IL-6 signaling pathway (Danio rerio)

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CYPlasma membraneDeubiquitinationPMCY->NUPalmitoylationTranslocationAutophosphorylationECRecruitmentCY->NUReceptorDesumoylationENEnzyme complexExtracellularDDGene SymbolProteolytic cleavageDemethylationMolecule in the pathwayCY->NUAccession Number: NetPath 18ControlCY->NUDGOPhosphorylationSumoylationEarly EndosomesMolecular associationMethylationComplex formationDephosphorylationDInhibitionMTDNUGolgi apparatusDDCytoplasmCY->ENDCY->NUDeacetylationDDLigandReactions through unknown mechanisms/moleculesERCY->NUGlycosylationD(Protein-Protein interaction)DEndoplasmic reticulumAcetylationDProteins in a complex interactionActivationDNucleusEndosomeMitochondrionUbiquitinationzgc:56064ppp2r4STAT5Bcebpbhnf1ail6stLOC557176IL6Rmap2k6hdac1zgc:123166pxnhsp90a.2cdk5ppp2r5ajuncebpbstat3nlk2zgc:77529STAT5AfynbBMXzgc:194486zgc:172209sgk1ppp2r5ebstat3jak1FESDKEYP-38B6.1stat1amap3k7stat3ep300aIL6Rptk2.1stat3ppp2r1bmapkapk2agsk3bppp2r5crps6kb1PRKCDcdk9LOC563639gab1ptk2bbIL6CD40sgk1ERBB3mapk14azgc:92124BADNFKB1LOC564517map3k7mapk1stat3fosTYK2pik3r2LOC562282hspb1zgc:110460stat1aerbb2NFKB1SOS1LOC559103stat3LOC567833map2k1grb2ptpn11ppp2cbjak2bstat1arb1LOC100001644VAV1foxo5CASP3plcg1btkwu:fc58a04zgc:101581raf1zgc:172250daxxim:6895423arPPP2R1ALOC571285cdk5r1zgc:175287ncoa1LOC563719ppp2r2drac1FOXO1Astat1astat3LOC792089casp9LOC792354wu:fc83c01IL6crebbpbHRASzgc:64137stat3SOCS3LOC569951mapk14ail6stmapk3


