriiodothyronine (T3)5,6-EpoxytetraeneR-Triiodothyronine (rT3)5-HETE5-HETEThyroxine (T4)5-HPETETriiodothyronine (T3)Thyroxine (T4)15-HETER-Triiodothyronine (rT3)75, 241, 249144, 227129, 24912960, 14424975, 241, 24960, 144144, 22760, 144144, 22775, 241, 249NADP+MPOCATMPO79, 169131107, 124, 131, 232Uric acid36, 89CysteineF7F2GGT1SERPINE1PLGSERPINE1PLATF7PLATF2PLG63636396636316, 162105, 1626316, 162105, 162GPX 4TXNRD2XDH22, 89PRDX5H2O2ALOX5ALOX15B82, 249118, 129, 130, 195, 197CopperUric acid36, 89Vitamin B12116, 1985,10-Methylene-THFSelR4, 45Tryptophan54, 2355-methyl-THFSOD3PRDX1RFK43H2OGPX3NiacinamideCTH255PNPO32Heme13, 55, 79, 97, 169NADPHLipoic acid253ManganeseFAD80Methionine sulfoxide4Dehydroascorbic acid103, 240Leukotriene A437, 146NADPHFAD80THFHydroxykynurenine54Folic acid93NADP+NADPHSeleniumSelenium8484SELENOKSep15113, 121, 201250GPX6GSH166Nicotinamidase235Calcium146Methionine4ManganeseNADPHFolic acid93FMN80SelenophosphateSelenideSelenocysteine137, 144137, 144137, 144CysteineLeukotriene C4Leukotriene C496, 146GPX3186Dehydroascorbic acid240GPX2SelP81Trx-S2185, 240, 253Ascorbic acid103Lipoic acid253PRDX4GPX 1NADP+HomocysteineROSRNS79, 2024, 6, 19, 22, 42...NADPHVitamin B12116, 198MTHFR93Homocysteine105SELENOVDIO2SelPSEPHS2SelHSELENOTSELENONSELENOODIO3DIO1SELENOISELENOSSELENOM3182, 192, 22560, 1443, 21260, 144, 1553, 19, 4836, 73, 81, 173176, 2093144, 23860, 144143, 154, 219SOD1Pyridoxal 5'-phosphate54SerineIron146HypoxanthinePRDX3GSR172LDLHDL-CSAA4APOBSAA3LDLAPOBSERPINA3-7SAA1APOA1ABCA1HDL/SAAVLDLSAA2FMNTAGoxLDLTAGSERPINA3-7CholesterolSCARB1HDLCholesterolHDLVLDL-TAGoxLDLVLDL-TAGHDL-CLDLRVLDL/APOBAPOA1APOA1HDL/APOA1VLDL24825170, 220, 232, 257, 267464646, 64, 136468046, 13611, 216, 26846, 6446461, 216, 26824870, 220, 232, 25713624846, 64248, 26446, 64464646, 64248, 2642482484624870, 220, 232, 25770, 220, 232, 257, 26746248O2230Pyridoxal 5'-phosphate548-OHdG8-OHdGFAD383880PRDX2ADPLeukotriene D4Leukotriene D496CopperChlorineChlorineCystathionineFAD80SOD2Dihydrolipoate94, 253SerineNADP+ATPZincNADP+GSSGNADPHZincNiacinLeukotriene B4Leukotriene B43737, 146Quinolinic Acid54, 235PMPO3HNO2NO2NOHOClNO107, 124107, 124NADP+GSH37, 166, 209ALOX5APINSHBGCCL2INSRFibrinIFNGIL6D-dimerIL1BCRPFibrinIFNGIFNGD-dimerICAM1FibrinogenTNFICAM1CCL2IL6INSHbA1cFibrinogenALBIL1BTNFHbA1cIFNGALBHBA27614024, 636111873, 155, 19614317324, 63612711, 115, 139, 140102, 17329, 102, 143, 19615511, 115, 139, 140, 2646127, 57, 15515529, 73, 14357, 70, 92, 26716, 63115, 140143173102, 17392, 194, 1964092, 194, 19616, 63SELENOW99, 166, 226Riboflavin234SOD3157TXNRD1185Ascorbate103, 240O2-“XanthineCalcium146KYNU54Methionine4ADPTrx-(SH)2185, 253ONOO-/ONOOHNitrotyrosineNitrotyrosine202202ATPLeukotriene E4Leukotriene E496GlucoseFructosamineFructosamineLeukotriene F44011, 6153, 9640Iron146HypoxanthineTXNRD3FLAD19, 43Ascorbic acid103, 215, 243


Description

The selenium-centred micronutrient biological network. The most relevant biochemical processes related to selenium in the context of metabolism, oxidation and inflammation are represented. Also, the compartmental separation (intracellular vs. plasma) is presented, identifying the selenium centred plasma metabolome. A selenoprotein database exists at: http://www.selenodb.org

Comments

HomologyMapper 
This pathway was inferred from Homo sapiens pathway WP15_96318 with a 81.0% conversion rate.

