Eukaryotic translation initiation (Homo sapiens)

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2819, 1510, 18, 29197, 27171, 2, 10, 185, 10, 18, 26, 2922, 2010-12, 18, 27...3, 6, 10, 16, 18...221384, 7, 2724139, 15cytosolEIF3A GDP FAU RPS4X RPL10A RPL40 RPL36A 5.8S rRNA RPS3A RPS21 RPS8 RPS8 RPL13AEIF4A2 RPS20 RPL37A RPS27 RPL14 RNA-binding protein in RNP (ribonucleoprotein) complexes RPS24 GTP RPL10L RPS3A RPS24 EIF3B RPL3 RPS13 RPL27A RPL27 RPS28 Met-tRNAi ATPMet-tRNAi mRNA RPS27 RPS26 RPS8 EIF3G EIF4H RPS5 RPS15A RPS6 RPS4X RPS26 EIF3F RPS4Y1 80S:Met-tRNAi:mRNARPL30 EIF3G RPS7 EIF3I EIF2S1 EIF3A RPS27A(77-156) RPL35 RPL13 RPL10 RPS27A(77-156) GDP RPS27 RPS27 RPS15 RPS28 RPS7 RPL23A RPL10L RPL17 RPS3 RPS7 43S:CeruloplasminmRNA:eIF4F:eIF4B:eIF4H:PABPEIF2S3 RPS8 RPL38 RPS28 RPL37 ADPRPS3 RPS19 EIF3G RPS3A RPLP0 RPL18A RPL12 RPL3L 5.8S rRNA RPS26 RPL27 RPS23 RPL14 RPS14 EIF4EBP1EIF2S2 PiRPSA RPS4Y1 RPS12 RPS28 EIF3J RPL12 EIF2B2 RPSA RPL13 EIF4G1 RPS16 GTP RPS5 EIF2B4 EIF1AX mRNA 18S rRNA EIF4H RPS4Y2 RPS29 RPS19 EIF3I EIF2B4 RPL8 EIF3B RPS23 RPL17 80S:Met-tRNAi:mRNA:eIF5B:GTPRPS5 RPS5 RPS29 mRNA EIF2S3 EIF4E EIF2S1:EIF2S2:EIF2S3RPS26 EIF3D EIF2S2 RPS25 RPL36AL RPS19 EIF4A2 RPS5 RPSA RPS4X ternary complexeIF2:GDPEIF3I RPS27A(77-156) RPL30 RPS27L EIF3H RPS9 EIF3L RNA-binding proteinin RNP(ribonucleoprotein)complexeseIF5B:GDPRPS27A(77-156) ADPRPL23 EIF4BRPS21 RPS4Y1 RPS27A(77-156) RPL37 RPL27A EIF3G RPL18A RPLP0 L13a kinaseEIF4E GTPRPL36AL RPL34 EIF4A1 RPL3L RPL36A RPS2 5.8S rRNA Met-tRNAi RPL28 RPS21 RPL21 RPS27 EIF3J EIF3E RPL37 RPLP0 RPL27 RPS15A RPL5 RPL9 RPS27L EIF3H RPS26 mRNPRPS12 RPL17 EIF3C 28S rRNA 18S rRNA 48S complexRPL23A eIF4A subunitscomplexRPS4Y2 RPL18 RPL24 RPL24 EIF2B2 RPL39L RPS13 RPS4X EIF2S3 RPS11 RPS6 RPS28 RPS20 RPS3A RPS17 RPS4Y2 EIF4A1 RPL22L1 RPS12 RPL7 EIF4G1 RPL28 RPL26L1 RPL6 RPLP1 eIF1RPS27L RPL3L RPS25 RPS17 EIF3H RPS10 RPS29 RPS29 RPS9 60S ribosomalcomplexphospho-L13aassociated wth the 3' UTR GAIT elementof ceruloplasminmRNA within thetranslationinitiation complexEIF2S1 RPS29 Met-tRNAiEIF3J RPS26 RPLP1 RPS20 RPS15 RPS8 RPS13 EIF1AX RPS3A RPS29 RPL11 EIF3D RPS8 RPL36 RPL37A RPSA RPL18A 18S rRNA RPS4Y2 EIF3M RPS7 EIF4G1 RPLP1 RPS17 EIF4G1 RPS7 RPS6 EIF3I RPL40 RPS27 5S rRNA RPS12 RPS15A RPS18 RPL39 RPL39L EIF3H EIF2S3 EIF5mRNA:eIF4F:eIF4B:eIF4HRPS19 RPS3A RPL17 RPS11 RPL5 EIF4E RPS4Y2 RPS20 RPS2 RPL7A RPL17 RPL10A FAU 18S rRNA RPS10 EIF5B RPS2 5S rRNA RPL37 RPL23 RPS15 RPL41 EIF3D RPS28 RPL7A EIF2S2 RPS21 RPL3 RPL37 RPL6 EIF4A1 RPL32 EIF1AX RPL22 RPL18 EIF3B RPL28 RPL34 RPS11 RPL13 EIF3K EIF1AX EIF4HRPS5 RPL19 EIF3L RPS12 RPL39 RPS4Y2 RPL27A EIF2S2 RPS5 Ceruloplasmin mRNA EIF3M EIF2S1 RPS3A ATPMet-tRNAi EIF1AX RPS3A EIF4B RPS15 RPSA EIF4E EIF3E RPL8 RPS26 RPS3A RPL26L1 18S rRNA RPS15A EIF3E RPS15 18S rRNA EIF2S3 GTP RPL28 43S complexEIF3E RPL24 EIF2S3 RPL11 EIF3G 5S rRNA EIF3G RPS6 Met-tRNAi 18S rRNA RPS18 RPS27 RPL29 RPS27 PiEIF2S3 RPS7 RPL41 RPS2 RPL26 5.8S rRNA EIF4G1 EIF4E FAU RPL15 EIF4A1 RPL32 EIF2B3 EIF3L EIF3M RPS21 RPS4X RPL32 RPS6 RPL14 RPL19 ATPRPL27A RPS20 RPS14 RPS13 EIF3M RPS16 RPS17 RPL30 EIF2S3 RPS20 RPS2 mRNA RPS6 RPS27A(77-156) RPS19 RPS27A(77-156) EIF5B RPS6 RPS4X RPL4 RPS27 RPS8 RPL22 RPS17 ADPRPL21 RPL22L1 EIF4A2 RPS7 RPS4X GTP RPS23 RPL10 RPS4X RPL22 EIF3F RPL29 mRNA RPL14 EIF4A2 RPS28 RPS5 EIF4G1 FAU RPS4Y2 RPS16 RPS4Y1 EIF3K RPS12 EIF3E eIF5B:GTPEIF2S2 RPS15A RPS9 RPL3L RPS23 RPS11 RPS13 RPL27 RPL22L1 EIF4E RPS21 EIF2S1 RPL26 RPS25 RPS18 RPL3L RPSA RPL5 