Description

No description

Comments

GenMAPP notes 
NetPath 18 - IL-6 signaling pathway. NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.
GenMAPP remarks 
http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP364(r28142) with a 81% conversion rate.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
116887view11:09, 15 May 2021EweitzModified title
86938view13:07, 15 July 2016MkutmonOntology Term : 'interleukin-6 signaling pathway' added !
68620view04:07, 6 July 2013MaintBotUpdated to 2013 gpml schema
40783view22:15, 1 March 2011MaintBotRemoved redundant pathway information and comments
34174view21:19, 9 December 2009MaintBotAutomatic update of empty xrefs
31351view20:30, 13 August 2009MaintBotFixed text labels
31032view01:14, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
BADGeneProduct58100 (Entrez Gene)
BMXGeneProduct
CASP3GeneProduct
CD40GeneProduct
DKEYP-38B6.1GeneProduct565849 (Entrez Gene)
ERBB3GeneProduct
FESGeneProduct
FOXO1AGeneProduct768121 (Entrez Gene)
HRASGeneProduct550286 (Entrez Gene)
IL6GeneProduct
IL6RGeneProduct100135755 (Entrez Gene)
LOC100001644GeneProduct100001644 (Entrez Gene)
LOC557176GeneProduct557176 (Entrez Gene)
LOC559103GeneProduct559103 (Entrez Gene)
LOC562282GeneProduct562282 (Entrez Gene)
LOC563639GeneProduct563639 (Entrez Gene)
LOC563719GeneProduct563719 (Entrez Gene)
LOC564517GeneProduct564517 (Entrez Gene)
LOC567833GeneProduct567833 (Entrez Gene)
LOC569951GeneProduct569951 (Entrez Gene)
LOC571285GeneProduct571285 (Entrez Gene)
LOC792089GeneProduct792089 (Entrez Gene)
LOC792354GeneProduct792354 (Entrez Gene)
NFKB1GeneProduct565756 (Entrez Gene)
PPP2R1AGeneProduct406685 (Entrez Gene)
PRKCDGeneProduct334571 (Entrez Gene)
SOCS3GeneProduct
SOS1GeneProduct
STAT5AGeneProduct
STAT5BGeneProduct
TYK2GeneProduct
VAV1GeneProduct
arGeneProduct100005148 (Entrez Gene)
btkGeneProduct568653 (Entrez Gene)
casp9GeneProduct492763 (Entrez Gene)
cdk5GeneProduct65234 (Entrez Gene)
cdk5r1GeneProduct436788 (Entrez Gene)
cdk9GeneProduct321602 (Entrez Gene)
cebpbGeneProduct140814 (Entrez Gene)
crebbpbGeneProduct503776 (Entrez Gene)
daxxGeneProduct561006 (Entrez Gene)
ep300aGeneProduct559273 (Entrez Gene)
erbb2GeneProduct386966 (Entrez Gene)
fosGeneProduct394198 (Entrez Gene)
foxo5GeneProduct30296 (Entrez Gene)
fynbGeneProduct574422 (Entrez Gene)
gab1GeneProduct406666 (Entrez Gene)
grb2GeneProduct406308 (Entrez Gene)
gsk3bGeneProduct30654 (Entrez Gene)
hdac1GeneProduct192302 (Entrez Gene)
hnf1aGeneProduct266961 (Entrez Gene)
hsp90a.2GeneProduct565155 (Entrez Gene)
hspb1GeneProduct368243 (Entrez Gene)
il6stGeneProduct100006778 (Entrez Gene)
im:6895423GeneProduct566032 (Entrez Gene)
jak1GeneProduct30280 (Entrez Gene)
jak2bGeneProduct30298 (Entrez Gene)
junGeneProduct335916 (Entrez Gene)
map2k1GeneProduct406728 (Entrez Gene)
map2k6GeneProduct65239 (Entrez Gene)
map3k7GeneProduct553788 (Entrez Gene)
mapk1GeneProduct360144 (Entrez Gene)
mapk14aGeneProduct65237 (Entrez Gene)
mapk3GeneProduct399480 (Entrez Gene)
mapkapk2aGeneProduct327321 (Entrez Gene)
ncoa1GeneProduct563288 (Entrez Gene)
nlk2GeneProduct563460 (Entrez Gene)
pik3r2GeneProduct404211 (Entrez Gene)
plcg1GeneProduct373867 (Entrez Gene)
ppp2cbGeneProduct406582 (Entrez Gene)
ppp2r1bGeneProduct449548 (Entrez Gene)
ppp2r2dGeneProduct327263 (Entrez Gene)
ppp2r4GeneProduct445031 (Entrez Gene)
ppp2r5aGeneProduct562460 (Entrez Gene)
ppp2r5cGeneProduct557208 (Entrez Gene)
ppp2r5ebGeneProduct373878 (Entrez Gene)
ptk2.1GeneProduct142986 (Entrez Gene)
ptk2bbGeneProduct245950 (Entrez Gene)
ptpn11GeneProduct333979 (Entrez Gene)
pxnGeneProduct399546 (Entrez Gene)
rac1GeneProduct327204 (Entrez Gene)
raf1GeneProduct30716 (Entrez Gene)
rb1GeneProduct777733 (Entrez Gene)
rps6kb1GeneProduct406349 (Entrez Gene)
sgk1GeneProduct324140 (Entrez Gene)
stat1aGeneProduct30768 (Entrez Gene)
stat3GeneProduct30767 (Entrez Gene)
wu:fc58a04GeneProduct325179 (Entrez Gene)
wu:fc83c01GeneProduct325488 (Entrez Gene)
zgc:101581GeneProduct493617 (Entrez Gene)
zgc:110460GeneProduct573991 (Entrez Gene)
zgc:123166GeneProduct100002802 (Entrez Gene)
zgc:172209GeneProduct562720 (Entrez Gene)
zgc:172250GeneProduct100002225 (Entrez Gene)
zgc:175287GeneProduct571588 (Entrez Gene)
zgc:194486GeneProduct568951 (Entrez Gene)
zgc:56064GeneProduct393885 (Entrez Gene)
zgc:64137GeneProduct799566 (Entrez Gene)
zgc:77529GeneProduct406610 (Entrez Gene)
zgc:92124GeneProduct447804 (Entrez Gene)

Annotated Interactions

No annotated interactions
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