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  239. Matsukura S, Kokubu F, Kurokawa M, Kawaguchi M, Ieki K, Kuga H, Odaka M, Suzuki S, Watanabe S, Takeuchi H, Kasama T, Adachi M; ''Synthetic double-stranded RNA induces multiple genes related to inflammation through Toll-like receptor 3 depending on NF-kappaB and/or IRF-3 in airway epithelial cells.''; Clin Exp Allergy, 2006 PubMed Europe PMC Scholia
  240. Tomohiro S, Kawaguti A, Kawabe Y, Kitada S, Kuge O; ''Purification and characterization of human phosphatidylserine synthase 1 and 2.''; Biochem J, 2008 PubMed Europe PMC Scholia
  241. Waterham HR, Wijburg FA, Hennekam RC, Vreken P, Poll-The BT, Dorland L, Duran M, Jira PE, Smeitink JA, Wevers RA, Wanders RJ; ''Smith-Lemli-Opitz syndrome is caused by mutations in the 7-dehydrocholesterol reductase gene.''; Am J Hum Genet, 1998 PubMed Europe PMC Scholia
  242. Betsholtz IH, Wikvall K; ''Cytochrome P450 CYP27-catalyzed oxidation of C27-steroid into C27-acid.''; J Steroid Biochem Mol Biol, 1995 PubMed Europe PMC Scholia
  243. Hink HU, Santanam N, Dikalov S, McCann L, Nguyen AD, Parthasarathy S, Harrison DG, Fukai T; ''Peroxidase properties of extracellular superoxide dismutase: role of uric acid in modulating in vivo activity.''; Arterioscler Thromb Vasc Biol, 2002 PubMed Europe PMC Scholia
  244. Sandrine A, Ferreiro A; ''Selenoproteins and protection against oxidative stress: selenoprotein N as a novel player at the crossroads of redox signalling and calcium homeostasis.''; Antioxid Redox Signal, 2009 PubMed Europe PMC Scholia
  245. Goriely S, Molle C, Nguyen M, Albarani V, Haddou NO, Lin R, De Wit D, Flamand V, Willems F, Goldman M; ''Interferon regulatory factor 3 is involved in Toll-like receptor 4 (TLR4)- and TLR3-induced IL-12p35 gene activation.''; Blood, 2006 PubMed Europe PMC Scholia
  246. Faust JR, Goldstein JL, Brown MS; ''Squalene synthetase activity in human fibroblasts: regulation via the low density lipoprotein receptor.''; Proc Natl Acad Sci U S A, 1979 PubMed Europe PMC Scholia
  247. Laden BP, Tang Y, Porter TD; ''Cloning, heterologous expression, and enzymological characterization of human squalene monooxygenase.''; Arch Biochem Biophys, 2000 PubMed Europe PMC Scholia
  248. Hahn FM, Xuan JW, Chambers AF, Poulter CD; ''Human isopentenyl diphosphate: dimethylallyl diphosphate isomerase: overproduction, purification, and characterization.''; Arch Biochem Biophys, 1996 PubMed Europe PMC Scholia
  249. Gautier G, Humbert M, Deauvieau F, Scuiller M, Hiscott J, Bates EE, Trinchieri G, Caux C, Garrone P; ''A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells.''; J Exp Med, 2005 PubMed Europe PMC Scholia
  250. Yang P, Chan D, Felix E, Cartwright C, Menter DG, Madden T, Klein RD, Fischer SM, Newman RA; ''Formation and antiproliferative effect of prostaglandin E(3) from eicosapentaenoic acid in human lung cancer cells.''; J Lipid Res, 2004 PubMed Europe PMC Scholia
  251. Gladyshev VN, Jeang KT, Wootton JC, Hatfield DL; ''A new human selenium-containing protein. Purification, characterization, and cDNA sequence.''; J Biol Chem, 1998 PubMed Europe PMC Scholia
  252. Johnson J, Albarani V, Nguyen M, Goldman M, Willems F, Aksoy E; ''Protein kinase Calpha is involved in interferon regulatory factor 3 activation and type I interferon-beta synthesis.''; J Biol Chem, 2007 PubMed Europe PMC Scholia
