ACE inhibitor pathway - for workshop (Homo sapiens)
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Description
**This pathway is a starter pathway for the Introduction to Pathway Modeling workshop. DO NOT DELETE.**
Description: The core of this pathway was elucidated over a century ago and involves the conversion of angiotensinogen to angiotensin I (Ang I) by renin, its subsequent conversion to angiotensin II (Ang II) by angiotensin converting enzyme. Ang II activates the angiotensin II receptor type 1 to induce aldosterone synthesis, increasing water and salt resorption and potassium excretion in the kidney and increasing blood pressure.
Source: PharmGKB (https://www.pharmgkb.org/pathway/PA2023)Quality Tags
Ontology Terms
Saving...Bibliography
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- Bassett MH, White PC, Rainey WE; ''The regulation of aldosterone synthase expression.''; Mol Cell Endocrinol, 2004 PubMed Europe PMC Scholia
- Weir MR; ''Effects of renin-angiotensin system inhibition on end-organ protection: can we do better?''; Clin Ther, 2007 PubMed Europe PMC Scholia
- Huang Y, Wongamorntham S, Kasting J, McQuillan D, Owens RT, Yu L, Noble NA, Border W; ''Renin increases mesangial cell transforming growth factor-beta1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms.''; Kidney Int, 2006 PubMed Europe PMC Scholia
- Maron BA, Leopold JA; ''Mineralocorticoid receptor antagonists and endothelial function.''; Curr Opin Investig Drugs, 2008 PubMed Europe PMC Scholia
- Hamming I, Cooper ME, Haagmans BL, Hooper NM, Korstanje R, Osterhaus AD, Timens W, Turner AJ, Navis G, van Goor H; ''The emerging role of ACE2 in physiology and disease.''; J Pathol, 2007 PubMed Europe PMC Scholia
- Schwartz GL, Turner ST; ''Pharmacogenetics of antihypertensive drug responses.''; Am J Pharmacogenomics, 2004 PubMed Europe PMC Scholia
- McDowell SE, Coleman JJ, Ferner RE; ''Systematic review and meta-analysis of ethnic differences in risks of adverse reactions to drugs used in cardiovascular medicine.''; BMJ, 2006 PubMed Europe PMC Scholia
- Ferreira AJ, Raizada MK; ''Are we poised to target ACE2 for the next generation of antihypertensives?''; J Mol Med, 2008 PubMed Europe PMC Scholia
- Batenburg WW, Jan Danser AH; ''The (pro)renin receptor: a new addition to the renin-angiotensin system?''; Eur J Pharmacol, 2008 PubMed Europe PMC Scholia
- Athyros VG, Mikhailidis DP, Kakafika AI, Tziomalos K, Karagiannis A; ''Angiotensin II reactivation and aldosterone escape phenomena in renin-angiotensin-aldosterone system blockade: is oral renin inhibition the solution?''; Expert Opin Pharmacother, 2007 PubMed Europe PMC Scholia
History
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External references
DataNodes
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| Name | Type | Database reference | Comment |
|---|---|---|---|
| ACE Inhibitor | Metabolite | CHEBI:35457 (ChEBI)  | |
| ACE | GeneProduct | 1636 (Entrez Gene) | |
| ACE2 | GeneProduct | 59272 (Entrez Gene) | |
| AGT | GeneProduct | 183 (Entrez Gene) | |
| AGTR1 | GeneProduct | 185 (Entrez Gene) | |
| AGTR2 | GeneProduct | 186 (Entrez Gene) | |
| ATP6AP2 | GeneProduct | 10159 (Entrez Gene) | |
| Aldosterone | Metabolite | HMDB0000037 (HMDB) | |
| Ang 1-5 | Metabolite | C15852 (KEGG Compound) | |
| Ang 1-7 | Metabolite | 110354 (Chemspider) | |
| Ang 1-9 | Metabolite | C15851 (KEGG Compound) | |
| Angiotensin I | Metabolite | 3081372 (PubChem-compound) | |
| Angiotensin II | Metabolite | HMDB0001035 (HMDB) | |
| CMA1 | GeneProduct | 1215 (Entrez Gene) | |
| CTSG | GeneProduct | 1511 (Entrez Gene) | |
| CYP11B2 | GeneProduct | 1585 (Entrez Gene) | |
| Ca++ | Metabolite | HMDB0000464 (HMDB) | |
| Deoxycorticosterone | Metabolite | HMDB0000016 (HMDB) | |
| MAS1 | GeneProduct | 4142 (Entrez Gene) | |
| NR3C2 | GeneProduct | 4306 (Entrez Gene) | |
| REN | GeneProduct | 5972 (Entrez Gene) | |
| TFs | GeneProduct | ||
| TGFB1 | GeneProduct | 7040 (Entrez Gene) |
Annotated Interactions
No annotated interactions
