Selenium metabolism and selenoproteins (Bos taurus)

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2, 4, 7-11Se = Selenium, SeMet = SelenoMethionine, SeC = Selcysteine, H2Se = Selenide, GSH = gluthatione, Trx = ThioredoxinSelenoproteinsSTOPSeCINORGANIC SeSecsynthesisSeCdemethylationSe transportand storageSelenium binding proteinscoding regionSeryl-tRNA[ser](sec)AUGRedoxsignallingDietUnkownfunctionGSHBody proteinsSelenocysteyl-tRNA secPhosphoseryl-tRNA[ser](sec)Sec tRNA[ser]secTrXnucleusProtein foldingmethyl transferaseThyroid hormonemetabolismORGANIC SeAntioxidantenzymesTranscription FactorsSeC BiosynthesisVIMPFOSRELATXNRD2SEPN1TRNAU1APSECISBP2MethylSelenol MeSeHTXNRD1SELENBP1SP3SELKDIO1SeMetFABP1Sep15GPX6SARS2SELTSEPSECSSeCGPX2NFKB1SeleniteCTHSeMetSECISBP2SelenatePOU2F1CREMTXNRD3SeCSelenateSEPP1SARSGPX4SelHGPX3GPX1TXNRD2SELVSeleniteSELMSEPHS2SelenophosphateDIO3Hydrogen selenideSEPHS2SEPW1NFE2L2EEFSECUGAJUNSEPHS1TXNRD1PSTKRPL30DIO2SELOSCLYEPT1TXNRD3SECISBP2SepX1SP1EEFSEC1, 3, 53, 6


Description

* Comments belonging to specific genes on the Selenoprotein pathway
    • TRXND3 gene: Although the geneID is correct, the sequence of this gene was guessed by analogy.
    • Cystathionine gamma-lyase is the mammalian form of bacterial methionine gamma-lyase
    • A selenoprotein database exists at: http://www.selenodb.org.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP28(71888) with a 83.0% conversion rate.