  253. Hosaka K, Tanaka S, Nikawa J, Yamashita S; ''Cloning of a human choline kinase cDNA by complementation of the yeast cki mutation.''; FEBS Lett, 1992 PubMed Europe PMC Scholia
  254. Lijnen HR; ''Elements of the fibrinolytic system.''; Ann N Y Acad Sci, 2001 PubMed Europe PMC Scholia
  255. Traber MG; ''Vitamin E regulatory mechanisms.''; Annu Rev Nutr, 2007 PubMed Europe PMC Scholia
  256. Bose R, Kolesnick R; ''Measurement of ceramide synthase activity.''; Methods Enzymol, 2000 PubMed Europe PMC Scholia
  257. Mamalakis G, Kafatos A, Tornaritis M, Alevizos B; ''Anxiety and adipose essential fatty acid precursors for prostaglandin E1 and E2.''; J Am Coll Nutr, 1998 PubMed Europe PMC Scholia
  258. Galijasevic S, Saed GM, Hazen SL, Abu-Soud HM; ''Myeloperoxidase metabolizes thiocyanate in a reaction driven by nitric oxide.''; Biochemistry, 2006 PubMed Europe PMC Scholia
  259. Levin G, Duffin KL, Obukowicz MG, Hummert SL, Fujiwara H, Needleman P, Raz A; ''Differential metabolism of dihomo-gamma-linolenic acid and arachidonic acid by cyclo-oxygenase-1 and cyclo-oxygenase-2: implications for cellular synthesis of prostaglandin E1 and prostaglandin E2.''; Biochem J, 2002 PubMed Europe PMC Scholia
  260. Kwak SE, Kim JE, Kim DW, Kwon OS, Choi SY, Kang TC; ''Pyridoxine 5'-phosphate oxidase, not pyridoxal kinase, involves in long-term potentiation induction in the rat dentate gyrus.''; Hippocampus, 2009 PubMed Europe PMC Scholia
  261. Sneddon AA, Wu HC, Farquharson A, Grant I, Arthur JR, Rotondo D, Choe SN, Wahle KW; ''Regulation of selenoprotein GPx4 expression and activity in human endothelial cells by fatty acids, cytokines and antioxidants.''; Atherosclerosis, 2003 PubMed Europe PMC Scholia
  262. Verrax J, Calderon PB; ''The controversial place of vitamin C in cancer treatment.''; Biochem Pharmacol, 2008 PubMed Europe PMC Scholia
  263. Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guigó R, Gladyshev VN; ''Characterization of mammalian selenoproteomes.''; Science, 2003 PubMed Europe PMC Scholia
  264. Glickman JF, Schmid A; ''Farnesyl pyrophosphate synthase: real-time kinetics and inhibition by nitrogen-containing bisphosphonates in a scintillation assay.''; Assay Drug Dev Technol, 2007 PubMed Europe PMC Scholia
  265. Huijghebaert SM, Hofmann AF; ''Influence of the amino acid moiety on deconjugation of bile acid amidates by cholylglycine hydrolase or human fecal cultures.''; J Lipid Res, 1986 PubMed Europe PMC Scholia
  266. Chen Y, Dennis EA; ''Expression and characterization of human group V phospholipase A2.''; Biochim Biophys Acta, 1998 PubMed Europe PMC Scholia
  267. Huwyler J, Bürgin M, Zeugin T, Gut J; ''Transformation of 5-hydroperoxyeicosatetraenoic acid into dihydroxy- and cysteinyl-leukotrienes by rat hepatocytes: effects of glutathione.''; Mol Pharmacol, 1991 PubMed Europe PMC Scholia
  268. Inoue T, Irikura D, Okazaki N, Kinugasa S, Matsumura H, Uodome N, Yamamoto M, Kumasaka T, Miyano M, Kai Y, Urade Y; ''Mechanism of metal activation of human hematopoietic prostaglandin D synthase.''; Nat Struct Biol, 2003 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
120914view06:18, 31 January 2022EgonwReplaced an old HMDB identifier with the current one
117599view11:37, 21 May 2021EweitzModified title
107072view14:15, 17 September 2019MaintBotChEBI identifier normalization
105975view11:50, 16 August 2019MaintBotHMDB identifier normalization
98244view14:15, 14 August 2018EgonwReplace a PubChem SID with a Wikidata ID (which has more links out).
