Burn wound healing (Rattus norvegicus)

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Pecam1PdgfaLtaCol1a1Igf1BaxActa1Krt6aCd44Col4a1Il1bVimTnfVegfaTimp1Dll4CNN2Cox2JunCasp3Il4Mmp9Tgfbr2Nfkb1Tgfb1Tgfbr1Glb1Col1a1Bcl-2EpoActa1Il10miR-let-7b1517104433143181512152123Lta41024, 181031831215181434, 17171818Mir7bCol1a222Mpo5TnfBcl26, 186HgfIl1b63, 6, 18Cxcl12Cxcr41313Vim13Fgf211SYCP116ANPEP16NTRK116BMP716TG16TSHRKLK816FRK1616GPR12PC16DPEP11616CACNA1SSRD5A116CCK16GABBR116AKAP116CD861616PDE4BBLVRA1616CCL316CHP116NOS216HK216CEACAM4TNC1616NF2ANKRD116CCNC1616PTGISADORA2B16TNFRSF11B16IGF1R16NRG116RSAD216MMP916SELL1616PTPN7KPNB116CNP1616CCNE1WFDC1816MAP3K1216Car416GCHFR1616LOC2490616PIK3R1FOS16IL1RL11616SMN116ADMRGS191616JAK2DLL11616CASP316PSEN1ROCK21616ARFGAP1SAFB16CXCL216SYK16CCR51616PRIM2stk31616SYPTP531616c5ar1PTGS21616GPR176ALOX5AP1616IL6ASNS16ACAT116ACVR116EDNRB16CPA11616cdc25bIL1B1616SHC316Upregulated GenesUp-& Down-regulated GenesDownregulated Genes


Description

Burn Wound Healing

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Quality Tags

Ontology Terms

 

