Angiopoietin-like protein 8 regulatory pathway (Homo sapiens)

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2337, 445364263712, 20186, 257, 359, 10, 1938363116626, 32426, 7272211, 177, 435224137343318, 26614271822233427266, 255, 28279, 10, 19146222221, 28, 292724, 30233418, 2636PI 3-Kinase isoformsErk SignalTransduction PathwayGlucose UptakeLegendHepatocyteAmpk isoformsp70 S6 KinasesPancreatic Beta-cell proliferationInsulin Receptor SubstratesT3mTORC1InhibitionActivationRASGlycolysis-GluconeogenesisGLUT4Cell GrowthDifferentiationamino acidsF-2,6-P2InsulinSIN1SREBP PathwayRictorPI(4,5)P2SREBP1a-cExo70SOS2PP2APIK3R3mTORPIK3C2GAutophagy SignalingGSINSRGCKLXRRPS6KB1RaptorPI(3,4,5)P3GRB2PIK3R2IRS1CD45+ hematopoietic- derived cell proliferation RAF1PIK3C3GlucoseSOS1PEPCKglycogenPIK3R1IRS4Protein synthesis and Translation RegulationRPS6KB2mlst8 AMPKPathwayGLUT1LPLPIK3CAFBPPIK3CBRHEBG-6-PX-5-PIRS2TSC2Triacylglyceride SynthesisPIK3CGPPARalphaPTPSEST3SREBP2GlycogenesisPIK3CDTSC1Insulin Signaling Pathway ChrebpPIK3C2AG6PCmTORCIP42PIK3R441216DIO2RXRATHRATHRBSLC16A2SLCO1C1T3T4RXRAANGPTL8T3 and T4 intracelullar uptakeSHC2SHC3SHC1GSK3AGSK3BPDKPKB/Akt isoformsAKT1pT308AKT2pT308EIF4EEIF4EBP1mlst8mTORSIN1pRictormlst8mTORC2FOXO1AFOXO3AmTORC2INSRCAP1CBLFLOT1FLOT2CRKRAPGEF1RHOQTransport of GLUT4 Transporters toPlasma MembraneRictorRXRA1, 8ABCG84FASNABCG5404CYP3A440CYP7A1CYP2B64040LXR target genesDrug and steroidmetabolism13Multi-drugresistancelipogenesisSCDTranscriptionfactorsMEK/MAP Kinasesp90 Rsk KinasesMAP2K1MAP3K7MAPK14MAPK1MAP2K2RPS6KA5MAP3K2MAP3K6MAPK8MAP4K1MAP3K11MAP4K3MAPK10RPS6KA6MAP2K7MAP3K4MAP3K1MAP3K12MAPK4RPS6KA4MAPK11MAP4K5MAPK6MAP4K4MAPK3MAP3K14MAPK12MAP2K5MAP2K4MAPK13RPS6KA1RPS6KA2MAP3K5RPS6KA3MAPK9MAPK7MAP3K3MAP3K9MAP3K8MAP2K6MAP3K13MAP4K2MAP2K3MAP3K10MINK1PI(3,4,5)P3PKB/Akt isoformsAKT1AKT2pT308pS473pT308pS473CBLCCBLBFOXO1AFOXO3AInsulinINSRLXR target genes13CatalysisInsulin Signaling Pathway Undefined MechanismT4Activation from within the PathwayAMPKy3AMPKa1AMPKy2AMPKy1AMPKb2AMPKb1AMPKa2Ampk isoforms1711, 17


Description

The hepatic ANGPTL8 (Angiopoietin Like Protein 8) regulatory pathway represents an up-to-date curated interactive pathway for all of the interactions from the known regulators of ANGPTL8 and updated signaling events of insulin signaling in the liver. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Ontology Terms

 

Bibliography

View all...
