Overview of nanoparticle effects (Homo sapiens)

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11, 18DNA damageGenotoxicity / CancerCell migrationAcute lung effects: hypercoagulation, hypofibrinolysis, etc.EndocytosisExocytosisPhagocytosisCoronary heart disease, plaques, DICCell deathAstrocytesMitochondrial potentialdepletion in hepatocytes1, 6, 122, 317NanoparticleCOX2 (PTGS2)DifferentiationBlood coagulationActinP-cadherinOxidative stressC-reactive proteinProstaglandin pathwayAKTNecrosisProstaglandin MetallothioneinCOX1 (PTGS1)PI3KTNF-a SignalingIntegrinAngiogenesisCytoskeletonferritinIl-6 signalingDNA damage responseImmune systemup or down regulationCell cycleApoptosisFAK (PTK2)Autophagic cell deathHMOX1Cell adhesionNecroptosisGlutathione Inflammation5, 196, 168118714, 18816104, 9158fibronectincollagen IVNF-kBBaxIL-6Il-8Bcl-2TNF-acyclin D310laminin


Description

This pathway is giving a summary of currently known nanoparticle effects on cells and organisms. Although there is currently no nanoparticle specific effect known, there is a cascade of effects triggered if cells or organisms are exposed to nanoparticles: The most abundantly observed event is oxidative stress which causes DNA damage, protein and lipid oxidation, and cell death. The mere overload of nanoparticles in the vesicular system lead to cytoskeleton and cell adhesion problems and interfere with the cells autophagic system. Some specific nanoparticles are reported to interfere with the cell membrane, others stimulate the blood coagulation system. The release of metal ions from specific nanoparticles challenges the metal disposal system of the cell.

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Bibliography

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  2. Chen T, Hu J, Chen C, Pu J, Cui X, Jia G; ''Cardiovascular effects of pulmonary exposure to titanium dioxide nanoparticles in ApoE knockout mice.''; J Nanosci Nanotechnol, 2013 PubMed Europe PMC Scholia
  3. Li JG, Li WX, Xu JY, Cai XQ, Liu RL, Li YJ, Zhao QF, Li QN; ''Comparative study of pathological lesions induced by multiwalled carbon nanotubes in lungs of mice by intratracheal instillation and inhalation.''; Environ Toxicol, 2007 PubMed Europe PMC Scholia
  4. Triboulet S, Aude-Garcia C, Carriere M, Diemer H, Proamer F, Habert A, Chevallet M, Collin-Faure V, Strub JM, Hanau D, Van Dorsselaer A, Herlin-Boime N, Rabilloud T; ''Molecular responses of mouse macrophages to copper and copper oxide nanoparticles inferred from proteomic analyses.''; Mol Cell Proteomics, 2013 PubMed Europe PMC Scholia
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  6. Ilinskaya AN, Dobrovolskaia MA; ''Immunosuppressive and anti-inflammatory properties of engineered nanomaterials.''; Br J Pharmacol, 2014 PubMed Europe PMC Scholia
  7. Hohnholt MC, Geppert M, Luther EM, Petters C, Bulcke F, Dringen R; ''Handling of iron oxide and silver nanoparticles by astrocytes.''; Neurochem Res, 2013 PubMed Europe PMC Scholia
  8. Nawrot TS, Perez L, Kuenzli N, Munters E, Nemery B; ''Public health importance of triggers of myocardial infarction: a comparative risk assessment.''; Lancet, 2011 PubMed Europe PMC Scholia
  9. Johnson-Lyles DN, Peifley K, Lockett S, Neun BW, Hansen M, Clogston J, Stern ST, McNeil SE; ''Fullerenol cytotoxicity in kidney cells is associated with cytoskeleton disruption, autophagic vacuole accumulation, and mitochondrial dysfunction.''; Toxicol Appl Pharmacol, 2010 PubMed Europe PMC Scholia
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History