Bibliography

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  1. ''''; , PubMed Europe PMC Scholia
  2. ''''; , PubMed Europe PMC Scholia
  3. ''''; , PubMed Europe PMC Scholia
  4. ''''; , PubMed Europe PMC Scholia
  5. Imam RA, Rizk AA; ''Efficacy of erythropoietin-pretreated mesenchymal stem cells in murine burn wound healing: possible in vivo transdifferentiation into keratinocytes.''; Folia Morphol (Warsz), 2019 PubMed Europe PMC Scholia
  6. Jeschke MG, Bolder U, Finnerty CC, Przkora R, Müller U, Maihöfer R, Thompson JC, Wolf SE, Herndon DN; ''The effect of hepatocyte growth factor on gut mucosal apoptosis and proliferation, and cellular mediators after severe trauma.''; Surgery, 2005 PubMed Europe PMC Scholia
  7. ''''; , PubMed Europe PMC Scholia
  8. Dasu MR, Herndon DN, Nesic O, Perez-Polo JR; ''IGF-I gene transfer effects on inflammatory elements present after thermal trauma.''; Am J Physiol Regul Integr Comp Physiol, 2003 PubMed Europe PMC Scholia
  9. Liu J, Luo C, Yin Z, Li P, Wang S, Chen J, He Q, Zhou J; ''Downregulation of let-7b promotes COL1A1 and COL1A2 expression in dermis and skin fibroblasts during heat wound repair.''; Mol Med Rep, 2016 PubMed Europe PMC Scholia
  10. Castleberry SA, Golberg A, Sharkh MA, Khan S, Almquist BD, Austen WG Jr, Yarmush ML, Hammond PT; ''Nanolayered siRNA delivery platforms for local silencing of CTGF reduce cutaneous scar contraction in third-degree burns.''; Biomaterials, 2016 PubMed Europe PMC Scholia
  11. Castleberry SA, Golberg A, Sharkh MA, Khan S, Almquist BD, Austen WG Jr, Yarmush ML, Hammond PT; ''Nanolayered siRNA delivery platforms for local silencing of CTGF reduce cutaneous scar contraction in third-degreeburns.''; Biomaterials, 2016 PubMed Europe PMC Scholia
  12. Abbas OL, Özatik O, Terzi YK, Özatik FY, Nar R, Turna G; ''The Notch Signaling System Is Involved in the Regulation of Reparative Angiogenesis in the Zone of Stasis.''; J Burn Care Res, 2017 PubMed Europe PMC Scholia
  13. Simonetti O, Lucarini G, Cirioni O, Zizzi A, Orlando F, Provinciali M, Di Primio R, Giacometti A, Offidani A; ''Delayed wound healing in aged skin rat models after thermal injury is associated with an increased MMP-9, K6 and CD44 expression.''; Burns, 2013 PubMed Europe PMC Scholia
  14. Avniel S, Arik Z, Maly A, Sagie A, Basst HB, Yahana MD, Weiss ID, Pal B, Wald O, Ad-El D, Fujii N, Arenzana-Seisdedos F, Jung S, Galun E, Gur E, Peled A; ''Involvement of the CXCL12/CXCR4 pathway in the recovery of skin following burns.''; J Invest Dermatol, 2006 PubMed Europe PMC Scholia
  15. Kibe Y, Takenaka H, Kishimoto S; ''Spatial and temporal expression of basic fibroblast growth factor protein during wound healing of rat skin.''; Br J Dermatol, 2000 PubMed Europe PMC Scholia
  16. Wei D, Ge S, Chen Y, Dai F, Su B; ''Expression of endogenous transforming growth factor-beta and its type I and type II receptors in rat burn wounds.''; Wound Repair Regen, 1997 PubMed Europe PMC Scholia
  17. Spies M, Dasu MR, Svrakic N, Nesic O, Barrow RE, Perez-Polo JR, Herndon DN; ''Gene expression analysis in burn wounds of rats.''; Am J Physiol Regul Integr Comp Physiol, 2002 PubMed Europe PMC Scholia