96319view09:10, 8 March 2018MkutmonUpdated homology conversion
95972view09:54, 11 February 2018EgonwIt had the PubChem CID from the start, but that entry is not the protein fibrin, but a small compound. I now took the Wikidata entry matching the proper Wikipedia page.
85066view11:35, 10 April 2016EgonwReplaced a Wikipedia ID with a ChEBI ID.
80897view15:30, 30 June 2015MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
15-HETEMetaboliteHMDB0003876 (HMDB) 15S-hydroxy-5Z,8Z,11Z,13E-eicosatetraenoic acid
5,10-Methylene-THFMetaboliteHMDB0001533 (HMDB) 5,10-Methylenetetrahydrofolate
5,6-EpoxytetraeneMetaboliteC14815 (KEGG Compound)
5-HETEMetaboliteHMDB0011134 (HMDB) 5-hydroxyeicosatetraenoic acid
5-HPETEMetaboliteHMDB0001193 (HMDB) 5(S)-Hydroperoxyeicosatetraenoic acid
5-methyl-THFMetaboliteHMDB0001396 (HMDB) 5-methyltetrahydrofolate
8-Isoprostaglandin F2aMetaboliteHMDB0005083 (HMDB)
8-OHdGMetaboliteHMDB0003333 (HMDB) 8-Hydroxy-deoxyguanosine
ABCA1ProteinENSBTAG00000020661 (Ensembl)
  • ATP-binding cassette, sub-family A (ABC1), member 1
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:19
ADPMetaboliteHMDB0001341 (HMDB) Adenosine diphosphate
ALAMetaboliteHMDB0001388 (HMDB) Alpha-Linolenic acid
ALBProteinENSBTAG00000017121 (Ensembl)
  • albumin
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:213
ALOX15BProteinENSBTAG00000008779 (Ensembl)
  • EC 1.13.11.33
  • arachidonate 15-lipoxygenase, type B
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:247
ALOX5APProteinENSBTAG00000013201 (Ensembl)
  • arachidonate 5-lipoxygenase-activating protein
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:241
ALOX5ProteinENSBTAG00000020319 (Ensembl)
  • EC 1.13.11.34
  • arachidonate 5-lipoxygenase
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:240
APOA1ProteinENSBTAG00000002258 (Ensembl)
  • apolipoprotein A-I
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:335
APOBProteinENSBTAG00000008505 (Ensembl)
  • apolipoprotein B
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:338
ATPMetaboliteHMDB0000538 (HMDB) Adenosine triphosphate
Arachidonic acidMetaboliteHMDB0001043 (HMDB)
AscorbateMetabolite38290 (ChEBI)
Ascorbic acidMetabolite29073 (ChEBI)
CATProteinENSBTAG00000020980 (Ensembl)
  • EC 1.11.1.6
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:847
CBSProteinENSBTAG00000000160 (Ensembl)
  • EC 4.2.1.22
  • cystathionine-beta-synthase
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:875
CCL2ProteinENSBTAG00000037811 (Ensembl)
  • chemokine (C-C motif) ligand 2
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6347
CRPProteinENSBTAG00000013907 (Ensembl)
  • C-reactive protein, pentraxin-related
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1401
CTHProteinENSBTAG00000014791 (Ensembl)
  • EC 4.4.1.1
  • cystathionase
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1491
CalciumMetaboliteHMDB0000464 (HMDB)
ChlorineMetaboliteHMDB0000492 (HMDB)
CholesterolMetaboliteHMDB0000067 (HMDB)
CopperMetaboliteHMDB0000657 (HMDB)
CystathionineMetaboliteHMDB0000099 (HMDB)
CysteineMetaboliteHMDB0000574 (HMDB)
D-dimerProteinhttp://en.wikipedia.org/wiki/Fibrin_degradation_product
DGLAMetaboliteHMDB0002925 (HMDB)
  • Dihomo-gamma-linolenic acid
  • 8,11,14-Eicosatrienoic acid
DHAMetaboliteHMDB0002183 (HMDB) Docosahexaenoic acid
DIO1ProteinENSBTAG00000010814 (Ensembl)