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  14. Cox AR, Barrandon O, Cai EP, Rios JS, Chavez J, Bonnyman CW, Lam CJ, Yi P, Melton DA, Kushner JA; ''Resolving Discrepant Findings on ANGPTL8 in β-Cell Proliferation: A Collaborative Approach to Resolving the Betatrophin Controversy.''; PLoS One, 2016 PubMed Europe PMC Scholia
  15. Taniguchi CM, Emanuelli B, Kahn CR; ''Critical nodes in signalling pathways: insights into insulin action.''; Nat Rev Mol Cell Biol, 2006 PubMed Europe PMC Scholia
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  17. Fu Z, Yao F, Abou-Samra AB, Zhang R; ''Lipasin, thermoregulated in brown fat, is a novel but atypical member of the angiopoietin-like protein family.''; Biochem Biophys Res Commun, 2013 PubMed Europe PMC Scholia
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  31. Rong Guo X, Li Wang X, Chen Y, Hong Yuan Y, Mei Chen Y, Ding Y, Fang J, Jiao Bian L, Sheng Li D; ''ANGPTL8/betatrophin alleviates insulin resistance via the Akt-GSK3β or Akt-FoxO1 pathway in HepG2 cells.''; Exp Cell Res, 2016 PubMed Europe PMC Scholia
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  37. Quagliarini F, Wang Y, Kozlitina J, Grishin NV, Hyde R, Boerwinkle E, Valenzuela DM, Murphy AJ, Cohen JC, Hobbs HH; ''Atypical angiopoietin-like protein that regulates ANGPTL3.''; Proc Natl Acad Sci U S A, 2012 PubMed Europe PMC Scholia
  38. Hay N; ''Interplay between FOXO, TOR, and Akt.''; Biochim Biophys Acta, 2011 PubMed Europe PMC Scholia
  39. Raghow R; ''Betatrophin: A liver-derived hormone for the pancreatic β-cell proliferation.''; World J Diabetes, 2013 PubMed Europe PMC Scholia
  40. Lartey LJ, Werneck-de-Castro JP, O-Sullivan I, Unterman TG, Bianco AC; ''Coupling between Nutrient Availability and Thyroid Hormone Activation''; , 2015 PubMed Europe PMC Scholia
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History

View all...
CompareRevisionActionTimeUserComment
134283view05:25, 20 July 2024EgonwRemoved template comments
128129view13:51, 27 January 2024EweitzOntology Term : 'angiopoietin signaling pathway' added !
128128view13:48, 27 January 2024EweitzOntology Term : 'hepatocyte' added !
128127view13:48, 27 January 2024EweitzRefine legend graphics
128126view13:36, 27 January 2024EweitzRefine layout, standardize case
123920view05:59, 31 August 2022Fehrhartremoved one "type your comment here"
123857view06:09, 19 August 2022EgonwRemoved the reference to a retracted article (pmid: 23623304)
123522view05:59, 1 August 2022EgonwMoved another KEGG pathway identifier to the comment as they are not reaction identifiers
123521view05:57, 1 August 2022EgonwMoved another KEGG pathway identifier to the comment as they are not reaction identifiers
123516view17:19, 31 July 2022EgonwMoved two KEGG pathway identifiers to the comment as they are not reaction identifiers
122574view11:00, 16 April 2022EgonwMade multiple pathways clickable (and fixed one data source)
120659view18:51, 22 December 2021EweitzOntology Term : 'PW:0000143' removed !
116786view09:55, 14 May 2021EweitzModified title
112155view17:57, 29 September 2020Khanspersremoved extraneous text from comments
110713view14:55, 28 May 2020Marvin M2changed unknown type to metabolite with chebi ID
106761view13:24, 17 September 2019MaintBotHMDB identifier normalization
106297view17:42, 20 August 2019KhanspersModified description
105529view06:01, 9 August 2019KhanspersModified description
94801view23:35, 5 October 2017AlexanderPicoConverted lines, removed nested groups and connected interactions
93137view15:19, 31 July 2017SiddiqaANGPTL8 role in CD45+ hematopoietic-derived cell proliferation
92444view06:37, 6 June 2017SiddiqaInteractions present exclusively in rat/mouse updated.
92359view08:00, 30 May 2017SusanLegend adapted
90629view14:45, 2 December 2016EgonwNo mim-conversion on gene-gene interactions.
