Ethanol metabolism resulting in production of ROS by CYP2E1 (Rattus norvegicus)

From WikiPathways

Revision as of 15:37, 23 June 2019 by Egonw (Talk | contribs)
Jump to: navigation, search
1PPSIsiRNAROSStressors converted by CYP2E12-Difluoromethoxy-2,2-difluoroacetic acidPromoterPKCζ siRNAARESP600125NucleusMapk8Nfe2l2Protein kinase CIsofluraneDiallyl sulfideSp1Map2k2StaurosporineHalothaneU0126FluorideNAPQISevofluraneMaffEnfluraneEthanolMafgCyp2e1MafkTrifluoroacetic acidMap2k1ChlorzoxazoneacetaldehydeVitamin CAcetaminophenMethoxyflurane6-HydroxychlorzoxazonePSp1Nfe2l2SubstrateOutcome metaboliteFluorideFluorideCyp2e1Cyp2e1


Description

Metabolism of Ethanol resulting in production of ROS by CYP2E1. Also includes a list of other CYP2E1 substrates and their metabolite outcomes. This pathway is also available for human and mouse.

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

  1. Jin M, Ande A, Kumar A, Kumar S; ''Regulation of cytochrome P450 2e1 expression by ethanol: role of oxidative stress-mediated pkc/jnk/sp1 pathway.''; Cell Death Dis, 2013 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129195view16:39, 15 March 2024EgonwOntology Term : 'ethanol oxidation pathway' added !
106992view13:45, 17 September 2019MaintBotHMDB identifier normalization
104896view15:37, 23 June 2019EgonwReplaced a secondary ChEBI identifiers with a primary identifier.
98052view05:54, 13 July 2018Fehrhartlayout
98051view05:52, 13 July 2018Fehrhartsome layout work
97871view12:02, 12 June 2018Marvin M2Modified description
97141view11:53, 1 May 2018AdoBioInfoNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
6-HydroxychlorzoxazoneMetaboliteHMDB0060998 (HMDB)
AcetaminophenMetaboliteCHEBI:46195 (ChEBI)
ChlorzoxazoneMetaboliteCHEBI:3655 (ChEBI)
Cyp2e1GeneProductENSRNOG00000012458 (Ensembl)
Diallyl sulfideMetaboliteCHEBI:4489 (ChEBI)
EnfluraneMetaboliteHMDB0014373 (HMDB)
EthanolMetaboliteCHEBI:16236 (ChEBI)
FluorideMetaboliteCHEBI:17051 (ChEBI)
HalothaneMetaboliteCHEBI:5615 (ChEBI)
IsofluraneMetaboliteCHEBI:6015 (ChEBI)
MaffGeneProductENSRNOG00000012886 (Ensembl)
MafgGeneProductENSRNOG00000036697 (Ensembl)
MafkGeneProductENSRNOG00000001277 (Ensembl)
Map2k1GeneProductENSRNOG00000010176 (Ensembl)
Map2k2GeneProductENSRNOG00000020005 (Ensembl)
Mapk8GeneProductENSRNOG00000020155 (Ensembl)
MethoxyfluraneMetaboliteCHEBI:6843 (ChEBI)
NAPQIMetaboliteCHEBI:29132 (ChEBI)
Nfe2l2GeneProductENSRNOG00000001548 (Ensembl)
Protein kinase CProteinA0A0G2K5Q0 (Uniprot-TrEMBL)
SevofluraneMetaboliteCHEBI:9130 (ChEBI)
Sp1GeneProductENSRNOG00000014084 (Ensembl)
StaurosporineMetaboliteCHEBI:57491 (ChEBI)
Trifluoroacetic acidMetaboliteCHEBI:45892 (ChEBI)
U0126MetaboliteCHEBI:90693 (ChEBI)
Vitamin CMetaboliteCHEBI:38290 (ChEBI)
acetaldehydeMetaboliteCHEBI:15343 (ChEBI)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP4268"
Personal tools