  • EC 1.97.1.10
  • Selenoprotein-deiodinase, iodothyronine, type I
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1733
DIO2ProteinENSBTAG00000001605 (Ensembl)
  • EC 1.97.1.10
  • Selenoprotein-deiodinase, iodothyronine, type II
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1734
DIO3ProteinENSBTAG00000037977 (Ensembl)
  • EC 1.97.1.11
  • Selenoprotein-deiodinase, iodothyronine type III
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1735
DPAMetaboliteHMDB0001976 (HMDB) Docosapentaenoic acid
Dehydroascorbic acidMetabolite17242 (ChEBI)
DihydrolipoateMetaboliteHMDB0012210 (HMDB)
EPAMetaboliteHMDB0001999 (HMDB) Eicosapentaenoic acid
F2-IsoprostaneMetaboliteQ33659470 (Wikidata)
F2ProteinENSBTAG00000007148 (Ensembl)
  • EC 3.4.21.5
  • coagulation factor II (thrombin)
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2147
F7ProteinENSBTAG00000007411 (Ensembl)
  • EC 3.4.21.21
  • coagulation factor VII (serum prothrombin conversion accelerator)
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2155
FADMetaboliteHMDB0001248 (HMDB) Flavin adenine dinucleotide
FLAD1ProteinENSBTAG00000000186 (Ensembl)
  • EC 2.7.7.2
  • FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae)
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:80308
FMNMetaboliteHMDB0001520 (HMDB) Flavin Mononucleotide
FibrinProtein
FibrinogenProtein
Folic acidMetaboliteHMDB0000121 (HMDB)
FructosamineMetaboliteHMDB0002030 (HMDB)
GGT1ProteinENSBTAG00000046900 (Ensembl)
  • EC 2.3.2.2
  • gamma-glutamyltransferase 1
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2678
GPX 1Protein
  • EC 1.11.1.9
  • Selenoprotein-glutathione peroxidase 1
  • No homologues found for original id L:2876
GPX 4ProteinENSBTAG00000046926 (Ensembl)
  • EC 1.11.1.12
  • Selenoprotein-glutathione peroxidase 4
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2879
GPX2ProteinENSBTAG00000048112 (Ensembl)
  • EC 1.11.1.9
  • Selenoprotein-glutathione peroxidase 2
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2877
GPX3ProteinENSBTAG00000043553 (Ensembl)
  • Selenoprotein-glutathione peroxidase 3
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2878
GPX6ProteinENSBTAG00000012023 (Ensembl)
  • EC 1.11.1.9
  • Selenoprotein-glutathione peroxidase 6
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:257202
GSHMetaboliteHMDB0000125 (HMDB) Glutathione
GSRProteinENSBTAG00000007115 (Ensembl)
  • EC 1.8.1.7
  • glutathione reductase
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2936
GSSGMetaboliteHMDB0000656 (HMDB) Glutathione disulfide
GlucoseMetaboliteHMDB0000122 (HMDB)
H2O2MetaboliteHMDB0003125 (HMDB) Hydrogen peroxide
H2OMetaboliteHMDB0002111 (HMDB) Glutathione disulfide
HBAProteinENSBTAG00000026418 (Ensembl)
  • hemoglobin, alpha 1
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3039
HBGProteinENSBTAG00000037644 (Ensembl)
  • hemoglobin, beta
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3043
HDL-CMetabolite47775 (ChEBI) high-density lipoprotein cholesterol
HDL/APOA1Metabolite39025 (ChEBI)
  • high-density lipoprotein
  • ApoA-I is present on the majority of HDL particles and constitutes aprox 70% of the apolipoprotein content of HDL particles
HDL/SAAMetabolite39025 (ChEBI)
  • high-density lipoprotein
  • SAA circulates in plasma as a constituent of high density lipoproteins (HDL).
