FAS pathway and stress induction of HSP regulation (Rattus norvegicus)

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13x-P3x-PProteasomeApoptosomeFAS PathwayInhibitionNucleusExtracellularSelf-activationROS3x-PCell SurvivalMitochondria PathwayNecrosisStressNFK-B PathwayApoptosisStress Induction of HSP regulationCutDNA presentationCytoplasmActivateCasp8Mapk8Hspb1Hspb1PhosphateFAP1Map3k7Bcl2Rb1JunPrkdcPhosphateSpna2Casp6DffbHspb1DffaMap3k1Il1aCasp9Hspb1Pak1PhosphatePhosphateParp1Map2k4LmnaDaxxFaslgHspb1FasPhosphateCeramideArhgdibMapkapk3Faf1Hspb1Lmnb1Casp3Mapkapk2Apaf1CycsCasp8GlutathioneCASP10Casp3actinFaddRipk2Hspb1Lmnb2PhosphateDffbTnfPhosphatePhosphateHspb1DaxxPak2Faf1Casp7CflarApaf1


Description

This pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. More info: BioCarta.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP314(r21341) with a 94% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Creagh EM, Sheehan D, Cotter TG; ''Heat shock proteins--modulators of apoptosis in tumour cells.''; Leukemia, 2000 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116961view10:09, 16 May 2021EweitzModified title
109406view17:50, 16 March 2020L DupuisFixed interactions
109386view15:41, 16 March 2020L DupuisConverted interactions to graphical lines
107008view13:46, 17 September 2019MaintBotHMDB identifier normalization
71788view20:32, 17 October 2013MaintBotAutomated update of data sources
69391view18:58, 8 July 2013MaintBotUpdated to 2013 gpml schema
67225view10:23, 26 June 2013Christine ChichesterOntology Term : 'FasL mediated signaling pathway' added !
47779view05:47, 6 April 2012Khanspersupdated xref
41708view02:37, 2 March 2011MaintBotRemoved redundant pathway information and comments
38245view21:23, 27 August 2010KhanspersRemoved receptor and protein complex graphics
35564view15:04, 12 February 2010Thomasadded literature
35559view15:01, 12 February 2010ThomasModified description
34087view19:15, 9 December 2009MaintBotAutomatic update of empty xrefs
33554view09:41, 1 December 2009MaintBotRemoved group label
31581view22:02, 13 August 2009MaintBotFixed text labels
30965view00:47, 30 July 2009MaintBotConverted from Homo sapiens
20869view11:30, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:Fas Pathway and Stress Induction of HSP Regulation Biocarta]] moved to [[Pathway:WP89]]: Moved to stable identifier
8020view13:46, 7 January 2008MaintBot[[Pathway:Rat:Fas Pathway and Stress Induction of HSP Regulation Biocarta]] moved to [[Pathway:Rattus norvegicus:Fas Pathway and Stress Induction of HSP Regulation Biocarta]]: Renaming species
7633view16:06, 18 December 2007MaintBotfixed category names
7221view12:41, 4 November 2007MaintBotAdded categories to GPML
6535view22:20, 22 May 2007169.230.77.174gpml file for [[Rat:Fas_Pathway_and_Stress_Induction_of_HSP_Regulation_Biocarta]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Apaf1GeneProduct78963 (Entrez Gene)
ArhgdibGeneProduct362456 (Entrez Gene) Interim Symbol: Arhgdib predicted and Name: Rho, GDP dissociation inhibitor (GDI) beta (predicted)
Bcl2GeneProduct24224 (Entrez Gene)
CASP10GeneProduct
Casp3GeneProduct25402 (Entrez Gene)
Casp6GeneProduct83584 (Entrez Gene)
Casp7GeneProduct64026 (Entrez Gene)
Casp8GeneProduct64044 (Entrez Gene)
Casp9GeneProduct58918 (Entrez Gene)
CeramideMetabolite
CflarGeneProduct117279 (Entrez Gene)
CycsGeneProduct25309 (Entrez Gene)
DaxxGeneProduct140926 (Entrez Gene)
DffaGeneProduct114214 (Entrez Gene)
DffbGeneProduct84359 (Entrez Gene)
FAP1GeneProduct
FaddGeneProduct266610 (Entrez Gene)
Faf1GeneProduct140657 (Entrez Gene)
FasGeneProduct246097 (Entrez Gene)
FaslgGeneProduct25385 (Entrez Gene)
GlutathioneMetaboliteHMDB0000125 (HMDB)
Hspb1GeneProduct24471 (Entrez Gene)
Il1aGeneProduct24493 (Entrez Gene)
JunGeneProduct24516 (Entrez Gene)
LmnaGeneProduct60374 (Entrez Gene)
Lmnb1GeneProduct116685 (Entrez Gene)
Lmnb2GeneProduct299625 (Entrez Gene)
Map2k4GeneProduct287398 (Entrez Gene)
Map3k1GeneProduct116667 (Entrez Gene)
Map3k7GeneProduct313121 (Entrez Gene)
Mapk8GeneProduct116554 (Entrez Gene)
Mapkapk2GeneProduct289014 (Entrez Gene)
Mapkapk3GeneProduct315994 (Entrez Gene)
Pak1GeneProduct29431 (Entrez Gene)
Pak2GeneProduct29432 (Entrez Gene)
Parp1GeneProduct25591 (Entrez Gene)
PhosphateMetaboliteHMDB0001429 (HMDB)
PrkdcGeneProduct360748 (Entrez Gene)
Rb1GeneProduct24708 (Entrez Gene)
Ripk2GeneProduct362491 (Entrez Gene) receptor (TNFRSF)-interacting serine-threonine kinase 2
Spna2GeneProduct64159 (Entrez Gene) Interim Symbol: Spna1 predicted and Name: spectrin alpha 1 (predicted)
TnfGeneProduct24835 (Entrez Gene)
actinGeneProduct

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP89"
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