90628view14:41, 2 December 2016EgonwRemoved type info from Entrez Gene ID.
90627view14:09, 2 December 2016EgonwUppercased c in KEGG identifier.
90610view22:11, 1 December 2016KhanspersModified description
90604view10:18, 1 December 2016Elisasolved unconnected lines
90499view14:52, 18 November 2016SusanOntology Term : 'insulin signaling pathway' added !
90498view14:51, 18 November 2016SusanModified description
90497view14:48, 18 November 2016SusanOntology Term : 'regulatory pathway' added !
90463view12:44, 17 November 2016SiddiqaModified title
90461view12:40, 17 November 2016SiddiqaAdded AUthor List
90460view11:58, 17 November 2016SiddiqaNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AMPK PathwayPathwayWP1403 (WikiPathways)
ABCG5GeneProductENSG00000138075 (Ensembl)
ABCG8GeneProductENSG00000143921 (Ensembl)
AKT1GeneProduct207 (Entrez Gene)
AKT2GeneProduct208 (Entrez Gene)
AMPKa1GeneProduct5562 (Entrez Gene)
AMPKa2GeneProduct5563 (Entrez Gene)
AMPKb1GeneProduct5564 (Entrez Gene)
AMPKb2GeneProduct5565 (Entrez Gene)
AMPKy1GeneProduct5571 (Entrez Gene)
AMPKy2GeneProduct51422 (Entrez Gene)
AMPKy3GeneProduct53632 (Entrez Gene)
ANGPTL8GeneProduct55908 (Entrez Gene)
  • synonyms: RIFL; TD26; PRO1185; PVPA599; C19orf80
  • Type your comment here
Autophagy SignalingPathway
CAP1GeneProduct10487 (Entrez Gene)
CBLGeneProduct867 (Entrez Gene)
CBLBGeneProduct868 (Entrez Gene)
CBLCGeneProduct23624 (Entrez Gene)
CD45+ hematopoietic- 
  derived cell
proliferation 		PathwayWP2849 (WikiPathways)
CIP42GeneProduct9322 (Entrez Gene)
CRKGeneProduct1398 (Entrez Gene)
CYP2B6GeneProductENSG00000197408 (Ensembl)
CYP3A4GeneProductENSG00000160868 (Ensembl)
CYP7A1GeneProductENSG00000167910 (Ensembl) is not affected in human
Cell Growth DifferentiationPathwayWP2029 (WikiPathways)
ChrebpGeneProduct51085 (Entrez Gene)
DIO2GeneProduct1734 (Entrez Gene)
Drug and steroid metabolismPathway
EIF4EGeneProduct1977 (Entrez Gene)
EIF4EBP1GeneProduct1978 (Entrez Gene)
Exo70GeneProduct23265 (Entrez Gene)
F-2,6-P2MetaboliteC00665 (KEGG Compound)
FASNGeneProductENSG00000169710 (Ensembl)
FBPGeneProduct2203 (Entrez Gene)
FLOT1GeneProduct10211 (Entrez Gene)
FLOT2GeneProduct2319 (Entrez Gene)
FOXO1AGeneProduct2308 (Entrez Gene)
FOXO3AGeneProduct2309 (Entrez Gene)
G-6-PMetaboliteC00092 (KEGG Compound)
G6PCGeneProduct2538 (Entrez Gene)
GCKGeneProduct2645 (KEGG Genes)
GLUT1GeneProduct6513 (Entrez Gene)
GLUT4GeneProduct6517 (Entrez Gene)
GRB2GeneProduct
GSGeneProduct2997 (Entrez Gene)
GSK3AGeneProduct2931 (Entrez Gene)
GSK3BGeneProduct2932 (Entrez Gene)
GlucoseMetaboliteC00031 (KEGG Compound)
GlycogenesisPathway
Glycolysis-GluconeogenesisPathwayWP534 (WikiPathways)