RPS4Y2 RPSA RPS14 RPL6 EIF3K RPS19 RPL4 eIF4FMet-tRNAi EIF4H mRNA RPS3 p-RPL13A RPL36 RPS14 RPS27L RPL8 RPS15 GTPCeruloplasminmRNA:eIF4F:eIF4B:eIF4HRPS4Y2 RPL35 EIF3J eIF4E:4E-BPRPS5 RPS13 RPS9 RPS4X RPL36AL RPL13A RPS28 EIF2S1 EIF4A2 FAU EIF3D RPS12 RPL41 RPS2 RPL7 RPL19 RPS24 RPS3A RPS21 RPL23 RPS27L RPLP0 RPS8 RPL23A RPS9 RPL18 RPS17 RPL15 EIF3K RPS3 RPS14 RPL34 EIF4H RPS20 EIF1AXEIF4A1 RPS4X RPS10 RPL37A RPL18A EIF2S2 EIF2B1 EIF3G EIF2S3 RPS24 eIF4F:mRNPEIF2S1 RPL10 EIF4EBP1 RPSA RPL30 RPL22 RPL26L1 EIF2S1 RPL26L1 RPS11 EIF3C RPS24 RPS27L EIF2S1:EIF2S2:EIF2S3RPL3 RPS3 RPS8 RPL10L 18S rRNA RPL40 RPS29 GDP RPL34 40S:Met-tRNAi:mRNARPS11 RPL11 RPS15A EIF3F RPS8 RPS21 EIF4G1EIF1AXRPL13 RPS18 FAU RPS24 18S rRNA EIF4B RPS4X EIF3E RPS20 RPS14 RPS10 EIF4A1 RPLP2 RPL10A RPS13 RPL35A RPL38 RPS24 EIF2S2 mRNA RPS27 RPS10 EIF5RPS12 EIF3M RPS14 EIF2B3 EIF2S1 RPS18 RPL3 RPS25 RPL7A RPLP2 RPS14 18S rRNA RPS29 p-RPL13AEIF3B EIF3J EIF3M RPL23 RPS28 RPS16 RPS7 RPS11 EIF4B Met-tRNAi RPL11 RPS15A RPL38 RPL39 EIF4G1 RPL8 RPS3 EIF3F RPS18 RPS4Y2 EIF4B RPS27 EIF4A1 EIF3D RPS20 RPL7A RPL10A RPL10 EIF1AXEIF3F Ceruloplasmin mRNA RPL35A GTP RPS3 eIF3 subunitscomplexEIF3D RPS21 28S rRNA RPS16 EIF3K RPL39L EIF3L FAU RPL36A RPL5 EIF5EIF3A RPS25 RPL21 RPS15A RPL4 RPS23 RPS23 RPS11 RPS2 RPL26L1 RPS29 RPS7 EIF3E EIF2S1 EIF2S2 RPL7 RPS19 RPL8 RPS18 RPL10A RPS19 RPS5 RPS3 RPL29 RPL26 RPS16 RPS6 RPS23 GTP RNA-binding protein in RNP (ribonucleoprotein) complexes Ceruloplasmin mRNA EIF3I RPLP2 RPS11 43S:mRNA:eIF4F:eIF4B:eIF4HeIF2B subunitscomplexRPS4Y1 PiRPL39L RPS2 eIF1RPLP2 EIF4E EIF3F RPL35 PABPC1RPL23A RPS26 RPSA RPS21 RPS25 RPS10 RPL32 EIF2B1 RPS27L RPL22L1 EIF2B5 EIF2S1 EIF3C RPS27A(77-156) RPS2 EIF3A RPS14 RPL15 RPS6 RPL29 RPS24 RPS13 RPS26 RPS15 RPL36A RPS28 RPS4Y2 RPL41 28S rRNA RPS24 EIF3H RPL38 RPL37A RPS21 RPS18 EIF3A RPL10 RPS27L RPL35A EIF2S2 RPL10L 5S rRNA RPS25 80S ribosomeEIF2S2 EIF2S3 RPL12 RPS11 RPL22L1 EIF3A RPS6 RPS17 RPL26 RPS10 RPL9 RPS16 EIF3B GTP RPS23 RPL26 RPS16 RPL6 RPS15A RPS9 EIF3D RPS4Y1 RPL12 RPL35A RPL9 EIF4E RPL27 RPS27L eIF2:GTPRPS10 RPL40 FAU RPL35 EIF3A RPS9 RPS7 RPS15A EIF2S3 RPS2 RPS16 RPS23 60s ribosomalcomplex lackingL13a subunit40S:eIF3:eIF1AEIF3F RPL31 RPS20 5.8S rRNA RPS25 RPL39 eIF2:GDP: eIF2BRPL38 EIF2S2 RPS3 RPL4 5S rRNA RPL13A EIF2S1 RPS19 RPL5 EIF3I EIF3M EIF1AX mRNA RPL36A RPL4 RPS20 RPL15 EIF3J EIF3J RPSA GTP EIF3C RPS10 GDPRPLP0 Met-tRNAi RPS12 RPS3 RPS4Y1 EIF3C RPS12 EIF5B RPS29 RPS9 EIF4B EIF3K 18S rRNA RPL14 EIF4A2 RPL6 RPS18 RPS27A(77-156) RPS27L EIF4A2 EIF4E RPS25 EIF3L EIF4G1 RPLP1 RPS6 EIF3B RPS26 RPS11 RPL27A RPL29 RPSA EIF4H RPL15 RPL31 RPL36 GTP RPS24 RPL36 RPS23 RPS13 EIF4A2 RPL31 RPS9 RPS27A(77-156) RPL41 RPL24 RPL35A RPS8 RPS3A RPS27L RPS15 eIF2:GTPRPS24 EIF4B RPL35 EIF2S2 RPS16 RPS4Y1 RPS5 RPL37A RPS27A(77-156) EIF1AXEIF3B RPLP2 RPL18 RPS4Y1 RPL13A EIF2B5 RPS10 Met-tRNAi RPL31 EIF3H RPS15 RPL36 RPS18 RPS25 EIF3L RPL18A RPL7 RPS3 RPL10L EIF2S1 RPL11 RPS14 RPS17 EIF4A1 RPS7 PABPC1 RPL21 EIF4ERPS17 RPL9 RPL9 EIF3C RPL13 RPL39L RPS15 RPS16 RPL22 FAU RPS12 RPL7A 28S rRNA RPL32 RPL19 RPS17 RPS29 RPS18 RPS9 RPLP1 RPL12 RPS13 RPL30 RPS9 28S rRNA EIF3C RPS17 RPS19 RPL39 EIF3H EIF2S3 40S ribosomalcomplexPiRPL18 RPS13 RPL28 RPL19 RPL21 RPS15A RPL31 EIF4A2 PABPC1 RPS4Y1 RPS10 RPS25 EIF3K RPL13A RPS14 EIF4H EIF4A1 GTP RPS26 RPL3 EIF3I RPS23 RPL23A RPS28 RPL23 RPL24 EIF3L RPS19 RPS4Y1 RPL34 RPS2 ATPFAU RPL36AL RPL7 FAU RPL40 RPL36AL RPS15 14, 2114, 2114, 2114, 2114, 2114, 212314, 2114, 2114, 2114, 21


