Mitochondrial complex III assembly (Homo sapiens)
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Description
Complex III or quinol-cytochrome c reductase performs electron transfer coupled to proton pumping. It occurs as a symmetrical, tightly bound dimer (referred to as cIII2). This dimerisation occurs prior to the pre CIII complex formation, annotated as pre-CIII(2). Each monomer is composed of a catalytic core containing MT-CYB, CYC1 and UQCRFS1. An additional seven subunits are required for stability and/or correct assembly of the enzyme, but are not involved in the catalysis, but .
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Ontology Terms
Saving...Bibliography
- Signes A, Fernandez-Vizarra E; ''Assembly of mammalian oxidative phosphorylation complexes I-V and supercomplexes.''; Essays Biochem, 2018 PubMed Europe PMC Scholia
History
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External references
DataNodes
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| Name | Type | Database reference | Comment |
|---|---|---|---|
| 2Fe-2S | Metabolite | CHEBI:30408 (ChEBI)  | |
| BCS1L | GeneProduct | ENSG00000074582 (Ensembl) | |
| CYC1 | GeneProduct | ENSG00000179091 (Ensembl) | |
| LYRM7 | GeneProduct | ENSG00000186687 (Ensembl) | |
| MT-CYB | GeneProduct | ENSG00000198727 (Ensembl) | |
| TTC19 | GeneProduct | ENSG00000011295 (Ensembl) | |
| UQCC1 | GeneProduct | ENSG00000101019 (Ensembl) | |
| UQCC2 | GeneProduct | ENSG00000137288 (Ensembl) | |
| UQCC3 | GeneProduct | ENSG00000204922 (Ensembl) | |
| UQCR10 | GeneProduct | ENSG00000184076 (Ensembl) | |
| UQCR11 | GeneProduct | ENSG00000127540 (Ensembl) | |
| UQCRB | GeneProduct | ENSG00000156467 (Ensembl) | |
| UQCRC1 | GeneProduct | ENSG00000010256 (Ensembl) | |
| UQCRC2 | GeneProduct | ENSG00000140740 (Ensembl) | |
| UQCRFS1 | GeneProduct | ENSG00000169021 (Ensembl) | |
| UQCRH | GeneProduct | ENSG00000173660 (Ensembl) | |
| UQCRQ | GeneProduct | ENSG00000164405 (Ensembl) | |
| heme b | Metabolite | CHEBI:60344 (ChEBI) |
Annotated Interactions
No annotated interactions