INSRGeneProduct3643 (Entrez Gene)
IRS1GeneProduct3667 (Entrez Gene)
IRS2GeneProduct8660 (Entrez Gene)
IRS4GeneProduct8471 (Entrez Gene)
Insulin Signaling Pathway Pathway
Insulin Signaling Pathway PathwayWP1982 (WikiPathways)
InsulinProteinA6XGL2 (Uniprot-TrEMBL)
LPLGeneProduct4023 (Entrez Gene)
LXRGeneProduct10062 (Entrez Gene)
MAP2K1GeneProduct5604 (Entrez Gene)
MAP2K2GeneProduct5605 (Entrez Gene)
MAP2K3GeneProduct5606 (Entrez Gene)
MAP2K4GeneProduct6416 (Entrez Gene)
MAP2K5GeneProduct5607 (Entrez Gene)
MAP2K6GeneProduct5608 (Entrez Gene)
MAP2K7GeneProduct5609 (Entrez Gene)
MAP3K10GeneProduct4294 (Entrez Gene)
MAP3K11GeneProduct4296 (Entrez Gene)
MAP3K12GeneProduct7786 (Entrez Gene)
MAP3K13GeneProduct9175 (Entrez Gene)
MAP3K1GeneProduct4214 (Entrez Gene)
MAP3K14GeneProduct9020 (Entrez Gene)
MAP3K2GeneProduct10746 (Entrez Gene)
MAP3K3GeneProduct4215 (Entrez Gene)
MAP3K4GeneProduct4216 (Entrez Gene)
MAP3K5GeneProduct4217 (Entrez Gene)
MAP3K6GeneProduct9064 (Entrez Gene)
MAP3K7GeneProduct6885 (Entrez Gene)
MAP3K8GeneProduct1326 (Entrez Gene)
MAP3K9GeneProduct4293 (Entrez Gene)
MAP4K1GeneProduct11184 (Entrez Gene)
MAP4K2GeneProduct5871 (Entrez Gene)
MAP4K3GeneProduct8491 (Entrez Gene)
MAP4K4GeneProduct9448 (Entrez Gene)
MAP4K5GeneProduct11183 (Entrez Gene)
MAPK10GeneProduct5602 (Entrez Gene)
MAPK11GeneProduct5600 (Entrez Gene)
MAPK12GeneProduct6300 (Entrez Gene)
MAPK13GeneProduct5603 (Entrez Gene)
MAPK14GeneProduct1432 (Entrez Gene)
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3GeneProduct5595 (Entrez Gene)
MAPK4GeneProduct5596 (Entrez Gene)
MAPK6GeneProduct5597 (Entrez Gene)
MAPK7GeneProduct5598 (Entrez Gene)
MAPK8GeneProduct5599 (Entrez Gene)
MAPK9GeneProduct5601 (Entrez Gene)
MINK1GeneProduct50488 (Entrez Gene)
Multi-drug resistancePathway
PDKGeneProduct5170 (Entrez Gene)
PEPCKGeneProduct5105 (Entrez Gene)
PI(3,4,5)P3MetaboliteC05981 (KEGG Compound) Phosphatidylinositol-3,4,5-trisphosphate(PIP3)
PI(4,5)P2MetaboliteC04637 (KEGG Compound)
PIK3C2AGeneProduct5286 (Entrez Gene)
PIK3C2GGeneProduct5288 (Entrez Gene)
PIK3C3GeneProduct5289 (Entrez Gene)
PIK3CAGeneProduct5290 (Entrez Gene)
PIK3CBGeneProduct5291 (Entrez Gene)
PIK3CDGeneProduct5293 (Entrez Gene)
PIK3CGGeneProduct5294 (Entrez Gene)
PIK3R1GeneProduct5295 (Entrez Gene)
PIK3R2GeneProduct5296 (Entrez Gene)
PIK3R3GeneProduct8503 (Entrez Gene)
PIK3R4GeneProduct30849 (Entrez Gene)
PP2AGeneProduct
PPARalphaGeneProduct
PTPGeneProduct5770 (Entrez Gene) PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase
Protein synthesis and Translation RegulationPathway
RAF1GeneProduct5894 (Entrez Gene)
RAPGEF1GeneProduct2889 (Entrez Gene)