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Bibliography

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  1. Ip C, Hayes C; ''Tissue selenium levels in selenium-supplemented rats and their relevance in mammary cancer protection.''; Carcinogenesis, 1989 PubMed Europe PMC Scholia
  2. Gromer S, Eubel JK, Lee BL, Jacob J; ''Human selenoproteins at a glance.''; Cell Mol Life Sci, 2005 PubMed Europe PMC Scholia
  3. Thompson HJ, Clement IP; ''''; , PubMed Europe PMC Scholia
  4. Commandeur JN, Andreadou I, Rooseboom M, Out M, de Leur LJ, Groot E, Vermeulen NP; ''''; , PubMed Europe PMC Scholia
  5. Wang H, Zhang J, Yu H; ''Elemental selenium at nano size possesses lower toxicity without compromising the fundamental effect on selenoenzymes: comparison with selenomethionine in mice.''; Free Radic Biol Med, 2007 PubMed Europe PMC Scholia
  6. Xia Y, Hill KE, Byrne DW, Xu J, Burk RF; ''Effectiveness of selenium supplements in a low-selenium area of China.''; Am J Clin Nutr, 2005 PubMed Europe PMC Scholia
  7. Boosalis MG; ''The role of selenium in chronic disease.''; Nutr Clin Pract, 2008 PubMed Europe PMC Scholia
  8. Soda K, Oikawa T, Esaki N; ''Vitamin B6 enzymes participating in selenium amino acid metabolism.''; Biofactors, 1999 PubMed Europe PMC Scholia
  9. Small-Howard AL, Berry MJ; ''Unique features of selenocysteine incorporation function within the context of general eukaryotic translational processes.''; Biochem Soc Trans, 2005 PubMed Europe PMC Scholia
  10. Xu XM, Carlson BA, Mix H, Zhang Y, Saira K, Glass RS, Berry MJ, Gladyshev VN, Hatfield DL; ''Biosynthesis of selenocysteine on its tRNA in eukaryotes.''; PLoS Biol, 2007 PubMed Europe PMC Scholia
  11. Papp LV, Lu J, Holmgren A, Khanna KK; ''From selenium to selenoproteins: synthesis, identity, and their role in human health.''; Antioxid Redox Signal, 2007 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
116453view09:56, 7 May 2021EweitzModified title
106014view11:53, 16 August 2019MaintBotHMDB identifier normalization
80672view15:21, 30 June 2015Mkutmonhomology conversion
71422view19:02, 17 October 2013MaintBotAutomated update of data sources
63397view00:04, 10 May 2013MaintBotUpdated to 2013 gpml schema
62710view23:19, 1 May 2013MaintBotUpdated UniProt data source
58824view23:19, 20 February 2013MaintBotUpdated Ensembl and UniProt data source
40570view19:32, 1 March 2011MaintBotRemoved redundant pathway information and comments
33808view00:20, 9 December 2009MaintBotAutomatic update of empty xrefs
32503view12:49, 17 August 2009MaintBotFixed text labels
32194view12:36, 15 August 2009MaintBotFixed text labels
31670view11:41, 14 August 2009MaintBotFixed group labels
31201view19:33, 13 August 2009MaintBotFixed text labels
30599view22:15, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
CREMGeneProductENSBTAG00000016060 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q03060
CTHGeneProductENSBTAG00000014791 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = Q:NP_001893
DIO1GeneProductENSBTAG00000010814 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1733
DIO2GeneProductENSBTAG00000001605 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1734
DIO3GeneProductENSBTAG00000037977 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1735
EEFSECGeneProductENSBTAG00000030962 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:60678
EPT1GeneProductENSBTAG00000007837 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:85465
FABP1GeneProductENSBTAG00000018054 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2168
FOSGeneProductENSBTAG00000004322 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000170345
GPX1GeneProduct
GPX2GeneProductENSBTAG00000048112 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2877
GPX3GeneProductENSBTAG00000043553 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2878
GPX4GeneProductENSBTAG00000046926 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2879
GPX6GeneProductENSBTAG00000012023 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:257202
Hydrogen selenideMetaboliteHMDB0011110 (HMDB)
JUNGeneProductENSBTAG00000004037 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000177606
MethylSelenol MeSeHMetabolite389633 (Chemspider)
NFE2L2GeneProductENSBTAG00000019255 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = Q:NM_006164
NFKB1GeneProductENSBTAG00000020270 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4790
POU2F1GeneProductENSBTAG00000024534 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P14859
PSTKGeneProductENSBTAG00000014028 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q8IV42
RELAGeneProductENSBTAG00000013895 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5970
RPL30GeneProductENSBTAG00000016278 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6156
SARS2GeneProductENSBTAG00000001780 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:54938
SARSGeneProductENSBTAG00000012962 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P49591
SCLYGeneProductENSBTAG00000017826 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51540
SECISBP2GeneProductENSBTAG00000001939 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q96T21
SELENBP1GeneProductENSBTAG00000008091 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8991
SELKGeneProductENSBTAG00000032374 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:58515
SELMGeneProductENSBTAG00000031279 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:140606
SELOGeneProductENSBTAG00000000647 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:83642
SELTGeneProductENSBTAG00000031435 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51714
SELVGeneProductENSBTAG00000010501 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:348303
SEPHS1GeneProductENSBTAG00000008821 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P49903
SEPHS2GeneProductENSBTAG00000010851 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:22928
SEPN1GeneProduct
SEPP1GeneProduct
SEPSECSGeneProductENSBTAG00000014616 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51091
SEPW1GeneProductENSBTAG00000008203 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6415
SP1GeneProductENSBTAG00000003021 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = Q:NP_612482
SP3GeneProductENSBTAG00000000176 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6670
SeCMetaboliteHMDB0003288 (HMDB)
SeMetMetaboliteHMDB0003966 (HMDB)
SelHGeneProduct
SelenateMetabolite24657 (Chemspider)
SeleniteMetaboliteHMDB0011119 (HMDB)
SelenophosphateMetaboliteHMDB0006407 (HMDB)
Sep15GeneProduct
SepX1GeneProduct
TRNAU1APGeneProductENSBTAG00000010393 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:54952
TXNRD1GeneProductENSBTAG00000013912 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7296
TXNRD2GeneProductENSBTAG00000043581 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10587
TXNRD3GeneProduct
UGAGeneProduct
VIMPGeneProductENSBTAG00000000640 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55829

Annotated Interactions

No annotated interactions
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