Nucleotide metabolism (Homo sapiens)

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dNTPsPolyamineSynthesisDNAdNDPsDNA SynthesisNDPsHypoxanthineAICARPRPS2RRM2BPRPPAdenylosuccinateMTHFD2AdenineSpermineIMPRRM1POLBOAZ1SRMPRPS1SpermidinePOLD1DHFRRRM2AMPHPRT1IMPDH1POLASATPutrescineGMPRRM1NME2GMPOrnithineGMPGuanineADSSRiboseXanthine monophosphateSAICARPOLGUric AcidADSL


Description

The pathway outlined above focuses on purine metabolism and in particular that of guanine metabolism.


Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
126434view10:13, 28 April 2023EgonwLicense is CCZero
124903view07:11, 31 December 2022EgonwConverted labels to data nodes
116530view11:50, 7 May 2021EweitzModified title
107158view14:24, 17 September 2019MaintBotChEBI identifier normalization
106774view13:25, 17 September 2019MaintBotHMDB identifier normalization
106576view21:22, 6 September 2019KhanspersModified description
105762view19:33, 15 August 2019KhanspersModified description
68960view17:39, 8 July 2013MaintBotUpdated to 2013 gpml schema
45328view20:14, 7 October 2011KhanspersOntology Term : 'PW:0000012' removed !
45327view20:14, 7 October 2011KhanspersOntology Term : 'purine metabolic pathway' added !
45326view20:14, 7 October 2011KhanspersOntology Term : 'nucleotide metabolic pathway' added !
41126view23:37, 1 March 2011MaintBotRemoved redundant pathway information and comments
38837view17:22, 24 September 2010Khanspers
38782view00:19, 24 September 2010KhanspersChanged line types
35286view22:50, 11 February 2010MjhModified description
32995view19:01, 30 September 2009MaintBotchanged unknowns to metabolites
32423view17:09, 15 August 2009MaintBotFixed text labels
32082view13:39, 14 August 2009MaintBotFixed group labels
21532view11:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:Nucleotide Metabolism]] moved to [[Pathway:WP404]]: Moved to stable identifier
14016view18:02, 20 May 2008Thomasadded RRM2/RRM2B alternative route
14013view17:47, 20 May 2008Thomasadded some metabolites and connected lines
14011view17:41, 20 May 2008ThomasPeriodical save, work in progress
13100view11:15, 17 May 2008MaintBotautomated metabolite conversion
11557view01:30, 11 April 2008Txr24RNR substrate, subunit and product fix
8302view13:46, 7 January 2008MaintBot[[Pathway:Human:Nucleotide Metabolism]] moved to [[Pathway:Homo sapiens:Nucleotide Metabolism]]: Renaming species
7771view16:16, 18 December 2007MaintBotfixed category names
7384view12:42, 4 November 2007MaintBotAdded categories to GPML
6358view22:18, 22 May 2007N.Fidelmangpml file for [[Human:Nucleotide_Metabolism]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADSLGeneProduct158 (Entrez Gene)
ADSSGeneProduct159 (Entrez Gene)
AICARMetabolite3031-94-5 (CAS)
AMPMetaboliteHMDB0003540 (HMDB)
AdenineMetabolite73-24-5 (CAS)
AdenylosuccinateMetaboliteCHEBI:15919 (ChEBI)
DHFRGeneProduct1719 (Entrez Gene)
GMPMetabolite85-32-5 (CAS)
GuanineMetabolite73-40-5 (CAS)
HPRT1GeneProduct3251 (Entrez Gene)
HypoxanthineMetabolite68-94-0 (CAS)
IMPMetaboliteCHEBI:17202 (ChEBI)
IMPDH1GeneProduct3614 (Entrez Gene)
MTHFD2GeneProduct10797 (Entrez Gene)
NME2GeneProduct4831 (Entrez Gene)
OAZ1GeneProduct4946 (Entrez Gene)
OrnithineMetabolite70-26-8 (CAS)
POLAGeneProduct5422 (Entrez Gene)
POLBGeneProduct5423 (Entrez Gene)
POLD1GeneProduct5424 (Entrez Gene)
POLGGeneProduct5428 (Entrez Gene)
PRPPMetabolite97-55-2 (CAS)
PRPS1GeneProduct5631 (Entrez Gene) Mouse: AA110812
PRPS2GeneProduct5634 (Entrez Gene)
PutrescineMetabolite110-60-1 (CAS)
RRM1GeneProduct6240 (Entrez Gene)
RRM2GeneProduct6241 (Entrez Gene)
RRM2BGeneProduct50484 (Entrez Gene)
RiboseMetabolite50-69-1 (CAS)
SAICARMetabolite3031-95-6 (CAS)
SATGeneProduct6303 (Entrez Gene)
SRMGeneProduct6723 (Entrez Gene)
SpermidineMetabolite124-20-9 (CAS)
SpermineMetabolite71-44-3 (CAS)
Uric AcidMetabolite69-93-2 (CAS)
Xanthine monophosphateMetabolite69-89-6 (CAS)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP404"
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