Description

Initiation of translation in the majority of eukaryotic cellular mRNAs depends on the 5'-cap (m7GpppN) and involves ribosomal scanning of the 5' untranslated region (5'-UTR) for an initiating AUG start codon. Therefore, this mechanism is often called cap-dependent translation initiation. Proximity to the cap, as well as the nucleotides surrounding an AUG codon, influence the efficiency of the start site recognition during the scanning process. However, if the recognition site is poor enough, scanning ribosomal subunits will ignore and skip potential starting AUGs, a phenomenon called leaky scanning. Leaky scanning allows a single mRNA to encode several proteins that differ in their amino-termini. Merrick (2010) provides an overview of this process and hghlights several features of it that remain incompletely understood.

Several eukaryotic cell and viral mRNAs initiate translation by an alternative mechanism that involves internal initiation rather than ribosomal scanning. These mRNAs contain complex nucleotide sequences, called internal ribosomal entry sites, where ribosomes bind in a cap-independent manner and start translation at the closest downstream AUG codon.

Initiation on several viral and cellular mRNAs is cap-independent and is mediated by binding of the ribosome to internal ribosome entry site (IRES) elements. These elements are often found in characteristically long structured regions on the 5'-UTR of an mRNA that may or may not have regulatory upstream open reading frames (uORFs). Both of these features on the 5'-end of the mRNA hinder ribosomal scanning, and thus promote a cap-independent translation initiation mechanism. IRESs act as specific translational enhancers that allow translation initiation to occur in response to specific stimuli and under the control of different trans-acting factors, as for example when cap-dependent protein synthesis is shut off during viral infection. Such regulatory elements have been identified in the mRNAs of growth factors, protooncogenes, angiogenesis factors, and apoptosis regulators, which are translated under a variety of stress conditions, including hypoxia, serum deprivation, irradiation and apoptosis. Thus, cap-independent translational control might have evolved to regulate cellular responses in acute but transient stress conditions that would otherwise lead to cell death, while the same mechanism is of major importance for viral mRNAs to bypass the shutting-off of host protein synthesis after infection. Encephalomyocarditis virus (EMCV) and hepatitis C virus exemplify two distinct mechanisms of IRES-mediated initiation. In contrast to cap-dependent initiation, the eIF4A and eIF4G subunits of eIF4F bind immediately upstream of the EMCV initiation codon and promote binding of a 43S complex. Accordingly, EMCV initiation does not involve scanning and does not require eIF1, eIF1A, and the eIF4E subunit of eIF4F. Nonetheless, initiation on some EMCV-like IRESs requires additional non-canonical initiation factors, which alter IRES conformation and promote binding of eIF4A/eIF4G. Initiation on the hepatitis C virus IRES is simpler: a 43S complex containing only eIF2 and eIF3 binds directly to the initiation codon as a result of specific interaction of the IRES and the 40S subunit.

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Pathway is converted from Reactome ID: 72613
Reactome-version 
Reactome version: 73