HDLMetabolite39025 (ChEBI) high-density lipoprotein
HNO2Metabolite25567 (ChEBI) Nitrous acid
HOClMetaboliteHMDB0001050 (HMDB) Hypochlorite
HbA1cProtein
  • Glycated hemoglobin
  • http://en.wikipedia.org/wiki/Glycated_hemoglobin
HemeMetaboliteHMDB0003178 (HMDB)
HomocysteineMetaboliteHMDB0000742 (HMDB)
HydroxykynurenineMetaboliteHMDB0000732 (HMDB)
HypoxanthineMetaboliteHMDB0000157 (HMDB)
ICAM1ProteinENSBTAG00000010303 (Ensembl)
  • soluble intercellular adhesion molecule 1
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3383
IFNGProteinENSBTAG00000012529 (Ensembl)
  • interferon, gamma
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3458
IL1BProteinENSBTAG00000001321 (Ensembl)
  • interleukin 1, beta
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3553
IL6ProteinENSBTAG00000014921 (Ensembl)
  • interleukin 6 (interferon, beta 2)
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3569
INSProtein
  • Insulin
  • No homologues found for original id L:3630
INSRProteinENSBTAG00000012687 (Ensembl)
  • Insulin receptor
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3643
IodineMetaboliteQ1103 (Wikidata)
IronMetaboliteQ26840996 (Wikidata)
KMOProteinENSBTAG00000014439 (Ensembl)
  • EC 1.14.13.9
  • kynurenine 3-hydroxylase
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8564
KYNUProteinENSBTAG00000032277 (Ensembl)
  • EC 3.7.1.3
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8942
KynurenineMetaboliteHMDB0000684 (HMDB)
LDLMetabolite39026 (ChEBI) low-density lipoprotein
LDLRProteinENSBTAG00000012314 (Ensembl)
  • low density lipoprotein receptor
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3949
Leukotriene A4MetaboliteHMDB0001337 (HMDB)
Leukotriene B4MetaboliteHMDB0001085 (HMDB)
Leukotriene C4MetaboliteHMDB0001198 (HMDB)
Leukotriene D4MetaboliteHMDB0003080 (HMDB)
Leukotriene E4MetaboliteHMDB0002200 (HMDB)
Leukotriene F4MetaboliteHMDB0006465 (HMDB)
Linoleic acidMetaboliteHMDB0000673 (HMDB)
Lipoic acidMetaboliteHMDB0001451 (HMDB)
Lipoxin A4MetaboliteHMDB0004385 (HMDB)
Lipoxin B4MetaboliteHMDB0005082 (HMDB)
MDAMetaboliteHMDB0006112 (HMDB) Malondialdehyde
MPOProteinENSBTAG00000011616 (Ensembl)
  • EC 1.11.1.7
  • Myeloperoxidase
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4353
MTHFRProteinENSBTAG00000020698 (Ensembl)
  • EC 1.5.1.20
  • 5,10-methylenetetrahydrofolate reductase
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4524
MTRProteinENSBTAG00000012251 (Ensembl)
  • EC 2.1.1.13
  • 5-methyltetrahydrofolate-homocysteine methyltransferase
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4548
ManganeseMetaboliteHMDB0001333 (HMDB)
Methionine sulfoxideMetaboliteHMDB0002005 (HMDB)
MethionineMetaboliteHMDB0000696 (HMDB)
NADP+MetaboliteHMDB0000217 (HMDB) Nicotinamide adenine dinucleotide phosphate-Oxidized
NADPHMetaboliteHMDB0000221 (HMDB) Nicotinamide adenine dinucleotide phosphate-Reduced
NFKB1GeneProductENSBTAG00000020270 (Ensembl)
  • nuclear factor NF-kappa-B p50 subunit
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4790
NFKB2GeneProductENSBTAG00000006017 (Ensembl)
  • nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4791
NO2Metabolite33101 (ChEBI) Nitrogen dioxide
NOMetaboliteHMDB0003378 (HMDB) Nitric oxide
NiacinMetaboliteHMDB0001488 (HMDB)
NiacinamideMetaboliteHMDB0001406 (HMDB)
NicotinamidaseProteinCatalysis of the reaction: nicotinamide + H2O = nicotinate + NH3 GO:0008936
NitrotyrosineMetaboliteHMDB0001904 (HMDB)
O2-“MetaboliteHMDB0002168 (HMDB) Superoxide
O2MetaboliteHMDB0001377 (HMDB)
O3Metabolite25812 (ChEBI) ozone
ONOO-/ONOOHMetaboliteHMDB0002179 (HMDB) Peroxynitrite
PGD2MetaboliteHMDB0001403 (HMDB) Prostaglandin D2
PGE1MetaboliteHMDB0001442 (HMDB) Prostaglandin E1
PGE2MetaboliteHMDB0001220 (HMDB) Prostaglandin E2
PGE3MetaboliteHMDB0002664 (HMDB) Prostaglandin E3