RASGeneProduct3265 (Entrez Gene)
RHEBGeneProduct6009 (Entrez Gene)
RHOQGeneProduct23433 (Entrez Gene)
RPS6KA1GeneProduct6195 (Entrez Gene)
RPS6KA2GeneProduct6196 (Entrez Gene)
RPS6KA3GeneProduct6197 (Entrez Gene)
RPS6KA4GeneProduct8986 (Entrez Gene)
RPS6KA5GeneProduct9252 (Entrez Gene)
RPS6KA6GeneProduct27330 (Entrez Gene)
RPS6KB1GeneProduct6198 (Entrez Gene)
RPS6KB2GeneProduct6199 (Entrez Gene)
RXRAGeneProduct6256 (Entrez Gene)
RXRAGeneProductENSG00000186350 (Ensembl)
RaptorGeneProduct57521 (Entrez Gene)
RictorGeneProduct253260 (Entrez Gene)
SCDGeneProductENSG00000099194 (Ensembl)
SEST3GeneProduct143686 (Entrez Gene)
SHC1GeneProduct6464 (Entrez Gene)
SHC2GeneProduct25759 (Entrez Gene)
SHC3GeneProduct53358 (Entrez Gene)
SIN1GeneProduct79109 (Entrez Gene)
SLC16A2GeneProduct6567 (Entrez Gene)
SLCO1C1GeneProduct53919 (Entrez Gene)
SOS1GeneProduct6654 (Entrez Gene)
SOS2GeneProduct6655 (Entrez Gene)
SREBP PathwayPathwayWP1982 (WikiPathways)
SREBP1a-cGeneProductENSG00000072310 (Ensembl)
SREBP2GeneProductENSG00000198911 (Ensembl)
T3Metabolite5707 (Chemspider)
T4MetaboliteHMDB0000248 (HMDB)
THRAGeneProduct7067 (Entrez Gene)
THRBGeneProduct7068 (Entrez Gene)
TSC1GeneProduct7248 (Entrez Gene)
TSC2GeneProduct7249 (Entrez Gene)
Transcription factorsPathway
Triacylglyceride SynthesisPathwayWP325 (KEGG Pathway)
X-5-PMetaboliteC00231 (KEGG Compound)
amino acidsMetaboliteCHEBI:33709 (ChEBI)
glycogenMetaboliteC00369 (KEGG Compound)
lipogenesisPathway
mTOR GeneProduct2475 (Entrez Gene)
mTORGeneProduct2475 (Entrez Gene)
mlst8GeneProduct64223 (Entrez Gene)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
ArrowWP1982 (WikiPathways)
ArrowWP2882 (WikiPathways)
Arrowhsa04910 (KEGG Pathway)
Cell Growth DifferentiationArrowhsa04910 (KEGG Pathway)
DIO2mim-catalysisR03734 (KEGG Reaction)
GSTBarhsa04910 (KEGG Pathway)
GlucoseArrowhsa04911 (KEGG Pathway)
INSRArrowhsa04910 (KEGG Pathway)
PTPINSRTBarhsa04910 (KEGG Pathway)
PTPTBarhsa04910 (KEGG Pathway)
RAF1Arrowhsa04910 (KEGG Pathway)
RASArrowhsa04910 (KEGG Pathway)
RASRAF1Arrowhsa04910 (KEGG Pathway)
RHOQArrowhsa04910 (KEGG Pathway)
SLC16A2T3Arrowhsa04919 (KEGG Pathway)
SLCO1C1T4Arrowhsa04919 (KEGG Pathway)
SLCO1C1hsa04919 (KEGG Pathway)
T4T3Arrowhsa04919 (KEGG Pathway)
  • In humans 80 percent T3 is contributed via regulation from deiodinases especially DIO2.
  • The local thyroid hormone signaling is coupled with nutritional availaibility via insulin signaling.
  • Type your comment here
TBarhsa04910 (KEGG Pathway)
mim-catalysisR04545 (KEGG Reaction)
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP3915"
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