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Bibliography

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  1. Pause A, Belsham GJ, Gingras AC, Donzé O, Lin TA, Lawrence JC, Sonenberg N.; ''Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function.''; PubMed Europe PMC Scholia
  2. Sampath P, Mazumder B, Seshadri V, Fox PL.; ''Transcript-selective translational silencing by gamma interferon is directed by a novel structural element in the ceruloplasmin mRNA 3' untranslated region.''; PubMed Europe PMC Scholia
  3. Pestova TV, Borukhov SI, Hellen CU.; ''Eukaryotic ribosomes require initiation factors 1 and 1A to locate initiation codons.''; PubMed Europe PMC Scholia
  4. Mazumder B, Sampath P, Seshadri V, Maitra RK, DiCorleto PE, Fox PL.; ''Regulated release of L13a from the 60S ribosomal subunit as a mechanism of transcript-specific translational control.''; PubMed Europe PMC Scholia
  5. Grifo JA, Tahara SM, Morgan MA, Shatkin AJ, Merrick WC.; ''New initiation factor activity required for globin mRNA translation.''; PubMed Europe PMC Scholia
  6. Safer B, Adams SL, Anderson WF, Merrick WC.; ''Binding of MET-TRNAf and GTP to homogeneous initiation factor MP.''; PubMed Europe PMC Scholia
  7. Pestova TV, Shatsky IN, Hellen CU.; ''Functional dissection of eukaryotic initiation factor 4F: the 4A subunit and the central domain of the 4G subunit are sufficient to mediate internal entry of 43S preinitiation complexes.''; PubMed Europe PMC Scholia
  8. Merrick WC.; ''Eukaryotic protein synthesis: still a mystery.''; PubMed Europe PMC Scholia
  9. Kozak M.; ''Evaluation of the "scanning model" for initiation of protein synthesis in eucaryotes.''; PubMed Europe PMC Scholia
  10. Chakrabarti A, Maitra U.; ''Function of eukaryotic initiation factor 5 in the formation of an 80 S ribosomal polypeptide chain initiation complex.''; PubMed Europe PMC Scholia
  11. Trachsel H, Erni B, Schreier MH, Staehelin T.; ''Initiation of mammalian protein synthesis. II. The assembly of the initiation complex with purified initiation factors.''; PubMed Europe PMC Scholia
  12. Rowlands AG, Panniers R, Henshaw EC.; ''The catalytic mechanism of guanine nucleotide exchange factor action and competitive inhibition by phosphorylated eukaryotic initiation factor 2.''; PubMed Europe PMC Scholia
  13. Iost I, Dreyfus M, Linder P.; ''Ded1p, a DEAD-box protein required for translation initiation in Saccharomyces cerevisiae, is an RNA helicase.''; PubMed Europe PMC Scholia
  14. Benne R, Hershey JW.; ''The mechanism of action of protein synthesis initiation factors from rabbit reticulocytes.''; PubMed Europe PMC Scholia
  15. Schreier MH, Erni B, Staehelin T.; ''Initiation of mammalian protein synthesis. I. Purification and characterization of seven initiation factors.''; PubMed Europe PMC Scholia
  16. Sonenberg N, Rupprecht KM, Hecht SM, Shatkin AJ.; ''Eukaryotic mRNA cap binding protein: purification by affinity chromatography on sepharose-coupled m7GDP.''; PubMed Europe PMC Scholia
  17. Dever TE, Wei CL, Benkowski LA, Browning K, Merrick WC, Hershey JW.; ''Determination of the amino acid sequence of rabbit, human, and wheat germ protein synthesis factor eIF-4C by cloning and chemical sequencing.''; PubMed Europe PMC Scholia
  18. Merrick WC, Kemper WM, Anderson WF.; ''Purification and characterization of homogeneous initiation factor M2A from rabbit reticulocytes.''; PubMed Europe PMC Scholia
  19. Asano K, Clayton J, Shalev A, Hinnebusch AG.; ''A multifactor complex of eukaryotic initiation factors, eIF1, eIF2, eIF3, eIF5, and initiator tRNA(Met) is an important translation initiation intermediate in vivo.''; PubMed Europe PMC Scholia
  20. Peterson DT, Merrick WC, Safer B.; ''Binding and release of radiolabeled eukaryotic initiation factors 2 and 3 during 80 S initiation complex formation.''; PubMed Europe PMC Scholia
  21. Goumans H, Thomas A, Verhoeven A, Voorma HO, Benne R.; ''The role of eIF-4C in protein synthesis initiation complex formation.''; PubMed Europe PMC Scholia
  22. Imataka H, Gradi A, Sonenberg N.; ''A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation.''; PubMed Europe PMC Scholia
  23. Chuang RY, Weaver PL, Liu Z, Chang TH.; ''Requirement of the DEAD-Box protein ded1p for messenger RNA translation.''; PubMed Europe PMC Scholia
  24. Lahn BT, Page DC.; ''Functional coherence of the human Y chromosome.''; PubMed Europe PMC Scholia
  25. Yoder-Hill J, Pause A, Sonenberg N, Merrick WC.; ''The p46 subunit of eukaryotic initiation factor (eIF)-4F exchanges with eIF-4A.''; PubMed Europe PMC Scholia
  26. Pestova TV, Lomakin IB, Lee JH, Choi SK, Dever TE, Hellen CU.; ''The joining of ribosomal subunits in eukaryotes requires eIF5B.''; PubMed Europe PMC Scholia
  27. Damoc E, Fraser CS, Zhou M, Videler H, Mayeur GL, Hershey JW, Doudna JA, Robinson CV, Leary JA.; ''Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry.''; PubMed Europe PMC Scholia
  28. Majumdar R, Bandyopadhyay A, Maitra U.; ''Mammalian translation initiation factor eIF1 functions with eIF1A and eIF3 in the formation of a stable 40 S preinitiation complex.''; PubMed Europe PMC Scholia
  29. Dholakia JN, Wahba AJ.; ''Mechanism of the nucleotide exchange reaction in eukaryotic polypeptide chain initiation. Characterization of the guanine nucleotide exchange factor as a GTP-binding protein.''; PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
128373view17:49, 3 February 2024Ash iyerFixing error (check)
128372view17:45, 3 February 2024Ash iyeridentifier added
128371view17:43, 3 February 2024Ash iyereif1 identifier added.
128323view00:28, 1 February 2024EweitzOntology Term : 'translation pathway' added !
117720view12:33, 22 May 2021EweitzModified title
114979view16:50, 25 January 2021ReactomeTeamReactome version 75
113423view11:49, 2 November 2020ReactomeTeamReactome version 74
112625view16:00, 9 October 2020ReactomeTeamReactome version 73
101541view11:40, 1 November 2018ReactomeTeamreactome version 66
101076view21:23, 31 October 2018ReactomeTeamreactome version 65
100606view19:57, 31 October 2018ReactomeTeamreactome version 64
100157view16:42, 31 October 2018ReactomeTeamreactome version 63
99707view15:11, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99288view12:46, 31 October 2018ReactomeTeamreactome version 62
93969view13:48, 16 August 2017ReactomeTeamreactome version 61
93568view11:27, 9 August 2017ReactomeTeamreactome version 61
86670view09:23, 11 July 2016ReactomeTeamreactome version 56
83337view10:49, 18 November 2015ReactomeTeamVersion54
76969view08:25, 17 July 2014ReactomeTeamFixed remaining interactions
76674view12:04, 16 July 2014ReactomeTeamFixed remaining interactions
76136view13:23, 11 June 2014AnweshaRe-fixing comment source
75707view11:05, 10 June 2014ReactomeTeamReactome 48 Update
75062view13:57, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74706view08:46, 30 April 2014ReactomeTeamReactome46
45250view18:36, 7 October 2011AlexanderPicoOntology Term : 'translation initiation pathway' added !
42035view21:51, 4 March 2011MaintBotAutomatic update
39838view05:52, 21 January 2011MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
18S rRNA ProteinX03205 (EMBL)
28S rRNA ProteinM11167 (EMBL)
40S ribosomal complexComplexR-HSA-72392 (Reactome)
40S:Met-tRNAi:mRNAComplexR-HSA-72508 (Reactome)
40S:eIF3:eIF1AComplexR-HSA-72570 (Reactome)
43S complexComplexR-HSA-72571 (Reactome)
43S:

Ceruloplasmin

mRNA:eIF4F:eIF4B:eIF4H:PABP
ComplexR-HSA-156804 (Reactome)
43S:mRNA:eIF4F:eIF4B:eIF4HComplexR-HSA-72592 (Reactome)
48S complexComplexR-HSA-72594 (Reactome)
5.8S rRNA ProteinJ01866 (EMBL)
5S rRNA ProteinV00589 (EMBL)
60S ribosomal complexComplexR-HSA-72499 (Reactome)
60s ribosomal

complex lacking

L13a subunit
ComplexR-HSA-156817 (Reactome)
80S ribosomeComplexR-HSA-72500 (Reactome)
80S:Met-tRNAi:mRNA:eIF5B:GTPComplexR-HSA-72504 (Reactome)
80S:Met-tRNAi:mRNAComplexR-HSA-72505 (Reactome)
ADPMetaboliteCHEBI:456216 (ChEBI)
ATPMetaboliteCHEBI:30616 (ChEBI)
Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4HComplexR-HSA-156809 (Reactome)
Ceruloplasmin mRNA ProteinM13699 (EMBL)
EIF1AX ProteinP47813 (Uniprot-TrEMBL)
EIF1AXProteinP47813 (Uniprot-TrEMBL)
EIF2B1 ProteinQ14232 (Uniprot-TrEMBL)
EIF2B2 ProteinP49770 (Uniprot-TrEMBL)
EIF2B3 ProteinQ9NR50 (Uniprot-TrEMBL)
EIF2B4 ProteinQ9UI10 (Uniprot-TrEMBL)
EIF2B5 ProteinQ13144 (Uniprot-TrEMBL)
EIF2S1 ProteinP05198 (Uniprot-TrEMBL)
EIF2S1:EIF2S2:EIF2S3ComplexR-HSA-72515 (Reactome)
EIF2S2 ProteinP20042 (Uniprot-TrEMBL)
EIF2S3 ProteinP41091 (Uniprot-TrEMBL)
EIF3A ProteinQ14152 (Uniprot-TrEMBL)
EIF3B ProteinP55884 (Uniprot-TrEMBL)
EIF3C ProteinQ99613 (Uniprot-TrEMBL)
EIF3D ProteinO15371 (Uniprot-TrEMBL)
EIF3E ProteinP60228 (Uniprot-TrEMBL)
EIF3F ProteinO00303 (Uniprot-TrEMBL)
EIF3G ProteinO75821 (Uniprot-TrEMBL)
EIF3H ProteinO15372 (Uniprot-TrEMBL)
EIF3I ProteinQ13347 (Uniprot-TrEMBL)
EIF3J ProteinO75822 (Uniprot-TrEMBL)
EIF3K ProteinQ9UBQ5 (Uniprot-TrEMBL)
EIF3L ProteinQ9Y262 (Uniprot-TrEMBL)
EIF3M ProteinQ7L2H7 (Uniprot-TrEMBL)
EIF4A1 ProteinP60842 (Uniprot-TrEMBL)
EIF4A2 ProteinQ14240 (Uniprot-TrEMBL)
EIF4B ProteinP23588 (Uniprot-TrEMBL)
EIF4BProteinP23588 (Uniprot-TrEMBL)
EIF4E ProteinP06730 (Uniprot-TrEMBL)
EIF4EBP1 ProteinQ13541 (Uniprot-TrEMBL)
EIF4EBP1ProteinQ13541 (Uniprot-TrEMBL)
EIF4EProteinP06730 (Uniprot-TrEMBL)
EIF4G1 ProteinQ04637 (Uniprot-TrEMBL)
EIF4G1ProteinQ04637 (Uniprot-TrEMBL)
EIF4H ProteinQ15056 (Uniprot-TrEMBL)
EIF4HProteinQ15056 (Uniprot-TrEMBL)
EIF5B ProteinO60841 (Uniprot-TrEMBL)
EIF5ProteinP55010 (Uniprot-TrEMBL)
FAU ProteinP62861 (Uniprot-TrEMBL)
GDP MetaboliteCHEBI:17552 (ChEBI)
GDPMetaboliteCHEBI:17552 (ChEBI)
GTP MetaboliteCHEBI:15996 (ChEBI)
GTPMetaboliteCHEBI:15996 (ChEBI)
L13a kinaseR-HSA-170641 (Reactome)
Met-tRNAi R-ALL-72393 (Reactome)
Met-tRNAiR-ALL-72393 (Reactome)
PABPC1 ProteinP11940 (Uniprot-TrEMBL)
PABPC1ProteinP11940 (Uniprot-TrEMBL)
PiMetaboliteCHEBI:18367 (ChEBI)
RNA-binding protein

in RNP (ribonucleoprotein)