PGF2aMetaboliteHMDB0001139 (HMDB) Prostaglandin F2a
PGG2MetaboliteHMDB0003235 (HMDB) Prostaglandin G2
PGH2MetaboliteHMDB0001381 (HMDB) Prostaglandin H2
PGH3MetaboliteHMDB0013040 (HMDB) Prostaglandin H3
PGI2MetaboliteHMDB0001335 (HMDB) Prostaglandin I2
PLATProteinENSBTAG00000001244 (Ensembl)
  • EC 3.4.21.68
  • plasminogen activator, tissue
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5327
PLGProteinENSBTAG00000001271 (Ensembl)
  • EC 3.4.21.7
  • Plasminogen
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5340
PMPMetaboliteHMDB0001555 (HMDB) Pyridoxamine 5'-phosphate
PNPOProteinENSBTAG00000012259 (Ensembl)
  • EC 1.4.3.5
  • pyridoxamine 5'-phosphate oxidase
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:55163
PRDX1ProteinENSBTAG00000003642 (Ensembl)
  • EC 1.11.1.15
  • peroxiredoxin 1
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5052
PRDX2ProteinENSBTAG00000012062 (Ensembl)
  • EC 1.11.1.15
  • peroxiredoxin 2
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7001
PRDX3ProteinENSBTAG00000008731 (Ensembl)
  • EC 1.11.1.15
  • peroxiredoxin 3
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10935
PRDX4ProteinENSBTAG00000006165 (Ensembl)
  • EC 1.11.1.15
  • peroxiredoxin 4
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10549
PRDX5ProteinENSBTAG00000008648 (Ensembl)
  • EC 1.11.1.15
  • peroxiredoxin 5
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:25824
PTGS1ProteinENSBTAG00000006716 (Ensembl)
  • EC 1.14.99.1
  • Cyclooxygenase 1
  • COX-1 constitutive
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5742
PTGS2ProteinENSBTAG00000014127 (Ensembl)
  • EC 1.14.99.1
  • Cyclooxygenase 2
  • COX-2 inducible
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5743
Pyridoxal 5'-phosphateMetaboliteHMDB0001491 (HMDB)
Quinolinic AcidMetaboliteHMDB0000232 (HMDB)
R-Triiodothyronine (rT3)Metabolite28774 (ChEBI) Reverse triiodothyronine
RELAGeneProductENSBTAG00000013895 (Ensembl)
  • nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5970
RFKProteinENSBTAG00000019345 (Ensembl)
  • EC 2.7.1.26
  • riboflavin kinase
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:55312
RNSMetaboliteCHEBI:62764 (ChEBI)
  • reactive nitrogen species
  • http://en.wikipedia.org/wiki/Reactive_nitrogen_species
ROSMetabolite26523 (ChEBI)
  • reactive oxygen species
  • http://en.wikipedia.org/wiki/Reactive_Oxygen_Species
RiboflavinMetaboliteHMDB0000244 (HMDB)
SAA1Protein
  • serum amyloid A1
  • No homologues found for original id L:6288
SAA2Protein
  • serum amyloid A2
  • No homologues found for original id L:6289
SAA3Protein
  • serum amyloid A3 pseudogene
  • No homologues found for original id L:6290
SAA4ProteinENSBTAG00000002963 (Ensembl)
  • serum amyloid A4, constitutive
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6291
SCARB1ProteinENSBTAG00000014269 (Ensembl)
  • scavenger receptor class B, member 1
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:949
SELENOIProteinENSBTAG00000007837 (Ensembl)
  • Selenoprotein-selenoprotein I
  • Unknown function
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:85465
SELENOKProteinENSBTAG00000032374 (Ensembl)
  • Selenoprotein-selenoprotein K
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:58515
SELENOMProteinENSBTAG00000031279 (Ensembl)
  • Selenoprotein-selenoprotein M
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:140606
SELENONProteinENSBTAG00000021778 (Ensembl)
  • Selenoprotein-selenoprotein N, 1
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:57190
SELENOOProteinENSBTAG00000000647 (Ensembl)
  • Selenoprotein-selenoprotein O
  • Unknown function
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:83642
SELENOSProteinENSBTAG00000000640 (Ensembl)
  • Selenoprotein-selenoprotein S
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:55829
