Physiological and pathological hypertrophy of the heart (Homo sapiens)

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5, 6, 153, 101, 132, 4, 89, 107, 81014911, 12Cytokines(mechanical, oxidative, metabolic)StressRASPhysioclogical HypertrophyPAKLabelGPCR agonistsSurvivalApoptosisPathological remodelingDecompensated heart failureContractilityCellular growthCompensatory hypertrophyContractilityGqHypertrophic gene expressionGiElectrophysiology defectsLIFRMKK3Rac1MEF-2ET-1JNKC-JUNCalNBp38aPKCEGATA-4CTF1p38CamKCalmodulinFOSerkSTAT3JNKgp130Ang IIPKCbp38bCalciumNFAT3PECalNARhoA


Description

Pathways in physiological and pathological hypertrophy of the heart. Largely based on the article from Wang et al, 'Signal transduction in cardiac hypertrophy--dissecting compensatory versus pathological pathways utilizing a transgenic approach.

Hypertrohpy of the heart can be a physiological compensation for exercise, but it can also be a pathological compensation for hypertension and stress.

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Ontology Terms

 

Bibliography

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  1. Wollert KC, Chien KR; ''Cardiotrophin-1 and the role of gp130-dependent signaling pathways in cardiac growth and development.''; J Mol Med, 1997 PubMed Europe PMC Scholia
  2. Wollert KC, Taga T, Saito M, Narazaki M, Kishimoto T, Glembotski CC, Vernallis AB, Heath JK, Pennica D, Wood WI, Chien KR; ''Cardiotrophin-1 activates a distinct form of cardiac muscle cell hypertrophy. Assembly of sarcomeric units in series VIA gp130/leukemia inhibitory factor receptor-dependent pathways.''; J Biol Chem, 1996 PubMed Europe PMC Scholia
  3. MacLellan WR; ''Advances in the molecular mechanisms of heart failure.''; Curr Opin Cardiol, 2000 PubMed Europe PMC Scholia
  4. Heineke J, Molkentin JD; ''Regulation of cardiac hypertrophy by intracellular signalling pathways.''; Nat Rev Mol Cell Biol, 2006 PubMed Europe PMC Scholia
  5. Lim HW, Molkentin JD; ''Calcineurin and human heart failure.''; Nat Med, 1999 PubMed Europe PMC Scholia
  6. Takeishi Y, Ping P, Bolli R, Kirkpatrick DL, Hoit BD, Walsh RA; ''Transgenic overexpression of constitutively active protein kinase C epsilon causes concentric cardiac hypertrophy.''; Circ Res, 2000 PubMed Europe PMC Scholia
  7. Wang Y; ''Signal transduction in cardiac hypertrophy--dissecting compensatory versus pathological pathways utilizing a transgenic approach.''; Curr Opin Pharmacol, 2001 PubMed Europe PMC Scholia
  8. Jalili T, Takeishi Y, Walsh RA; ''Signal transduction during cardiac hypertrophy: the role of G alpha q, PLC beta I, and PKC.''; Cardiovasc Res, 1999 PubMed Europe PMC Scholia
  9. Clerk A, Sugden PH; ''Small guanine nucleotide-binding proteins and myocardial hypertrophy.''; Circ Res, 2000 PubMed Europe PMC Scholia
  10. Molkentin JD, Lu JR, Antos CL, Markham B, Richardson J, Robbins J, Grant SR, Olson EN; ''A calcineurin-dependent transcriptional pathway for cardiac hypertrophy.''; Cell, 1998 PubMed Europe PMC Scholia
  11. Olson EN, Molkentin JD; ''Prevention of cardiac hypertrophy by calcineurin inhibition: hope or hype?''; Circ Res, 1999 PubMed Europe PMC Scholia
  12. Wang Y, Su B, Sah VP, Brown JH, Han J, Chien KR; ''Cardiac hypertrophy induced by mitogen-activated protein kinase kinase 7, a specific activator for c-Jun NH2-terminal kinase in ventricular muscle cells.''; J Biol Chem, 1998 PubMed Europe PMC Scholia
  13. Hunter JJ, Chien KR; ''Signaling pathways for cardiac hypertrophy and failure.''; N Engl J Med, 1999 PubMed Europe PMC Scholia
  14. Molkentin JD; ''Calcineurin and beyond: cardiac hypertrophic signaling.''; Circ Res, 2000 PubMed Europe PMC Scholia
  15. Bueno OF, De Windt LJ, Tymitz KM, Witt SA, Kimball TR, Klevitsky R, Hewett TE, Jones SP, Lefer DJ, Peng CF, Kitsis RN, Molkentin JD; ''The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice.''; EMBO J, 2000 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
129017view23:03, 6 March 2024EweitzOntology Term : 'hypertrophic cardiomyopathy' added !
129016view22:59, 6 March 2024EweitzEconomize layout
126391view15:22, 26 April 2023EgonwLicense is CCZero
121714view13:36, 26 February 2022EweitzFix typo, use gene symbols
116468view10:08, 7 May 2021EweitzModified title
106695view13:04, 17 September 2019MaintBotHMDB identifier normalization
106538view00:03, 6 September 2019KhanspersModified description
106537view00:02, 6 September 2019KhanspersModified description
105787view19:46, 15 August 2019KhanspersModified description
97641view14:32, 31 May 2018AMTanOntology Term : 'cardiac muscle cell' added !
94723view14:21, 5 October 2017EgonwConnected lines.
88320view15:40, 1 August 2016FehrhartOntology Term : 'hypertrophic cardiomyopathy pathway' added !
78581view14:50, 7 January 2015MaintBotadded missing graphIds
68953view17:37, 8 July 2013MaintBotUpdated to 2013 gpml schema
45248view18:35, 7 October 2011KhanspersOntology Term : 'heart disease' added !
41110view23:22, 1 March 2011MaintBotRemoved redundant pathway information and comments
39763view07:39, 17 January 2011AlexanderPicomore complete title
37536view13:21, 9 June 2010MLevelsSpecify description
37535view13:19, 9 June 2010MLevelsModified description
37279view07:30, 24 May 2010MLevelsID
37157view14:57, 18 May 2010MLevelsMoved Line
37156view14:49, 18 May 2010MLevelsLabels
37155view14:45, 18 May 2010MLevelsLabels
37154view14:42, 18 May 2010MLevelsLabels
37124view13:45, 17 May 2010MLevelsModified description
37121view13:34, 17 May 2010MLevelsName changed
37120view13:26, 17 May 2010MLevelsRemoved some of the added things, making a separate pathway for those.
37116view13:02, 17 May 2010MLevelsAdded some lines and literature
37114view12:40, 17 May 2010MLevelsLiterature
37098view09:24, 17 May 2010MLevelsLiterature
37097view09:19, 17 May 2010MLevelsLiterature
37096view09:16, 17 May 2010MLevelsLiterature
37090view08:01, 17 May 2010MLevelsLiterature
37089view07:56, 17 May 2010MLevelsLiterature
37087view07:41, 17 May 2010MLevelsLiterature
37085view07:32, 17 May 2010MLevelsLiterature
37084view07:26, 17 May 2010MLevelsAdded Literature
36876view13:02, 12 May 2010MLevelsminor change
36875view12:49, 12 May 2010SusanID phenylephrine
36874view12:44, 12 May 2010SusanID calcineurin
36873view12:34, 12 May 2010SusanID calmodulin
36871view12:05, 12 May 2010MLevelsLiterature
36870view12:00, 12 May 2010MLevelsMinor changes
36863view10:01, 12 May 2010MLevelsAdded Literature, changed title
36856view14:52, 11 May 2010MLevelsPeriodical save, work in progress
36855view14:31, 11 May 2010MLevelsPeriodical save, work in progress
36854view14:21, 11 May 2010MLevelsPeriodical save, work in progress
36853view13:29, 11 May 2010MLevelsMinor Change
36852view13:19, 11 May 2010MLevelsminor change
36851view12:13, 11 May 2010MLevelsminor change