complexes
R-ALL-72595 (Reactome)
RNA-binding protein in RNP (ribonucleoprotein) complexes R-ALL-72595 (Reactome)
RPL10 ProteinP27635 (Uniprot-TrEMBL)
RPL10A ProteinP62906 (Uniprot-TrEMBL)
RPL10L ProteinQ96L21 (Uniprot-TrEMBL)
RPL11 ProteinP62913 (Uniprot-TrEMBL)
RPL12 ProteinP30050 (Uniprot-TrEMBL)
RPL13 ProteinP26373 (Uniprot-TrEMBL)
RPL13A ProteinP40429 (Uniprot-TrEMBL)
RPL13AProteinP40429 (Uniprot-TrEMBL)
RPL14 ProteinP50914 (Uniprot-TrEMBL)
RPL15 ProteinP61313 (Uniprot-TrEMBL)
RPL17 ProteinP18621 (Uniprot-TrEMBL)
RPL18 ProteinQ07020 (Uniprot-TrEMBL)
RPL18A ProteinQ02543 (Uniprot-TrEMBL)
RPL19 ProteinP84098 (Uniprot-TrEMBL)
RPL21 ProteinP46778 (Uniprot-TrEMBL)
RPL22 ProteinP35268 (Uniprot-TrEMBL)
RPL22L1 ProteinQ6P5R6 (Uniprot-TrEMBL)
RPL23 ProteinP62829 (Uniprot-TrEMBL)
RPL23A ProteinP62750 (Uniprot-TrEMBL)
RPL24 ProteinP83731 (Uniprot-TrEMBL)
RPL26 ProteinP61254 (Uniprot-TrEMBL)
RPL26L1 ProteinQ9UNX3 (Uniprot-TrEMBL)
RPL27 ProteinP61353 (Uniprot-TrEMBL)
RPL27A ProteinP46776 (Uniprot-TrEMBL)
RPL28 ProteinP46779 (Uniprot-TrEMBL)
RPL29 ProteinP47914 (Uniprot-TrEMBL)
RPL3 ProteinP39023 (Uniprot-TrEMBL)
RPL30 ProteinP62888 (Uniprot-TrEMBL)
RPL31 ProteinP62899 (Uniprot-TrEMBL)
RPL32 ProteinP62910 (Uniprot-TrEMBL)
RPL34 ProteinP49207 (Uniprot-TrEMBL)
RPL35 ProteinP42766 (Uniprot-TrEMBL)
RPL35A ProteinP18077 (Uniprot-TrEMBL)
RPL36 ProteinQ9Y3U8 (Uniprot-TrEMBL)
RPL36A ProteinP83881 (Uniprot-TrEMBL)
RPL36AL ProteinQ969Q0 (Uniprot-TrEMBL)
RPL37 ProteinP61927 (Uniprot-TrEMBL)
RPL37A ProteinP61513 (Uniprot-TrEMBL)
RPL38 ProteinP63173 (Uniprot-TrEMBL)
RPL39 ProteinP62891 (Uniprot-TrEMBL)
RPL39L ProteinQ96EH5 (Uniprot-TrEMBL)
RPL3L ProteinQ92901 (Uniprot-TrEMBL)
RPL4 ProteinP36578 (Uniprot-TrEMBL)
RPL40 ProteinP62987 (Uniprot-TrEMBL)
RPL41 ProteinP62945 (Uniprot-TrEMBL)
RPL5 ProteinP46777 (Uniprot-TrEMBL)
RPL6 ProteinQ02878 (Uniprot-TrEMBL)
RPL7 ProteinP18124 (Uniprot-TrEMBL)
RPL7A ProteinP62424 (Uniprot-TrEMBL)
RPL8 ProteinP62917 (Uniprot-TrEMBL)
RPL9 ProteinP32969 (Uniprot-TrEMBL)
RPLP0 ProteinP05388 (Uniprot-TrEMBL)
RPLP1 ProteinP05386 (Uniprot-TrEMBL)
RPLP2 ProteinP05387 (Uniprot-TrEMBL)
RPS10 ProteinP46783 (Uniprot-TrEMBL)
RPS11 ProteinP62280 (Uniprot-TrEMBL)
RPS12 ProteinP25398 (Uniprot-TrEMBL)
RPS13 ProteinP62277 (Uniprot-TrEMBL)
RPS14 ProteinP62263 (Uniprot-TrEMBL)
RPS15 ProteinP62841 (Uniprot-TrEMBL)
RPS15A ProteinP62244 (Uniprot-TrEMBL)
RPS16 ProteinP62249 (Uniprot-TrEMBL)
RPS17 ProteinP08708 (Uniprot-TrEMBL)
RPS18 ProteinP62269 (Uniprot-TrEMBL)
RPS19 ProteinP39019 (Uniprot-TrEMBL)
RPS2 ProteinP15880 (Uniprot-TrEMBL)
RPS20 ProteinP60866 (Uniprot-TrEMBL)
RPS21 ProteinP63220 (Uniprot-TrEMBL)
RPS23 ProteinP62266 (Uniprot-TrEMBL)
RPS24 ProteinP62847 (Uniprot-TrEMBL)
RPS25 ProteinP62851 (Uniprot-TrEMBL)
RPS26 ProteinP62854 (Uniprot-TrEMBL)
RPS27 ProteinP42677 (Uniprot-TrEMBL)
RPS27A(77-156) ProteinP62979 (Uniprot-TrEMBL)
RPS27L ProteinQ71UM5 (Uniprot-TrEMBL)
RPS28 ProteinP62857 (Uniprot-TrEMBL)
RPS29 ProteinP62273 (Uniprot-TrEMBL)
RPS3 ProteinP23396 (Uniprot-TrEMBL)
RPS3A ProteinP61247 (Uniprot-TrEMBL)
RPS4X ProteinP62701 (Uniprot-TrEMBL)
RPS4Y1 ProteinP22090 (Uniprot-TrEMBL)
RPS4Y2 ProteinQ8TD47 (Uniprot-TrEMBL)
RPS5 ProteinP46782 (Uniprot-TrEMBL)
RPS6 ProteinP62753 (Uniprot-TrEMBL)
RPS7 ProteinP62081 (Uniprot-TrEMBL)
RPS8 ProteinP62241 (Uniprot-TrEMBL)
RPS9 ProteinP46781 (Uniprot-TrEMBL)
RPSA ProteinP08865 (Uniprot-TrEMBL)
eIF1R-ALL-72617 (Reactome)
eIF2:GDP: eIF2BComplexR-HSA-72529 (Reactome)
eIF2:GDPComplexR-HSA-72530 (Reactome)
eIF2:GTPComplexR-HSA-72531 (Reactome)
eIF2B subunits complexComplexR-HSA-72526 (Reactome)
eIF3 subunits complexComplexR-HSA-72555 (Reactome)
eIF4A subunits complexComplexR-HSA-72576 (Reactome)
eIF4E:4E-BPComplexR-HSA-72581 (Reactome)
eIF4F:mRNPComplexR-HSA-72597 (Reactome)
eIF4FComplexR-HSA-72587 (Reactome)
eIF5B:GDPComplexR-HSA-72502 (Reactome)
eIF5B:GTPComplexR-HSA-72503 (Reactome)
mRNA R-HSA-72323 (Reactome)
mRNA:eIF4F:eIF4B:eIF4HComplexR-HSA-72593 (Reactome)
mRNPComplexR-HSA-72596 (Reactome)
p-RPL13A ProteinP40429 (Uniprot-TrEMBL)
p-RPL13AProteinP40429 (Uniprot-TrEMBL)
phospho-L13a

associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation

initiation complex
ComplexR-HSA-156824 (Reactome)
ternary complexComplexR-HSA-72532 (Reactome)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
40S ribosomal complexArrowR-HSA-72673 (Reactome)
40S ribosomal complexR-HSA-72676 (Reactome)
40S:Met-tRNAi:mRNAArrowR-HSA-72619 (Reactome)
40S:Met-tRNAi:mRNAR-HSA-72672 (Reactome)
40S:eIF3:eIF1AArrowR-HSA-72676 (Reactome)
40S:eIF3:eIF1AR-HSA-72691 (Reactome)
43S complexArrowR-HSA-72691 (Reactome)
43S complexR-HSA-156808 (Reactome)
43S complexR-HSA-157849 (Reactome)
43S:

Ceruloplasmin

mRNA:eIF4F:eIF4B:eIF4H:PABP
ArrowR-HSA-156808 (Reactome)
43S:

Ceruloplasmin

mRNA:eIF4F:eIF4B:eIF4H:PABP
R-HSA-156823 (Reactome)
43S:mRNA:eIF4F:eIF4B:eIF4HArrowR-HSA-157849 (Reactome)
43S:mRNA:eIF4F:eIF4B:eIF4HR-HSA-72621 (Reactome)
48S complexArrowR-HSA-72621 (Reactome)
48S complexArrowR-HSA-72697 (Reactome)
48S complexR-HSA-72619 (Reactome)
48S complexR-HSA-72697 (Reactome)
60S ribosomal complexArrowR-HSA-72673 (Reactome)
60S ribosomal complexR-HSA-156826 (Reactome)
60S ribosomal complexR-HSA-72672 (Reactome)
60s ribosomal

complex lacking

L13a subunit
ArrowR-HSA-156826 (Reactome)
80S ribosomeR-HSA-72673 (Reactome)
80S:Met-tRNAi:mRNA:eIF5B:GTPArrowR-HSA-72672 (Reactome)
80S:Met-tRNAi:mRNA:eIF5B:GTPR-HSA-72671 (Reactome)
80S:Met-tRNAi:mRNAArrowR-HSA-72671 (Reactome)
ADPArrowR-HSA-156832 (Reactome)
ADPArrowR-HSA-72621 (Reactome)
ADPArrowR-HSA-72647 (Reactome)
ATPArrowR-HSA-72621 (Reactome)
ATPR-HSA-156832 (Reactome)
ATPR-HSA-72621 (Reactome)
ATPR-HSA-72647 (Reactome)
Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4HR-HSA-156808 (Reactome)
EIF1AXArrowR-HSA-156808 (Reactome)
EIF1AXArrowR-HSA-157849 (Reactome)
EIF1AXArrowR-HSA-72619 (Reactome)
EIF1AXArrowR-HSA-72673 (Reactome)
EIF1AXArrowR-HSA-72697 (Reactome)
EIF1AXR-HSA-156808 (Reactome)
EIF1AXR-HSA-157849 (Reactome)
EIF1AXR-HSA-72673 (Reactome)
EIF1AXR-HSA-72676 (Reactome)
EIF1AXR-HSA-72697 (Reactome)
EIF2S1:EIF2S2:EIF2S3ArrowR-HSA-72697 (Reactome)
EIF2S1:EIF2S2:EIF2S3R-HSA-72663 (Reactome)
EIF2S1:EIF2S2:EIF2S3R-HSA-72697 (Reactome)
EIF4BArrowR-HSA-72619 (Reactome)
EIF4BR-HSA-72647 (Reactome)
EIF4EArrowR-HSA-72619 (Reactome)
EIF4EArrowR-HSA-72622 (Reactome)
EIF4EBP1ArrowR-HSA-72622 (Reactome)
EIF4ER-HSA-72631 (Reactome)
EIF4G1ArrowR-HSA-72619 (Reactome)
EIF4G1R-HSA-72631 (Reactome)
EIF4HArrowR-HSA-72619 (Reactome)
EIF4HR-HSA-72647 (Reactome)
EIF5ArrowR-HSA-72619 (Reactome)
EIF5ArrowR-HSA-72697 (Reactome)
EIF5R-HSA-72619 (Reactome)
EIF5R-HSA-72697 (Reactome)
GDPArrowR-HSA-72722 (Reactome)
GTPArrowR-HSA-72669 (Reactome)
GTPR-HSA-72663 (Reactome)
GTPR-HSA-72722 (Reactome)
L13a kinasemim-catalysisR-HSA-156832 (Reactome)
Met-tRNAiR-HSA-72669 (Reactome)
PABPC1R-HSA-156808 (Reactome)
PiArrowR-HSA-72619 (Reactome)
PiArrowR-HSA-72621 (Reactome)
PiArrowR-HSA-72647 (Reactome)
PiArrowR-HSA-72671 (Reactome)
R-HSA-156808 (Reactome) The precise order of events leading to the circularization of poly (A) mRNA during translation initiation is unknown. Here the association of PABP with the poly (A) mRNA and the association of PABP with eIF4F are represented as occuring simultaneously after formation of the initiation complex. However, it is also possible that these interactions occur during the formation of the translation initiation complex. The binding of eIF4F to the cap and binding of PABP to the poly (A) tail, for example, may occur at the same time. In fact, the eIF4G-PABP interaction helps eIF4F to bind tighter to the cap (Borman et al. 2000.) In addition, eIF4B and eIF4H bind more transiently to the mRNA and may not be part of an initial complex in which PABP has not yet touched eIF4G.
R-HSA-156823 (Reactome) Although the mechanism through which L13a prevents translation initiation has not been determined, Mazumder et al. (2003) have described four alternatives. L13a could (1) inhibit the function of eIF4F, (2) block the recruitment of the 43S preinitiation complex, (3) prevent scanning of the 43S complex to the initiation codon, or 4) interfere with joining of the 60S ribosomal subunit.
R-HSA-156826 (Reactome) The L13a subunit of the 60s ribosome is phosphorylated about 16 hours after INF gamma induction by an unknown kinase. At this time, L13a is also released from the 60s subunit (Mazumder et al.,2003). It is unclear, however, whether phosphorylation occurs before or after the release of L13a. Here, phosphorylation is shown as occurring after release.
R-HSA-156832 (Reactome) The L13a subunit of the 60s ribosome is phosphorylated about 16 hours after INF gamma induction by an unknown kinase. At this time, L13a is also released from the 60s subunit (Mazumder et al.,2003). It is unclear, however, whether phosphorylation occurs before or after the release of L13a. Here, phosphorylation is shown as occurring after release.
R-HSA-157849 (Reactome) The translation initiation complex forms when the 43S complex binds the mRNA that is associated with eIF4F, eIF4B and eIF4H. eIF4G in the eIF4F complex can directly contact eIF3 in the 43S complex. eIF1A is necessary for the formation of this complex.
R-HSA-72619 (Reactome) Once the Met-tRNAi has recognized the AUG, eIF2-bound GTP is hydrolyzed. The reaction is catalyzed by eIF5 (or eIF5B) and is thought to cause dissociation of all other initiation factors and allow joining of the large 60S ribosomal subunit. Release of the initiation factors from 40S leaves the Met-tRNAi in the ribosomal P-site base-paired to the start codon on the mRNA.
R-HSA-72621 (Reactome) The mRNA-bound ribosomal complex moves along the 5'-untranslated region (5'-UTR) of the mRNA from its initial site to the initiation codon to form a 48S complex, in which the initiation codon (AUG) is base paired to the anticodon of the Met-tRNAi. It is not known whether eIF4A (or another ATPase, such as DED1) facilitates scanning by melting mRNA secondary structures or by actively propelling the ribosome.
R-HSA-72622 (Reactome) eIF4E gets released from the inactive eIF4E:4EBP complex.
R-HSA-72631 (Reactome) eIF4A interacts with eIF4G, and eIF4E interacts with the amino-terminal domain of eIF4G to form the cap-binding complex eIF4F.
R-HSA-72635 (Reactome) The factor eIF4E within the eIF4F (cap-binding) complex directly binds the 5'-cap on eukaryotic mRNAs. Note that the mRNA is in complex with cytoplasmic proteins constituting an mRNP complex.
R-HSA-72647 (Reactome) The DEAD-box RNA helicase eIF4A, together with the RNA-binding proteins eIF4B or eIF4H, is thought to unwind RNA secondary structures near the 5'-end of the mRNA and in the presence of ATP.
R-HSA-72663 (Reactome) Activation of eIF2 through direct binding of GTP.
R-HSA-72669 (Reactome) The ternary complex forms upon binding of the initiator methionyl-tRNA to the active eIF2:GTP complex.
R-HSA-72670 (Reactome) Inactive eIF2:GDP binds eIF2B to form an eIF2:GDP:eIF2B intermediate.
R-HSA-72671 (Reactome) Once the 60S subunit joins the translation initiation complex, eIF5B hydrolyzes its GTP and is released from the now 80S monosome. The fully assembled 80s ribosome is now ready to start elongation of the polypeptide chain.
R-HSA-72672 (Reactome) Joining of the 60S subunit to form the 80S ribosome is catalyzed by the presence of GTP-bound eIF5B.
R-HSA-72673 (Reactome) 80S monosomes dissociate into 40S and 60S ribosomal subunits. eIF1A promotes this dissociation.
R-HSA-72676 (Reactome) eIF3 and eIF1A bind to the 40S ribosomal subunit.
R-HSA-72691 (Reactome) The ternary complex (Met-tRNAi:eIF2:GTP) binds to the complex formed by the 40S subunit, eIF3 and eIF1A, to form the 43S complex. eIF1A promotes binding of the ternary complex to the 40S subunit within 43S. The initiator methionyl-tRNA from the ternary complex is positioned at the ribosomal P site.
R-HSA-72697 (Reactome) The AUG initiation codon in the mRNA is recognized by base pairing with the anticodon of the Met-tRNAi. This reaction requires eIF1, eIF1A, eIF2 and eIF5.
R-HSA-72722 (Reactome) eIF2B is a guanine nucleotide releasing factor that is required to cause GDP release so that a new GTP molecule can bind and activate eIF2, so that it can be reused.
RNA-binding protein