SELENOTProteinENSBTAG00000031435 (Ensembl)
  • Selenoprotein-selenoprotein T
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:51714
SELENOVProteinENSBTAG00000010501 (Ensembl)
  • Selenoprotein-selenoprotein V
  • Unknown function
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:348303
SELENOWProteinENSBTAG00000008203 (Ensembl)
  • Selenoprotein-selenoprotein W
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6415
SEPHS2ProteinENSBTAG00000010851 (Ensembl)
  • EC2.7.9.3
  • Selenoprotein-selenophosphate synthetase 2
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:22928
SERPINA3-7ProteinENSBTAG00000026917 (Ensembl)
  • alpha-1-antichymotrypsin
  • serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:12
SERPINE1ProteinENSBTAG00000014465 (Ensembl)
  • Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5054
SOD1ProteinENSBTAG00000027412 (Ensembl)
  • EC 1.15.1.1
  • superoxide dismutase 1, soluble
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6647
SOD2ProteinENSBTAG00000006523 (Ensembl)
  • EC 1.15.1.1
  • superoxide dismutase 2, mitochondrial
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6648
SOD3ProteinENSBTAG00000013980 (Ensembl)
  • EC 1.15.1.1
  • superoxide dismutase 3, extracellular
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6649
SelHProteinSelenoprotein-selenoprotein H-chromosome 11 open reading frame 31
SelPProtein
  • Selenoprotein-selenoprotein P
  • No homologues found for original id L:6414
SelRProtein
  • EC 1.8.4.-
  • Selenoprotein-selenoprotein X
  • No homologues found for original id L:51734
SelenideMetabolite15076 (ChEBI)
SeleniumMetaboliteHMDB0001349 (HMDB)
SelenocysteineMetaboliteHMDB0003288 (HMDB)
SelenophosphateMetabolite16144 (ChEBI)
Sep15Protein
  • Selenoprotein-15 kDa selenoprotein
  • No homologues found for original id L:9403
SerineMetaboliteHMDB0000187 (HMDB)
TAGMetabolite17855 (ChEBI)
  • Triglyceride
  • Triacylglycerol
THFMetaboliteHMDB0001846 (HMDB) Tetrahydrofolic acid
TNFProteinENSBTAG00000025471 (Ensembl)
  • tumor necrosis factor (TNF superfamily, member 2)
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7124
TXNRD1ProteinENSBTAG00000013912 (Ensembl)
  • Selenoprotein-thioredoxin reductase 1
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7296
TXNRD2ProteinENSBTAG00000043581 (Ensembl)
  • EC 1.8.1.9
  • Selenoprotein-thioredoxin reductase 2
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10587
TXNRD3ProteinENSBTAG00000011795 (Ensembl)
  • EC 1.8.1.9
  • Selenoprotein-thioredoxin reductase 3
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:114112
Thromboxane A2MetaboliteHMDB0001452 (HMDB)
Thromboxane B2MetaboliteHMDB0003252 (HMDB)
Thyroxine (T4)Metabolite30660 (ChEBI)
Triiodothyronine (T3)Metabolite18258 (ChEBI)
Trx-(SH)2Protein
  • reduced thioredoxin
  • No homologues found for original id L:7295
Trx-S2Protein
  • oxidized thioredoxin
  • No homologues found for original id L:7295
TryptophanMetaboliteHMDB0000929 (HMDB)
Uric acidMetaboliteHMDB0000289 (HMDB)
VLDL-TAGMetabolite47776 (ChEBI)
  • very-low-density lipoprotein-triglyceride
  • Triglyceride transport
VLDL/APOBMetabolite39027 (ChEBI)
  • very-low-density lipoprotein
  • The VLDL is produced in the liver, contains one molecule of apoB100
VLDLMetabolite39027 (ChEBI) very-low-density lipoprotein
Vitamin B12MetaboliteHMDB0002174 (HMDB)
XDHProteinENSBTAG00000012519 (Ensembl)
  • EC 1.17.3.2
  • http://en.wikipedia.org/wiki/Xanthine_oxidase
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7498
XanthineMetaboliteHMDB0000292 (HMDB)
ZincMetaboliteHMDB0001303 (HMDB)
a-TocopherolMetaboliteHMDB0001893 (HMDB)
oxLDLMetaboliteCHEBI:60151 (ChEBI) oxidized low-density lipoprotein

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP3257"
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