External references

DataNodes

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NameTypeDatabase referenceComment
Ang IIGeneProduct183 (Entrez Gene)
C-JUNGeneProduct3725 (Entrez Gene)
CTF1GeneProduct1489 (Entrez Gene)
CalNAGeneProduct5530 (Entrez Gene)
CalNBGeneProduct5532 (Entrez Gene)
CalciumMetaboliteHMDB00464 (HMDB)
CalmodulinProtein801 (Entrez Gene)
CamKGeneProduct817 (Entrez Gene)
ET-1GeneProduct1906 (Entrez Gene)
FOSGeneProduct2353 (Entrez Gene)
GATA-4GeneProduct2626 (Entrez Gene)
JNKGeneProduct5599 (Entrez Gene)
LIFRGeneProduct3977 (Entrez Gene)
MEF-2GeneProduct50804 (Entrez Gene)
MKK3GeneProduct5606 (Entrez Gene)
NFAT3GeneProduct4776 (Entrez Gene)
PEMetaboliteHMDB02182 (HMDB)
PKCEGeneProduct5581 (Entrez Gene)
PKCbGeneProduct5579 (Entrez Gene)
Rac1GeneProduct5879 (Entrez Gene)
RhoAGeneProduct387 (Entrez Gene)
STAT3GeneProduct6774 (Entrez Gene)
erkGeneProduct5594 (Entrez Gene)
gp130GeneProduct3572 (Entrez Gene)
p38GeneProduct1432 (Entrez Gene)
p38aGeneProduct1432 (Entrez Gene)
p38bGeneProduct5600 (Entrez Gene)

Annotated Interactions

No annotated interactions

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