Mitochondrial complex inhibition leading to liver injury (Homo sapiens)

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KCNKE1545: Decrease in mitochondrial phosphorilationKE888: Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)Assembly of mitochondrial complex IImpaired proteostasisUnfolded Protein ResponseKE887: Inhibition, NADH-ubiquinone oxidoreductase (complex I)KE177: N/A, Mitochondrial dysfunction 1KE889: Impaired, ProteostasisAutophagyNecrosisApoptosisFerroptosisKE55: N/A, Cell injury/deathElectron Transport Chain (oxidative phosphorylation)KE1549: Liver injuryKE1548: Necrotic tissueNecrosisKE1543: Mitochondrial Complex IV inhibitionKE1654: Binding of inhibitor to mitochondrial complex IVKE1542: Mitochondrial Complex III antagonismKE1653: Binding of inhibitor to mitochondrial complex IIIKE1544: Mitochondrial Complex V inhibitionKE1655: Binding of inhibitor to mitochondrial complex VAssembly of mitochondrial complex IIIAssembly of mitochondrial complex IVNefazodoneMetforminEntacaponeAmiodaroneBenzbromaroneAntimycin A1OligomycinAurovertinNefazodoneAmiodaroneDiclofenac sodiumFenpyroximatePyridabenRotenone


Description

This is the AOP represented in https://aopwiki.org/aops/273: Mitochondrial complex inhibition leading to liver injury.

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Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

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CompareRevisionActionTimeUserComment
129109view20:50, 11 March 2024AlexanderPicomanually fixed ontology encoding
129100view06:30, 11 March 2024EgonwOntology Term : 'disease pathway' added !
128629view03:09, 17 February 2024EweitzFix typo, standardize case
128608view20:49, 15 February 2024Marvin M2Removed stressors
128607view20:29, 15 February 2024Marvin M2
118505view09:15, 28 May 2021FinterlyReplace DataNode Type "Key Event" with "Event"
116642view11:33, 9 May 2021EweitzModified title
115244view17:16, 7 February 2021EgonwReplaced links to a deleted pathway to another necrosis pathway
114318view17:02, 6 January 2021Marvin M2New pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Amiodarone
Antimycin A1
ApoptosisPathwayWP1772 (WikiPathways)
Assembly of mitochondrial complex IIIPathwayWP4921 (WikiPathways)
Assembly of mitochondrial complex IVPathwayWP4922 (WikiPathways)
Assembly of mitochondrial complex IPathwayWP4324 (WikiPathways)
Aurovertin
AutophagyPathwayWP4923 (WikiPathways)
Benzbromarone
Diclofenac sodium
Electron Transport Chain (oxidative phosphorylation)PathwayWP111 (WikiPathways)
Entacapone
Fenpyroximate
FerroptosisPathwayWP4313 (WikiPathways)
Impaired proteostasisPathwayWP4918 (WikiPathways)
KCN
KE1542: Mitochondrial Complex III antagonism1542 (AOP-Wiki KE)
KE1543: Mitochondrial Complex IV inhibition1543 (AOP-Wiki KE)
KE1544: Mitochondrial Complex V inhibition1544 (AOP-Wiki KE)
KE1545: Decrease in mitochondrial phosphorilation
KE1548: Necrotic tissue1548 (AOP-Wiki KE)
KE1549: Liver injury1549 (AOP-Wiki KE)
KE1653: Binding of inhibitor to mitochondrial complex III1653 (AOP-Wiki KE)
KE1654: Binding of inhibitor to mitochondrial complex IV1654 (AOP-Wiki KE)
KE1655: Binding of inhibitor to mitochondrial complex V1655 (AOP-Wiki KE)
KE177: N/A, Mitochondrial dysfunction 1Key Event177 (AOP-Wiki KE)
KE55: N/A, Cell injury/death Key Event55 (AOP-Wiki KE)
KE887: Inhibition, NADH-ubiquinone oxidoreductase (complex I)Key Event887 (AOP-Wiki KE)
KE888: Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)Key Event888 (AOP-Wiki KE)
KE889: Impaired, Proteostasis Key Event889 (AOP-Wiki KE)
Metformin
NecrosisPathwayWP5022 (WikiPathways)
Nefazodone
Oligomycin
Pyridaben
Rotenone
Unfolded Protein ResponsePathwayWP4925 (WikiPathways)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5034"