in RNP (ribonucleoprotein)

complexes
ArrowR-HSA-72647 (Reactome)
RPL13AArrowR-HSA-156826 (Reactome)
RPL13AR-HSA-156832 (Reactome)
eIF1ArrowR-HSA-72697 (Reactome)
eIF1R-HSA-72619 (Reactome)
eIF1R-HSA-72697 (Reactome)
eIF1mim-catalysisR-HSA-72621 (Reactome)
eIF1mim-catalysisR-HSA-72697 (Reactome)
eIF2:GDP: eIF2BArrowR-HSA-72670 (Reactome)
eIF2:GDP: eIF2BR-HSA-72722 (Reactome)
eIF2:GDPArrowR-HSA-72619 (Reactome)
eIF2:GDPR-HSA-72670 (Reactome)
eIF2:GTPArrowR-HSA-72663 (Reactome)
eIF2:GTPArrowR-HSA-72722 (Reactome)
eIF2:GTPR-HSA-72669 (Reactome)
eIF2B subunits complexArrowR-HSA-72722 (Reactome)
eIF2B subunits complexR-HSA-72670 (Reactome)
eIF2B subunits complexmim-catalysisR-HSA-72722 (Reactome)
eIF3 subunits complexArrowR-HSA-72619 (Reactome)
eIF3 subunits complexR-HSA-72676 (Reactome)
eIF4A subunits complexArrowR-HSA-72619 (Reactome)
eIF4A subunits complexArrowR-HSA-72647 (Reactome)
eIF4A subunits complexR-HSA-72631 (Reactome)
eIF4A subunits complexR-HSA-72647 (Reactome)
eIF4A subunits complexmim-catalysisR-HSA-72647 (Reactome)
eIF4E:4E-BPR-HSA-72622 (Reactome)
eIF4F:mRNPArrowR-HSA-72635 (Reactome)
eIF4F:mRNPR-HSA-72647 (Reactome)
eIF4FArrowR-HSA-72631 (Reactome)
eIF4FR-HSA-72635 (Reactome)
eIF5B:GDPArrowR-HSA-72671 (Reactome)
eIF5B:GTPR-HSA-72672 (Reactome)
mRNA:eIF4F:eIF4B:eIF4HArrowR-HSA-72647 (Reactome)
mRNA:eIF4F:eIF4B:eIF4HR-HSA-157849 (Reactome)
mRNPR-HSA-72635 (Reactome)
p-RPL13AArrowR-HSA-156832 (Reactome)
p-RPL13AR-HSA-156823 (Reactome)
phospho-L13a

associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation

initiation complex
ArrowR-HSA-156823 (Reactome)
ternary complexArrowR-HSA-72669 (Reactome)
ternary complexR-HSA-72691 (Reactome)

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