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CompareRevisionActionTimeUserComment
121705view04:38, 26 February 2022EweitzUse gene symbol
118405view14:13, 27 May 2021Mkutmonfix publication refs
113822view16:55, 28 November 2020EgonwChanged to use rounded rectangles
110681view13:07, 28 May 2020Fehrhartgave nanoparticle a class and ID
107141view14:22, 17 September 2019MaintBotChEBI identifier normalization
89371view06:15, 10 September 2016EgonwConnected lines.
88835view13:18, 15 August 2016Fehrhartconnecting unconnected lines
88266view14:32, 1 August 2016FehrhartOntology Term : 'nanomaterial response pathway' added !
87252view13:14, 20 July 2016LindarieswijkChanged necroptosis instead of necrotopsis
84570view12:23, 3 March 2016Mkutmonfix literature references
84569view12:18, 3 March 2016Mkutmonadded missing graph ids
82926view12:57, 13 November 2015FehrhartAdded identifiers (now complete, except nanoparticle)
82925view12:51, 13 November 2015FehrhartAdded identifiers
82924view10:27, 13 November 2015FehrhartAdded identifiers
80967view11:41, 6 July 2015MkutmonModified title
80961view12:25, 2 July 2015FehrhartModified description
80960view12:20, 2 July 2015FehrhartNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKTGeneProductENSG00000117020 (Ensembl)
ActinGeneProductPF00022 (Pfam)
AngiogenesisPathwayWP1539 (WikiPathways)
ApoptosisPathwayWP2507 (WikiPathways)
Autophagic cell deathPathwayWP2509 (WikiPathways)
BaxGeneProductENSG00000087088 (Ensembl)
Bcl-2GeneProductENSG00000171791 (Ensembl)
Blood coagulationPathwayWP558 (WikiPathways)
C-reactive proteinGeneProductENSG00000132693 (Ensembl)
COX1 (PTGS1)GeneProductENSG00000095303 (Ensembl)
COX2 (PTGS2)GeneProductENSG00000073756 (Ensembl)
Cell adhesionPathwayWP306 (WikiPathways)
Cell cyclePathwayWP179 (WikiPathways)
CytoskeletonPathwayWP51 (WikiPathways)
DNA damage responsePathwayWP707 (WikiPathways)
DifferentiationPathwayWP2848 (WikiPathways)
FAK (PTK2)GeneProductENSG00000169398 (Ensembl)
Glutathione MetaboliteCHEBI:16856 (ChEBI)
HMOX1GeneProductENSG00000100292 (Ensembl)
IL-6GeneProductENSG00000136244 (Ensembl)
Il-6 signalingPathwayWP364 (WikiPathways)
Il-8GeneProductENSG00000169429 (Ensembl)
Immune system up or down regulationPathwayWP2783 (WikiPathways)
InflammationPathwayWP453 (WikiPathways)
IntegrinGeneProductENSG00000156886 (Ensembl)
MetallothioneinGeneProductPF00131 (Pfam)
NF-kBGeneProductENSG00000170322 (Ensembl)
Nanoparticle
NecroptosisPathwayWP2513 (WikiPathways)
NecrosisPathwayWP2513 (WikiPathways)
Oxidative stressPathwayWP408 (WikiPathways)
P-cadherinGeneProductENSG00000062038 (Ensembl)
PI3KGeneProductENSG00000171608 (Ensembl)
Prostaglandin MetaboliteCHEBI:26333 (ChEBI)
Prostaglandin pathwayPathwayWP98 (WikiPathways)
TNF-a SignalingPathwayWP231 (WikiPathways)
TNF-aGeneProductENSG00000232810 (Ensembl)
collagen IVGeneProductENSG00000187498 (Ensembl)
cyclin D3GeneProductENSG00000112576 (Ensembl)
ferritinGeneProductPF00210 (Pfam)
fibronectinGeneProductENSG00000115414 (Ensembl)
lamininGeneProductENSG00000053747 (Ensembl)

Annotated Interactions

No annotated interactions

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