Methylation pathways (Homo sapiens)

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1, 2SAM synthesis (co-substrate)O-methylationN-methylationS-methylationINMTPNMTTPMTN-methylated substrateS-methylated substrateSubstrateS-AdenosylhomocysteineS-AdenosylhomocysteineMAT2BS-AdenosylmethionineS-AdenosylmethioninePhosphateHNMTMAT1AS-AdenosylhomocysteineCOMTNNMTS-AdenosylmethionineMAT2AO-methylated substratePhosphateL-MethionineATP


Description

This pathway describes the addition of methyl groups to small molecules. SAM, S-Adenosyl methionine, is utilized as a methyl donor and SAH is produced. This process is important in drug metabolism. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Testa B, Kramer SD; ''The biochemistry of drug metabolism--an introduction: part 4. reactions of conjugation and their enzymes.''; Chem Biodivers, 2008 PubMed Europe PMC Scholia
  2. Weinshilboum RM; ''Pharmacogenomics: catechol O-methyltransferase to thiopurine S-methyltransferase.''; Cell Mol Neurobiol, 2006 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
117787view14:04, 22 May 2021EweitzModified title
107581view05:35, 23 October 2019KhanspersModified description
107579view05:33, 23 October 2019KhanspersModified description
107578view05:32, 23 October 2019KhanspersModified description
107577view05:32, 23 October 2019KhanspersModified description
107576view05:31, 23 October 2019KhanspersModified description
107575view05:29, 23 October 2019KhanspersModified description
106829view13:30, 17 September 2019MaintBotHMDB identifier normalization
106645view21:07, 12 September 2019KhanspersModified description
105503view05:56, 8 August 2019KhanspersModified description
88909view09:24, 17 August 2016MirellaKalafatiOntology Term : 'classic metabolic pathway' added !
79563view16:07, 25 March 2015ZariChanged ID for INMT gene
68981view17:42, 8 July 2013MaintBotUpdated to 2013 gpml schema
59186view18:51, 22 February 2013MaintBotUpdated Ensembl and UniProt data source
44906view10:26, 6 October 2011MartijnVanIerselOntology Term : 'protein modification pathway' added !
41158view23:41, 1 March 2011MaintBotRemoved redundant pathway information and comments
39758view07:23, 17 January 2011AlexanderPicomore specific title
33416view14:51, 30 November 2009MaintBotRemoved group label
30265view20:06, 25 July 2009AlexanderPico
30035view10:24, 29 June 2009Pieter GiesbertzAdded literature reference
30033view09:38, 29 June 2009Pieter GiesbertzAdded literature reference
29741view22:38, 1 June 2009KhanspersModified categories
29687view11:37, 27 May 2009Pieter GiesbertzSpecify description
29671view08:09, 26 May 2009Pieter GiesbertzAdded co-substrate synthesis
29349view07:55, 28 April 2009Pieter GiesbertzNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ATPMetaboliteHMDB0000538 (HMDB)
COMTGeneProductENSG00000093010 (Ensembl)
HNMTGeneProductENSG00000150540 (Ensembl)
INMTGeneProductENSG00000241644 (Ensembl)
L-MethionineMetaboliteHMDB0000696 (HMDB)
MAT1AGeneProductENSG00000151224 (Ensembl)
MAT2AGeneProductENSG00000168906 (Ensembl)
MAT2BGeneProductENSG00000038274 (Ensembl)
N-methylated substrateMetabolite
NNMTGeneProductENSG00000166741 (Ensembl)
O-methylated substrateMetabolite
PNMTGeneProductENSG00000141744 (Ensembl)
PhosphateMetaboliteHMDB0001429 (HMDB)
S-AdenosylhomocysteineMetaboliteHMDB0000939 (HMDB)
S-AdenosylmethionineMetaboliteHMDB0001185 (HMDB)
S-methylated substrateMetabolite
SubstrateMetabolite
TPMTGeneProductENSG00000137364 (Ensembl)

Annotated Interactions

No annotated interactions

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