  18. Spies M, Nesic O, Barrow RE, Perez-Polo JR, Herndon DN; ''Liposomal IGF-1 gene transfer modulates pro- and anti-inflammatory cytokine mRNA expression in the burn wound.''; Gene Ther, 2001 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
134366view13:09, 21 July 2024EgonwRemoved template comments
125312view20:44, 31 January 2023LarsgwFix references
119585view07:17, 21 July 2021ExperiMedModified description
119565view11:45, 15 July 2021ExperiMedOntology Term : 'endothelial cell' added !
119564view11:45, 15 July 2021ExperiMedOntology Term : 'myofibroblast cell' added !
119563view11:45, 15 July 2021ExperiMedOntology Term : 'fibroblast' added !
119562view11:44, 15 July 2021ExperiMedOntology Term : 'keratinocyte' added !
119561view11:44, 15 July 2021ExperiMedOntology Term : 'immune response pathway' added !
119560view11:44, 15 July 2021ExperiMedOntology Term : 'cell-extracellular matrix signaling pathway' added !
117965view10:57, 23 May 2021EweitzModified title
116241view17:14, 21 April 2021EgonwUse Uniprot-TrEMBL instead of Uniprot-SwissProt
115636view09:50, 3 March 2021ExperiMededited references
115635view09:45, 3 March 2021ExperiMedadded full references
115634view09:39, 3 March 2021ExperiMedadded full references
115394view16:44, 17 February 2021ExperiMedfixed an interaction
115391view16:40, 17 February 2021ExperiMedremoved some comments
115375view16:30, 16 February 2021ExperiMedNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ACAT1GeneProductENSRNOG00000007862 (Ensembl)
ACVR1RnaENSRNOG00000005033 (Ensembl)
ADMRnaENSRNOG00000027030 (Ensembl)
ADORA2BGeneProductENSRNOG00000002922 (Ensembl)
AKAP1RnaENSRNOG00000002373 (Ensembl)
ALOX5APRnaENSRNOG00000000907 (Ensembl)
ANKRD1GeneProductENSRNOG00000018598 (Ensembl)
ANPEPRnaENSRNOG00000014610 (Ensembl)
ARFGAP1GeneProductENSRNOG00000043150 (Ensembl)
ASNSRnaENSRNOG00000007546 (Ensembl)
Acta1RnaENSRNOG00000017786 (Ensembl)
Acta1ProteinP68136 (Uniprot-SwissProt)
BLVRARnaENSRNOG00000011778 (Ensembl)
BMP7RnaENSRNOG00000053384 (Ensembl)
BaxProteinQ63690 (Uniprot-SwissProt)
Bcl-2RnaENSRNOG00000002791 (Ensembl)
Bcl2ProteinP10417 (Uniprot-SwissProt)
CACNA1SRnaENSRNOG00000046231 (Ensembl)
CASP3RnaENSRNOG00000010475 (Ensembl)
CCKRnaENSRNOG00000019321 (Ensembl)
CCL3RnaENSRNOG00000011205 (Ensembl)
CCNCRnaENSRNOG00000007719 (Ensembl)
CCNE1RnaENSRNOG00000014786 (Ensembl)
CCR5RnaENSRNOG00000049115 (Ensembl)
CD86RnaENSRNOG00000038835 (Ensembl)
CEACAM4RnaENSRNOG00000050105 (Ensembl)
CHP1GeneProductENSRNOG00000004742 (Ensembl)
CNN2ProteinQ9R1E9 (Uniprot-SwissProt)
CNPRnaENSRNOG00000017496 (Ensembl)
CPA1RnaENSRNOG00000010725 (Ensembl)
CXCL2RnaENSRNOG00000002792 (Ensembl)
Car4RnaENSRNOG00000002916 (Ensembl)
Casp3ProteinP55213 (Uniprot-SwissProt)
Cd44ProteinP26051 (Uniprot-SwissProt)
Col1a1 RnaENSRNOG00000003897 (Ensembl)
Col1a1ProteinP02454 (Uniprot-SwissProt)
Col1a2ProteinP02466 (Uniprot-SwissProt)
Col4a1ProteinF1MA59 (Uniprot-SwissProt)
Cox2ProteinS5RZM8 (Uniprot-SwissProt)
Cxcl12ProteinP40224 (Uniprot-SwissProt)
Cxcr4ProteinP70658 (Uniprot-SwissProt) Type your comment here
DLL1RnaENSRNOG00000059984 (Ensembl)
DPEP1RnaENSRNOG00000015880 (Ensembl)
Dll4ProteinD3ZHH1 (Uniprot-SwissProt)
EDNRBRnaENSRNOG00000010997 (Ensembl)
EpoProteinP29676 (Uniprot-SwissProt)
FOSRnaENSRNOG00000008015 (Ensembl)
FRKRnaENSRNOG00000000543 (Ensembl)
Fgf2ProteinP15655 (Uniprot-SwissProt)
GABBR1RnaENSRNOG00000000774 (Ensembl)
GCHFRRnaENSRNOG00000012290 (Ensembl)
GPR12RnaENSRNOG00000039832 (Ensembl)
GPR176GeneProductENSRNOG00000005971 (Ensembl)
Glb1ProteinD3ZUM4 (Uniprot-SwissProt)
HK2RnaENSRNOG00000006116 (Ensembl)
HgfProteinQ08048 (Uniprot-SwissProt)
IGF1RRnaENSRNOG00000014187 (Ensembl)
IL1BGeneProductENSRNOG00000004649 (Ensembl)
IL1RL1GeneProductENSRNOG00000014835 (Ensembl)
IL6RnaENSRNOG00000010278 (Ensembl)
Igf1ProteinP08025 (Uniprot-SwissProt)
Il10ProteinP29456 (Uniprot-SwissProt)
Il1bRnaENSRNOG00000004649 (Ensembl)
Il1bProteinP10749 (Uniprot-SwissProt)
Il4RnaENSRNOG00000007624 (Ensembl)
JAK2RnaENSRNOG00000059968 (Ensembl)
JunProteinP17325 (Uniprot-SwissProt) Type your comment here
KLK8RnaENSRNOG00000018580 (Ensembl)
KPNB1RnaENSRNOG00000009275 (Ensembl)
Krt6aProteinQ4FZU2 (Uniprot-SwissProt) Type your comment here
LOC24906RnaENSRNOG00000002820 (Ensembl)
LtaRnaENSRNOG00000000838 (Ensembl) Type your comment here
MAP3K12RnaENSRNOG00000015134 (Ensembl)
MMP9GeneProductENSRNOG00000017539 (Ensembl)
Mir7bRna3619435 (miRBase Sequence)
Mmp9ProteinP50282 (Uniprot-SwissProt)
MpoProteinP11247 (Uniprot-SwissProt) Type your comment here
NF2RnaENSRNOG00000007948 (Ensembl)
NOS2RnaENSRNOG00000057443 (Ensembl)
NRG1RnaENSRNOG00000010392 (Ensembl)
NTRK1RnaENSRNOG00000013953 (Ensembl)
Nfkb1ProteinQ63369 (Uniprot-SwissProt)
PCRnaENSRNOG00000019372 (Ensembl)
PDE4BRnaENSRNOG00000005905 (Ensembl)
PIK3R1RnaENSRNOG00000018903 (Ensembl)
PRIM2RnaENSRNOG00000012486 (Ensembl)
PSEN1RnaENSRNOG00000009110 (Ensembl)
PTGISGeneProductENSRNOG00000008245 (Ensembl)
PTGS2RnaENSRNOG00000002525 (Ensembl)
PTPN7RnaENSRNOG00000005807 (Ensembl)
PdgfaProteinP28576 (Uniprot-SwissProt)
Pecam1ProteinQ3SWT0 (Uniprot-SwissProt)
  • CD31
  • Type your comment here
RGS19RnaENSRNOG00000016547 (Ensembl)
ROCK2RnaENSRNOG00000004496 (Ensembl)
RSAD2RnaENSRNOG00000007539 (Ensembl)
SAFBGeneProductENSRNOG00000050543 (Ensembl)
SELLRnaENSRNOG00000002776 (Ensembl)
SHC3RnaENSRNOG00000014366 (Ensembl)
SMN1RnaENSRNOG00000018067 (Ensembl)
SRD5A1RnaENSRNOG00000017601 (Ensembl)
SYCP1RnaENSRNOG00000016835 (Ensembl)
SYKGeneProductENSRNOG00000012160 (Ensembl)
SYPGeneProductENSRNOG00000059720 (Ensembl)
TGRnaENSRNOG00000006104 (Ensembl)
TNCRnaENSRNOG00000058645 (Ensembl)
TNFRSF11BGeneProductENSRNOG00000008336 (Ensembl)
TP53GeneProductENSRNOG00000010756 (Ensembl)
TSHRRnaENSRNOG00000003972 (Ensembl)
Tgfb1RnaENSRNOG00000020652 (Ensembl)
Tgfbr1RnaENSRNOG00000007036 (Ensembl)
Tgfbr2RnaENSRNOG00000013265 (Ensembl)
Timp1RnaENSRNOG00000010208 (Ensembl)
TnfRnaENSRNOG00000000837 (Ensembl)
TnfProteinP06804 (Uniprot-SwissProt)
VegfaProteinP16612 (Uniprot-SwissProt)
VimProteinP20152 (Uniprot-SwissProt) Type your comment here
VimProteinP31000 (Uniprot-SwissProt)
WFDC18RnaENSRNOG00000037097 (Ensembl)
c5ar1GeneProductENSRNOG00000047800 (Ensembl)
cdc25bGeneProductENSRNOG00000021248 (Ensembl)
miR-let-7bRna
stk3RnaENSRNOG00000011278 (Ensembl)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5057"
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